Diagnostic Performance of CMR Parametric Mapping as per Modified Lake Louise Criteria in Acute Myocarditis: An Updated Systematic Review and Meta-Analysis

Diagnostic Performance of CMR Parametric Mapping as per Modified Lake Louise Criteria in Acute Myocarditis: An Updated Systematic Review and Meta-Analysis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Diagnostic Performance of CMR Parametric Mapping as per Modified Lake Louise Criteria in Acute Myocarditis: An Updated Systematic Review and Meta-Analysis Latika Giri, Roshan Singh, Ahmed Marey, Yupeng Li, Bharath Venkatesh, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5026991/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Cardiovascular Magnetic Resonance Imaging (CMR) mapping parameters—Native T1, T2 mapping, and Extracellular Volume (ECV)—are pivotal for diagnosing acute myocarditis according to the modified 2018 Lake Louise Criteria (mLLC). This systematic review and meta-analysis aim to evaluate their diagnostic performance and establish optimal thresholds for acute myocarditis diagnosis. Methods We systematically reviewed articles published in the past decade that utilized parametric mapping techniques for myocarditis diagnosis. Data on sensitivity, specificity, and Area Under Curve (AUC) were included, and quality assessment was conducted using the QUADAS-2 tool by two independent reviewers. Results Eleven studies involving 677 patients were included. Native T1 showed sensitivity of 83%, specificity of 86%, diagnostic odds ratio (DOR) of 39, and an AUC of 0.91. T2 mapping had sensitivity of 81%, specificity of 86%, DOR of 25, and an AUC of 0.89. ECV demonstrated sensitivity of 71%, specificity of 81%, DOR of 13, and an AUC of 0.83. Mean values in controls for myocarditis were: Native T1 (1039 ms ± 39.23), T2 mapping (57 ms ± 5.18), ECV (31% ± 5.60). The optimal thresholds were 1021 ms for Native T1, 54 ms for T2 mapping, and 28% for ECV generated through Receiver-operating characteristic (ROC) analysis. Native T1 exhibited the highest accuracy among the parameters assessed. Subgroup analysis indicated no significant sensitivity differences based on biopsy or clinical criteria, while Native T1 specificity varied significantly. Conclusions Parametric mapping, particularly Native T1, demonstrates robust diagnostic performance for myocarditis compared to T2 mapping and ECV within the mLLC framework. Integrating these CMR parameters could enhance diagnostic accuracy. Further research is essential to refine these findings and optimize diagnostic strategies for myocarditis. myocarditis modified Lake Louise parametric mapping diagnostic test Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Introduction Myocarditis, an inflammatory condition of the myocardium, can arise from viral infections, autoimmune disorders, and certain medications.[ 1 ] Left untreated, it can lead to severe complications including heart failure, arrhythmias, cardiogenic shock, and dilated cardiomyopathy.[ 2 ] Diagnosing myocarditis is challenging due to its heterogeneous and atypical presentation.[ 3 ] Endomyocardial biopsy (EMB), while occasionally used, has drawbacks such as invasiveness, sampling limitations, and difficulty in capturing patchy inflammation.[ 4 ] CMR is a common non-invasive modality for detecting myocarditis, employing techniques like early gadolinium enhancement (EGE), T2-weighted images, and late gadolinium enhancement (LGE) from the classical Lake Louise Criteria to visualize myocardial inflammation.[ 3 , 5 , 6 ] The addition of quantitative parametric techniques, including native T1 mapping, T2 mapping, and ECV in the modified Lake Louise Criteria (mLLC), has further enhanced the diagnostic capability.[ 7 , 8 , 9 ] The advantages of parametric mapping include quantitative and objective myocarditis assessment and visualization of global myocardial changes.[ 10 , 11 ] Several studies have proposed parametric CMR mapping as a gold standard non-invasive technique for myocarditis diagnosis.[ 11 , 12 ] The values of parametric CMR mapping are influenced by field strength, vendors, and acquisition techniques, leading to a lack of universally reliable cutoff values for diagnosing myocarditis.[ 9 , 13 , 14 ] Our study aims to determine specific native T1 mapping, T2 mapping, and ECV cutoff values that reliably differentiate acute myocarditis from healthy controls. An accurate cut-off for parametric technique like native T1 mapping can help to differentiate acute myocarditis patients from healthy controls and narrow non-definitive diagnosis cases.[ 6 ] Both native T1 and T2 mapping are sufficient as single markers and can increase diagnostic confidence when used together.[ 15 ] Additionally, combining parametric techniques, such as native T1 and T2 mapping along with ECV, has proven beneficial in increasing sensitivity and specificity for myocarditis detection.[ 16 ] The aim of this study is also to evaluate the diagnostic performance of these single and combined mapping techniques in diagnosing myocarditis. Methods We conducted a systematic review and meta-analysis to assess the diagnostic performance of parametric CMR parameters—Native T1, T2 mapping, and ECV for myocarditis diagnosis (individual or combined) and provide their respective cut-off values in acute myocarditis cases. The study adhered to PRISMA guidelines, and the protocol was registered in PROSPERO (CRD42023484275). 1. Study search and selection criteria Two reviewers (L.G. and R.S.) independently searched PubMed and Google Scholar for relevant studies using predefined keywords: including ["myocarditis" AND “magnetic resonance imaging” AND “Lake Louise Criteria AND "Modified Lake Louise Criteria,” AND "New Lake Louise Criteria," AND "2018 Lake Louise Criteria") AND “ECV”]. Studies from 2014 to 2024 were included. Inclusion criteria encompassed prospective and retrospective studies evaluating the diagnostic accuracy of the three parametric CMR techniques: Native T1, T2 mapping and ECV compared to EMB or accurate clinical assessment as reference. Despite the introduction of the mLLC in 2018, our inclusive approach considered studies dating back to 2014, as many authors had incorporated mapping techniques and ECV in their research even before the formal introduction of the mLLC in 2018. Exclusion criteria eliminated case reports, reviews, and studies lacking sufficient data on calculating sensitivity or specificity. Disagreements were resolved through discussion or involvement of a third reviewer (M.U.). Risk of bias was assessed using QUADAS-2 forms. ( Fig. 1 ) 2. Statistical Analysis The meta-analysis was performed using R version 4.3.2. Pooled Diagnostic Odds Ratios (DORs) and 95% Confidence Intervals (CIs) were calculated for single parametric techniques and, if available, for combined parametric mapping. Diagnostic accuracy was evaluated using the AUC from Summary Receiver Operating Characteristic (SROC) curves. A univariate random-effects model assessed pooled sensitivity and specificity, and statistical heterogeneity was evaluated using the I² statistic, with significant heterogeneity defined as I² > 60%. ROC analysis was performed to calculate the optimal thresholds of native T1, T2 mapping, and ECV along with their respective AUC, sensitivities and specificities. Pooled mean native T1, T2 mapping, and ECV values were calculated by combining means and standard deviations from multiple studies, and optimal thresholds were calculated by Receiver operating curves (ROC). Subgroup analyses were conducted based on study reference standards. Funnel plots and Egger's regression test were used to inspect and test for publication bias. Continuous variables were expressed as means ± standard deviations, and categorical values as numbers and percentages. Results Search results A total of 1199 articles were initially identified, with 180 undergoing full-text review. Ultimately, 11 studies from 2014 to 2022 were included in the meta-analysis. These comprised seven prospective and four retrospective designs, primarily conducted in Germany. (Table 1 ) (Table 2) Table 1: Summary of study characteristics, demography of included studies. SN Author (First Author) Year Study design Baseline characteristics of patients Reference Standard Age Male (%) N Presentation 1 Huber 2018 Retrospective cohort with case-control element 45(29-61) 60/40 60 Acute CLINICAL 2 Radunski 2014 Retrospective case control 44 76/24 125 Acute CLINICAL 3 Isaaki 2021 Retrospective case control 17(14-20) 77/23 56 Acute EMB 4 Palmisano 2020 Prospective case control 39(28-46) 51/49 43 Acute CLINICAL 5 Luetkens 2015 Prospective case control 44.9(26.2-63.17) 50/50 84 Acute CLINICAL 6 Li 2021 Retrospective cohort with case-control element 32 (18-50 71.2/28.8 73 Acute EMB 7 Lurz 2016 Prospective cohort with case-control element 40 83/17 129 Acute EMB 8 Knobelsdorff-Brenkenhoff 2017 Prospective cohort with case-control element 24.5 78/22 36 Acute CLINICAL 9 Luetkens 2019 Prospective cohort with case-control element 41(23-64) 72.5/27.5 66 Acute CLINICAL 10 Dabir 2019 Prospective cohort with case-control element 38(22-54) 77/23 80 Acute CLINICAL 11 Brendel 2022 Prospective cohort with case-control element 48 (30–63) 44/56 48 Acute EMB Ms: millisecond T1: Native T1 Acute myocarditis: patients presenting with symptoms within 28 days. Table 2: CMR characteristics of included studies Study ID Native T1 Control Native T1 Cases T2 Control T2 Cases ECV Control ECV Cases Native T1 mapping technique T2 mapping technique Vendor Magnet strength Huber 2028 965 (940-990) 1044 (981-1107) 48 (46-50) 53 (49-57) 22 (19-25) 24 (17-31) MOLLI bSSFP Siemens 1.5 T Radunski 2014 1051 (1010-1063) 1098 (1057-1139) 55 (54-60) 61 (58-65) 25 (24-27) 31 (28-34) MOLLI N/A Philips 1.5 T Isaaki 2021 962 (945-979) 1031 (985-1077) 51 (49-53) 58 (53-63) 26.5 (23.7-29.3) 29.2 (23.3-35.1) MOLLI GraSE Philips 1.5 T Palmisano 2020 1008 (988-1033) 1093 (1050-1201) 47 (46-47.6) 55 (52-59) 25 (24-26) 30 (27-32) MOLLI N/A Philips 1.5 T Luetkens 2015 966.9 (939.1-994.7) 1048.6 (996.7-1100.5) 52.42 (49.86-54.98) 60.43 (52.96-67.9) 27.68 (21.86-33.5) 34.47 (25.95-43.99) MOLLI/ShMOLLI GraSE Philips 1.5 T Li 2021 1195 (1152-1238) 1252 (1210-1294) 54.5 (50.8-58.2) 63.2 (57.1-69.3) 29.3 (25.2-33.4) 32.7 (29.4-36) MOLLI GraSE Philips 3 T Lurz 2016 1044 (1002-1086) 1113 (1046-1180) 56.9 (49.7-64.1) 62.2 (57.7-66.7) 31.8 (26.9-36.7) 37.2 (30.7-43.7) MOLLI N/A Philips 1.5 T Knobelsdorff-Brenkenhoff 2017 975 (957-1004) 1004 (988-1048) 50.2 (49.2-52) 55.1 (53.3-57.2) 24 (24-25) 26 (25-28) MOLLI bSSFP Philips 1.5 T Luetkens 2019 965.8 (940.7-990.9) 1047.0 (993.2-1100.8) 52.8 (50.4-55.2) 61.8 (53.6-70) 26.1 (21.9-30.3) 28.6 (23.3-33.9) MOLLI GraSE Philips 1.5 T Dabir 2019 958.9 (936.4-981.4) 1027.2 (977.9-1076.5) 51.6 (49.7-53.5) 58 (52-64) 27.7 (24.5-30.9) 32 (25.6-38.4) MOLLI GraSE Philips 1.5 T Brendel 2022 1015 (1015-1015) 1069 (1024-1127) 50 (50-50) 53 (52-56) 30 (30-30) 33 (31-35) MOLLI bSSFP Philips Optimal Diagnostic Thresholds* Native T1 Threshold=1021 ms ROC AUC=0.82 Sensitivity=91% Specificity=73% T2 mapping threshold=54 ms ROC AUC=0.93 Sensitivity=82% Specificity=82% ECV threshold=28% ROC AUC=0.79 Sensitivity=82% Specificity=73% *Optimal diagnostic thresholds were determined using ROCs curve Diagnostic accuracy results Pooled mean T1 time was 1075.16±64.22 ms, and pooled mean T2 time was 58.25±3.58 ms for myocarditis cases. ECV cutoffs ranged from 22% to 34.47%, and post-contrast T1 timing ranged from 10 to 15 minutes. Out of the eleven studies, only two studies had Siemens as a vendor. 17 , 8 Ten studies utilized MOLLI (Modified Look-Locker Inversion recovery) for native T1 mapping, with one using both ShMOLLI (Shortened Modified Look-Locker Inversion recovery) and MOLLI. We had five studies utilizing GraSE (Gradient and Spin Echo), three using bSSFP (balanced Steady-state free precession) as a T2 mapping technique and three studies did not report the T2 mapping technique utilized. Diagnostic accuracy for Native T1, T2 mapping, and ECV was reported in all studies (Table 3 ). Native T1 demonstrated the highest sensitivity (83%) and specificity (86%) among the evaluated parameters, with an inconsistency (I-square I2) of 69% for sensitivity and 75% for specificity. It also had a DOR of 39 and an AUC of 0.91. T2 mapping showed similar sensitivity (81%) and specificity (86%) with I2 of 72.2% and 69% respectively, and a DOR of 25 with an AUC of 0.89. ECV exhibited moderate sensitivity (71%) and specificity (81%) with I2 of 72% and 37%, along with a lower DOR of 13 and an AUC of 0.83. (Figure 2, 3, 4, 5) Table 3: Diagnostic accuracies and heterogeneity indices of individual mapping parameters Native T1, T2 mapping and ECV Parameter Sensitivity Inconsistency (I-square) Specificity Inconsistency (I-square) Diagnostic Odds Ratio (DOR) Area Under Curve (AUC) Native T1 83% 69% 86% 75% 39 0.91 T2 81% 72% 86% 69% 25 0.89 ECV 71% 72% 81% 37% 13 0.83 The optimal cut-off for native T1 mapping was 1021 ms (ROC AUC=0.82, Sensitivity=91%, Specificity=73%). For ECV, the threshold was 28% (ROC AUC=0.79, Sensitivity=82%, Specificity=73%) and T2 mapping had an optimal threshold of 54 ms (ROC AUC=0.93, Sensitivity=82%, Specificity=82%). (Figure 6) Subgroup analyses revealed no significant differences in diagnostic accuracy based on clinical criteria or EMB reference standards. Meta-regression showed no significant sensitivity differences for Native T1, T2, and ECV (P-value>0.05), though Native T1 mapping specificity varied significantly (P-value 0.05 for all on Egger’s test). Table 4: Results of meta-regression and subgroup analyses based on reference standard of studies. Mapping technique Approach Study number sensitivity p-value specificity p-value Native T1 Clinical 7 79% (70-87) 0.77 92% (87-96) 0.001 EMB 4 88% (82-93) 70% (50-84) T2 Clinical 7 78% (67-87) 0.205 90% (84-93) 0.076 EMB 4 85% (79-90) 77% (56-90) ECV Clinical 7 67% (55-78) 0.174 84% (78-89) 0.102 EMB 4 81% (64-91) 74% (62-84) Study quality assessment and integrated diagnostic performance of different CMR approaches Overall study quality was moderate and acceptable per QUADAS-2, with one study showing high risk of bias due to non-uniform EMB performance, case control selection. ( Figure 7) (Table 5) . Five studies investigated combined CMR approaches, with various combinations showing high sensitivity, specificity, and AUC ( Table 6 ). Table 5: Quality Assessment (QADAS-2) Study Number Study ID Domain 1 Domain 2 Domain 3 Domain 4 Overall Risk of Bias 1 Huber 2018 Low Low Low Low Low 2 Radunski 2014 Low Low Low Low Low 3 Isaak 2021 Low Low Low Low Low 4 Palmisano 2020 Low Low Low Unclear Low 5 Luetkens 2015 Low Low Low Unclear Low 6 Li 2021 Low Low Low Low Low 7 Lurz 2016 Low Low Low Low Low 8 Knobelsdorff-Brenkenhoff 2017 Low Low Low Low Low 9 Luetkens 2019 Low Low Low Unclear Low 10 Dabir 2019 Low Low Low Low Low 11 Brendel 2022 Low Unclear High Low High Domain 1: Was the patient population representative of the population under investigation, with clear criteria for patient inclusion and exclusion, enrollment through consecutive or random sampling, and balanced reporting of patient demographics (age, gender) across study groups? , Domain 2: Were the CMR parameters (T1, T2, ECV) described in sufficient detail, with consistency in the application and interpretation of CMR techniques across studies, blinded assessment of CMR parameters to the reference standard results, and a pre-specified threshold for abnormal CMR findings?, Domain 3: Was endomyocardial biopsy deemed an appropriate reference standard for myocarditis diagnosis, with blinded interpretation of biopsy findings to CMR parameter results, consistency in the application of clinical criteria across studies, and uniform timing of clinical criteria utilization in relation to symptom presentation?, Domain 4: Was there inclusion of all eligible patients in the analysis, with consistent intervals between symptom presentation and CMR testing, CMR testing and the reference standard (EMB/clinical criteria), and analysis of patients in the groups to which they were initially assigned? Table 6: Results of diagnostic values of combined parametric mapping techniques S.N. Author Combination Sensitivity Specificity 1. Radunski et al LGE+ECV 94% (88-98) 71% (48-89) 2. Isaak et al T1+T2 mapping 85% (64–96) 100% (79–100) 3. Li et al T1+T2 mapping LGE + T2 mapping a. 82.2% b. 79.5% 4. Brenkenhoff et al a. T1+T2 b. T2+ECV c. T1+LGE d. T2+LGE e. T1+T2+LGE a.77.8% (52.4-93.6) b.82.4% (56.6-96.2) c.72.2% (46.5-90.3) d.66.7% (41-86.7) e. 66.7% (41-86.7) a. 94.4% (72.7-99.9) b.94.4% (72.7-99.9) c.100% (81.5-100) d. 100% (81.5-100) e. 100% (81.5-100) 5. Brendel et al T1 + ECV T2 + ECV a. 96% b. 83% a. 83% b. 92% All the combinations are based on Native T1 mapping. Discussion Our study focused on evaluating the diagnostic accuracies of individual parametric mapping techniques for acute myocarditis. Prolonged T1 values, attributed to cellular edema, increased extracellular space, inflammation, and myocyte necrosis, are consistently observed in myocarditis cases.[ 18 , 19 ] Native T1 mapping showed the highest accuracy among the studied techniques, consistently demonstrating good diagnostic performance (AUC 0.90, DOR 39) compared to T2 mapping (AUC 0.88, DOR 25) and ECV (AUC 0.83, DOR 13). This aligns with findings by several other studies indicating superior diagnostic efficacy of T1 mapping techniques over original LLC 2009 techniques (T2-Weighted imaging, LGE, and EGE).[ 15 , 20 , 18 , 19 ] It is well known that native T1 values can be affected by mapping sequence used and field strength. 21 In the current study, however, we found relative uniformity among the studies included in the meta-analysis with respect to these parameters. Ten of eleven studies used the MOLLI sequence, and ten studies used a 1.5 T strength magnet. Hence the inter-study variation in Native T1 values in the current study are likely secondary to other factors. Caution should be taken in applying the current results if not using MOLLI on a 1.5T scanner. For native T1 mapping an optimal cut-off of 1021 ms (ROC AUC = 0.82, Sensitivity = 91%, Specificity = 73%) was found. However, this is a statistical threshold, and its clinical significance still needs to be completely determined. ECV, derived from pre- and post-contrast T1 and hematocrit values, exhibited promise with an AUC of 0.83. However, it is well known that edema itself elevates ECV, which may make the utility of ECV even less reliable among the hyper acute and acute phase of inflammation.[ 21 ] A median time of less than 14 days from symptom onset to CMR acquisition in our analysis likely contributed to ECV's lower sensitivity, as observed in study by Luetkens et al.[ 7 ] ECV values vary with CMR sequences but remain unaffected by field strength, distinguishing them from native T1 and T2 mapping.[ 22 ] Li et al. reported an ECV of 32.7% (29.4–36) for acute myocarditis cases, and 29.3% (25.2–33.4) for controls (p < 0.01) using a 3T magnet. In comparison, Dabir et al. found an ECV of 32% (25.6–38.4) for myocarditis patients and 27.7% ( 24.5–30.9) for controls (p = 0.01) using a 1.5 T magnet.[ 14 , 20 ] ECV had an optimal threshold of 28% (ROC AUC = 0.79, Sensitivity = 82%, Specificity = 73%) however it is a statistical measure. Myocardial T2 relaxation time emerged as a promising marker, with significantly elevated values in patients during acute presentation compared to controls. Myocardial T2 relaxation time, closely linked to free tissue water content, with significantly elevated values in acute myocarditis patients.[ 20 ] In our study, T2 mapping demonstrated comparable diagnostic efficacy to native T1, with an AUC of 0.88. Variations in T2 mapping techniques and thresholds necessitate consideration of acquisition types, patient populations, and clinical contexts.[ 23 , 24 ] A statistical analysis identified an optimal threshold of 54 ms for detecting myocarditis using T2 mapping, with a ROC AUC of 0.93, 82% sensitivity, and 82% specificity. This meta-analysis includes combined mapping techniques from recent studies. This combined approach is most reflective of clinical practice. Five studies reported enhanced diagnostic outcomes by use of several different integrated mapping techniques, such as native T1 + T2, native T1 + ECV.[ 17 , 25 , 26 , 20 , 16 ] A study by Li et al. demonstrated high diagnostic performance when combining native T1 + T2 mapping over a single parameter of mLLC.[ 20 ] A small number of studies precluded a pooled analysis in our meta-analysis. Subgroup analysis with fewer than 4 studies would be unreliable due to low statistical power to detect true differences between subgroups. The study supports the notion that native T1 and T2 mapping allow for a reliable distinction between injured and normal myocardium but may struggle to discriminate between acute myocarditis and other noninflammatory cardiomyopathy or myocarditis with a chronic presentation. The diagnostic accuracy of parametric mapping techniques has been established to be superior to older techniques. Available parametric mapping evaluations demonstrate that at least one of the main modified LL criteria can effectively diagnose myocarditis with little less accuracy as an alternative to EMB (Sensitivity 88% for EMB > 80% for parametric mapping in CMR).[ 27 ] Limitations The results of this meta-analysis should be interpreted cautiously due to possible selection and reference biases. Most studies included in our analysis exhibited variability in population, study design, patient characteristics, observer interpretations, and CMR acquisition protocols. EMB was utilized as reference in four studies, while the other studies relied on clinical diagnoses and case-control designs. Some studies did not report local normal data for Native T1 mapping, potentially affecting diagnostic accuracy. Variations in T2 mapping techniques (Gradient and Spin Echo or Steady-state free precession) and CMR vendors (Philips or Siemens) at 1.5 T field strength may limit generalizability. The small number of studies on updated LLC combined mapping parameters precluded a reliable sensitivity analysis, particularly for combined T1 and T2 mapping techniques. Clinical Implications and Future Directions Our investigation underscores Native T1 mapping as the most effective modality for diagnosing acute myocarditis, with T2 mapping and ECV presenting viable alternatives. Future studies should refine diagnostic protocols based on patient presentation timing, standardize CMR methods across large, matched cohorts, and consider diagnostic network meta-analyses to optimize approaches. This approach aims to reduce diagnostic costs and clinical workload associated with myocarditis, facilitating more precise and efficient diagnosis. Conclusion The utilization of CMR based parametric mapping emerges as a valuable diagnostic strategy for acute myocarditis with native T1 mapping exhibiting highest diagnostic accuracy across the board, followed by T2 mapping and ECV. The pooled optimal threshold values of each native T1, T2 mapping, and ECV obtained from ROC aid in adequate diagnosis of myocarditis. We recommend further studies to explore the diagnostic performance of combined parametric mapping techniques. Declarations Acknowledgment We would like to express our sincere gratitude to all the researchers and clinicians whose work contributed to the studies included in this systematic review and meta-analysis. Additionally, we extend our appreciation to Dr. Alireza Ghodsi for his contribution in literature search. We also acknowledge the contributions of the PROSPERO team for their assistance with study registration. Author contributions LG conceived and designed the study, conducted literature search, performed data extraction and analysis, and drafted the manuscript. RS conducted literature search, performed data extraction, and contributed to the interpretation of results. AM participated in the study design, conducted literature search, contributed to the interpretation of results, and provided critical feedback on the manuscript. BV assisted in the study design, conducted literature search, and contributed to the interpretation of results. YL contributed to the study design, performed data extraction and analysis, contributed to the interpretation of results, and provided valuable input during manuscript preparation. JA participated in the study design and provided critical revisions to the manuscript. SZ participated in the study design and provided critical revisions to the manuscript. MU supervised the study, provided guidance on study design and methodology, contributed to the interpretation of results, critically reviewed the manuscript for intellectual content. Abbreviations AUC: Area Under Curve bSSFP: Balanced Steady-state Free Precession CMR: Cardiovascular Magnetic Resonance Imaging DOR: Diagnostic Odds Ratio ECV: Extracellular Volume EMB: Endomyocardial Biopsy EGE: Early Gadolinium Enhancement GraSE: Gradient and Spin Echo LLC: Lake Louise Criteria LGE: Late Gadolinium Enhancement mLLC: Modified Lake Louise Criteria MOLLI: Modified Look-Locker Inversion recovery ms: milliseconds PPV: Positive Predictive Value PROSPERO: International Prospective Register of Systematic Reviews QUADAS-2: Quality Assessment of Diagnostic Accuracy Studies ROC: Receiver-operating Characteristic SD: Standard Deviation ShMOLLI: Shortened Modified Look-Locker Inversion recovery SROC: Summary Receiver Operating Characteristic T2: T2 mapping T1: Native T1 mapping 1.5T: 1.5 Tesla 3T: 3 Tesla References Lampejo T, Durkin SM, Bhatt N, Guttmann O (2021) Acute myocarditis: aetiology, diagnosis and management. Clin Med 21(5):e505–e510. 10.7861/clinmed.2021-0121 Tschöpe C, Ammirati E, Bozkurt B et al (2021) Myocarditis and inflammatory cardiomyopathy: current evidence and future directions. Nat Rev Cardiol 18(3):169–193. 10.1038/s41569-020-00435-x Caforio ALP, Pankuweit S, Arbustini E et al (2013) Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 34(33):2636–2648. 2648a-2648d Kiamanesh O, Toma M (2021) The State of the Heart Biopsy: A Clinical Review. CJC Open 3(4):524–531. 10.1016/j.cjco.2020.11.017 Ferreira VM, Schulz-Menger J, Holmvang G et al (2018) Cardiovascular Magnetic Resonance in Nonischemic Myocardial Inflammation. J Am Coll Cardiol 72(24):3158–3176. 10.1016/j.jacc.2018.09.072 Kersten J, Heck T, Tuchek L, Rottbauer W, Buckert D (2020) The Role of Native T1 Mapping in the Diagnosis of Myocarditis in a Real-World Setting. J Clin Med 9(12):3810. 10.3390/jcm9123810 Luetkens JA, Faron A, Isaak A et al (2019) Comparison of Original and 2018 Lake Louise Criteria for Diagnosis of Acute Myocarditis: Results of a Validation Cohort. Radiol Cardiothorac Imaging 1(3):e190010. 10.1148/ryct.2019190010 Lurz P, Luecke C, Eitel I et al (2016) Comprehensive Cardiac Magnetic Resonance Imaging in Patients With Suspected Myocarditis. J Am Coll Cardiol 67(15):1800–1811. 10.1016/j.jacc.2016.02.013 Haaf P, Garg P, Messroghli DR, Broadbent DA, Greenwood JP, Plein S (2017) Cardiac T1 Mapping and Extracellular Volume (ECV) in clinical practice: a comprehensive review. J Cardiovasc Magn Reson 18(1):89. 10.1186/s12968-016-0308-4 Bohnen S, Radunski UK, Lund GK et al (2015) Performance of T1 and T2 Mapping Cardiovascular Magnetic Resonance to Detect Active Myocarditis in Patients With Recent-Onset Heart Failure. Circ Cardiovasc Imaging 8(6):e003073. 10.1161/CIRCIMAGING.114.003073 Laissy JP, Hyafil F, Feldman LJ et al (2005) Differentiating Acute Myocardial Infarction from Myocarditis: Diagnostic Value of Early- and Delayed-Perfusion Cardiac MR Imaging. Radiology 237(1):75–82. 10.1148/radiol.2371041322 Zhu L, Wang Y, Zhao S, Lu M (2022) Detection of myocardial fibrosis: Where we stand. Front Cardiovasc Med 9:926378. 10.3389/fcvm.2022.926378 Baessler B, Luecke C, Lurz J et al (2019) Cardiac MRI and Texture Analysis of Myocardial T1 and T2 Maps in Myocarditis with Acute versus Chronic Symptoms of Heart Failure. Radiology 292(3):608–617. 10.1148/radiol.2019190101 Dabir D, Child N, Kalra A et al (2014) Reference values for healthy human myocardium using a T1 mapping methodology: results from the International T1 Multicenter cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 16(1):69. 10.1186/s12968-014-0069-x Von Knobelsdorff-Brenkenhoff F, Schüler J, Dogangüzel S et al (2017) Detection and Monitoring of Acute Myocarditis Applying Quantitative Cardiovascular Magnetic Resonance. Circ Cardiovasc Imaging 10(2):e005242. 10.1161/CIRCIMAGING.116.005242 Brendel JM, Klingel K, Kübler J et al (2022) Comprehensive Cardiac Magnetic Resonance to Detect Subacute Myocarditis. J Clin Med 11(17):5113. 10.3390/jcm11175113 Huber AT, Bravetti M, Lamy J et al (2018) Non-invasive differentiation of idiopathic inflammatory myopathy with cardiac involvement from acute viral myocarditis using cardiovascular magnetic resonance imaging T1 and T2 mapping. J Cardiovasc Magn Reson 20(1):11. 10.1186/s12968-018-0430-6 Lurz P, Eitel I, Adam J et al (2012) Diagnostic Performance of CMR Imaging Compared With EMB in Patients With Suspected Myocarditis. JACC Cardiovasc Imaging 5(5):513–524. 10.1016/j.jcmg.2011.11.022 Luetkens JA, Homsi R, Sprinkart AM et al (2016) Incremental value of quantitative CMR including parametric mapping for the diagnosis of acute myocarditis. Eur Heart J Cardiovasc Imaging 17(2):154–161. 10.1093/ehjci/jev246 Li S, Duan X, Feng G et al (2021) Multiparametric Cardiovascular Magnetic Resonance in Acute Myocarditis: Comparison of 2009 and 2018 Lake Louise Criteria With Endomyocardial Biopsy Confirmation. Front Cardiovasc Med 8:739892. 10.3389/fcvm.2021.739892 Ugander M, Oki AJ, Hsu LY et al (2012) Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology. Eur Heart J 33(10):1268–1278. 10.1093/eurheartj/ehr481 Scully PR, Bastarrika G, Moon JC, Treibel TA (2018) Myocardial Extracellular Volume Quantification by Cardiovascular Magnetic Resonance and Computed Tomography. Curr Cardiol Rep 20(3):15. 10.1007/s11886-018-0961-3 Triadyaksa P, Oudkerk M, Sijens PE (2020) Cardiac T2 * mapping: Techniques and clinical applications. J Magn Reson Imaging JMRI 52(5):1340–1351. 10.1002/jmri.27023 Topriceanu CC, Pierce I, Moon JC, Captur G (2022) T2 and T2⁎ mapping and weighted imaging in cardiac MRI. Magn Reson Imaging 93:15–32. 10.1016/j.mri.2022.07.012 Radunski UK, Lund GK, Stehning C et al (2014) CMR in Patients With Severe Myocarditis. JACC Cardiovasc Imaging 7(7):667–675. 10.1016/j.jcmg.2014.02.005 Isaak A, Bischoff LM, Faron A et al (2021) Multiparametric cardiac magnetic resonance imaging in pediatric and adolescent patients with acute myocarditis. Pediatr Radiol 51(13):2470–2480. 10.1007/s00247-021-05169-7 Baccouche H, Mahrholdt H, Meinhardt G et al (2009) Diagnostic synergy of non-invasive cardiovascular magnetic resonance and invasive endomyocardial biopsy in troponin-positive patients without coronary artery disease. Eur Heart J 30(23):2869–2879. 10.1093/eurheartj/ehp328 Additional Declarations No competing interests reported. Supplementary Files TABLES.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5026991","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":358466713,"identity":"1b8c22cc-524a-435b-b4bd-8e8369c01ee0","order_by":0,"name":"Latika Giri","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA4ElEQVRIiWNgGAWjYBACAwbGBoaECrZ6fvYGENeCWC1n+BIkew6AuBLEaAECxja5BIMbCSAmMVr4F7d9eMBmlic58/nVDT8KJBj427sT8GuReNg8I4EnrZhfOqfsZg/QYRJnzm4goOVgM0OCxDHGmbNz0m7wALUYSOQSo8XgP+OGm2fSbv4hSgt/I1BLAlvihhvsx24TaQsjUMsBNmPJnhy22zIGEjwE/WLff/wx489/bHL87Mef3Xzzx0aOv70XvxYGiQQYiwccRzz4lYMA/wEYi/0BYdWjYBSMglEwIgEANgFJD0PwMZQAAAAASUVORK5CYII=","orcid":"","institution":"Kathmandu University School of Medical Sciences","correspondingAuthor":true,"prefix":"","firstName":"Latika","middleName":"","lastName":"Giri","suffix":""},{"id":358466714,"identity":"e24d74d4-f410-4b36-8df4-996f6a0e4d38","order_by":1,"name":"Roshan Singh","email":"","orcid":"","institution":"Kathmandu University School of Medical Sciences","correspondingAuthor":false,"prefix":"","firstName":"Roshan","middleName":"","lastName":"Singh","suffix":""},{"id":358466715,"identity":"0ae3357b-3d89-47a2-9b72-8dec58b2f3ff","order_by":2,"name":"Ahmed Marey","email":"","orcid":"","institution":"Alexandria University","correspondingAuthor":false,"prefix":"","firstName":"Ahmed","middleName":"","lastName":"Marey","suffix":""},{"id":358466716,"identity":"11c03edb-b34c-4feb-8ec4-d9ba08921c05","order_by":3,"name":"Yupeng Li","email":"","orcid":"","institution":"Rowan University","correspondingAuthor":false,"prefix":"","firstName":"Yupeng","middleName":"","lastName":"Li","suffix":""},{"id":358466717,"identity":"3e53d674-9738-4c42-a312-0fa36817f385","order_by":4,"name":"Bharath Venkatesh","email":"","orcid":"","institution":"Johns Hopkins Medicine","correspondingAuthor":false,"prefix":"","firstName":"Bharath","middleName":"","lastName":"Venkatesh","suffix":""},{"id":358466718,"identity":"b02f19df-3883-45ba-864c-63ac5d481229","order_by":5,"name":"Jawdat Abdulla","email":"","orcid":"","institution":"Amager and Hvidovre Hospital","correspondingAuthor":false,"prefix":"","firstName":"Jawdat","middleName":"","lastName":"Abdulla","suffix":""},{"id":358466719,"identity":"c085c534-fb3b-4436-9a56-70e42c6a26ff","order_by":6,"name":"Stefan Zimmerman","email":"","orcid":"","institution":"Johns Hopkins Medicine","correspondingAuthor":false,"prefix":"","firstName":"Stefan","middleName":"","lastName":"Zimmerman","suffix":""},{"id":358466720,"identity":"8e24e21f-c2ff-44e3-8748-f56ed4685662","order_by":7,"name":"Muhammad Umair","email":"","orcid":"","institution":"Johns Hopkins Medicine","correspondingAuthor":false,"prefix":"","firstName":"Muhammad","middleName":"","lastName":"Umair","suffix":""}],"badges":[],"createdAt":"2024-09-03 18:58:43","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-5026991/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-5026991/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":65733736,"identity":"19f10b6f-c9c2-455b-8b47-e0841b492a0f","added_by":"auto","created_at":"2024-10-01 22:39:11","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":35162,"visible":true,"origin":"","legend":"\u003cp\u003eReviews and Meta-Analyses (PRISMA) guideline flowchart for studies selection.\u003c/p\u003e","description":"","filename":"1.png","url":"https://assets-eu.researchsquare.com/files/rs-5026991/v1/a3c717be29f0040b96728dba.png"},{"id":65734338,"identity":"ec8534aa-4988-4c48-a08a-f777f5c7665b","added_by":"auto","created_at":"2024-10-01 22:55:12","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":347133,"visible":true,"origin":"","legend":"\u003cp\u003eForest plot of Diagnostic Odds Ratio of Native T1, T2 mapping and ECV for myocarditis diagnosis\u003c/p\u003e","description":"","filename":"2.png","url":"https://assets-eu.researchsquare.com/files/rs-5026991/v1/431ce169ac684ba388a4e6bb.png"},{"id":65733741,"identity":"0ceb32d8-603e-4738-97ae-25fd87bd8832","added_by":"auto","created_at":"2024-10-01 22:39:12","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":386091,"visible":true,"origin":"","legend":"\u003cp\u003eSensitivity forest plot of Native T1, T2 mapping and ECV for diagnosis ofmyocarditis\u003c/p\u003e","description":"","filename":"3.png","url":"https://assets-eu.researchsquare.com/files/rs-5026991/v1/bbb971c43967698c1163502e.png"},{"id":65734426,"identity":"58d5f2a0-3298-442a-8302-7d0f39ad726c","added_by":"auto","created_at":"2024-10-01 23:03:12","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":382805,"visible":true,"origin":"","legend":"\u003cp\u003eSpecificity forest plot of Native T1, T2 mapping and ECV for diagnosis ofmyocarditis\u003c/p\u003e","description":"","filename":"4.png","url":"https://assets-eu.researchsquare.com/files/rs-5026991/v1/5883cf7b512923c95ea7d517.png"},{"id":65733738,"identity":"626d43d4-44bc-4af1-98da-39659d2bad70","added_by":"auto","created_at":"2024-10-01 22:39:12","extension":"png","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":150527,"visible":true,"origin":"","legend":"\u003cp\u003ePlot of symmetric summary receiver operating curve characteristic of Native T1, T2 mapping and ECV for diagnosis ofmyocarditis\u003c/p\u003e","description":"","filename":"5.png","url":"https://assets-eu.researchsquare.com/files/rs-5026991/v1/c8d1aacc32ad4f491df7e0aa.png"},{"id":65733737,"identity":"cb36fe45-9e1c-4a10-bf24-12dc85ae5416","added_by":"auto","created_at":"2024-10-01 22:39:12","extension":"png","order_by":6,"title":"Figure 6","display":"","copyAsset":false,"role":"figure","size":94519,"visible":true,"origin":"","legend":"\u003cp\u003eROC curve for Native T1, T2 mapping and ECV threshold in diagnosing myocarditis\u003c/p\u003e","description":"","filename":"6.png","url":"https://assets-eu.researchsquare.com/files/rs-5026991/v1/f75592cea5ae3cd41bc49528.png"},{"id":65733998,"identity":"8a99615e-1e3d-4a39-895c-4414e514fe24","added_by":"auto","created_at":"2024-10-01 22:47:12","extension":"png","order_by":7,"title":"Figure 7","display":"","copyAsset":false,"role":"figure","size":224930,"visible":true,"origin":"","legend":"\u003cp\u003eSummary bar diagram and Traffic Light Plot of Risk of Bias\u003c/p\u003e","description":"","filename":"7.png","url":"https://assets-eu.researchsquare.com/files/rs-5026991/v1/32a3589d744696877f4882a7.png"},{"id":75204552,"identity":"a108f140-f00e-4a30-943b-17d6d734c503","added_by":"auto","created_at":"2025-02-01 02:16:30","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2439120,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5026991/v1/92c94329-85eb-46dc-bb90-c74b83c30e81.pdf"},{"id":65733997,"identity":"d8d50ae3-633d-45ad-9eba-70aecb6d41f7","added_by":"auto","created_at":"2024-10-01 22:47:12","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":45085,"visible":true,"origin":"","legend":"","description":"","filename":"TABLES.docx","url":"https://assets-eu.researchsquare.com/files/rs-5026991/v1/7f23cba2f502ad4ab3aea83d.docx"}],"financialInterests":"No competing interests reported.","formattedTitle":"Diagnostic Performance of CMR Parametric Mapping as per Modified Lake Louise Criteria in Acute Myocarditis: An Updated Systematic Review and Meta-Analysis","fulltext":[{"header":"Introduction","content":"\u003cp\u003eMyocarditis, an inflammatory condition of the myocardium, can arise from viral infections, autoimmune disorders, and certain medications.[\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e] Left untreated, it can lead to severe complications including heart failure, arrhythmias, cardiogenic shock, and dilated cardiomyopathy.[\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e] Diagnosing myocarditis is challenging due to its heterogeneous and atypical presentation.[\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e] Endomyocardial biopsy (EMB), while occasionally used, has drawbacks such as invasiveness, sampling limitations, and difficulty in capturing patchy inflammation.[\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e] CMR is a common non-invasive modality for detecting myocarditis, employing techniques like early gadolinium enhancement (EGE), T2-weighted images, and late gadolinium enhancement (LGE) from the classical Lake Louise Criteria to visualize myocardial inflammation.[\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e, \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e] The addition of quantitative parametric techniques, including native T1 mapping, T2 mapping, and ECV in the modified Lake Louise Criteria (mLLC), has further enhanced the diagnostic capability.[\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e, \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e, \u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e] The advantages of parametric mapping include quantitative and objective myocarditis assessment and visualization of global myocardial changes.[\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e, \u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e] Several studies have proposed parametric CMR mapping as a gold standard non-invasive technique for myocarditis diagnosis.[\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e, \u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e] The values of parametric CMR mapping are influenced by field strength, vendors, and acquisition techniques, leading to a lack of universally reliable cutoff values for diagnosing myocarditis.[\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e, \u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e] Our study aims to determine specific native T1 mapping, T2 mapping, and ECV cutoff values that reliably differentiate acute myocarditis from healthy controls. An accurate cut-off for parametric technique like native T1 mapping can help to differentiate acute myocarditis patients from healthy controls and narrow non-definitive diagnosis cases.[\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e] Both native T1 and T2 mapping are sufficient as single markers and can increase diagnostic confidence when used together.[\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e] Additionally, combining parametric techniques, such as native T1 and T2 mapping along with ECV, has proven beneficial in increasing sensitivity and specificity for myocarditis detection.[\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e] The aim of this study is also to evaluate the diagnostic performance of these single and combined mapping techniques in diagnosing myocarditis.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003eWe conducted a systematic review and meta-analysis to assess the diagnostic performance of parametric CMR parameters\u0026mdash;Native T1, T2 mapping, and ECV for myocarditis diagnosis (individual or combined) and provide their respective cut-off values in acute myocarditis cases. The study adhered to PRISMA guidelines, and the protocol was registered in PROSPERO (CRD42023484275).\u003c/p\u003e \u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003e1. Study search and selection criteria\u003c/h2\u003e \u003cp\u003eTwo reviewers (L.G. and R.S.) independently searched PubMed and Google Scholar for relevant studies using predefined keywords: including [\"myocarditis\" AND \u0026ldquo;magnetic resonance imaging\u0026rdquo; AND \u0026ldquo;Lake Louise Criteria AND \"Modified Lake Louise Criteria,\u0026rdquo; AND \"New Lake Louise Criteria,\" AND \"2018 Lake Louise Criteria\") AND \u0026ldquo;ECV\u0026rdquo;]. Studies from 2014 to 2024 were included. Inclusion criteria encompassed prospective and retrospective studies evaluating the diagnostic accuracy of the three parametric CMR techniques: Native T1, T2 mapping and ECV compared to EMB or accurate clinical assessment as reference. Despite the introduction of the mLLC in 2018, our inclusive approach considered studies dating back to 2014, as many authors had incorporated mapping techniques and ECV in their research even before the formal introduction of the mLLC in 2018. Exclusion criteria eliminated case reports, reviews, and studies lacking sufficient data on calculating sensitivity or specificity. Disagreements were resolved through discussion or involvement of a third reviewer (M.U.). Risk of bias was assessed using QUADAS-2 forms. \u003cb\u003e(\u003c/b\u003eFig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e\u003cb\u003e)\u003c/b\u003e\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec4\" class=\"Section2\"\u003e \u003ch2\u003e2. Statistical Analysis\u003c/h2\u003e \u003cp\u003eThe meta-analysis was performed using R version 4.3.2. Pooled Diagnostic Odds Ratios (DORs) and 95% Confidence Intervals (CIs) were calculated for single parametric techniques and, if available, for combined parametric mapping. Diagnostic accuracy was evaluated using the AUC from Summary Receiver Operating Characteristic (SROC) curves. A univariate random-effects model assessed pooled sensitivity and specificity, and statistical heterogeneity was evaluated using the I\u0026sup2; statistic, with significant heterogeneity defined as I\u0026sup2; \u0026gt; 60%. ROC analysis was performed to calculate the optimal thresholds of native T1, T2 mapping, and ECV along with their respective AUC, sensitivities and specificities. Pooled mean native T1, T2 mapping, and ECV values were calculated by combining means and standard deviations from multiple studies, and optimal thresholds were calculated by Receiver operating curves (ROC). Subgroup analyses were conducted based on study reference standards. Funnel plots and Egger's regression test were used to inspect and test for publication bias. Continuous variables were expressed as means\u0026thinsp;\u0026plusmn;\u0026thinsp;standard deviations, and categorical values as numbers and percentages.\u003c/p\u003e \u003c/div\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cu\u003eSearch results\u003c/u\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA total of 1199 articles were initially identified, with 180 undergoing full-text review. Ultimately, 11 studies from 2014 to 2022 were included in the meta-analysis. These comprised seven prospective and four retrospective designs, primarily conducted in Germany. \u003cstrong\u003e(Table 1\u003c/strong\u003e) \u003cstrong\u003e(Table 2)\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTable 1: Summary of study characteristics, demography of included studies.\u003c/p\u003e\n\u003cdiv align=\"center\" style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\n \u003ctable style=\"border-collapse: collapse;border: none;width: 599px;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 22pt;border: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 48.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eSN\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 97.9pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 48.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eAuthor (First Author)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 40.05pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 48.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eYear\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 68.5pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 48.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eStudy design\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width: 162.85pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 48.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;Baseline characteristics of patients\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 57.85pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 48.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eReference Standard\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 37.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 31.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eAge\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 31.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eMale (%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 22.65pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 31.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eN\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 31.2pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003ePresentation\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 22pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eHuber\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.05pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e2018\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eRetrospective cohort with case-control element\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003ctable style=\"border: none;border-collapse: collapse;width: 40px;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 30.15pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e45(29-61)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 30.15pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 30.15pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 30.15pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 30.15pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 30.15pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 30.15pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 30.15pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 30.15pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003ctable style=\"border: none;border-collapse: collapse;width: 41px;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 30.75pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003e60/40\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 30.75pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 30.75pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 30.75pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 30.75pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 30.75pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 30.75pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 30.75pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 30.75pt;padding: 0in 5.75pt;height: 3.05pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 22.65pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e60\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eAcute\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.85pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eCLINICAL\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 22pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 61.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 61.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003ctable style=\"border: none;border-collapse: collapse;width: 60px;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 45.1pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;line-height:115%;font-family:\"Times New Roman\",serif;'\u003eRadunski\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 45.1pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 45.1pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 45.1pt;padding: 0in 5.75pt;height: 5.6pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 45.1pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 45.1pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 45.1pt;padding: 0in 5.75pt;height: 15.2pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 45.1pt;padding: 0in 5.75pt;height: 3.05pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.05pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 61.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e2014\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 61.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eRetrospective case control\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 61.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e44\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 61.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e76/24\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 22.65pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 61.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e125\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 61.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eAcute\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.85pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 61.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eCLINICAL\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 22pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;Isaaki\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.05pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e2021\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eRetrospective case control\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e17(14-20)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e77/23\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 22.65pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e56\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eAcute\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.85pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eEMB\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 22pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 26.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 26.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003ePalmisano\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.05pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 26.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e2020\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 26.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eProspective case control\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 26.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e39(28-46)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 26.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e51/49\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 22.65pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 26.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e43\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 26.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eAcute\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.85pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 26.3pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eCLINICAL\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 22pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eLuetkens\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.05pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e2015\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eProspective case control\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e44.9(26.2-63.17)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e50/50\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 22.65pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e84\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eAcute\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.85pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eCLINICAL\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 22pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 13.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 13.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eLi\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.05pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 13.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e2021\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 13.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eRetrospective cohort with case-control element\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 13.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e32 (18-50\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 13.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e71.2/28.8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 22.65pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 13.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e73\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 13.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eAcute\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.85pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 13.6pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eEMB\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 22pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eLurz\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.05pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e2016\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eProspective cohort with case-control element\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e40\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e83/17\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 22.65pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e129\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eAcute\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.85pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.1pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eEMB\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 22pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eKnobelsdorff-Brenkenhoff\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.05pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e2017\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eProspective cohort with case-control element\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e24.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e78/22\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 22.65pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e36\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eAcute\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.85pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.45pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eCLINICAL\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 22pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 18.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 18.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eLuetkens\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.05pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 18.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e2019\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 18.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eProspective cohort with case-control element\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 18.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e41(23-64) \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 18.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e72.5/27.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 22.65pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 18.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e66\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 18.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eAcute\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.85pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 18.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eCLINICAL\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 22pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 18.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e10\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 18.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eDabir\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.05pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 18.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e2019\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 18.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eProspective cohort with case-control element\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 18.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e38(22-54)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 18.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e77/23\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 22.65pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 18.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e80\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 18.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eAcute\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.85pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 18.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eCLINICAL\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 22pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 25.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e11\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 97.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eBrendel\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.05pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e2022\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eProspective cohort with case-control element\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 37.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;48 (30\u0026ndash;63)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 41.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e44/56\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 22.65pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e48\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.1pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eAcute\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.85pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 25.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eEMB\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003e\u003cem\u003eMs: millisecond\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eT1: Native T1\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003e\u003cem\u003e\u0026nbsp;Acute myocarditis: patients presenting with symptoms within 28 days.\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eTable 2: CMR characteristics of included studies\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse;border: none;width: 690px;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 40.25pt;border: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eStudy ID\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eNative T1 Control\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.5pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eNative T1 Cases\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width: 45pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eT2 Control\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eT2 Cases\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.75in;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eECV Control\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eECV Cases\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 0.75in;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eNative T1 mapping technique\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.75in;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eT2 mapping technique\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eVendor\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eMagnet strength\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 40.25pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eHuber 2028\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e965 (940-990)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1044 (981-1107)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e48 (46-50)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e53 (49-57)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e22 (19-25)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e24 (17-31)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eMOLLI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003ebSSFP\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eSiemens\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1.5 T\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 40.25pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eRadunski 2014\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1051 (1010-1063)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1098 (1057-1139)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e55 (54-60)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e61 (58-65)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e25 (24-27)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e31 (28-34)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eMOLLI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eN/A\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003ePhilips\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1.5 T\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 40.25pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eIsaaki 2021\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e962 (945-979)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1031 (985-1077)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e51 (49-53)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e58 (53-63)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e26.5 (23.7-29.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e29.2 (23.3-35.1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eMOLLI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eGraSE\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003ePhilips\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1.5 T\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 40.25pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003ePalmisano 2020\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1008 (988-1033)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1093 (1050-1201)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e47 (46-47.6)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e55 (52-59)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e25 (24-26)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e30 (27-32)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eMOLLI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eN/A\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003ePhilips\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1.5 T\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 40.25pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eLuetkens 2015\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e966.9 (939.1-994.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1048.6 (996.7-1100.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e52.42 (49.86-54.98)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e60.43 (52.96-67.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e27.68 (21.86-33.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e34.47 (25.95-43.99)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eMOLLI/ShMOLLI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eGraSE\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003ePhilips\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1.5 T\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 40.25pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eLi 2021\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1195 (1152-1238)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1252 (1210-1294)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e54.5 (50.8-58.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e63.2 (57.1-69.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e29.3 (25.2-33.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e32.7 (29.4-36)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eMOLLI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eGraSE\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003ePhilips\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e3 T\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 40.25pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eLurz 2016\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1044 (1002-1086)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1113 (1046-1180)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e56.9 (49.7-64.1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e62.2 (57.7-66.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e31.8 (26.9-36.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e37.2 (30.7-43.7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eMOLLI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eN/A\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003ePhilips\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1.5 T\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 62.6pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eKnobelsdorff-Brenkenhoff 2017\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 63.15pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e975 (957-1004)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1004 (988-1048)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e50.2 (49.2-52)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.5in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e55.1 (53.3-57.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 0.25in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e24 (24-25)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e26 (25-28)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eMOLLI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003ebSSFP\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003ePhilips\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1.5 T\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 62.6pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eLuetkens 2019\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 63.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e965.8 (940.7-990.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.85pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1047.0 (993.2-1100.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 55.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e52.8 (50.4-55.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 38.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e61.8 (53.6-70)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 15.4pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e26.1 (21.9-30.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 75.05pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e28.6 (23.3-33.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 39.4pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eMOLLI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eGraSE\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 50.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003ePhilips\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1.5 T\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 62.6pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eDabir 2019\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 63.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e958.9 (936.4-981.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.85pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1027.2 (977.9-1076.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 55.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e51.6 (49.7-53.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 38.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e58 (52-64)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 15.4pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e27.7 (24.5-30.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 75.05pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e32 (25.6-38.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 39.4pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eMOLLI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eGraSE\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 50.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003ePhilips\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1.5 T\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 62.6pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eBrendel 2022\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 63.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1015 (1015-1015)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.85pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e1069 (1024-1127)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 55.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e50 (50-50)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 38.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e53 (52-56)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 15.4pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e30 (30-30)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 75.05pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e33 (31-35)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 39.4pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eMOLLI\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 32.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003ebSSFP\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 50.8pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003ePhilips\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 62.6pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eOptimal Diagnostic Thresholds*\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width: 97.35pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eNative T1 Threshold=1021 ms\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eROC AUC=0.82\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eSensitivity=91%\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eSpecificity=73%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width: 94.4pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eT2 mapping threshold=54 ms\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eROC AUC=0.93\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eSensitivity=82%\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eSpecificity=82%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width: 90.45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eECV threshold=28%\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eROC AUC=0.79\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eSensitivity=82%\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eSpecificity=73%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width: 172.45pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cem\u003e*Optimal diagnostic thresholds were determined using ROCs curve\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cu\u003eDiagnostic accuracy results\u0026nbsp;\u003c/u\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003ePooled mean T1 time was 1075.16\u0026plusmn;64.22 ms, and pooled mean T2 time was 58.25\u0026plusmn;3.58 ms for myocarditis cases. ECV cutoffs ranged from 22% to 34.47%, and post-contrast T1 timing ranged from 10 to 15 minutes. Out of the eleven studies, only two studies had Siemens as a vendor.\u003ca href=\"https://www.zotero.org/google-docs/?c0mB57\"\u003e\u003csup\u003e17\u003c/sup\u003e\u003c/a\u003e\u003csup\u003e,\u003c/sup\u003e\u003ca href=\"https://www.zotero.org/google-docs/?QfJcab\"\u003e\u003csup\u003e8\u003c/sup\u003e\u003c/a\u003e Ten studies utilized MOLLI (Modified Look-Locker Inversion recovery) for native T1 mapping, with one using both ShMOLLI (Shortened Modified Look-Locker Inversion recovery) and MOLLI. We had five studies utilizing GraSE (Gradient and Spin Echo), three using bSSFP (balanced Steady-state free precession) as a T2 mapping technique and three studies did not report the T2 mapping technique utilized. Diagnostic accuracy for Native T1, T2 mapping, and ECV was reported in all studies \u003cstrong\u003e(Table 3\u003c/strong\u003e). Native T1 demonstrated the highest sensitivity (83%) and specificity (86%) among the evaluated parameters, with an inconsistency (I-square I2) of 69% for sensitivity and 75% for specificity. It also had a DOR of 39 and an AUC of 0.91. T2 mapping showed similar sensitivity (81%) and specificity (86%) with I2 of 72.2% and 69% respectively, and a DOR of 25 with an AUC of 0.89. ECV exhibited moderate sensitivity (71%) and specificity (81%) with I2 of 72% and 37%, along with a lower DOR of 13 and an AUC of 0.83. \u003cstrong\u003e(Figure 2, 3, 4, 5)\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eTable 3: Diagnostic accuracies and heterogeneity indices of individual mapping parameters Native T1, T2 mapping and ECV\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003ctable style=\"width: 609px;border-collapse: collapse;border: none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"border: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 15.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eParameter\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.9pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 15.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eSensitivity\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.3pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 15.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eInconsistency (I-square)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.35pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 15.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eSpecificity\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 15.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eInconsistency (I-square)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 15.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eDiagnostic Odds Ratio (DOR)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 15.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eArea Under Curve (AUC)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 22.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eNative T1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 22.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e83%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.3pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 22.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e69%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.35pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 22.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e86%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 22.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e75%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 22.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e39\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 22.9pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e0.91\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 27.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eT2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e81%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.3pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e72%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.35pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e86%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e69%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e25\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 27.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e0.89\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 23.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eECV\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.9pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 23.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e71%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.3pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 23.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e72%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.35pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 23.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e81%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 23.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e37%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 23.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e13\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 23.8pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e0.83\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003eThe optimal cut-off for native T1 mapping was 1021 ms (ROC AUC=0.82, Sensitivity=91%, Specificity=73%). For ECV, the threshold was 28% (ROC AUC=0.79, Sensitivity=82%, Specificity=73%) and T2 mapping had an optimal threshold of 54 ms (ROC AUC=0.93, Sensitivity=82%, Specificity=82%). \u003cstrong\u003e(Figure 6)\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eSubgroup analyses revealed no significant differences in diagnostic accuracy based on clinical criteria or EMB reference standards. Meta-regression showed no significant sensitivity differences for Native T1, T2, and ECV (P-value\u0026gt;0.05), though Native T1 mapping specificity varied significantly (P-value\u0026lt;0.05). (\u003cstrong\u003eTable 4\u003c/strong\u003e) Funnel plot examination and Egger\u0026rsquo;s test indicated no significant publication bias for T1, T2, and ECV parameters (p \u0026gt; 0.05 for all on Egger\u0026rsquo;s test).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eTable 4: Results of meta-regression and subgroup analyses based on reference standard of studies.\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;text-align:justify;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse;border: none;width: 623px;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003eMapping technique\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 59.05pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003eApproach\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.65pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003eStudy number\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.5pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003esensitivity\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 59.6pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003ep-value\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.55pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003especificity\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 59.65pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003ep-value\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 71.5pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003eNative T1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 59.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003eClinical\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e79% (70-87)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 59.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e0.77\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e92% (87-96)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 59.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 59.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003eEMB\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e88% (82-93)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e70% (50-84)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 71.5pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003eT2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 59.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003eClinical\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e78% (67-87)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 59.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e0.205\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e90% (84-93)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 59.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e0.076\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 59.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003eEMB\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e85% (79-90)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e77% (56-90)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 71.5pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003eECV\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 59.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003eClinical\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e67% (55-78)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 59.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e0.174\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e84% (78-89)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 59.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-family:Cambria;color:black;background:white;\"\u003e0.102\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 59.05pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-size:13px;font-family:Cambria;color:black;background:white;\"\u003eEMB\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-size:13px;font-family:Cambria;color:black;background:white;\"\u003e4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-size:13px;font-family:Cambria;color:black;background:white;\"\u003e81% (64-91)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 77.55pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style=\"font-size:13px;font-family:Cambria;color:black;background:white;\"\u003e74% (62-84)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003e\u003cu\u003eStudy quality assessment and integrated diagnostic performance of different CMR approaches\u003c/u\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eOverall study quality was moderate and acceptable per QUADAS-2, with one study showing high risk of bias due to non-uniform EMB performance, case control selection. (\u003cstrong\u003eFigure 7) (Table 5)\u003c/strong\u003e. Five studies investigated combined CMR approaches, with various combinations showing high sensitivity, specificity, and AUC (\u003cstrong\u003eTable 6\u003c/strong\u003e).\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eTable 5: Quality Assessment (QADAS-2)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003ctable style=\"width: 623px;border-collapse: collapse;border: none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.75pt;border: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eStudy Number\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.75pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eStudy ID\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eDomain 1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eDomain 2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003e\u0026nbsp;Domain 3\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eDomain 4\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 94.5pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eOverall Risk of Bias\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.75pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003e1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eHuber 2018\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 94.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.75pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003e2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eRadunski 2014\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 94.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.75pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003e3\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eIsaak 2021\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 94.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.75pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003e4\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003ePalmisano 2020\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eUnclear\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 94.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.75pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003e5\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLuetkens 2015\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eUnclear\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 94.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.75pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003e6\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLi 2021\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 94.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.75pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003e7\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLurz 2016\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 94.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.75pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003e8\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eKnobelsdorff-Brenkenhoff 2017\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 94.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.75pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003e9\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLuetkens 2019\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eUnclear\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 94.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.75pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003e10\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eDabir 2019\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 94.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.75pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003e11\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.75pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eBrendel 2022\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.75in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eUnclear\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eHigh\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eLow\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 94.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;height: 14.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\";color:black;'\u003eHigh\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;font-size:15px;font-family:\"Cambria\",serif;'\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp style='margin:0in;font-size:15px;font-family:\"Cambria\",serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp style='margin:0in;font-size:15px;font-family:\"Cambria\",serif;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;'\u003eDomain 1: Was the patient population representative of the population under investigation, with clear criteria for patient inclusion and exclusion, enrollment through consecutive or random sampling, and balanced reporting of patient demographics (age, gender) across study groups? , Domain 2: Were the CMR parameters (T1, T2, ECV) described in sufficient detail, with consistency in the application and interpretation of CMR techniques across studies, blinded assessment of CMR parameters to the reference standard results, and a pre-specified threshold for abnormal CMR findings?, Domain 3: Was endomyocardial biopsy deemed an appropriate reference standard for myocarditis diagnosis, with blinded interpretation of biopsy findings to CMR parameter results, consistency in the application of clinical criteria across studies, and uniform timing of clinical criteria utilization in relation to symptom presentation?, Domain 4: Was there inclusion of all eligible patients in the analysis, with consistent intervals between symptom presentation and CMR testing, CMR testing and the reference standard (EMB/clinical criteria), and analysis of patients in the groups to which they were initially assigned?\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;text-align:justify;text-indent:-.1pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eTable 6: Results of diagnostic values of combined parametric mapping techniques\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse;border: none;width: 624px;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.75pt;border: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height: normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eS.N.\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 94.5pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height: normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eAuthor\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 117pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height: normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eCombination\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.5in;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height: normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eSensitivity\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 112.25pt;border-top: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height: normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;text-align:justify;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eSpecificity\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.75pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003e1.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 94.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eRadunski et al\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 117pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eLGE+ECV\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.5in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003e94% (88-98)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 112.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003e71% (48-89)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.75pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003e2.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 94.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eIsaak et al\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 117pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eT1+T2 mapping\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.5in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003e85% (64\u0026ndash;96)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 112.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003e100% (79\u0026ndash;100)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.75pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003e3.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 94.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eLi et al\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 117pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\n \u003col style=\"margin-bottom:0in;list-style-type: lower-alpha;\"\u003e\n \u003cli style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eT1+T2 mapping\u003c/span\u003e\u003c/li\u003e\n \u003cli style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eLGE + T2 mapping\u003c/span\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.5in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003ea. 82.2%\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eb. 79.5%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 112.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.75pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003e4.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 94.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eBrenkenhoff et al\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 117pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003ea. T1+T2\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eb. T2+ECV\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003ec. T1+LGE\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003ed. T2+LGE\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003ee. T1+T2+LGE\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.5in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003ea.77.8% (52.4-93.6)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eb.82.4% (56.6-96.2)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003ec.72.2% (46.5-90.3)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003ed.66.7% (41-86.7)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003ee. 66.7% (41-86.7)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 112.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003ea. 94.4% (72.7-99.9)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eb.94.4% (72.7-99.9)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003ec.100% (81.5-100)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003ed. 100% (81.5-100)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003ee. 100% (81.5-100)\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 35.75pt;border-right: 1pt solid rgb(191, 191, 191);border-bottom: 1pt solid rgb(191, 191, 191);border-left: 1pt solid rgb(191, 191, 191);border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003e5.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 94.5pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eBrendel et al\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 117pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cdiv style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\n \u003col style=\"margin-bottom:0in;list-style-type: lower-alpha;\"\u003e\n \u003cli style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eT1 + ECV\u003c/span\u003e\u003c/li\u003e\n \u003cli style='margin:0in;line-height:115%;font-size:15px;font-family:\"Arial\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eT2 + ECV\u003c/span\u003e\u003c/li\u003e\n \u003c/ol\u003e\n \u003c/div\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1.5in;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003ea. 96%\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eb. 83%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 112.25pt;border-top: none;border-left: none;border-bottom: 1pt solid rgb(191, 191, 191);border-right: 1pt solid rgb(191, 191, 191);padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003ea. 83%\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;line-height:normal;font-size:15px;font-family:\"Arial\",sans-serif;margin-bottom:8.0pt;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;color:black;'\u003eb. 92%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;font-size:15px;font-family:\"Cambria\",serif;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003eAll the combinations are based on Native T1 mapping.\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eOur study focused on evaluating the diagnostic accuracies of individual parametric mapping techniques for acute myocarditis. Prolonged T1 values, attributed to cellular edema, increased extracellular space, inflammation, and myocyte necrosis, are consistently observed in myocarditis cases.[\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e, \u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e] Native T1 mapping showed the highest accuracy among the studied techniques, consistently demonstrating good diagnostic performance (AUC 0.90, DOR 39) compared to T2 mapping (AUC 0.88, DOR 25) and ECV (AUC 0.83, DOR 13). This aligns with findings by several other studies indicating superior diagnostic efficacy of T1 mapping techniques over original LLC 2009 techniques (T2-Weighted imaging, LGE, and EGE).[\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e, \u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e, \u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e, \u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e]\u003c/p\u003e \u003cp\u003eIt is well known that native T1 values can be affected by mapping sequence used and field strength.\u003csup\u003e21\u003c/sup\u003e In the current study, however, we found relative uniformity among the studies included in the meta-analysis with respect to these parameters. Ten of eleven studies used the MOLLI sequence, and ten studies used a 1.5 T strength magnet. Hence the inter-study variation in Native T1 values in the current study are likely secondary to other factors. Caution should be taken in applying the current results if not using MOLLI on a 1.5T scanner. For native T1 mapping an optimal cut-off of 1021 ms (ROC AUC\u0026thinsp;=\u0026thinsp;0.82, Sensitivity\u0026thinsp;=\u0026thinsp;91%, Specificity\u0026thinsp;=\u0026thinsp;73%) was found. However, this is a statistical threshold, and its clinical significance still needs to be completely determined.\u003c/p\u003e \u003cp\u003eECV, derived from pre- and post-contrast T1 and hematocrit values, exhibited promise with an AUC of 0.83. However, it is well known that edema itself elevates ECV, which may make the utility of ECV even less reliable among the hyper acute and acute phase of inflammation.[\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e] A median time of less than 14 days from symptom onset to CMR acquisition in our analysis likely contributed to ECV's lower sensitivity, as observed in study by Luetkens et al.[\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e] ECV values vary with CMR sequences but remain unaffected by field strength, distinguishing them from native T1 and T2 mapping.[\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e] Li et al. reported an ECV of 32.7% (29.4\u0026ndash;36) for acute myocarditis cases, and 29.3% (25.2\u0026ndash;33.4) for controls (p\u0026thinsp;\u0026lt;\u0026thinsp;0.01) using a 3T magnet. In comparison, Dabir et al. found an ECV of 32% (25.6\u0026ndash;38.4) for myocarditis patients and 27.7% ( 24.5\u0026ndash;30.9) for controls (p\u0026thinsp;=\u0026thinsp;0.01) using a 1.5 T magnet.[\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e, \u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e] ECV had an optimal threshold of 28% (ROC AUC\u0026thinsp;=\u0026thinsp;0.79, Sensitivity\u0026thinsp;=\u0026thinsp;82%, Specificity\u0026thinsp;=\u0026thinsp;73%) however it is a statistical measure.\u003c/p\u003e \u003cp\u003eMyocardial T2 relaxation time emerged as a promising marker, with significantly elevated values in patients during acute presentation compared to controls. Myocardial T2 relaxation time, closely linked to free tissue water content, with significantly elevated values in acute myocarditis patients.[\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e] In our study, T2 mapping demonstrated comparable diagnostic efficacy to native T1, with an AUC of 0.88. Variations in T2 mapping techniques and thresholds necessitate consideration of acquisition types, patient populations, and clinical contexts.[\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e, \u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e] A statistical analysis identified an optimal threshold of 54 ms for detecting myocarditis using T2 mapping, with a ROC AUC of 0.93, 82% sensitivity, and 82% specificity.\u003c/p\u003e \u003cp\u003eThis meta-analysis includes combined mapping techniques from recent studies. This combined approach is most reflective of clinical practice. Five studies reported enhanced diagnostic outcomes by use of several different integrated mapping techniques, such as native T1\u0026thinsp;+\u0026thinsp;T2, native T1\u0026thinsp;+\u0026thinsp;ECV.[\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e, \u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e, \u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e, \u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e, \u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e] A study by Li et al. demonstrated high diagnostic performance when combining native T1\u0026thinsp;+\u0026thinsp;T2 mapping over a single parameter of mLLC.[\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e] A small number of studies precluded a pooled analysis in our meta-analysis. Subgroup analysis with fewer than 4 studies would be unreliable due to low statistical power to detect true differences between subgroups. The study supports the notion that native T1 and T2 mapping allow for a reliable distinction between injured and normal myocardium but may struggle to discriminate between acute myocarditis and other noninflammatory cardiomyopathy or myocarditis with a chronic presentation.\u003c/p\u003e \u003cp\u003eThe diagnostic accuracy of parametric mapping techniques has been established to be superior to older techniques. Available parametric mapping evaluations demonstrate that at least one of the main modified LL criteria can effectively diagnose myocarditis with little less accuracy as an alternative to EMB (Sensitivity 88% for EMB\u0026thinsp;\u0026gt;\u0026thinsp;80% for parametric mapping in CMR).[\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e]\u003c/p\u003e \u003cdiv id=\"Sec13\" class=\"Section2\"\u003e \u003ch2\u003eLimitations\u003c/h2\u003e \u003cp\u003eThe results of this meta-analysis should be interpreted cautiously due to possible selection and reference biases. Most studies included in our analysis exhibited variability in population, study design, patient characteristics, observer interpretations, and CMR acquisition protocols. EMB was utilized as reference in four studies, while the other studies relied on clinical diagnoses and case-control designs. Some studies did not report local normal data for Native T1 mapping, potentially affecting diagnostic accuracy. Variations in T2 mapping techniques (Gradient and Spin Echo or Steady-state free precession) and CMR vendors (Philips or Siemens) at 1.5 T field strength may limit generalizability. The small number of studies on updated LLC combined mapping parameters precluded a reliable sensitivity analysis, particularly for combined T1 and T2 mapping techniques.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec14\" class=\"Section2\"\u003e \u003ch2\u003eClinical Implications and Future Directions\u003c/h2\u003e \u003cp\u003eOur investigation underscores Native T1 mapping as the most effective modality for diagnosing acute myocarditis, with T2 mapping and ECV presenting viable alternatives. Future studies should refine diagnostic protocols based on patient presentation timing, standardize CMR methods across large, matched cohorts, and consider diagnostic network meta-analyses to optimize approaches. This approach aims to reduce diagnostic costs and clinical workload associated with myocarditis, facilitating more precise and efficient diagnosis.\u003c/p\u003e \u003c/div\u003e"},{"header":"Conclusion","content":"\u003cp\u003eThe utilization of CMR based parametric mapping emerges as a valuable diagnostic strategy for acute myocarditis with native T1 mapping exhibiting highest diagnostic accuracy across the board, followed by T2 mapping and ECV. The pooled optimal threshold values of each native T1, T2 mapping, and ECV obtained from ROC aid in adequate diagnosis of myocarditis. We recommend further studies to explore the diagnostic performance of combined parametric mapping techniques.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgment\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe would like to express our sincere gratitude to all the researchers and clinicians whose work contributed to the studies included in this systematic review and meta-analysis. Additionally, we extend our appreciation to Dr. Alireza Ghodsi for his contribution in literature search. We also acknowledge the contributions of the PROSPERO team for their assistance with study registration.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor contributions\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eLG conceived and designed the study, conducted literature search, performed data extraction and analysis, and drafted the manuscript. RS conducted literature search, performed data extraction, and contributed to the interpretation of results. AM participated in the study design, conducted literature search, contributed to the interpretation of results, and provided critical feedback on the manuscript. BV assisted in the study design, conducted literature search, and contributed to the interpretation of results. YL contributed to the study design, performed data extraction and analysis, contributed to the interpretation of results, and provided valuable input during manuscript preparation. JA participated in the study design and provided critical revisions to the manuscript. SZ participated in the study design and provided critical revisions to the manuscript. MU supervised the study, provided guidance on study design and methodology, contributed to the interpretation of results, critically reviewed the manuscript for intellectual content.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eAUC: Area Under Curve\u003c/p\u003e\n\u003cp\u003ebSSFP: Balanced Steady-state Free Precession\u003c/p\u003e\n\u003cp\u003eCMR: Cardiovascular Magnetic Resonance Imaging\u003c/p\u003e\n\u003cp\u003eDOR: Diagnostic Odds Ratio\u003c/p\u003e\n\u003cp\u003eECV: Extracellular Volume\u003c/p\u003e\n\u003cp\u003eEMB: Endomyocardial Biopsy\u003c/p\u003e\n\u003cp\u003eEGE: Early Gadolinium Enhancement\u003c/p\u003e\n\u003cp\u003eGraSE: Gradient and Spin Echo\u003c/p\u003e\n\u003cp\u003eLLC: Lake Louise Criteria\u003c/p\u003e\n\u003cp\u003eLGE: Late Gadolinium Enhancement\u003c/p\u003e\n\u003cp\u003emLLC: Modified Lake Louise Criteria\u003c/p\u003e\n\u003cp\u003eMOLLI: Modified Look-Locker Inversion recovery\u003c/p\u003e\n\u003cp\u003ems: milliseconds\u003c/p\u003e\n\u003cp\u003ePPV: Positive Predictive Value\u003c/p\u003e\n\u003cp\u003ePROSPERO: International Prospective Register of Systematic Reviews\u003c/p\u003e\n\u003cp\u003eQUADAS-2: Quality Assessment of Diagnostic Accuracy Studies\u003c/p\u003e\n\u003cp\u003eROC: Receiver-operating Characteristic\u003c/p\u003e\n\u003cp\u003eSD: Standard Deviation\u003c/p\u003e\n\u003cp\u003eShMOLLI: Shortened Modified Look-Locker Inversion recovery\u003c/p\u003e\n\u003cp\u003eSROC: Summary Receiver Operating Characteristic\u003c/p\u003e\n\u003cp\u003eT2: T2 mapping\u003c/p\u003e\n\u003cp\u003eT1: Native T1 mapping\u003c/p\u003e\n\u003cp\u003e1.5T: 1.5 Tesla\u003c/p\u003e\n\u003cp\u003e3T: 3 Tesla\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eLampejo T, Durkin SM, Bhatt N, Guttmann O (2021) Acute myocarditis: aetiology, diagnosis and management. Clin Med 21(5):e505\u0026ndash;e510. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.7861/clinmed.2021-0121\u003c/span\u003e\u003cspan address=\"10.7861/clinmed.2021-0121\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eTsch\u0026ouml;pe C, Ammirati E, Bozkurt B et al (2021) Myocarditis and inflammatory cardiomyopathy: current evidence and future directions. Nat Rev Cardiol 18(3):169\u0026ndash;193. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/s41569-020-00435-x\u003c/span\u003e\u003cspan address=\"10.1038/s41569-020-00435-x\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eCaforio ALP, Pankuweit S, Arbustini E et al (2013) Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 34(33):2636\u0026ndash;2648. 2648a-2648d\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eKiamanesh O, Toma M (2021) The State of the Heart Biopsy: A Clinical Review. CJC Open 3(4):524\u0026ndash;531. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.cjco.2020.11.017\u003c/span\u003e\u003cspan address=\"10.1016/j.cjco.2020.11.017\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eFerreira VM, Schulz-Menger J, Holmvang G et al (2018) Cardiovascular Magnetic Resonance in Nonischemic Myocardial Inflammation. J Am Coll Cardiol 72(24):3158\u0026ndash;3176. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.jacc.2018.09.072\u003c/span\u003e\u003cspan address=\"10.1016/j.jacc.2018.09.072\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eKersten J, Heck T, Tuchek L, Rottbauer W, Buckert D (2020) The Role of Native T1 Mapping in the Diagnosis of Myocarditis in a Real-World Setting. J Clin Med 9(12):3810. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.3390/jcm9123810\u003c/span\u003e\u003cspan address=\"10.3390/jcm9123810\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLuetkens JA, Faron A, Isaak A et al (2019) Comparison of Original and 2018 Lake Louise Criteria for Diagnosis of Acute Myocarditis: Results of a Validation Cohort. Radiol Cardiothorac Imaging 1(3):e190010. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1148/ryct.2019190010\u003c/span\u003e\u003cspan address=\"10.1148/ryct.2019190010\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLurz P, Luecke C, Eitel I et al (2016) Comprehensive Cardiac Magnetic Resonance Imaging in Patients With Suspected Myocarditis. J Am Coll Cardiol 67(15):1800\u0026ndash;1811. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.jacc.2016.02.013\u003c/span\u003e\u003cspan address=\"10.1016/j.jacc.2016.02.013\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eHaaf P, Garg P, Messroghli DR, Broadbent DA, Greenwood JP, Plein S (2017) Cardiac T1 Mapping and Extracellular Volume (ECV) in clinical practice: a comprehensive review. J Cardiovasc Magn Reson 18(1):89. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1186/s12968-016-0308-4\u003c/span\u003e\u003cspan address=\"10.1186/s12968-016-0308-4\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBohnen S, Radunski UK, Lund GK et al (2015) Performance of T1 and T2 Mapping Cardiovascular Magnetic Resonance to Detect Active Myocarditis in Patients With Recent-Onset Heart Failure. Circ Cardiovasc Imaging 8(6):e003073. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1161/CIRCIMAGING.114.003073\u003c/span\u003e\u003cspan address=\"10.1161/CIRCIMAGING.114.003073\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLaissy JP, Hyafil F, Feldman LJ et al (2005) Differentiating Acute Myocardial Infarction from Myocarditis: Diagnostic Value of Early- and Delayed-Perfusion Cardiac MR Imaging. Radiology 237(1):75\u0026ndash;82. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1148/radiol.2371041322\u003c/span\u003e\u003cspan address=\"10.1148/radiol.2371041322\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eZhu L, Wang Y, Zhao S, Lu M (2022) Detection of myocardial fibrosis: Where we stand. Front Cardiovasc Med 9:926378. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.3389/fcvm.2022.926378\u003c/span\u003e\u003cspan address=\"10.3389/fcvm.2022.926378\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBaessler B, Luecke C, Lurz J et al (2019) Cardiac MRI and Texture Analysis of Myocardial T1 and T2 Maps in Myocarditis with Acute versus Chronic Symptoms of Heart Failure. Radiology 292(3):608\u0026ndash;617. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1148/radiol.2019190101\u003c/span\u003e\u003cspan address=\"10.1148/radiol.2019190101\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eDabir D, Child N, Kalra A et al (2014) Reference values for healthy human myocardium using a T1 mapping methodology: results from the International T1 Multicenter cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 16(1):69. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1186/s12968-014-0069-x\u003c/span\u003e\u003cspan address=\"10.1186/s12968-014-0069-x\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eVon Knobelsdorff-Brenkenhoff F, Sch\u0026uuml;ler J, Dogang\u0026uuml;zel S et al (2017) Detection and Monitoring of Acute Myocarditis Applying Quantitative Cardiovascular Magnetic Resonance. Circ Cardiovasc Imaging 10(2):e005242. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1161/CIRCIMAGING.116.005242\u003c/span\u003e\u003cspan address=\"10.1161/CIRCIMAGING.116.005242\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBrendel JM, Klingel K, K\u0026uuml;bler J et al (2022) Comprehensive Cardiac Magnetic Resonance to Detect Subacute Myocarditis. J Clin Med 11(17):5113. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.3390/jcm11175113\u003c/span\u003e\u003cspan address=\"10.3390/jcm11175113\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eHuber AT, Bravetti M, Lamy J et al (2018) Non-invasive differentiation of idiopathic inflammatory myopathy with cardiac involvement from acute viral myocarditis using cardiovascular magnetic resonance imaging T1 and T2 mapping. J Cardiovasc Magn Reson 20(1):11. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1186/s12968-018-0430-6\u003c/span\u003e\u003cspan address=\"10.1186/s12968-018-0430-6\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLurz P, Eitel I, Adam J et al (2012) Diagnostic Performance of CMR Imaging Compared With EMB in Patients With Suspected Myocarditis. JACC Cardiovasc Imaging 5(5):513\u0026ndash;524. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.jcmg.2011.11.022\u003c/span\u003e\u003cspan address=\"10.1016/j.jcmg.2011.11.022\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLuetkens JA, Homsi R, Sprinkart AM et al (2016) Incremental value of quantitative CMR including parametric mapping for the diagnosis of acute myocarditis. Eur Heart J Cardiovasc Imaging 17(2):154\u0026ndash;161. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1093/ehjci/jev246\u003c/span\u003e\u003cspan address=\"10.1093/ehjci/jev246\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLi S, Duan X, Feng G et al (2021) Multiparametric Cardiovascular Magnetic Resonance in Acute Myocarditis: Comparison of 2009 and 2018 Lake Louise Criteria With Endomyocardial Biopsy Confirmation. Front Cardiovasc Med 8:739892. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.3389/fcvm.2021.739892\u003c/span\u003e\u003cspan address=\"10.3389/fcvm.2021.739892\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eUgander M, Oki AJ, Hsu LY et al (2012) Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology. Eur Heart J 33(10):1268\u0026ndash;1278. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1093/eurheartj/ehr481\u003c/span\u003e\u003cspan address=\"10.1093/eurheartj/ehr481\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eScully PR, Bastarrika G, Moon JC, Treibel TA (2018) Myocardial Extracellular Volume Quantification by Cardiovascular Magnetic Resonance and Computed Tomography. Curr Cardiol Rep 20(3):15. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1007/s11886-018-0961-3\u003c/span\u003e\u003cspan address=\"10.1007/s11886-018-0961-3\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eTriadyaksa P, Oudkerk M, Sijens PE (2020) Cardiac T2 * mapping: Techniques and clinical applications. J Magn Reson Imaging JMRI 52(5):1340\u0026ndash;1351. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1002/jmri.27023\u003c/span\u003e\u003cspan address=\"10.1002/jmri.27023\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eTopriceanu CC, Pierce I, Moon JC, Captur G (2022) T2 and T2⁎ mapping and weighted imaging in cardiac MRI. Magn Reson Imaging 93:15\u0026ndash;32. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.mri.2022.07.012\u003c/span\u003e\u003cspan address=\"10.1016/j.mri.2022.07.012\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eRadunski UK, Lund GK, Stehning C et al (2014) CMR in Patients With Severe Myocarditis. JACC Cardiovasc Imaging 7(7):667\u0026ndash;675. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.jcmg.2014.02.005\u003c/span\u003e\u003cspan address=\"10.1016/j.jcmg.2014.02.005\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eIsaak A, Bischoff LM, Faron A et al (2021) Multiparametric cardiac magnetic resonance imaging in pediatric and adolescent patients with acute myocarditis. Pediatr Radiol 51(13):2470\u0026ndash;2480. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1007/s00247-021-05169-7\u003c/span\u003e\u003cspan address=\"10.1007/s00247-021-05169-7\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBaccouche H, Mahrholdt H, Meinhardt G et al (2009) Diagnostic synergy of non-invasive cardiovascular magnetic resonance and invasive endomyocardial biopsy in troponin-positive patients without coronary artery disease. Eur Heart J 30(23):2869\u0026ndash;2879. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1093/eurheartj/ehp328\u003c/span\u003e\u003cspan address=\"10.1093/eurheartj/ehp328\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"myocarditis, modified Lake Louise, parametric mapping, diagnostic test","lastPublishedDoi":"10.21203/rs.3.rs-5026991/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-5026991/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e \u003cp\u003eCardiovascular Magnetic Resonance Imaging (CMR) mapping parameters\u0026mdash;Native T1, T2 mapping, and Extracellular Volume (ECV)\u0026mdash;are pivotal for diagnosing acute myocarditis according to the modified 2018 Lake Louise Criteria (mLLC). This systematic review and meta-analysis aim to evaluate their diagnostic performance and establish optimal thresholds for acute myocarditis diagnosis.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eWe systematically reviewed articles published in the past decade that utilized parametric mapping techniques for myocarditis diagnosis. Data on sensitivity, specificity, and Area Under Curve (AUC) were included, and quality assessment was conducted using the QUADAS-2 tool by two independent reviewers.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eEleven studies involving 677 patients were included. Native T1 showed sensitivity of 83%, specificity of 86%, diagnostic odds ratio (DOR) of 39, and an AUC of 0.91. T2 mapping had sensitivity of 81%, specificity of 86%, DOR of 25, and an AUC of 0.89. ECV demonstrated sensitivity of 71%, specificity of 81%, DOR of 13, and an AUC of 0.83. Mean values in controls for myocarditis were: Native T1 (1039 ms\u0026thinsp;\u0026plusmn;\u0026thinsp;39.23), T2 mapping (57 ms\u0026thinsp;\u0026plusmn;\u0026thinsp;5.18), ECV (31% \u0026plusmn; 5.60). The optimal thresholds were 1021 ms for Native T1, 54 ms for T2 mapping, and 28% for ECV generated through Receiver-operating characteristic (ROC) analysis. Native T1 exhibited the highest accuracy among the parameters assessed. Subgroup analysis indicated no significant sensitivity differences based on biopsy or clinical criteria, while Native T1 specificity varied significantly.\u003c/p\u003e\u003ch2\u003eConclusions\u003c/h2\u003e \u003cp\u003eParametric mapping, particularly Native T1, demonstrates robust diagnostic performance for myocarditis compared to T2 mapping and ECV within the mLLC framework. Integrating these CMR parameters could enhance diagnostic accuracy. Further research is essential to refine these findings and optimize diagnostic strategies for myocarditis.\u003c/p\u003e","manuscriptTitle":"Diagnostic Performance of CMR Parametric Mapping as per Modified Lake Louise Criteria in Acute Myocarditis: An Updated Systematic Review and Meta-Analysis","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-10-01 22:39:07","doi":"10.21203/rs.3.rs-5026991/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"2ca0a8ea-8e4a-4f8a-8028-1679a2e3bd21","owner":[],"postedDate":"October 1st, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-02-01T02:08:22+00:00","versionOfRecord":[],"versionCreatedAt":"2024-10-01 22:39:07","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-5026991","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-5026991","identity":"rs-5026991","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}