INTRAUTERINE SYSTEM

An intrauterine system is disclosed for use in the treatment of dysfunctional uterine bleeding menorraghia dysmenorrhoea endometriosis uterine fibroids climacteric complaints osteoporosis and urogenital atrophy. The system is formed by a frame defining an interior space for receipt of a deposit of a therapeutically effective dose of a biologically active compound. The frame has an open structure allowing access to a substantial part of an outer surface of the deposit, and the deposit has a rate controlling structure that controls a rate of release of the compound within the uterus. One or more retention elements are provided on the frame for retaining the frame within the uterus of a female mammal.