Expression of vascular endothelial growth factors receptors difference between women in Tibetan and Han nationalities of endometriosis

Objective To detect the expression of vascular endothelial growth factor receptors(VEGFR) kinase insert domain containing receptor (KDR) in the ectopic and entopic endometrial of Tibetan and Han nationalities patients with endometriosis(EM) and endometria. Methods 30 cases of ovarian endometrioma, and matched entopic endometria were biopsied from Tibetan patients with EM, another 30 cases of endometrium were biopsied from Han nationality women with EM.Reverse transcript-polymease chain reaction(RT-PCR) analysis were utilized to examine KDR mRNA and levels in the endometrium. Results Among EM lesions, KDR mRNA expressed higher level than women without EM. The expressed of KDR mRNA has same level in the 2 groups. Conclusion The VEGFR KDR mRNA expressed the ectopic and entopic endometria of women with EM in Tibetan and Han nationality, showed the expression of KDR in endometria with might be related to the transfer and development of EM, and pronounced menstrual cycle-dependent expression in cycle endometria. But the express level was not related to the nationalities between 2 groups.