The Relationship between Osteocalcin, Leptin and Testosterone Hormones and Infertility in Syrian Males

The Relationship between Osteocalcin, Leptin and Testosterone Hormones and Infertility in Syrian Males | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article The Relationship between Osteocalcin, Leptin and Testosterone Hormones and Infertility in Syrian Males Amr Alshashou, Amena Roumieh, Nour Ajlouni, Munira Arab, Sahar Al-Fahoum, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-9320821/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Infertility is a complex and multifactorial issue affecting numerous individuals worldwide. While numerous studies have explored the etiology of infertility, precise mechanisms underlying the condition remains elusive, particularly in specific population such as Syrian males. This comprehensive study aims to investigate the relationship between three key hormones, namely osteocalcin, leptin and testosterone and their potential impact on Syrian males with infertility. Osteocalcin is a bone-derived hormone that stimulates testosterone production in the testes. Leptin is an adipose-derived hormone that inhibits testosterone synthesis. Testosterone is the main androgen that supports spermatogenesis and male reproductive functions. The dysregulation of osteocalcin, leptin and testosterone has been associated with impaired spermatogenesis, decreased sperm motility, altered semen parameters and various other reproductive abnormalities. Furthermore, factors such as stress, malnutrition and exposure to toxins, may further disrupt the delicate hormonal balance, exacerbating infertility issues. Understanding the intricate relationship between osteocalcin, leptin and testosterone in the context of infertility is of paramount importance in developing strategies for diagnosis, treatment and prevention of male infertility. Osteocalcin Uncarboxylated osteocalcin Leptin Testosterone BMI Sperm count Infertility Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-9320821","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":617546791,"identity":"080143d6-c4b4-4b55-a755-8ea2bdb3587c","order_by":0,"name":"Amr 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While numerous studies have explored the etiology of infertility, precise mechanisms underlying the condition remains elusive, particularly in specific population such as Syrian males. This comprehensive study aims to investigate the relationship between three key hormones, namely osteocalcin, leptin and testosterone and their potential impact on Syrian males with infertility.\u003c/p\u003e\n\u003cp\u003eOsteocalcin is a bone-derived hormone that stimulates testosterone production in the testes.\u003cbr\u003e\nLeptin is an adipose-derived hormone that inhibits testosterone synthesis.\u003cbr\u003e\nTestosterone is the main androgen that supports spermatogenesis and male reproductive functions.\u003c/p\u003e\n\u003cp\u003eThe dysregulation of osteocalcin, leptin and testosterone has been associated with impaired spermatogenesis, decreased sperm motility, altered semen parameters and various other reproductive abnormalities. 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