TREM1 as a Potential Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma

Background: This study aims to find immune-related hub gene as potential novel biomarker for KIRC. Methods: : We constructed a KIRC immune prognostic signature. The receiver operating characteristic (ROC) curves, survival curves, univariate and multivariate Cox regression analysis were utilized to validate the signature. Immunohistochemical staining was used to detect the expression of TRME1 in renal clear cell carcinoma tissues. The clinical characteristics, the status of the tumor microenvironment, and immune infiltration were analyzed through the ESTIMATE and CIBERSORT algorithms for the hub gene, while the Gene Set Enrichment Analysis and PPI analysis were performed to predict the function of the hub gene. Results: : In Immunohistochemical staining, we found that the expression of TREM1 was significantly upregulated with increasing tumor grade in renal clear cell carcinoma, and elevated TREM1 expression was associated with poor prognosis.The CIBERSORT and ESTIMATE algorithms revealed that TREM1 was correlated with the infiltration of 12 types of immune cells. Therefore, it was determined that TREM1 was involved in numerous classical pathways in the immune response via GSEA analysis. Conclusions: : The results suggest that TREM1 may act as an implicit novel prognostic biomarker in KIRC that could be utilized to facilitate immunotherapeutic strategy.