A NEW LOOK AT THE PATHOGENESIS OF ADENOMYOSIS

M. M. Damirov, A. M. Shabanov
In: Неотложная медицинская помощь, Vol 0, Iss 3, Pp 23-27 (2016) · 2016 · W4310635351
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study investigated morphological features of adenomyosis in 40 patients, finding increased myometrial microvasculature, lymphostasis, edema, basophils, and glycosaminoglycans, suggesting local uterine connective tissue failure is involved.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

This paper studied morphological features in 40 surgically treated patients with histologically verified adenomyosis (mean age 44.1 years), using clinical evaluation alongside survey, histochemical, and morphometric methods. The authors found that growth of heterotopic lesions was accompanied by increased microvascularization in the myometrium, lymphostasis, myometrial tissue edema, increased numbers of tissue basophils around endometriosis, and high alcian-positive glycosaminoglycan content in the intercellular substance. They conclude that local uterine tissue failure of connective tissue plays an important role in adenomyosis onset and progression, but the main limitation is that the analysis is based on an operated cohort with histology rather than broader clinical sampling. This paper is centrally about adenomyosis—morphological mechanisms of heterotopic lesion growth and associated vascular/lymphatic and connective-tissue changes.

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Abstract

PURPOSE. Сomprehensive study of morphological features in patients with adenomyosis.MATERIAL AND METHODS. Comprehensive clinical and morphological study was performed in 40 adenomyosis patients who had been operated (the average age 44,1±3,47 years) with histologically verified diagnosis. A comprehensive morphological study using survey, histochemical and morphometric methods was carried out.RESULTS. Growth of heterotopic lesions was accompanied by a marked plethora microvasculature of the myometrium, lymphostasis, oedema of the tissues of the myometrium, number of tissue basophils increase around the endometriosis, alcian-positive glycosaminoglycans high content in the intercellular substance. Local changes taking place in the uterus play important role in adenomyosis occurrence. The research results allow to consider the onset and progression of adenomyosis from the position of the concept of the local failure of the uterus connective tissue. Knowledge of the morphological basis of adenomyosis allows to diagnose the pathology better and to interpret the results obtained by the application of additional methods of examination .
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Неотложная медицинская помощь (Mar 2016) A NEW LOOK AT THE PATHOGENESIS OF ADENOMYOSIS Abstract PURPOSE. Сomprehensive study of morphological features in patients with adenomyosis.MATERIAL AND METHODS. Comprehensive clinical and morphological study was performed in 40 adenomyosis patients who had been operated (the average age 44,1±3,47 years) with histologically verified diagnosis. A comprehensive morphological study using survey, histochemical and morphometric methods was carried out.RESULTS. Growth of heterotopic lesions was accompanied by a marked plethora microvasculature of the myometrium, lymphostasis, oedema of the tissues of the myometrium, number of tissue basophils increase around the endometriosis, alcian-positive glycosaminoglycans high content in the intercellular substance. Local changes taking place in the uterus play important role in adenomyosis occurrence. The research results allow to consider the onset and progression of adenomyosis from the position of the concept of the local failure of the uterus connective tissue. Knowledge of the morphological basis of adenomyosis allows to diagnose the pathology better and to interpret the results obtained by the application of additional methods of examination .

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endometriosisadenomyosis

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