New evidence about malignant transformation of endometriosis - systematic review v1

Background:Endometriosis is a disorder in which the presence of endometrial-like tissue is found outside the uterus and affects 5-15% of women. It may undergo malignant transformation, generally presenting with ovarian cancers of endometrioid and clear cell adenocarcinomas, in 0.5-1% of women. Genetic mutations lead to disruption in chromatin remodeling, particularly targeting ARID1A, and activation of oncogenic pathways, which include targets such as the mTOR pathway.Methods:Thesearch in PubMed, Europe PMC, and Google Scholar will be done comprehensively using the keywords "endometriosis," "malignant transformation," and "cancer" for articles ever published until December 2024.Only those studies will be included that provided information specifically on the malignant transformation of endometriosis. Studies with a random diagnosis of cancer among endometriosispatients will be excluded.Data will be extracted by two authors using predefined criteria.