Earliest observation of the tetracycline destructasetet(X3)
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Abstract
Tigecycline is an antibiotic of last resort for infections with carbapenem-resistant Acinetobacter baumannii . Plasmids harboring variants of the tetracycline destructase tet(X) promote rising tigecycline resistance rates. We report the earliest observation of tet(X3) in a clinical strain predating tigecycline’s commercialization, suggesting selective pressures other than tigecycline contributed to its emergence.
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- europepmc
- last seen: 2026-05-19T01:45:01.086888+00:00