Narrative Review of Chronic Inflammation in Uterine Myoma: Lack of Specialized Pro-Resolving Lipid Mediators (SPMs) and Vitamin D as a Potential Reason for the Development of Uterine Fibroids

Pedro‐Antonio Regidor, Manuela Mayr, Fernando Gonzalez Santos, Fernando González Santos, Benjamin F. Calvo, Beatriz Lazcoz Calvo, Rocío Gutiérrez, Rocio Gutierrez, Jose Miguel Rizo
Biomedicines · 2025 · vol. 13(8) , pp. 1832 · doi:10.3390/biomedicines13081832 · PMID:40868086 · W4412691373
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review explores the role of chronic inflammation, a potential deficiency in specialized pro-resolving lipid mediators (SPMs), and low vitamin D levels in the development and growth of uterine fibroids.

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Abstract

Uterine leiomyoma (uterine fibroids, UF) are benign myometrium tumors that affect up to 70% of the female population and may lead to severe clinical symptoms. Despite the high prevalence, pathogenesis of UF is not understood and involves cytokines, steroid hormones, and growth factors. Additionally, an increased deposition and remodelling of the extracellular matrix is characteristic for UF. Vitamin D seems to play a new role in UF. Interestingly, hypovitaminosis D correlates with a higher prevalence of myomas and the severity of the myomas. Administration of vitamin D in women with insufficiency (serum level <30 ng/mL) restored the vitamin D status and reduced the mild symptoms of myomas. In addition, inflammatory processes may play a role. In the past years, it has become clear that cessation of inflammation is an active process driven by a class of lipid mediator molecules called specialized pro-resolving mediators (SPM). Inadequate resolution of inflammation is related to several chronic inflammatory diseases and several studies have proven the crucial role of SPMs in improving these diseases. In this review, we will give an overview on processes involved in UF growth and will give an overview on the modern view regarding the concept of inflammation and the role of SPMs in resolution of inflammation, especially in chronic inflammatory diseases.

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