Ascertaining structural dynamics for a conformational plasticity  in lncRNA-HSP90 interactions

Abstract Heat Shock Protein 90 (HSP90) and long non-coding RNAs (LncRNAs) are found to be upregulated in human cancer cells and play a significant role in cancer progression and aggression. The lncRNAs have the capability to interact with coding regions of genes, RNA and proteins as well as regulate their functions. Here, we sought to study the lncRNAs in HSP90 gene interactions with HSP90 protein to identify the structural dynamics of HSP90. Furthermore, we attempted to find the potential phytochemicals targeted to HSP90 protein as potential anticancer drugs. It was observed that theaflavin, epigallocatechin gallate, procyanidin, rutin and myricetin are potential anticancer drugs. These phytochemicals can be validated by in vitro studies in the future.