Level of serum soluble Tim-3 expression in early-phase acute pancreatitis.

Lin M, Huang J, Liu SL, Chen WC
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019 · doi:10.5152/tjg.2018.18137 · PMID:30459127 · PMC6408170
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This prospective clinical study investigated the role of serum soluble Tim-3 (sTim-3) in the early phase of acute pancreatitis by comparing 44 patients with varying disease severity against 20 healthy volunteers. The researchers measured levels of sTim-3 alongside pro-inflammatory cytokines IL-6 and TNF-alpha, as well as the anti-inflammatory cytokine IL-10, using enzyme-linked immunosorbent assays. Results showed that sTim-3 levels were significantly elevated in both mild and non-mild acute pancreatitis groups compared to controls, correlating positively with inflammatory markers and the APACHE II score. The authors concluded that sTim-3 participates in early disease progression by regulating pro-inflammatory cytokines and serves as an early predictive marker for acute pancreatitis severity. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Background/aimsT-cell immunoglobulin and mucin domain 3 (Tim-3) assumedly play a crucial immunomodulatory role in inflammatory response. Data on the potential role of soluble Tim-3 (sTim-3) in acute pancreatitis (AP) are scarce. We conducted a prospective clinical study to characterize its role in the early-phase AP.MethodsIn total, 44 patients with AP (16 mild and 28 none-mild) who presented within 24 hours on admission and 20 healthy volunteers (NC) were included in our study. Serum interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α, and sTim-3 levels were detected using enzyme-linked immunosorbent assay (ELISA).ResultsLevels of the pro-inflammatory cytokines IL-6 and TNF-α and the anti-inflammatory cytokine IL-10 in the none-mild and mild groups were significantly elevated compared with those of the NC group. The sTim-3 levels of the none-mild and mild group were significantly increased compared with the NC. The sTim-3 level positively correlated with the IL-6 and TNF-α but showed no obvious correlations with the IL-10 level. The sTim-3 level positively correlated with the APACHE II score.ConclusionThe results indicate that sTim-3 participates in the early progression of AP by positively regulating the pro-inflammatory cytokines and that the measurement of serum sTim-3 is an early marker for predicting AP.
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Abstract

Background/Aims: T-cell immunoglobulin and mucin domain 3 (Tim-3) assumedly play a crucial immunomodulatory role in inflammatory response. Data on the potential role of soluble Tim-3 (sTim-3) in acute pancreatitis (AP) are scarce. We conducted a prospective clinical study to characterize its role in the early-phase AP.

Methods

In total, 44 patients with AP (16 mild and 28 none-mild) who presented within 24 hours on admission and 20 healthy volunteers (NC) were included in our study. Serum interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α, and sTim-3 levels were detected using enzyme-linked immunosorbent assay (ELISA).

Results

Levels of the pro-inflammatory cytokines IL-6 and TNF-α and the anti-inflammatory cytokine IL-10 in the none-mild and mild groups were significantly elevated compared with those of the NC group. The sTim-3 levels of the none-mild and mild group were significantly increased compared with the NC. The sTim-3 level positively correlated with the IL-6 and TNF-α but showed no obvious correlations with the IL-10 level. The sTim-3 level positively correlated with the APACHE II score.

Conclusion

The results indicate that sTim-3 participates in the early progression of AP by positively regulating the pro-inflammatory cytokines and that the measurement of serum sTim-3 is an early marker for predicting AP. Cite this article as: Lin M, Huang J, Huang J, Liu SI, Chen WC. Level of serum soluble Tim-3 expression in early-phase acute pancreatitis. Turk J Gastroenterol 2019; 30(2): 188-91. Article Info Published In Journal Turkish Journal of Gastroenterology Volume / Issue Volume 30 · Issue 2 Pages 188-191 History Published Online July 25, 2019 Copyright Copyright (c) 2019 Min Lin, Jin Huang, Jian Huang, Sheng-lan Liu, Wei-Chang Chen Affiliations Min Lin Department of Gastroenterology the Affiliated Changzhou No.2 People’s Hospital with Nanjing Medical University Changzhou China Jin Huang Department of Gastroenterology the Affiliated Changzhou No.2 People’s Hospital with Nanjing Medical University Changzhou China Jian Huang Department of Gastroenterology the First Affiliated Hospital of Soochow University Suzhou China Sheng-lan Liu Department of ICU the First Affiliated Hospital of Soochow University Suzhou China Wei-Chang Chen Department of Gastroenterology the First Affiliated Hospital of Soochow University Suzhou China Cite this Article Lin, M., Huang, J., Huang, J., Liu, S.- lan, & Chen, W.-C. (2019). Level of serum soluble Tim-3 expression in early-phase acute pancreatitis. Turkish Journal of Gastroenterology, 30(2), 188–191. https://doi.org/10.5152/tjg.2018.18137 Outlines

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