Bio-Medical Applications of Chitosan Linked Rosmarinus Officinalis Leaf Extract Nanopolymer

Abstract Nanotechnology has numerous applications in science and technology. The nanomaterial which are plant based have drawn more attention due to its immense application in various fields because of their physico-chemical properties. Physical, chemical, and biological processes are used to create nanomaterials. Physiochemical processes are costly and hazardous to the environment, whereas biological processes involving nanoparticles are thought to be environmentally friendly. In recent times considerable research interest has evolved using chitosan nanoparticles as they have emerged as one of the most exciting tools due to their increased surface-volume ratio and are of great interest for nanomedicine and development of new therapeutic drug release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity. In the present investigation, we have synthesized chitosan nanoparticles using Rosmarinus officinalis leaf extract by the ionic gelation technique and was characterized using UV spectrophotometer and FTIR. The optical density of the broad peak of Chitosan-Rosemary Leaf nanopolymer was found to be at 0.587. The FTIR results recorded the absorption peaks at 3381 cm‾ 1 , and 1666 cm‾ 1 which represented the O-H stretch and C=C bond stretching respectively. Thus, there was a stretching from higher wavelength region to lower wavelength region demonstrating the interaction of tripolyphosphate with chitosan and biomolecules by reduced hydrogen bonding. Further, the study was designed to determine the cytoprotective and DNA protection activity. The results of our study lend pharmacological credence to the bio-medical applications, ethno medical use of this plant in traditional system of medicine.