Estradiol-releasing vaginal ring delivery system for urogenital atrophy. Experience over the past decade.

OBJECTIVE: To critically assess the world literature on the efficacy and safety of the vaginal ring estradiol delivery system for the local treatment of urogenital atrophy due to hypoestrogenism. STUDY DESIGN: Published data over the past decade on the vaginal ring delivery system were reviewed. RESULTS: Data from comparative clinical trials indicate that the vaginal ring delivery system is comparable in efficacy, safety and tolerability to other vaginal delivery systems and may enhance compliance because of its ease of use. CONCLUSION: The vaginal ring delivery system offers an alternative to other vaginal delivery systems with the advantages of accurate and sustained dosing and minimal need for patient intervention.