NOVEL TETRAHYDRONAPHTHOFURANONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME

Compounds represented by general formula (I) and pharmaceutically acceptable salts thereof, which have progesterone receptor binding inhibitory activities and so are used as remedies and preventives for diseases in which progesterone participates, more particularly, as anticancer agents against mammary and ovarian cancers, remedies for uterine myoma, endometriosis, meningioma and myeloma, abortifacient, peroral contraceptive, and remedies and preventives for osteoporosis and climacteric disturbance, wherein R1 and R2 represent each hydroxy, alkyloxy, alkenyloxy, alkynyloxy, cycloalkyloxy, alkoxyalkyloxy, oxygenous cycloalkyloxy, aralkyloxy, alkylcarbonyloxy, alkenylcarbonyloxy, alkynylcarbonyloxy, cycloalkylcarbonyloxy, alkoxycarbonyloxy, aryloxycarbonyloxy, aralkylcarbonyloxy, aromatic acyloxy, heteroaromatic acyloxy, saturated heterocyclic carbonyloxy, alkylsulfonyloxy, aromatic sulfonyloxy, alkylcarbamoyloxy, or aromatic carbamoyloxy, the R1 optionally representing hydrogen alkyl, alkenyl, or alkynyl; and R3, R4, and R5 represent each independently hydrogen, alkyl, or alkenyl.