Contezolid blood concentration changes in a patient with lung transplant and continuous renal replacement therapy: A case report

not-yet-known not-yet-known not-yet-known unknown Following lung transplantation (LTx), an increased risk of acute kidney injury (AKI) and the need for continuous renal replacement therapy (CRRT) are observed, and approximately half of all infections are caused by bacterial lung infections. The optimization of antibiotic dosage and selection is crucial for infection control and mortality reduction in patients with LTx receiving CRRT. Here we report a case that a 66-year-old male patient with chronic obstructive pulmonary disease who underwent bilateral lung transplant and received vancomycin for five days following the procedure. As he developed methicillin-resistant Staphylococcus aureus infection and the fever persisted and was accompanied by bone marrow suppression, vancomycin was replaced with contezolid. Our case study indicates that contezolid may effectively treat pulmonary infections and can be cleared by CRRT in patients with LTx. Keywords: Lung transplantation; Continuous renal replacement therapy; Lung infections; Contezolid;