Investıgatıon of the Effects of Treatment with Enoxaparın Sodıum and Hyperbarıc on the Recovery of Rats Wıth Achılles Tendon Rupture

Background: Tendons can be easily injured acutely or chronically due to repetitive movements, degeneration and trauma. To make the tendon more robust after healing, several biomaterials have been tested in different studies; skeletal structures have been created from cells containing fibroblasts, and growth factors and cytokines have been applied exogenously. In this study, we aimed to investigate the effects of hyperbaric oxygen therapy and enoxaparin sodium, which are known to accelerate bone tissue healing as well as tendon and soft tissue healing, on the healing of Achilles tendon rupture. Methods: Thirty-six rats were used in the present study. All rats were divided into groups of nine. The groups were the enoxaparin sodium group, enoxaparin sodium and hyperbaric oxygen group, hyperbaric oxygen group and control group. After 21 days, the process was completed, and the rats were sacrificed. Achilles tendon samples were evaluated histopathologically. Results: The groups were compared according to the results of statistical analysis based on the histopathological data. There was no significant difference between the groups in terms of acute inflammation (p=0.785) or chronic inflammation (p=0.827) scores, but there were significant differences in neovascularization (p=0.009), proliferation (p<0.001) and fibrosis (p=0.006) scores. Conclusion: Our study showed that the use of enoxaparin sodium and hyperbaric oxygen had a positive effect on the healing of the Achilles tendon. Based on these results, we believe that the use of enoxaparin sodium and hyperbaric oxygen therapy after Achilles tendon rupture will be beneficial for healing and preventing complications.