Local luteolytic effect of prostaglandin F2 in the human corpus luteum
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This paper investigated the local luteolytic effect of prostaglandin F2 on the human corpus luteum, detailing its impact on luteal function.
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Abstract
ObjectiveTo evaluate the effects of prostaglandin (PG)F2 alpha on human corpus luteum (CL) function in vivo.DesignThe effects of a single injection of PGF2 alpha into the CL was studied.SettingThe patients underwent elective surgery at the Department of Obstetrics and Gynecology, Sahlgrenska Hospital, University of Göteborg, Sweden.ParticipantsTwenty women with regular menstrual cycles undergoing laparoscopy for legal sterilization with tubal clips volunteered for the study.InterventionsProstaglandin F2 alpha (3 mg) was injected through the abdominal wall into the CL. In control cases, vehicle was injected into the CL or PGF2 alpha into the contralateral ovary.Main outcome measureAfter the injections, serum was analyzed for progesterone (P) and luteinizing hormone using fluoroimmunoassay and enzyme-immunoassay, respectively. Menstrual data were recorded.ResultsIn contrast to control cases, intraluteal injection of PGF2 alpha caused both an immediate fall of greater than 30% in serum P and a shortening of the luteal phase by 2 to 5 days. Luteinizing hormone varied independently of the changes in serum P levels.ConclusionThe results suggest a local role for PGF2 alpha in human luteolysis.
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Cites (3)
- Functional Activity of the Corpus Luteum Following Hysterectomy<sup>1</sup> 1970
- Assessment of possible luteolytic effect of intra-ovarian injection of prostaglandin F2α in the human 1975
- Ovarian stromal and luteal tissue prostaglandins, 17β-estradiol, and progesterone in relation to the phases of the menstrual cycle in women 1987
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