Iridium(III)-catalyzed remote B(9)−H alkylation of o-carboranes with nitrile template

Iridium(III)-catalyzed remote B(9)−H alkylation of o-carboranes with nitrile template | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Iridium(III)-catalyzed remote B(9)−H alkylation of o -carboranes with nitrile template Phil Ho Lee, Kyungsup Lee, Jiwon Kim, Bora Yang, Dongwook Kim This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4750231/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 27 Nov, 2025 Read the published version in Nature Communications → Version 1 posted You are reading this latest preprint version Abstract Although the directing group assisted ortho -B − H activation reactions of o -carboranes have been well established during the past decade, the meta -B − H activation reactions are unexplored so far. Herein, iridium(III)-catalyzed remote B( 9 ) − H alkylation reactions of o -carboranes with nitrile template have been demonstrated for the first time. It was revealed that fine tuning of the template structures is essential for high reaction efficiency and regioselectivity. This alkylation process exhibits a broad substrate scope with good functional group tolerance under simple reaction conditions. The nitrile template, readily accessible from o -carborane acids, can be removed conveniently after completion of the reaction. The present method provides a powerful synthetic route to complex o -carborane derivatives, demonstrating successful larger scale alkylation and further molecular transformations of the B( 9 )-alkylated products. Physical sciences/Chemistry/Catalysis Physical sciences/Chemistry/Chemical synthesis/Synthetic chemistry methodology Physical sciences/Chemistry/Organic chemistry/Synthetic chemistry methodology Figures Figure 1 Figure 2 Figure 3 Figure 4 Introduction Carboranes, which are icosahedral cluster molecules composed of carbon and boron atoms, have great potential as novel ligands for coordinating metals 1–3 and can serve as versatile building blocks in material chemistry 4–6 due to their distinctive properties such as thermal stability, hydrophobicity, and three-dimensional aromaticity 7,8 . Moreover, carboranes are receiving considerable attention as unique pharmacophores for boron neutron capture therapy agents (BNCT) 9–11 . Consequently, the development of functionalization reactions for carboranes is becoming an attractive and significant challenge. To date, extensive research has been conducted to introduce various functional groups onto the cage vertices of carborane clusters. While the acidic cage C − H bond can be readily functionalized through a substitution reaction 12–14 , the cage B − H bond is relatively difficult to functionalize. Although electrophilic substitution reactions at electron-rich cage boron have been previously accomplished 15–19 , there are significant regioselectivity issues due to the small difference in electron density among the similar B − H bonds 20,21 . Accordingly, the development of efficient and site-selective cage boron functionalization merits considerable attention 22–27 . In this context, transition metal catalysis has emerged as a powerful synthetic method for enabling direct and regioselective B − H functionalization reactions (Fig. 1 ). These strategies include B( 8 , 9 , 10 , 12 ) − H functionalization via electrophilic substitution without use of directing group 28–33 ( a ) and B − H activation reactions assisted by directing groups (DG) 34–37 ( b and c ). Over the past decade, the B − H activation strategy has received much attention, due in particular to its advantage in enabling direct and selective construction of new B − C or B − heteroatom bond, which allows rapid access to a wide range of B( 4 )-functionalized carborane derivatives. In this context, we have previously reported the Pd(II)-catalyzed B( 5 , 8 , 9 )-triarylation reaction, which harnesses the B( 4 )-amido group as a directing group 38 . This iterative reaction introduces three aryl groups onto the B − H vertex, demonstrating an efficient approach to multi-substituted o -carboranes. After the pioneering development of the Pd-catalyzed remote meta -C − H alkenylation using a U-shaped nitrile template by Yu and co-workers 39 , this idea has been extensively adopted to provide a versatile toolbox for distal C − H functionalization 40–43 . Accordingly, we envisioned that such a nitrile template, tethered by a linker on o -carborane substrate, could play a key role in enabling a site-selective B − H activation reaction by essentially locking the metal catalyst at the specific meta -B − H position ( d ). In considering such a strategy, we realized that there are several important requirments to achieve a facile, template-assisted remote B − H functionalization reaction. The primary consideration was to design the template with the precise length required to direct the metal catalyst to the specific meta -B − H position. Furthermore, suitable metal and reagents are necessary for efficient B − H functionalization. It is also essential to control the regioselectivity because the substitution at B(8/10) and B( 9 ) positions generates corresponding regioisomers. In our continuing efforts to develop efficient and regioselective B − H functionalization of o -carboranes 44–57 , we demonstrate herein the iridium(III)-catalyzed template-assisted remote B( 9 ) − H alkylation reaction of o -carboranes ( e ). This unprecedented alkylation reaction of readily accessible o -carboranes possessing nitrile template shows high regioselectivity. After a successful remote B − H alkylation reaction, the template could be removed easily via facile methanolysis. The alkylation process disclosed herein demonstrates high yields and a broad substrate scope, exhibiting good functional group tolerance under simple reaction conditions. Results and discussion Reaction optimization We initiated our study with the investigation of the reaction between o -carborane amide 1a (0.20 mmol) as a model substrate and methyl acrylate 2a (1.5 equiv) in the presence of transition metal catalyst (2.0 mol %) and Cu(TFA) 2 .H 2 O (1.0 equiv) (Table 1 ). When the reaction mixture was stirred in 1,2-dichloroethane (DCE) at 90 o C for 12 h, mediated by either [( p -cymene)RuCl 2 ] or [Cp*RhCl 2 ] 2 catalysts, the desired transformation did not take place (entries 1 and 2). Interestingly, the B( 9 )-alkylated product 3a was obtained exclusively in 31% yield with the use of [Cp*IrCl 2 ] 2 catalyst (entry 3). After an examination of solvents such as toluene, PhCF 3 , MeCN, dioxane, and trifluoroethanol (TFE) (entries 4–8), the best result was obtained with TFE, affording the desired product 3a in 50% yield (entry 8). Encouraged by these results, a screening of additives, including NaOAc, AgOAc, AgTFA, and AgF, was conducted (entries 9–12), whereupon it was discovered that AgF was the optimal additive, which furnished 3a in 85% yield (entry 12). When 1a was treated with 2a without additive, 4a was obtained in trace, indicating that AgF was essential for the B( 9 )-alkylation reaction (entry 13). Gratifyingly, the use of hexafluoroisopropanol (HFIP) as solvent considerably improved the reaction, affording the B( 9 )-alkylated product 3a in 91% isolated yield (entry 14). Surprisingly, no alkenylated product is formed in any conditions. Table. 1. Reaction Optimization a . a Reaction conditions: 1a (0.20 mmol, 1.0 equiv), 2a (1.5 equiv), cat. (2.0 mol %), and additive (1.0 equiv) were dissolved in solvent (2.0 mL). The resulting solution was stirred at 90 o C for 12 h. b NMR yields using CH 2 Br 2 as an internal standard. c Isolated yield. Substrate scope With the optimized conditions in hand, we investigated how structural differences of the template could affect the efficiency in this remote B( 9 ) − H alkylation reaction (Fig. 2 , top). In the reaction with 1b in which the N -substituent of amide was replaced with a Ns (4-nitrophenylsulfonyl) group, the yield of corresponding product 3b was greatly reduced to 39%. When the ether linker was modified to an alkyl linker such as one seen in compound 1c , the reaction afforded the desired B( 9 )-alkylated product 3c alongside the undesired B( 8 )-alkylated compound as an inseparable mixture [B( 9 ):B( 8 ) = 7.3:1], indicating deteroriation of regioselectiviy. The two regioisomers were separated after methanolysis, and their exact structures were undoubtedly identified by X-ray crystallography (see the Supplementary Information for details). In the case of carborane amide 1d , which has a relatively less flexible linker due to the presence of a pyrrolidine ring, the yield of corresponding product 3d decreased to 50%. However, it is noteworthy that the reaction proceeded with high regioselectivity. On the one hand, secondary amide 1e , which is sterically encumbered due to germinal dimethyl groups at the α-position, gave the desired product 3e in 52% yield with poor regioselectivity [B( 9 ):B( 8 ) = 2.5:1] under optimized reaction conditions. The absence of the cyano group in 1a was ineffective, demonstrating that the nitrile template is essential for B( 9 ) − H metalation and alkylation process (Fig. 2 , bottom). Other template moieties containing carboxylic acid, pyridine, and another nitrile as a coordinating group were also evaluated in this regioselective B − H alkylation reaction but the reaction did not proceed, establishing the fact that the fine tuning of the template structure is also critical in this transformation. 39,58,59 As a result, it was determined by us that the carborane amide 1a was the optimal template to employ in the regioselective remote B( 9 ) − H alkylation reaction. To demonstrate the efficiency and scope of the iridium-catalyzed remote B( 9 ) − H alkylation reaction, we applied this catalytic system to a variety of alkenes 2 with 1a . For example, alkyl acrylates bearing n -Bu, benzyl, and t -Bu were successfully employed, affording B( 9 )-alkylated o -carborane amide ( 4a - 4c ) in high to excellent yields, ranging from 82–99%. After evaluation of the aryl acrylates possessing methoxy and halogens, we found that electronic and steric effect of the aryl substituents were not obvious, which provided the corresponding product ( 4d , 4e , 4f , 4h , and 4i ) in high yields, varing from 86–99% with the extended reaction time. In particular, 4-nitrophenyl acrylate underwent the alkylation reaction at 60 o C for 24 h, leading to the formation of 4g in 51% yield. Besides acrylate derivatives, it was seen that methyl vinyl ketone, acrylonitrile, and phenyl vinyl sulfone were also compatible in these reaction conditions. In this context, the ketone and nitrile products ( 4j and 4k ) were obtained in 85% and 73% yields, respectively, under the modified conditions. Phenyl vinyl sulfone gave the corresponding product 4l in 91% yield. When the complex estrone-derived acrylate was employed as the substrate, the B( 9 )-alkylation reaction smoothly proceeded, affording the product 4m in 92% yield. It is worth mentioning that no alkenylated product was detected. Furthermore, a variety of o -carboranes bearing nitrile template were investigated with methyl acrylate 2a . The reaction of C( 2 )-unsubstituted o -carborane amide 1f was accomplished with 2a (3.0 equiv), providing the product 5a in 82% yield. n -Butyl, benzyl, cyclohexyl, and t -butyl groups were all compatible under optimized reaction conditions without undue steric interference, affording the corresponding products 5b - 5e in high yields ranging from 85–99%. The structure of 5b was unambiguously confirmed by X-ray crystallography (see the Supplementary Information for details). It has also been found that the reaction proceeds successfully even with a variety of aryl groups on the C( 2 )-position. Phenyl-substituted o -carborane amide was quantitatively converted to the alkylated product 5f . Besides, o -carborane amides possessing 3-methyl, 4-methoxy, 4-bromo, or 4-fluoro group on the aryl ring were subjected to the remote B − H alkylation reaction and provided the corresponding products 5g - 5j in high yields, indicating the electronic effect does not largely affect this transformation. Notably, the reaction of 2-thiophenyl o -carborane amide afforded the product 5k in 90% yield with 2a (3.0 equiv). Gram Scale Reaction and Synthetic Application To demonstrate the utility of our regioselective remote B( 9 ) − H alkylation reaction, a gram-scale reaction of o -carborane amide 1a was carried out, affording 3a in 98% yield with methyl acrylate and 4l in 91% yield with phenyl vinyl sulfone (Fig. 3 ). The amide template facilitating effective B( 9 ) − H alkylation can be easily removed through methanolysis, providing the o -carboranes 6 and 7 in high yield. B( 9 )-Alkylated o -carborane 6 was hydrolyzed to form carboxylic acid 8 in 87% yield. Furthermore, reduction with DIBAL-H provided carboranyl propanol 9 in 88% yield. The carboxylation reaction of the sulfone 7 was smoothly proceeded, affording the B( 9 )-alkylated o -carborane acid 10 in 83% yield. Since carboxylic acid is versatile ortho -directing group, we applied the o -carborane 10 to the previously reported decarboxylative B( 4 )-H functionalization reaction. 47,48 The Ir(III)-catalyzed B − H amidation reaction with phenyldioxazolone was performed successfully, leading to the B( 9 )-alkyl-B( 4 )-amido o -carborane 11 in 92% yield. On the other hand, o -carborane 10 was converted to B( 9 )-alkyl-B( 4 )-phenacyl o -carborane 12 in 81% yield. A Proposed Mechanism On the basis of the previous studies in the literature 60–63 , a plausible mechanism for the present remote B( 9 ) − H alkylation reaction is proposed (Fig. 4 ). The complex I is generated by coordination of o -carborane amide 1 to a Ir(III) catalyst followed by template-assisted B( 9 ) − H activation. Then, it would undergo consecutive coordination ( II ) and 1,2-insertion of alkene 2 to afford the iridacyclic intermediate III . Finally, B( 9 )-alkylated product ( 3 , 4 , and 5 ) are released through protodemetallation from the intermediate III , resulting in the regeneration of Ir(III) catalyst. It is noteworthy that alkenylated product, which could be produced through β -hydride elimination from the intermediate III , was not observed at all 61 . Conclusion In conclusion, we have demonstrated a Ir(III)-catalyzed remote B( 9 ) − H alkylation reaction of o -carborane amides with alkenes under simple reaction conditions. Employment of the nitrile template facilitates the regioselective B( 9 ) − H activation thus introducing a variety of alkyl groups onto distal cage boron with good functional group tolerance. Moreover, not only is the template readily accessible, but it can also be removed conveniently through simple methanolysis, offering the opportunity for further derivatization. This new template strategy for remote B( 9 ) − H functionalization provides an efficient route for the synthesis of complex carborane derivatives. Declarations Data availability The X-ray crystallographic data for structures have been deposited at the Cambridge Crystallographic Data Centre (CCDC) under deposition numbers 2330895, 2193880, 2196032, and 2324602 and can be obtained free of charge from https://www.ccdc.cam.ac.uk/structures/ . All other data are available in the main text or the Supplementary Information. Competing interests The authors declare no competing financial interest. Author contributions Project administration & supervision: P.H.L.; Experimental study: K.L., J.K., and B.Y.; Crystallographic analysis: D.K.; Writing – review & editing: P.H.L. and K.L.; K.L. and J.K. contributed equally to this work. Acknowledgments This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (RS-2024-00342573 and RS-2023-00271205). References Xie Z (2002) Advances in the chemistry of metallacarboranes of f-block elements. Coord Chem Rev 231:23–46 Xie Z (2003) Cyclopentadienyl-carboranyl hybrid compounds: a new class of versatile ligands for organometallic chemistry. Acc Chem Res 36:1–9 Spokoyny AM et al (2011) A coordination chemistry dichotomy for icosahedral carborane-based ligands. Nat Chem 3:590–596 Cioran AM et al (2012) Mercaptocarborane-capped gold nanoparticles: electron pools and ion traps with switchable hydrophilicity. J Am Chem Soc 134:212–221 Mukherjee S, Thilagar P (2016) Boron clusters in luminescent materials. Chem Commun 52:1070–1093 Wee K-R et al (2012) Carborane-based optoelectronically active organic molecules: wide band gap host materials for blue phosphorescence. J Am Chem Soc 134:17982–17990 Grimes R (2016) N. Carboranes , 3rd edn. Elsevier Hosmane NS (2011) Boron Science: New Technologies and Applications. Taylor & Francis Books/CRC Hawthorne MF (1993) The role of chemistry in the development of boron neutron capture therapy of cancer. Angew Chem Int Ed 32:950–984 Dymova MA, Taskaev SY, Richter VA, Kuligina E (2020) V. Boron neutron capture therapy: current status and future perspectives. Cancer Commun 40:406–421 Chen Y (2022) at al. Carboranes as unique pharmacophores in antitumor medicinal chemistry. Molecular Therapy Oncolytics 24, 400–416 Nakamura H, Aoyagi K, Yamamoto Y (1998) Tetrabutylammonium fluoride promoted novel reactions of o -carborane: inter- and intramolecular additions to aldehydes and ketones and annulation via enals and enones. J Am Chem Soc 120:1167–1171 Nekvinda J, Gruner B, Gabel D, Nau WM, Assaf K (2018) I. Host-guest chemistry of carboranes: synthesis of carboxylate derivatives and their binding to cyclodextrins. Chem Eur J 24:12970–12975 Lu J-Y, Zhao B, Du Y, Yang J, Lu J (2019) Transition-metal-free direct nucleophilic substitution of carboranyllithium and 2-halopyridines. Org Biomol Chem 17:7438–7441 Andrew JS, Zayas J, Jones M (1985) Jr. 9-Iodo- o -carborane. Inorg Chem 24:3716–3718 Herzog A, Maderna A, Harakas GN, Knobler CB, Hawthorne MF (1999) A camouflaged nido -carborane anion: facile synthesis of octa- B -methyl-1,2-dicarba- closo -dodecaborane(12) and its deboration reaction. Chem Eur J 5:1212–1217 Potenza JA, Lipscomb WN, Vickers GD, Schroeder H (1966) Order of electrophilic substitution in 1,2-dicarbaclovododecaborane(12) and nuclear magnetic resonance assignment. J Am Chem Soc 88:628–629 Guo W, Guo C, Ma Y-N, Chen X (2022) Practical synthesis of B(9)-halogenated carboranes with N -haloamides in hexafluoroisopropanol. Inorg Chem 61:5326–5334 e) Ma, Y.-N. et al. B(9)-OH- o- Carboranes: synthesis, mechanism, and property exploration. J Am Chem Soc 145, 7331–7342 (2023) Hermansson K, Wójcik M, Sjöberg S (1999) o -, m -, and p -Carboranes and their anions: ab initio calculations of structures, electron affinities, and acidities. Inorg. Chem. 38, 6039–6048 Teixidor F et al (2005) Are methyl groups electron-donating or electron-withdrawing in boron clusters? permethylation of o -carborane. J Am Chem Soc 127:10158–10159 Olid D, Nunez R, Vinas C, Teixidor F (2013) Methods to produce B–C, B–P, B–N and B–S bonds in boron clusters. Chem Soc Rev 42:3318–3336 Quan Y, Xie Z (2019) Controlled functionalization of o -carborane via transition metal catalyzed B – H activation. Chem Soc Rev 48:3660–3673 Qiu Z, Xie Z (2021) A strategy for selective catalytic B – H functionalization of o –carboranes. Acc Chem Res 54:4065–4079 Wang Q, Liu B, Feng K, Hasimi AS (2022) K. Recent advance in transition metal-catalyzed carboxylic acid guided B – H functionalization of carboranes. Adv Synth Catal 364:4174–4188 Qiu Z, Xie Z (2022) Functionalization of o -carboranes via carboryne intermediates. Chem Soc Rev 51:3164–3180 Yang L, Zhang Z-J, Jei BB, Ackermann L (2022) Electrochemical cage activation of carboranes. Angew Chem Int Ed 61:e202200323 Cao K, Huang Y, Yang J, Wu J (2015) Palladium catalyzed selective mono-arylation of o -carboranes via B–H activation. Chem Commun 51:7257–7260 Wu J et al (2015) Palladium catalyzed regioselective mono-alkenylation of o -carboranes via Heck type coupling reaction of a cage B–H bond. RSC Adv 5:91683–91685 Cao K, Xu T-T, Wu J, Jiang L, Yang J (2016) Palladium catalyzed/silver tuned selective mono-/ tetra-acetoxylation of o -carboranes via B–H activation. Chem Commun 52:11446–11449 Xu T-T et al (2017) Palladium-catalyzed selective mono-chlorination of o -carboranes: changing the concept of FeCl 3 from Lewis acid to chlorine source in Carboranes. ChemistrySelect 2:3396–3399 Xu T-T, Cao K, Wu J, Zhang C-Y, Yang J (2018) Palladium-catalyzed selective mono-/tetraacetoxylation of o –carboranes with acetic acid via cross dehydrogenative coupling of cage B – H/O – H bonds. Inorg Chem 57:2925–2932 Ma Y-N et al (2022) Palladium-catalyzed regioselective B(9)-amination of o –carboranes and m –carboranes in HFIP with broad nitrogen sources. J Am Chem Soc 144:8371–8378 Quan Y, Xie Z (2014) Iridium catalyzed regioselective cage boron alkenylation of o -carboranes via direct cage B – H activation. J Am Chem Soc 136:15513–15516 Lyu H, Quan Y, Xie Z (2016) Transition metal catalyzed direct amination of the cage B(4) – H bond in o –carboranes: synthesis of tertiary, secondary, and primary o –carboranyl amines. J Am Chem Soc 136:12727–12730 Zhang X et al (2017) Selective catalytic B – H arylation of o –carboranyl aldehydes by a transient directing strategy. J Am Chem Soc 139:14511–14517 Cheng R, Zhang J, Zhang H, Qiu Z, Xie Z (2021) Ir-catalyzed enantioselective B – H alkenylation for asymmetric synthesis of chiral-at-cage o –carboranes. Nat Commun 12:7146 Baek Y, Cheong K, Kim D, Lee PH, Selective (2021) B(5,8,9)-triarylation reaction of o –carboranes through determination of the order of introduction of aryl groups into B(4)-acylamino– o –carboranes. Org Lett 23:1188–1193 Leow D, Li G, Mei T-S, Yu J-Q (2012) Activation of remote meta -C–H bonds assisted by an end-on template. Nature 468:518–522 Fang L et al (2017) Experimental and computational development of a conformationally flexible template for the meta -C – H functionalization of benzoic acids. J Am Chem Soc 139:10702–10714 Xu H-J et al (2017) Rh(III)-catalyzed meta -C – H olefination directed by a nitrile template. J Am Chem Soc 139:2200–2203 Sinha SK et al (2022) Toolbox for distal C – H bond functionalizations in organic molecules. Chem Rev 122:5682–5841 Dutta U, Maiti D (2022) Emergence of pyrimidine-based meta -directing group: journey from weak to strong coordination in diversifying meta -C – H functionalization. Acc Chem Res 55:354–372 Baek Y et al (2019) Rhodium-catalyzed amidation of the cage B(4) – H bond in o -carboranes with dioxazolones by carboxylic acid-assisted B(4) – H bond activation. ACS Catal 9:10418–10425 Baek Y et al (2020) Iridium-catalyzed cyclative indenylation and dienylation through sequential B(4) – C bond formation, cyclization, and elimination from o -carboranes and propargyl alcohols. J Am Chem Soc 142:9890–9895 Ham H et al (2021) Direct and regioselective palladium(II)-catalyzed B(4) – H monoacyloxylation and B(4,5) – H diacetoxylation of o –carborane acids with phenyliodonium dicarboxylates. J Org Chem 86:15153–15163 Han GU et al (2021) Iridium-catalyzed cage B(4)-amidation reaction of o –carboranes with dioxazolones: selective synthesis of amidated o –carboranes and amidated and methoxycarbonylated nido -carboranes. Org Lett 23:416–420 Ko GH et al (2022) Iridium(III)-catalyzed B(4)-acylmethylation and B(3,5)–diacylmethylation from o –carboranes and sulfoxonium ylides. Org Lett 24:1604–1609 Maeng C et al (2022) Synthesis of o –carborane-fused pyrazoles through sequential C – N bond formation. Org Lett 24:3526–3531 Lee K et al (2023) Regiodivergent metal-catalyzed B(4)- and C(1)-selenylation of o -carboranes. Chem Sci 14:643–649 Han GU et al (2021) Iridium-catalyzed cage B(4)-amidation reaction of o -carboranes with dioxazolones: selective synthesis of amidated o -carboranes and amidated and methoxycarbonylated nido -carboranes. Org Lett 23:8622–8627 Ko GH, Lee JK, Han S, Lee PH (2022) Rhodium-catalyzed B(4) – H and B(3) – H alkylation reaction of pyridyl o -carboranes with α-diazodicarboxylates. Org Lett 24:1507–1512 Shin S et al (2022) Iridium(III)-catalyzed regioselective B(4) – H allenylation of o -carboranes by ball milling. Org Lett 24:3128–3133 Yang H, Noh HC, Lee PH (2023) Ruthenium-catalyzed selective B(4) – H amidation of o -carboranes with dioxazolones. Asian J Org Chem 12:e202200630 Maeng C et al (2023) Synthesis of o -carboranyl-acyl-substituted diazo compounds from B(4)-acylmethyl carboranes and 2-azido-1,3-dimethylimidazolinium hexafluorophosphate. Bull Korean Chem Soc 44:693–699 Park K et al (2023) Iridium(III)-catalyzed regioselective B(4)–H amination of o -carboranes with sufilimines. Org Lett 25:5989–5994 Noh HC, Kim C-E, Lee K, Kim D, Lee PH (2023) Iridium-catalyzed regioselective B(4)-alkenylation and B(3,5)–dialkenylation of o –carboranes. Org Lett 25:6643–6648 Li S, Wang H, Weng Y, Li G (2019) Carboxy group as a remote and selective chelating group for C – H activation of arenes. Angew Chem Int Ed 58:18502–18507 Chu L et al (2015) Remote meta -C – H activation using a pyridine-based template: achieving site-selectivity via the recognition of distance and geometry. ACS Cent Sci 1:394–399 Mandal D, Roychowdhury S, Biswas JP, Maiti S, Maiti D (2022) Transition-metal-catalyzed C–H bond alkylation using olefins: recent advances and mechanistic aspects. Chem Soc Rev 51:7358–7426 Kim J, Park S-W, Baik M-H, Chang S (2015) Complete switch of selectivity in the C – H alkenylation and hydroarylation catalyzed by iridium: the role of directing groups. J Am Chem Soc 137:13448–13451 Chen S-Q et al (2020) Aldehyde as a traceless directing group for regioselective C – H alkylation catalyzed by rhodium(III) in air. Org Lett 22:1259–1264 Xu H-J et al (2019) Rh(III)-catalyzed meta -C – H alkenylation with alkynes. J Am Chem Soc 141:76–79 Additional Declarations There is NO Competing Interest. Supplementary Files Xray.zip CIF files NCSI4.docx Cite Share Download PDF Status: Published Journal Publication published 27 Nov, 2025 Read the published version in Nature Communications → Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4750231","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":330817179,"identity":"84653cd0-0e09-4576-87f2-3ffbf575c663","order_by":0,"name":"Phil Ho Lee","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA2UlEQVRIiWNgGAWjYDACCeYGBoaKBCQRHoJaGIFazpCshbGNFC3m0o2NDz7OS5M3519j+LiAwU6egefsA7xaLOccbDacuS3HcOeMN8bGMxiSDRt42w3wajG4kdgmzbutgnHDjbPbpHkYmBMY+NnwOwyopf333zkV9lAt9URpaWNmbMhJ3HC+F6TlcAIDbxt+LZYzEpsle46lJW+4wf/ZmMfguGEbzzH8Wswlkg9++FGTbLvh/LHExzwV1fL8PGkEHAZnSSRAuAR8gqyF/wAhtaNgFIyCUTBSAQDHNUPY6W3bywAAAABJRU5ErkJggg==","orcid":"https://orcid.org/0000-0001-8377-1107","institution":"Kangwon National University","correspondingAuthor":true,"prefix":"","firstName":"Phil","middleName":"Ho","lastName":"Lee","suffix":""},{"id":330817180,"identity":"a5557398-f1e2-4c74-b8da-f6abf3b0c64b","order_by":1,"name":"Kyungsup Lee","email":"","orcid":"","institution":"Kangwon National University","correspondingAuthor":false,"prefix":"","firstName":"Kyungsup","middleName":"","lastName":"Lee","suffix":""},{"id":330817181,"identity":"1c481c31-5fd1-4b9c-9701-624695d7f9f0","order_by":2,"name":"Jiwon Kim","email":"","orcid":"","institution":"Kangwon National University","correspondingAuthor":false,"prefix":"","firstName":"Jiwon","middleName":"","lastName":"Kim","suffix":""},{"id":330817182,"identity":"a345ce8a-40fb-4aa2-ae86-769dd4a3af4a","order_by":3,"name":"Bora Yang","email":"","orcid":"","institution":"Kangwon National University","correspondingAuthor":false,"prefix":"","firstName":"Bora","middleName":"","lastName":"Yang","suffix":""},{"id":330817183,"identity":"558f1e0e-9c26-43f4-a50c-d566b8371273","order_by":4,"name":"Dongwook Kim","email":"","orcid":"https://orcid.org/0000-0003-4432-371X","institution":"Institute of Basic Science (IBS)","correspondingAuthor":false,"prefix":"","firstName":"Dongwook","middleName":"","lastName":"Kim","suffix":""}],"badges":[],"createdAt":"2024-07-16 13:56:41","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4750231/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4750231/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1038/s41467-025-65616-z","type":"published","date":"2025-11-27T05:00:00+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":60968378,"identity":"942cbcc7-9f70-4f4b-8c99-7f2771d982e8","added_by":"auto","created_at":"2024-07-24 06:32:57","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":62119,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eCage B−H Functionalization of \u003c/strong\u003e\u003cem\u003e\u003cstrong\u003eo\u003c/strong\u003e\u003c/em\u003e\u003cstrong\u003e-Carboranes.\u003c/strong\u003e \u003cstrong\u003eA\u003c/strong\u003e Electrophilic substitution without directing group (DG). \u003cstrong\u003eB\u003c/strong\u003eDG-assisted proximal B−Hfunctionalization. \u003cstrong\u003eC\u003c/strong\u003e Palladium(II)-catalyzed B(5,8,9)-triarylation reaction. \u003cstrong\u003eD\u003c/strong\u003e Idea for template-assisted remote B(9)−Hfunctionalization. \u003cstrong\u003eE\u003c/strong\u003e This work.\u003c/p\u003e","description":"","filename":"image1.png","url":"https://assets-eu.researchsquare.com/files/rs-4750231/v1/04008a2b1465dbb1da29de67.png"},{"id":60968380,"identity":"4fba9504-8fee-4531-b0b1-c4992ade6aeb","added_by":"auto","created_at":"2024-07-24 06:32:58","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":136369,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eSubstrate scope.\u003c/strong\u003e Reaction conditions: \u003cstrong\u003e1\u003c/strong\u003e (0.20 mmol, 1.0 equiv), \u003cstrong\u003e2\u003c/strong\u003e (1.5 equiv), [Cp*IrCl\u003csub\u003e2\u003c/sub\u003e]\u003csub\u003e2\u003c/sub\u003e (2.0 mol %), and AgF (1.0 equiv) were dissolved in HFIP (2.0 mL). The resulting solution was stirred at 90 \u003csup\u003eo\u003c/sup\u003eC for 12 h. Isolated yield. \u003csup\u003ea\u003c/sup\u003eInseparable mixture of regioisomers [B(9) and B(8)] was obtained. \u003csup\u003eb\u003c/sup\u003e24 h. \u003csup\u003ec\u003c/sup\u003e60 \u003csup\u003eo\u003c/sup\u003eC. \u003csup\u003ed\u003c/sup\u003e\u003cstrong\u003e2\u003c/strong\u003e (3.0 equiv) was used.\u0026nbsp;\u003c/p\u003e","description":"","filename":"image3.png","url":"https://assets-eu.researchsquare.com/files/rs-4750231/v1/2371e4132eda7ca37fa98146.png"},{"id":60969032,"identity":"dea59b2f-1814-4feb-a82b-2df76029d458","added_by":"auto","created_at":"2024-07-24 06:40:58","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":24457,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eGram Scale Reaction and Synthetic Applications.\u003c/strong\u003e (i) \u003cstrong\u003e1a\u003c/strong\u003e (1.00 g, 2.77 mmol), \u003cstrong\u003e2 \u003c/strong\u003e(1.5 equiv), [Cp*IrCl\u003csub\u003e2\u003c/sub\u003e]\u003csub\u003e2\u003c/sub\u003e (2.0 mol %), AgF (1.0 equiv), HFIP (28 mL), 90 \u003csup\u003eo\u003c/sup\u003eC, 12 h. (ii) \u003cstrong\u003e3a\u003c/strong\u003e or \u003cstrong\u003e4l\u003c/strong\u003e (2.0 mmol), K\u003csub\u003e2\u003c/sub\u003eCO\u003csub\u003e3\u003c/sub\u003e (5.0 equiv), MeOH (20 mL), 25 \u003csup\u003eo\u003c/sup\u003eC, 12 h. (iii) \u003cstrong\u003e6\u003c/strong\u003e (0.2 mmol), LiOH\u003csup\u003e.\u003c/sup\u003eH\u003csub\u003e2\u003c/sub\u003eO (3.0 equiv), THF/MeOH/H\u003csub\u003e2\u003c/sub\u003eO (4.8 mL/3.2 mL/1.6 mL), 25 \u003csup\u003eo\u003c/sup\u003eC, 12 h. (iv) \u003cstrong\u003e6\u003c/strong\u003e (0.2 mmol), DIBAL-H (2.2 equiv), DCM (6.0 mL), -78 \u003csup\u003eo\u003c/sup\u003eC, then 25 \u003csup\u003eo\u003c/sup\u003eC, 2 h. (v) \u003cstrong\u003e7\u003c/strong\u003e (1.0 mmol), LDA (1.1 equiv), CO\u003csub\u003e2\u003c/sub\u003e (gas, excess), THF (10 mL), -78 \u003csup\u003eo\u003c/sup\u003eC, then 25 \u003csup\u003eo\u003c/sup\u003eC, 3 h. (vi) \u003cstrong\u003e10\u003c/strong\u003e (0.2 mmol), phenyldioxazolone (2.0 equiv), [Cp*IrCl\u003csub\u003e2\u003c/sub\u003e]\u003csub\u003e2\u003c/sub\u003e (2.5 mol %), AgSbF\u003csub\u003e6\u003c/sub\u003e (10 mol %), NaOAc (1.0 equiv), DCE (2.0 mL), 25 \u003csup\u003eo\u003c/sup\u003eC, 1 h, then 80 \u003csup\u003eo\u003c/sup\u003eC, 1 h. (vii) \u003cstrong\u003e10\u003c/strong\u003e (0.2 mmol), phenylsulfoxonium ylide (2.0 equiv), [Cp*IrCl\u003csub\u003e2\u003c/sub\u003e]\u003csub\u003e2\u003c/sub\u003e (4.0 mol %), AgSbF\u003csub\u003e6\u003c/sub\u003e (16 mol %), NaOAc (1.0 equiv), DCE (2.0 mL), 25 \u003csup\u003eo\u003c/sup\u003eC, 1 h, then 80 \u003csup\u003eo\u003c/sup\u003eC, 1 h.\u003c/p\u003e","description":"","filename":"image4.png","url":"https://assets-eu.researchsquare.com/files/rs-4750231/v1/e4f1a7bc919722f3dab6917e.png"},{"id":60968384,"identity":"93086166-02dd-41c6-9bc4-ace50ef4d7a3","added_by":"auto","created_at":"2024-07-24 06:32:58","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":10196,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eA Proposed Mechanism. \u003c/strong\u003eA plausible mechanism for the present remote B(9)−H alkylation reaction\u003c/p\u003e","description":"","filename":"image5.png","url":"https://assets-eu.researchsquare.com/files/rs-4750231/v1/0707e81018560c930f69f160.png"},{"id":96974317,"identity":"3041ac2e-e461-4433-8da5-dcb8c2b309c6","added_by":"auto","created_at":"2025-11-28 08:16:00","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":922377,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4750231/v1/86789b90-71b0-45ee-b71a-9599d6d006b4.pdf"},{"id":60968381,"identity":"ae592414-4903-46a2-9e28-fd72ec63a62f","added_by":"auto","created_at":"2024-07-24 06:32:58","extension":"zip","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":1449666,"visible":true,"origin":"","legend":"CIF files","description":"","filename":"Xray.zip","url":"https://assets-eu.researchsquare.com/files/rs-4750231/v1/a5b37f5a24342986547cba45.zip"},{"id":60968383,"identity":"2c7ad96e-eab6-43f9-9c79-df3f43eab2f5","added_by":"auto","created_at":"2024-07-24 06:32:58","extension":"docx","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":11028339,"visible":true,"origin":"","legend":"","description":"","filename":"NCSI4.docx","url":"https://assets-eu.researchsquare.com/files/rs-4750231/v1/21eb4da7fece730e6a2a922f.docx"}],"financialInterests":"There is \u003cb\u003eNO\u003c/b\u003e Competing Interest.","formattedTitle":"Iridium(III)-catalyzed remote B(9)−H alkylation of \u003ci\u003eo\u003c/i\u003e-carboranes with nitrile template","fulltext":[{"header":"Introduction","content":"\u003cp\u003eCarboranes, which are icosahedral cluster molecules composed of carbon and boron atoms, have great potential as novel ligands for coordinating metals\u003csup\u003e1\u0026ndash;3\u003c/sup\u003e and can serve as versatile building blocks in material chemistry\u003csup\u003e4\u0026ndash;6\u003c/sup\u003e due to their distinctive properties such as thermal stability, hydrophobicity, and three-dimensional aromaticity\u003csup\u003e7,8\u003c/sup\u003e. Moreover, carboranes are receiving considerable attention as unique pharmacophores for boron neutron capture therapy agents (BNCT)\u003csup\u003e9\u0026ndash;11\u003c/sup\u003e. Consequently, the development of functionalization reactions for carboranes is becoming an attractive and significant challenge. To date, extensive research has been conducted to introduce various functional groups onto the cage vertices of carborane clusters. While the acidic cage C\u0026thinsp;\u0026minus;\u0026thinsp;H bond can be readily functionalized through a substitution reaction\u003csup\u003e12\u0026ndash;14\u003c/sup\u003e, the cage B\u0026thinsp;\u0026minus;\u0026thinsp;H bond is relatively difficult to functionalize. Although electrophilic substitution reactions at electron-rich cage boron have been previously accomplished\u003csup\u003e15\u0026ndash;19\u003c/sup\u003e, there are significant regioselectivity issues due to the small difference in electron density among the similar B\u0026thinsp;\u0026minus;\u0026thinsp;H bonds\u003csup\u003e20,21\u003c/sup\u003e. Accordingly, the development of efficient and site-selective cage boron functionalization merits considerable attention\u003csup\u003e22\u0026ndash;27\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eIn this context, transition metal catalysis has emerged as a powerful synthetic method for enabling direct and regioselective B\u0026thinsp;\u0026minus;\u0026thinsp;H functionalization reactions (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e). These strategies include B(\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e, \u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e, \u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e)\u0026thinsp;\u0026minus;\u0026thinsp;H functionalization \u003cem\u003evia\u003c/em\u003e electrophilic substitution without use of directing group\u003csup\u003e28\u0026ndash;33\u003c/sup\u003e (\u003cem\u003ea\u003c/em\u003e) and B\u0026thinsp;\u0026minus;\u0026thinsp;H activation reactions assisted by directing groups (DG)\u003csup\u003e34\u0026ndash;37\u003c/sup\u003e (\u003cem\u003eb\u003c/em\u003e and \u003cem\u003ec\u003c/em\u003e). Over the past decade, the B\u0026thinsp;\u0026minus;\u0026thinsp;H activation strategy has received much attention, due in particular to its advantage in enabling direct and selective construction of new B\u0026thinsp;\u0026minus;\u0026thinsp;C or B\u0026thinsp;\u0026minus;\u0026thinsp;heteroatom bond, which allows rapid access to a wide range of B(\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e)-functionalized carborane derivatives. In this context, we have previously reported the Pd(II)-catalyzed B(\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e, \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e, \u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e)-triarylation reaction, which harnesses the B(\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e)-amido group as a directing group\u003csup\u003e38\u003c/sup\u003e. This iterative reaction introduces three aryl groups onto the B\u0026thinsp;\u0026minus;\u0026thinsp;H vertex, demonstrating an efficient approach to multi-substituted \u003cem\u003eo\u003c/em\u003e-carboranes.\u003c/p\u003e \u003cp\u003eAfter the pioneering development of the Pd-catalyzed remote \u003cem\u003emeta\u003c/em\u003e-C\u0026thinsp;\u0026minus;\u0026thinsp;H alkenylation using a U-shaped nitrile template by Yu and co-workers\u003csup\u003e39\u003c/sup\u003e, this idea has been extensively adopted to provide a versatile toolbox for distal C\u0026thinsp;\u0026minus;\u0026thinsp;H functionalization\u003csup\u003e40\u0026ndash;43\u003c/sup\u003e. Accordingly, we envisioned that such a nitrile template, tethered by a linker on \u003cem\u003eo\u003c/em\u003e-carborane substrate, could play a key role in enabling a site-selective B\u0026thinsp;\u0026minus;\u0026thinsp;H activation reaction by essentially locking the metal catalyst at the specific \u003cem\u003emeta\u003c/em\u003e-B\u0026thinsp;\u0026minus;\u0026thinsp;H position (\u003cem\u003ed\u003c/em\u003e). In considering such a strategy, we realized that there are several important requirments to achieve a facile, template-assisted remote B\u0026thinsp;\u0026minus;\u0026thinsp;H functionalization reaction. The primary consideration was to design the template with the precise length required to direct the metal catalyst to the specific \u003cem\u003emeta\u003c/em\u003e-B\u0026thinsp;\u0026minus;\u0026thinsp;H position. Furthermore, suitable metal and reagents are necessary for efficient B\u0026thinsp;\u0026minus;\u0026thinsp;H functionalization. It is also essential to control the regioselectivity because the substitution at B(8/10) and B(\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e) positions generates corresponding regioisomers. In our continuing efforts to develop efficient and regioselective B\u0026thinsp;\u0026minus;\u0026thinsp;H functionalization of \u003cem\u003eo\u003c/em\u003e-carboranes\u003csup\u003e44\u0026ndash;57\u003c/sup\u003e, we demonstrate herein the iridium(III)-catalyzed template-assisted remote B(\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e)\u0026thinsp;\u0026minus;\u0026thinsp;H alkylation reaction of \u003cem\u003eo\u003c/em\u003e-carboranes (\u003cem\u003ee\u003c/em\u003e). This unprecedented alkylation reaction of readily accessible \u003cem\u003eo\u003c/em\u003e-carboranes possessing nitrile template shows high regioselectivity. After a successful remote B\u0026thinsp;\u0026minus;\u0026thinsp;H alkylation reaction, the template could be removed easily \u003cem\u003evia\u003c/em\u003e facile methanolysis. The alkylation process disclosed herein demonstrates high yields and a broad substrate scope, exhibiting good functional group tolerance under simple reaction conditions.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e"},{"header":"Results and discussion","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e\n \u003ch2\u003eReaction optimization\u003c/h2\u003e\n \u003cp\u003eWe initiated our study with the investigation of the reaction between \u003cem\u003eo\u003c/em\u003e-carborane amide \u003cstrong\u003e1a\u003c/strong\u003e (0.20 mmol) as a model substrate and methyl acrylate \u003cstrong\u003e2a\u003c/strong\u003e (1.5 equiv) in the presence of transition metal catalyst (2.0 mol %) and Cu(TFA)\u003csub\u003e2\u003c/sub\u003e.H\u003csub\u003e2\u003c/sub\u003eO (1.0 equiv) (Table \u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e). When the reaction mixture was stirred in 1,2-dichloroethane (DCE) at 90 \u003csup\u003eo\u003c/sup\u003eC for 12 h, mediated by either [(\u003cem\u003ep\u003c/em\u003e-cymene)RuCl\u003csub\u003e2\u003c/sub\u003e] or [Cp*RhCl\u003csub\u003e2\u003c/sub\u003e]\u003csub\u003e2\u003c/sub\u003e catalysts, the desired transformation did not take place (entries 1 and 2). Interestingly, the B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)-alkylated product \u003cstrong\u003e3a\u003c/strong\u003e was obtained exclusively in 31% yield with the use of [Cp*IrCl\u003csub\u003e2\u003c/sub\u003e]\u003csub\u003e2\u003c/sub\u003e catalyst (entry 3). After an examination of solvents such as toluene, PhCF\u003csub\u003e3\u003c/sub\u003e, MeCN, dioxane, and trifluoroethanol (TFE) (entries 4\u0026ndash;8), the best result was obtained with TFE, affording the desired product \u003cstrong\u003e3a\u003c/strong\u003e in 50% yield (entry 8). Encouraged by these results, a screening of additives, including NaOAc, AgOAc, AgTFA, and AgF, was conducted (entries 9\u0026ndash;12), whereupon it was discovered that AgF was the optimal additive, which furnished \u003cstrong\u003e3a\u003c/strong\u003e in 85% yield (entry 12). When \u003cstrong\u003e1a\u003c/strong\u003e was treated with \u003cstrong\u003e2a\u003c/strong\u003e without additive, \u003cstrong\u003e4a\u003c/strong\u003e was obtained in trace, indicating that AgF was essential for the B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)-alkylation reaction (entry 13). Gratifyingly, the use of hexafluoroisopropanol (HFIP) as solvent considerably improved the reaction, affording the B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)-alkylated product \u003cstrong\u003e3a\u003c/strong\u003e in 91% isolated yield (entry 14). Surprisingly, no alkenylated product is formed in any conditions.\u003c/p\u003e\n \u003cp\u003e\u003cstrong\u003eTable. 1. Reaction Optimization\u003csup\u003ea\u003c/sup\u003e.\u0026nbsp;\u003c/strong\u003e\u003csup\u003ea\u003c/sup\u003eReaction conditions: \u003cstrong\u003e1a\u003c/strong\u003e (0.20 mmol, 1.0 equiv), \u003cstrong\u003e2a\u003c/strong\u003e (1.5 equiv), cat. (2.0 mol %), and additive (1.0 equiv) were dissolved in solvent (2.0 mL). The resulting solution was stirred at 90 \u003csup\u003eo\u003c/sup\u003eC for 12 h. \u003csup\u003eb\u003c/sup\u003eNMR yields using CH\u003csub\u003e2\u003c/sub\u003eBr\u003csub\u003e2\u003c/sub\u003e as an internal standard. \u003csup\u003ec\u003c/sup\u003eIsolated yield.\u003c/p\u003e\n \u003cp\u003e\u0026nbsp;\u003cimg src=\"data:image/png;base64,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\"\u003e\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec4\" class=\"Section2\"\u003e\n \u003ch2\u003eSubstrate scope\u003c/h2\u003e\n \u003cp\u003eWith the optimized conditions in hand, we investigated how structural differences of the template could affect the efficiency in this remote B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)\u0026thinsp;\u0026minus;\u0026thinsp;H alkylation reaction (Fig. \u003cspan class=\"InternalRef\"\u003e2\u003c/span\u003e, top). In the reaction with \u003cstrong\u003e1b\u003c/strong\u003e in which the \u003cem\u003eN\u003c/em\u003e-substituent of amide was replaced with a Ns (4-nitrophenylsulfonyl) group, the yield of corresponding product \u003cstrong\u003e3b\u003c/strong\u003e was greatly reduced to 39%. When the ether linker was modified to an alkyl linker such as one seen in compound \u003cstrong\u003e1c\u003c/strong\u003e, the reaction afforded the desired B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)-alkylated product \u003cstrong\u003e3c\u003c/strong\u003e alongside the undesired B(\u003cspan class=\"CitationRef\"\u003e8\u003c/span\u003e)-alkylated compound as an inseparable mixture [B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e):B(\u003cspan class=\"CitationRef\"\u003e8\u003c/span\u003e)\u0026thinsp;=\u0026thinsp;7.3:1], indicating deteroriation of regioselectiviy. The two regioisomers were separated after methanolysis, and their exact structures were undoubtedly identified by X-ray crystallography (see the Supplementary Information for details). In the case of carborane amide \u003cstrong\u003e1d\u003c/strong\u003e, which has a relatively less flexible linker due to the presence of a pyrrolidine ring, the yield of corresponding product \u003cstrong\u003e3d\u003c/strong\u003e decreased to 50%. However, it is noteworthy that the reaction proceeded with high regioselectivity. On the one hand, secondary amide \u003cstrong\u003e1e\u003c/strong\u003e, which is sterically encumbered due to germinal dimethyl groups at the \u0026alpha;-position, gave the desired product \u003cstrong\u003e3e\u003c/strong\u003e in 52% yield with poor regioselectivity [B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e):B(\u003cspan class=\"CitationRef\"\u003e8\u003c/span\u003e)\u0026thinsp;=\u0026thinsp;2.5:1] under optimized reaction conditions. The absence of the cyano group in \u003cstrong\u003e1a\u003c/strong\u003e was ineffective, demonstrating that the nitrile template is essential for B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)\u0026thinsp;\u0026minus;\u0026thinsp;H metalation and alkylation process (Fig. \u003cspan class=\"InternalRef\"\u003e2\u003c/span\u003e, bottom). Other template moieties containing carboxylic acid, pyridine, and another nitrile as a coordinating group were also evaluated in this regioselective B\u0026thinsp;\u0026minus;\u0026thinsp;H alkylation reaction but the reaction did not proceed, establishing the fact that the fine tuning of the template structure is also critical in this transformation.\u003csup\u003e39,58,59\u003c/sup\u003e As a result, it was determined by us that the carborane amide \u003cstrong\u003e1a\u003c/strong\u003e was the optimal template to employ in the regioselective remote B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)\u0026thinsp;\u0026minus;\u0026thinsp;H alkylation reaction.\u003c/p\u003e\n \u003cp\u003eTo demonstrate the efficiency and scope of the iridium-catalyzed remote B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)\u0026thinsp;\u0026minus;\u0026thinsp;H alkylation reaction, we applied this catalytic system to a variety of alkenes \u003cstrong\u003e2\u003c/strong\u003e with \u003cstrong\u003e1a\u003c/strong\u003e. For example, alkyl acrylates bearing \u003cem\u003en\u003c/em\u003e-Bu, benzyl, and \u003cem\u003et\u003c/em\u003e-Bu were successfully employed, affording B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)-alkylated \u003cem\u003eo\u003c/em\u003e-carborane amide (\u003cstrong\u003e4a\u003c/strong\u003e-\u003cstrong\u003e4c\u003c/strong\u003e) in high to excellent yields, ranging from 82\u0026ndash;99%. After evaluation of the aryl acrylates possessing methoxy and halogens, we found that electronic and steric effect of the aryl substituents were not obvious, which provided the corresponding product (\u003cstrong\u003e4d\u003c/strong\u003e, \u003cstrong\u003e4e\u003c/strong\u003e, \u003cstrong\u003e4f\u003c/strong\u003e, \u003cstrong\u003e4h\u003c/strong\u003e, and \u003cstrong\u003e4i\u003c/strong\u003e) in high yields, varing from 86\u0026ndash;99% with the extended reaction time. In particular, 4-nitrophenyl acrylate underwent the alkylation reaction at 60 \u003csup\u003eo\u003c/sup\u003eC for 24 h, leading to the formation of \u003cstrong\u003e4g\u003c/strong\u003e in 51% yield. Besides acrylate derivatives, it was seen that methyl vinyl ketone, acrylonitrile, and phenyl vinyl sulfone were also compatible in these reaction conditions. In this context, the ketone and nitrile products (\u003cstrong\u003e4j\u003c/strong\u003e and \u003cstrong\u003e4k\u003c/strong\u003e) were obtained in 85% and 73% yields, respectively, under the modified conditions. Phenyl vinyl sulfone gave the corresponding product \u003cstrong\u003e4l\u003c/strong\u003e in 91% yield. When the complex estrone-derived acrylate was employed as the substrate, the B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)-alkylation reaction smoothly proceeded, affording the product \u003cstrong\u003e4m\u003c/strong\u003e in 92% yield. It is worth mentioning that no alkenylated product was detected.\u003c/p\u003e\n \u003cp\u003eFurthermore, a variety of \u003cem\u003eo\u003c/em\u003e-carboranes bearing nitrile template were investigated with methyl acrylate \u003cstrong\u003e2a\u003c/strong\u003e. The reaction of C(\u003cspan class=\"CitationRef\"\u003e2\u003c/span\u003e)-unsubstituted \u003cem\u003eo\u003c/em\u003e-carborane amide \u003cstrong\u003e1f\u003c/strong\u003e was accomplished with \u003cstrong\u003e2a\u003c/strong\u003e (3.0 equiv), providing the product \u003cstrong\u003e5a\u003c/strong\u003e in 82% yield. \u003cem\u003en\u003c/em\u003e-Butyl, benzyl, cyclohexyl, and \u003cem\u003et\u003c/em\u003e-butyl groups were all compatible under optimized reaction conditions without undue steric interference, affording the corresponding products \u003cstrong\u003e5b\u003c/strong\u003e-\u003cstrong\u003e5e\u003c/strong\u003e in high yields ranging from 85\u0026ndash;99%. The structure of \u003cstrong\u003e5b\u003c/strong\u003e was unambiguously confirmed by X-ray crystallography (see the Supplementary Information for details). It has also been found that the reaction proceeds successfully even with a variety of aryl groups on the C(\u003cspan class=\"CitationRef\"\u003e2\u003c/span\u003e)-position. Phenyl-substituted \u003cem\u003eo\u003c/em\u003e-carborane amide was quantitatively converted to the alkylated product \u003cstrong\u003e5f\u003c/strong\u003e. Besides, \u003cem\u003eo\u003c/em\u003e-carborane amides possessing 3-methyl, 4-methoxy, 4-bromo, or 4-fluoro group on the aryl ring were subjected to the remote B\u0026thinsp;\u0026minus;\u0026thinsp;H alkylation reaction and provided the corresponding products \u003cstrong\u003e5g\u003c/strong\u003e-\u003cstrong\u003e5j\u003c/strong\u003e in high yields, indicating the electronic effect does not largely affect this transformation. Notably, the reaction of 2-thiophenyl \u003cem\u003eo\u003c/em\u003e-carborane amide afforded the product \u003cstrong\u003e5k\u003c/strong\u003e in 90% yield with \u003cstrong\u003e2a\u003c/strong\u003e (3.0 equiv).\u003c/p\u003e\n \u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec5\" class=\"Section2\"\u003e\n \u003ch2\u003eGram Scale Reaction and Synthetic Application\u003c/h2\u003e\n \u003cp\u003eTo demonstrate the utility of our regioselective remote B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)\u0026thinsp;\u0026minus;\u0026thinsp;H alkylation reaction, a gram-scale reaction of \u003cem\u003eo\u003c/em\u003e-carborane amide \u003cstrong\u003e1a\u003c/strong\u003e was carried out, affording \u003cstrong\u003e3a\u003c/strong\u003e in 98% yield with methyl acrylate and \u003cstrong\u003e4l\u003c/strong\u003e in 91% yield with phenyl vinyl sulfone (Fig. \u003cspan class=\"InternalRef\"\u003e3\u003c/span\u003e). The amide template facilitating effective B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)\u0026thinsp;\u0026minus;\u0026thinsp;H alkylation can be easily removed through methanolysis, providing the \u003cem\u003eo\u003c/em\u003e-carboranes \u003cstrong\u003e6\u003c/strong\u003e and \u003cstrong\u003e7\u003c/strong\u003e in high yield. B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)-Alkylated \u003cem\u003eo\u003c/em\u003e-carborane \u003cstrong\u003e6\u003c/strong\u003e was hydrolyzed to form carboxylic acid \u003cstrong\u003e8\u003c/strong\u003e in 87% yield. Furthermore, reduction with DIBAL-H provided carboranyl propanol \u003cstrong\u003e9\u003c/strong\u003e in 88% yield. The carboxylation reaction of the sulfone \u003cstrong\u003e7\u003c/strong\u003e was smoothly proceeded, affording the B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)-alkylated \u003cem\u003eo\u003c/em\u003e-carborane acid \u003cstrong\u003e10\u003c/strong\u003e in 83% yield. Since carboxylic acid is versatile \u003cem\u003eortho\u003c/em\u003e-directing group, we applied the \u003cem\u003eo\u003c/em\u003e-carborane \u003cstrong\u003e10\u003c/strong\u003e to the previously reported decarboxylative B(\u003cspan class=\"CitationRef\"\u003e4\u003c/span\u003e)-H functionalization reaction.\u003csup\u003e47,48\u003c/sup\u003e The Ir(III)-catalyzed B\u0026thinsp;\u0026minus;\u0026thinsp;H amidation reaction with phenyldioxazolone was performed successfully, leading to the B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)-alkyl-B(\u003cspan class=\"CitationRef\"\u003e4\u003c/span\u003e)-amido \u003cem\u003eo\u003c/em\u003e-carborane \u003cstrong\u003e11\u003c/strong\u003e in 92% yield. On the other hand, \u003cem\u003eo\u003c/em\u003e-carborane \u003cstrong\u003e10\u003c/strong\u003e was converted to B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)-alkyl-B(\u003cspan class=\"CitationRef\"\u003e4\u003c/span\u003e)-phenacyl \u003cem\u003eo\u003c/em\u003e-carborane \u003cstrong\u003e12\u003c/strong\u003e in 81% yield.\u003c/p\u003e\n \u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec6\" class=\"Section2\"\u003e\n \u003ch2\u003eA Proposed Mechanism\u003c/h2\u003e\n \u003cp\u003eOn the basis of the previous studies in the literature\u003csup\u003e60\u0026ndash;63\u003c/sup\u003e, a plausible mechanism for the present remote B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)\u0026thinsp;\u0026minus;\u0026thinsp;H alkylation reaction is proposed (Fig. \u003cspan class=\"InternalRef\"\u003e4\u003c/span\u003e). The complex \u003cstrong\u003eI\u003c/strong\u003e is generated by coordination of \u003cem\u003eo\u003c/em\u003e-carborane amide \u003cstrong\u003e1\u003c/strong\u003e to a Ir(III) catalyst followed by template-assisted B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)\u0026thinsp;\u0026minus;\u0026thinsp;H activation. Then, it would undergo consecutive coordination (\u003cstrong\u003eII\u003c/strong\u003e) and 1,2-insertion of alkene \u003cstrong\u003e2\u003c/strong\u003e to afford the iridacyclic intermediate \u003cstrong\u003eIII\u003c/strong\u003e. Finally, B(\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e)-alkylated product (\u003cspan class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan class=\"CitationRef\"\u003e4\u003c/span\u003e, and \u003cspan class=\"CitationRef\"\u003e5\u003c/span\u003e) are released through protodemetallation from the intermediate \u003cstrong\u003eIII\u003c/strong\u003e, resulting in the regeneration of Ir(III) catalyst. It is noteworthy that alkenylated product, which could be produced through \u003cem\u003e\u0026beta;\u003c/em\u003e-hydride elimination from the intermediate \u003cstrong\u003eIII\u003c/strong\u003e, was not observed at all\u003csup\u003e61\u003c/sup\u003e.\u003c/p\u003e\n \u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003c/div\u003e"},{"header":"Conclusion","content":"\u003cp\u003eIn conclusion, we have demonstrated a Ir(III)-catalyzed remote B(\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e)\u0026thinsp;\u0026minus;\u0026thinsp;H alkylation reaction of \u003cem\u003eo\u003c/em\u003e-carborane amides with alkenes under simple reaction conditions. Employment of the nitrile template facilitates the regioselective B(\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e)\u0026thinsp;\u0026minus;\u0026thinsp;H activation thus introducing a variety of alkyl groups onto distal cage boron with good functional group tolerance. Moreover, not only is the template readily accessible, but it can also be removed conveniently through simple methanolysis, offering the opportunity for further derivatization. This new template strategy for remote B(\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e)\u0026thinsp;\u0026minus;\u0026thinsp;H functionalization provides an efficient route for the synthesis of complex carborane derivatives.\u003c/p\u003e "},{"header":"Declarations","content":"\u003cdiv id=\"Sec8\" class=\"Section2\"\u003e \u003ch2\u003eData availability\u003c/h2\u003e \u003cp\u003eThe X-ray crystallographic data for structures have been deposited at the Cambridge Crystallographic Data Centre (CCDC) under deposition numbers 2330895, 2193880, 2196032, and 2324602 and can be obtained free of charge from \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://www.ccdc.cam.ac.uk/structures/\u003c/span\u003e\u003cspan address=\"https://www.ccdc.cam.ac.uk/structures/\" targettype=\"URL\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e. All other data are available in the main text or the Supplementary Information.\u003c/p\u003e \u003c/div\u003e\u003cp\u003e \u003ch2\u003eCompeting interests\u003c/h2\u003e \u003cp\u003eThe authors declare no competing financial interest.\u003c/p\u003e \u003c/p\u003e\u003ch2\u003eAuthor contributions\u003c/h2\u003e \u003cp\u003eProject administration \u0026amp; supervision: P.H.L.; Experimental study: K.L., J.K., and B.Y.; Crystallographic analysis: D.K.; Writing \u0026ndash; review \u0026amp; editing: P.H.L. and K.L.; K.L. and J.K. contributed equally to this work.\u003c/p\u003e\u003ch2\u003eAcknowledgments\u003c/h2\u003e \u003cp\u003eThis work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (RS-2024-00342573 and RS-2023-00271205).\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eXie Z (2002) Advances in the chemistry of metallacarboranes of f-block elements. Coord Chem Rev 231:23\u0026ndash;46\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eXie Z (2003) Cyclopentadienyl-carboranyl hybrid compounds: a new class of versatile ligands for organometallic chemistry. Acc Chem Res 36:1\u0026ndash;9\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eSpokoyny AM et al (2011) A coordination chemistry dichotomy for icosahedral carborane-based ligands. Nat Chem 3:590\u0026ndash;596\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eCioran AM et al (2012) Mercaptocarborane-capped gold nanoparticles: electron pools and ion traps with switchable hydrophilicity. J Am Chem Soc 134:212\u0026ndash;221\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eMukherjee S, Thilagar P (2016) Boron clusters in luminescent materials. Chem Commun 52:1070\u0026ndash;1093\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eWee K-R et al (2012) Carborane-based optoelectronically active organic molecules: wide band gap host materials for blue phosphorescence. J Am Chem Soc 134:17982\u0026ndash;17990\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eGrimes R (2016) N. \u003cem\u003eCarboranes\u003c/em\u003e, 3rd edn. Elsevier\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eHosmane NS (2011) Boron Science: New Technologies and Applications. Taylor \u0026amp; Francis Books/CRC\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eHawthorne MF (1993) The role of chemistry in the development of boron neutron capture therapy of cancer. Angew Chem Int Ed 32:950\u0026ndash;984\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eDymova MA, Taskaev SY, Richter VA, Kuligina E (2020) V. Boron neutron capture therapy: current status and future perspectives. Cancer Commun 40:406\u0026ndash;421\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eChen Y (2022) at al. Carboranes as unique pharmacophores in antitumor medicinal chemistry. \u003cem\u003eMolecular Therapy Oncolytics\u003c/em\u003e 24, 400\u0026ndash;416\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eNakamura H, Aoyagi K, Yamamoto Y (1998) Tetrabutylammonium fluoride promoted novel reactions of \u003cem\u003eo\u003c/em\u003e-carborane: inter- and intramolecular additions to aldehydes and ketones and annulation via enals and enones. J Am Chem Soc 120:1167\u0026ndash;1171\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eNekvinda J, Gruner B, Gabel D, Nau WM, Assaf K (2018) I. Host-guest chemistry of carboranes: synthesis of carboxylate derivatives and their binding to cyclodextrins. Chem Eur J 24:12970\u0026ndash;12975\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLu J-Y, Zhao B, Du Y, Yang J, Lu J (2019) Transition-metal-free direct nucleophilic substitution of carboranyllithium and 2-halopyridines. Org Biomol Chem 17:7438\u0026ndash;7441\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eAndrew JS, Zayas J, Jones M (1985) Jr. 9-Iodo-\u003cem\u003eo\u003c/em\u003e-carborane. Inorg Chem 24:3716\u0026ndash;3718\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eHerzog A, Maderna A, Harakas GN, Knobler CB, Hawthorne MF (1999) A camouflaged \u003cem\u003enido\u003c/em\u003e-carborane anion: facile synthesis of octa-\u003cem\u003eB\u003c/em\u003e-methyl-1,2-dicarba-\u003cem\u003ecloso\u003c/em\u003e-dodecaborane(12) and its deboration reaction. Chem Eur J 5:1212\u0026ndash;1217\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003ePotenza JA, Lipscomb WN, Vickers GD, Schroeder H (1966) Order of electrophilic substitution in 1,2-dicarbaclovododecaborane(12) and nuclear magnetic resonance assignment. J Am Chem Soc 88:628\u0026ndash;629\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eGuo W, Guo C, Ma Y-N, Chen X (2022) Practical synthesis of B(9)-halogenated carboranes with \u003cem\u003eN\u003c/em\u003e-haloamides in hexafluoroisopropanol. Inorg Chem 61:5326\u0026ndash;5334\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003ee) Ma, Y.-N. et al. B(9)-OH-\u003cem\u003eo-\u003c/em\u003eCarboranes: synthesis, mechanism, and property exploration. J Am Chem Soc 145, 7331\u0026ndash;7342 (2023)\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eHermansson K, W\u0026oacute;jcik M, Sj\u0026ouml;berg S (1999) \u003cem\u003eo\u003c/em\u003e-, \u003cem\u003em\u003c/em\u003e-, and \u003cem\u003ep\u003c/em\u003e-Carboranes and their anions: ab initio calculations of structures, electron affinities, and acidities. \u003cem\u003eInorg. Chem.\u003c/em\u003e 38, 6039\u0026ndash;6048\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eTeixidor F et al (2005) Are methyl groups electron-donating or electron-withdrawing in boron clusters? permethylation of \u003cem\u003eo\u003c/em\u003e-carborane. J Am Chem Soc 127:10158\u0026ndash;10159\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eOlid D, Nunez R, Vinas C, Teixidor F (2013) Methods to produce B\u0026ndash;C, B\u0026ndash;P, B\u0026ndash;N and B\u0026ndash;S bonds in boron clusters. Chem Soc Rev 42:3318\u0026ndash;3336\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eQuan Y, Xie Z (2019) Controlled functionalization of \u003cem\u003eo\u003c/em\u003e-carborane \u003cem\u003evia\u003c/em\u003e transition metal catalyzed B\u0026thinsp;\u0026ndash;\u0026thinsp;H activation. Chem Soc Rev 48:3660\u0026ndash;3673\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eQiu Z, Xie Z (2021) A strategy for selective catalytic B\u0026thinsp;\u0026ndash;\u0026thinsp;H functionalization of \u003cem\u003eo\u003c/em\u003e\u0026ndash;carboranes. Acc Chem Res 54:4065\u0026ndash;4079\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eWang Q, Liu B, Feng K, Hasimi AS (2022) K. Recent advance in transition metal-catalyzed carboxylic acid guided B\u0026thinsp;\u0026ndash;\u0026thinsp;H functionalization of carboranes. Adv Synth Catal 364:4174\u0026ndash;4188\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eQiu Z, Xie Z (2022) Functionalization of \u003cem\u003eo\u003c/em\u003e-carboranes \u003cem\u003evia\u003c/em\u003e carboryne intermediates. Chem Soc Rev 51:3164\u0026ndash;3180\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eYang L, Zhang Z-J, Jei BB, Ackermann L (2022) Electrochemical cage activation of carboranes. Angew Chem Int Ed 61:e202200323\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eCao K, Huang Y, Yang J, Wu J (2015) Palladium catalyzed selective mono-arylation of \u003cem\u003eo\u003c/em\u003e-carboranes \u003cem\u003evia\u003c/em\u003e B\u0026ndash;H activation. Chem Commun 51:7257\u0026ndash;7260\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eWu J et al (2015) Palladium catalyzed regioselective mono-alkenylation of \u003cem\u003eo\u003c/em\u003e-carboranes \u003cem\u003evia\u003c/em\u003e Heck type coupling reaction of a cage B\u0026ndash;H bond. RSC Adv 5:91683\u0026ndash;91685\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eCao K, Xu T-T, Wu J, Jiang L, Yang J (2016) Palladium catalyzed/silver tuned selective mono-/ tetra-acetoxylation of \u003cem\u003eo\u003c/em\u003e-carboranes \u003cem\u003evia\u003c/em\u003e B\u0026ndash;H activation. Chem Commun 52:11446\u0026ndash;11449\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eXu T-T et al (2017) Palladium-catalyzed selective mono-chlorination of \u003cem\u003eo\u003c/em\u003e-carboranes: changing the concept of FeCl\u003csub\u003e3\u003c/sub\u003e from Lewis acid to chlorine source in Carboranes. ChemistrySelect 2:3396\u0026ndash;3399\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eXu T-T, Cao K, Wu J, Zhang C-Y, Yang J (2018) Palladium-catalyzed selective mono-/tetraacetoxylation of \u003cem\u003eo\u003c/em\u003e\u0026ndash;carboranes with acetic acid via cross dehydrogenative coupling of cage B\u0026thinsp;\u0026ndash;\u0026thinsp;H/O\u0026thinsp;\u0026ndash;\u0026thinsp;H bonds. Inorg Chem 57:2925\u0026ndash;2932\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eMa Y-N et al (2022) Palladium-catalyzed regioselective B(9)-amination of \u003cem\u003eo\u003c/em\u003e\u0026ndash;carboranes and \u003cem\u003em\u003c/em\u003e\u0026ndash;carboranes in HFIP with broad nitrogen sources. J Am Chem Soc 144:8371\u0026ndash;8378\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eQuan Y, Xie Z (2014) Iridium catalyzed regioselective cage boron alkenylation of \u003cem\u003eo\u003c/em\u003e-carboranes via direct cage B\u0026thinsp;\u0026ndash;\u0026thinsp;H activation. J Am Chem Soc 136:15513\u0026ndash;15516\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLyu H, Quan Y, Xie Z (2016) Transition metal catalyzed direct amination of the cage B(4) \u0026ndash;\u0026thinsp;H bond in \u003cem\u003eo\u003c/em\u003e\u0026ndash;carboranes: synthesis of tertiary, secondary, and primary \u003cem\u003eo\u003c/em\u003e\u0026ndash;carboranyl amines. J Am Chem Soc 136:12727\u0026ndash;12730\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eZhang X et al (2017) Selective catalytic B\u0026thinsp;\u0026ndash;\u0026thinsp;H arylation of \u003cem\u003eo\u003c/em\u003e\u0026ndash;carboranyl aldehydes by a transient directing strategy. J Am Chem Soc 139:14511\u0026ndash;14517\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eCheng R, Zhang J, Zhang H, Qiu Z, Xie Z (2021) Ir-catalyzed enantioselective B\u0026thinsp;\u0026ndash;\u0026thinsp;H alkenylation for asymmetric synthesis of chiral-at-cage \u003cem\u003eo\u003c/em\u003e\u0026ndash;carboranes. Nat Commun 12:7146\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBaek Y, Cheong K, Kim D, Lee PH, Selective (2021) B(5,8,9)-triarylation reaction of \u003cem\u003eo\u003c/em\u003e\u0026ndash;carboranes through determination of the order of introduction of aryl groups into B(4)-acylamino\u0026ndash;\u003cem\u003eo\u003c/em\u003e\u0026ndash;carboranes. Org Lett 23:1188\u0026ndash;1193\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLeow D, Li G, Mei T-S, Yu J-Q (2012) Activation of remote \u003cem\u003emeta\u003c/em\u003e-C\u0026ndash;H bonds assisted by an end-on template. Nature 468:518\u0026ndash;522\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eFang L et al (2017) Experimental and computational development of a conformationally flexible template for the \u003cem\u003emeta\u003c/em\u003e-C\u0026thinsp;\u0026ndash;\u0026thinsp;H functionalization of benzoic acids. J Am Chem Soc 139:10702\u0026ndash;10714\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eXu H-J et al (2017) Rh(III)-catalyzed \u003cem\u003emeta\u003c/em\u003e-C\u0026thinsp;\u0026ndash;\u0026thinsp;H olefination directed by a nitrile template. J Am Chem Soc 139:2200\u0026ndash;2203\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eSinha SK et al (2022) Toolbox for distal C\u0026thinsp;\u0026ndash;\u0026thinsp;H bond functionalizations in organic molecules. Chem Rev 122:5682\u0026ndash;5841\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eDutta U, Maiti D (2022) Emergence of pyrimidine-based \u003cem\u003emeta\u003c/em\u003e-directing group: journey from weak to strong coordination in diversifying \u003cem\u003emeta\u003c/em\u003e-C\u0026thinsp;\u0026ndash;\u0026thinsp;H functionalization. Acc Chem Res 55:354\u0026ndash;372\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBaek Y et al (2019) Rhodium-catalyzed amidation of the cage B(4) \u0026ndash;\u0026thinsp;H bond in \u003cem\u003eo\u003c/em\u003e-carboranes with dioxazolones by carboxylic acid-assisted B(4) \u0026ndash;\u0026thinsp;H bond activation. ACS Catal 9:10418\u0026ndash;10425\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBaek Y et al (2020) Iridium-catalyzed cyclative indenylation and dienylation through sequential B(4) \u0026ndash;\u0026thinsp;C bond formation, cyclization, and elimination from \u003cem\u003eo\u003c/em\u003e-carboranes and propargyl alcohols. J Am Chem Soc 142:9890\u0026ndash;9895\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eHam H et al (2021) Direct and regioselective palladium(II)-catalyzed B(4) \u0026ndash;\u0026thinsp;H monoacyloxylation and B(4,5) \u0026ndash;\u0026thinsp;H diacetoxylation of \u003cem\u003eo\u003c/em\u003e\u0026ndash;carborane acids with phenyliodonium dicarboxylates. J Org Chem 86:15153\u0026ndash;15163\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eHan GU et al (2021) Iridium-catalyzed cage B(4)-amidation reaction of \u003cem\u003eo\u003c/em\u003e\u0026ndash;carboranes with dioxazolones: selective synthesis of amidated \u003cem\u003eo\u003c/em\u003e\u0026ndash;carboranes and amidated and methoxycarbonylated \u003cem\u003enido\u003c/em\u003e-carboranes. Org Lett 23:416\u0026ndash;420\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eKo GH et al (2022) Iridium(III)-catalyzed B(4)-acylmethylation and B(3,5)\u0026ndash;diacylmethylation from \u003cem\u003eo\u003c/em\u003e\u0026ndash;carboranes and sulfoxonium ylides. Org Lett 24:1604\u0026ndash;1609\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eMaeng C et al (2022) Synthesis of \u003cem\u003eo\u003c/em\u003e\u0026ndash;carborane-fused pyrazoles through sequential C\u0026thinsp;\u0026ndash;\u0026thinsp;N bond formation. Org Lett 24:3526\u0026ndash;3531\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLee K et al (2023) Regiodivergent metal-catalyzed B(4)- and C(1)-selenylation of \u003cem\u003eo\u003c/em\u003e-carboranes. Chem Sci 14:643\u0026ndash;649\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eHan GU et al (2021) Iridium-catalyzed cage B(4)-amidation reaction of \u003cem\u003eo\u003c/em\u003e-carboranes with dioxazolones: selective synthesis of amidated \u003cem\u003eo\u003c/em\u003e-carboranes and amidated and methoxycarbonylated \u003cem\u003enido\u003c/em\u003e-carboranes. Org Lett 23:8622\u0026ndash;8627\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eKo GH, Lee JK, Han S, Lee PH (2022) Rhodium-catalyzed B(4) \u0026ndash;\u0026thinsp;H and B(3) \u0026ndash;\u0026thinsp;H alkylation reaction of pyridyl \u003cem\u003eo\u003c/em\u003e-carboranes with α-diazodicarboxylates. Org Lett 24:1507\u0026ndash;1512\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eShin S et al (2022) Iridium(III)-catalyzed regioselective B(4) \u0026ndash;\u0026thinsp;H allenylation of \u003cem\u003eo\u003c/em\u003e-carboranes by ball milling. Org Lett 24:3128\u0026ndash;3133\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eYang H, Noh HC, Lee PH (2023) Ruthenium-catalyzed selective B(4) \u0026ndash;\u0026thinsp;H amidation of \u003cem\u003eo\u003c/em\u003e-carboranes with dioxazolones. Asian J Org Chem 12:e202200630\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eMaeng C et al (2023) Synthesis of \u003cem\u003eo\u003c/em\u003e-carboranyl-acyl-substituted diazo compounds from B(4)-acylmethyl carboranes and 2-azido-1,3-dimethylimidazolinium hexafluorophosphate. Bull Korean Chem Soc 44:693\u0026ndash;699\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003ePark K et al (2023) Iridium(III)-catalyzed regioselective B(4)\u0026ndash;H amination of \u003cem\u003eo\u003c/em\u003e-carboranes with sufilimines. Org Lett 25:5989\u0026ndash;5994\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eNoh HC, Kim C-E, Lee K, Kim D, Lee PH (2023) Iridium-catalyzed regioselective B(4)-alkenylation and B(3,5)\u0026ndash;dialkenylation of \u003cem\u003eo\u003c/em\u003e\u0026ndash;carboranes. Org Lett 25:6643\u0026ndash;6648\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLi S, Wang H, Weng Y, Li G (2019) Carboxy group as a remote and selective chelating group for C\u0026thinsp;\u0026ndash;\u0026thinsp;H activation of arenes. Angew Chem Int Ed 58:18502\u0026ndash;18507\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eChu L et al (2015) Remote \u003cem\u003emeta\u003c/em\u003e-C\u0026thinsp;\u0026ndash;\u0026thinsp;H activation using a pyridine-based template: achieving site-selectivity via the recognition of distance and geometry. ACS Cent Sci 1:394\u0026ndash;399\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eMandal D, Roychowdhury S, Biswas JP, Maiti S, Maiti D (2022) Transition-metal-catalyzed C\u0026ndash;H bond alkylation using olefins: recent advances and mechanistic aspects. Chem Soc Rev 51:7358\u0026ndash;7426\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eKim J, Park S-W, Baik M-H, Chang S (2015) Complete switch of selectivity in the C\u0026thinsp;\u0026ndash;\u0026thinsp;H alkenylation and hydroarylation catalyzed by iridium: the role of directing groups. J Am Chem Soc 137:13448\u0026ndash;13451\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eChen S-Q et al (2020) Aldehyde as a traceless directing group for regioselective C\u0026thinsp;\u0026ndash;\u0026thinsp;H alkylation catalyzed by rhodium(III) in air. Org Lett 22:1259\u0026ndash;1264\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eXu H-J et al (2019) Rh(III)-catalyzed \u003cem\u003emeta\u003c/em\u003e-C\u0026thinsp;\u0026ndash;\u0026thinsp;H alkenylation with alkynes. J Am Chem Soc 141:76\u0026ndash;79\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"nature-portfolio","isNatureJournal":true,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"","title":"Nature Portfolio","twitterHandle":"","acdcEnabled":false,"dfaEnabled":false,"editorialSystem":"ejp","reportingPortfolio":"","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-4750231/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4750231/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eAlthough the directing group assisted \u003cem\u003eortho\u003c/em\u003e-B\u0026thinsp;\u0026minus;\u0026thinsp;H activation reactions of \u003cem\u003eo\u003c/em\u003e-carboranes have been well established during the past decade, the \u003cem\u003emeta\u003c/em\u003e-B\u0026thinsp;\u0026minus;\u0026thinsp;H activation reactions are unexplored so far. Herein, iridium(III)-catalyzed remote B(\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e)\u0026thinsp;\u0026minus;\u0026thinsp;H alkylation reactions of \u003cem\u003eo\u003c/em\u003e-carboranes with nitrile template have been demonstrated for the first time. It was revealed that fine tuning of the template structures is essential for high reaction efficiency and regioselectivity. This alkylation process exhibits a broad substrate scope with good functional group tolerance under simple reaction conditions. The nitrile template, readily accessible from \u003cem\u003eo\u003c/em\u003e-carborane acids, can be removed conveniently after completion of the reaction. The present method provides a powerful synthetic route to complex \u003cem\u003eo\u003c/em\u003e-carborane derivatives, demonstrating successful larger scale alkylation and further molecular transformations of the B(\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e)-alkylated products.\u003c/p\u003e","manuscriptTitle":"Iridium(III)-catalyzed remote B(9)−H alkylation of o-carboranes with nitrile template","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-07-24 06:32:53","doi":"10.21203/rs.3.rs-4750231/v1","editorialEvents":[],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"nature-communications","isNatureJournal":true,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"NCOMMS","sideBox":"Learn more about [Nature Communications](http://www.nature.com/ncomms/)","snPcode":"","submissionUrl":"https://mts-ncomms.nature.com/","title":"Nature Communications","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"ejp","reportingPortfolio":"Nature Communications","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"89acfe4d-b735-440b-bff7-8e18ef69bef4","owner":[],"postedDate":"July 24th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":35022265,"name":"Physical sciences/Chemistry/Catalysis"},{"id":35022266,"name":"Physical sciences/Chemistry/Chemical synthesis/Synthetic chemistry methodology"},{"id":35022267,"name":"Physical sciences/Chemistry/Organic chemistry/Synthetic chemistry methodology"}],"tags":[],"updatedAt":"2025-11-28T08:15:55+00:00","versionOfRecord":{"articleIdentity":"rs-4750231","link":"https://doi.org/10.1038/s41467-025-65616-z","journal":{"identity":"nature-communications","isVorOnly":false,"title":"Nature Communications"},"publishedOn":"2025-11-27 05:00:00","publishedOnDateReadable":"November 27th, 2025"},"versionCreatedAt":"2024-07-24 06:32:53","video":"","vorDoi":"10.1038/s41467-025-65616-z","vorDoiUrl":"https://doi.org/10.1038/s41467-025-65616-z","workflowStages":[]},"version":"v1","identity":"rs-4750231","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4750231","identity":"rs-4750231","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}