Purging Autologous HSCs via Detection of Clonal Mutations

Allogeneic hematopoietic stem cell (HSC) transplants are usually used in cases where patients have active cancerous illness in their bone marrow, but allogeneic transplants can cause graft vs. host disease. If autologous HSCs could be purged of cancer cells, they could then be used for transplantation purposes without concern. A novel method of purging is discussed herein that does not require chemotherapy and is targeted for each patient. It could be applied either in vitroor in vivo.