Clinical Lipid Metabolism Correlates with Urinary Calculus: TyG Index Has a Closer Correlation

Aims: : We aimed to assess the association between lipid metabolism and kidney stones in Chinese adults. Methods: : Data were obtained from the clinical data of our center in the past 3 years. The analysis included complete data on blood lipids and kidney stones in participants aged ≥18 years and non-stone controls. Weighted multivariate regression analysis and subgroup analysis were used to estimate the relationship between various lipid indexes and nephrolithiasis and burden and recurrence. Results: : A total of 414 participants were included in the study, and their gender, age and other basic indicators showed no significant differences. In the adjusted logistic regression analysis results, the prevalence of kidney stones increased with the increase of triglyceride (TG), triglyceride-glucose (TyG) index and Apolipoprotein A-I (AIP) [TG: odds ratio (OR)= 2.14; 95% CI: 1.62-2.81; p < 0.001; TyG: OR=4.30; 95% CI: 2.75-6.72; p < 0.001; AIP: OR=10.12; 95% CI: 4.58-22.35; p < 0.001]. There was still a significant correlation with TyG index in the subgroup analysis of burden (OR=1.52; 95% CI: 1.04-2.22; p < 0.05) and recurrence (OR=2.77; 95% CI: 1.08-7.13; p < 0.05). Conclusions: : Lipid metabolism is closely related to urinary system stones, and a higher TyG index is associated with an increased risk of kidney stone incidence, burden, and recurrence. We hypothesize that timely treatment and management of abnormal lipid metabolism may help improve or alleviate the occurrence, burden, and recurrence of urinary system stones. However, further large-scale prospective studies and basic experiments are still needed to clarify the exact causal relationship of this association.