The Negative Effects of Monosodium Glutamate on Endocrine and Reproductive Health: A literature review 2

The Negative Effects of Monosodium Glutamate on Endocrine and Reproductive Health: A literature review 2 | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 15 August 2025 V1 Latest version Share on The Negative Effects of Monosodium Glutamate on Endocrine and Reproductive Health: A literature review 2 Authors : Muhammad Haddad 0000-0001-6590-6098 [email protected] and Rafat Esmail Authors Info & Affiliations https://doi.org/10.22541/au.175527511.12540632/v1 576 views 156 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Monosodium glutamate (MSG), also known by its commercial name E621, is frequently utilized as a flavor enhancer in prepackaged meals and cooking to impart dishes with an "umami" taste. The potential toxicity of this substance is a subject of debate, with numerous studies highlighting its potential negative impacts on the hypothalamic-pituitarygonadal axis, as well as the thyroid and adrenal glands. Numerous investigations, primarily conducted on rodent models like rats and mice, have elucidated the deleterious consequences of MSG exposure on the hypothalamus, resulting in structural impairments to significant nuclei, notably the arcuate nucleus (ARC) and suprachiasmatic nucleus (SCN), subsequently correlating with obesity and disruptions in circadian rhythms in the experimental animals. Moreover, MSG exposure has been associated with structural irregularities in the pituitary, thyroid, adrenal glands, ovaries, and testes, thereby influencing essential reproductive hormone levels, encompassing testosterone, progesterone, and estradiol, within the serum. Noteworthy effects extend to the reproductive system, manifesting as adverse impacts on testicular morphology and functionality, ovarian dysfunctions, and increased uterine contractions. This literature review provides a thorough exploration of the structural and functional disturbances induced by MSG exposure, whether administered via peritoneal or intravenous routes, or through gavage techniques, affecting the hypothalamus, pituitary, thyroid, adrenal glands, and gonads. Supplementary Material File (manuscript.pdf) Download 1.53 MB Information & Authors Information Version history V1 Version 1 15 August 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords gonads hypothalamus monosodium glutamate pituitary gland testis thyroid gland uterus Authors Affiliations Muhammad Haddad 0000-0001-6590-6098 [email protected] Department of Zoology, Faculty of Life Sciences, Aleppo University View all articles by this author Rafat Esmail Department of Food Sciences, Faculty of Agriculture, Damascus University, Damascus, Syria. View all articles by this author Metrics & Citations Metrics Article Usage 576 views 156 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Muhammad Haddad, Rafat Esmail. The Negative Effects of Monosodium Glutamate on Endocrine and Reproductive Health: A literature review 2. Authorea . 15 August 2025. DOI: https://doi.org/10.22541/au.175527511.12540632/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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