The Association Between Maternal Cytomegalovirus Urinary Excretion and Congenital Infection Rate

Background: Cytomegalovirus (CMV) vertical transmission occurs predominantly during primary maternal infection. There are no known non-invasive methods for diagnosis of fetal infection before delivery, however some risk factors have been suggested. We aimed to evaluate the association between maternal CMV urinary excretion and congenital CMV infection. Methods: : A retrospective cohort study of all women who were diagnosed with primary CMV infection during pregnancy in a single university affiliated tertiary medical center, between 2012 and 2016. We examined congenital CMV infection and disease rates in women with and without CMV urinary excretion. Results: Overall, 126 women were included. There was no difference in maternal symptoms between the groups. We found no difference in congenital CMV infection and disease rates between women with and without urinary excretion of CMV (congenital infection rate 37.1% vs. 24.4%, p=0.209, congenital disease rate of 18.2% vs. 22.4%, p=0.648). Women with positive urinary CMV excretion had lower IgG avidity (36.7% vs 54.6%, p=0.007), with no additional difference in serology pattern. Compared to asymptomatic women, those with CMV related symptoms did not have significantly higher rates of urinary excretion of CMV (70% vs. 60.5%, p=0.38) or congenital infection rates (40.7% vs. 31.2%, p=0.48) Conclusion: Among women with primary CMV infection in pregnancy, we did not find an association between urinary excretion of CMV and congenital CMV infection.