Effect of mifepristone on-expression of survivin in endometriotic rats

Objective To explore the effect of mifepristone on expression of survivin in endometriotic rats. Methods Endometriotic rats were randomly divided into control group and mifepristone group (including low-dose and high -dose groups). 4 weeks after gastrogavage with tuwen-80 only (control group) or tuwen-80 plus mifepristone 0.62 mg/d (low -dose group) or 1.24 mg/d(high-dose group), all of the rats were killed and tissues of ectopic and eutopic endometrium were removed for detecting survivin-expression via immunohistochemistry (SP method).Results (1) In the eutopic endometium,the expression intensity of survivin in the high-dose group was lower than that in the low-dose group and the control group (P 0.05). (2) In the ectopic endometium , the expression intensity of survivin in the high -dose group was lower than that in the low -dose group (P 0.05) and the control group (P 0.01). The expression intensity of survivin in the low dose group was lower than that in the control group (P 0.01).(3) In both high -dose and low -dose groups, the expression intensity of survivin in the ectopic endometrium was lower than that in the eutopic endometrium (P 0.01), but in the control group, the expression intensity of survivin in the ectopic endometrium was higher than that in the eutopic endometrium (P 0.05). Conclusion The treatment effect of mifepristone on EMS might be related with decreased expression of survivin.