Assessing Prevalence and Risk Factors for REM Sleep Behavior Disorder Among Patients with Inflammatory Bowel Disease

Abstract REM Sleep Behavior Disorder (RBD) and Inflammatory Bowel Disease (IBD) are associated with Parkinson’s Disease. We hypothesized that RBD prevalence is greater in IBD than controls. 158 controls and 462 IBD patients completed IBD-related history questionnaires and the RBD Single-Question Screen (RBD1Q) and RBD-Screening Questionnaire assessing RBD. RBD prevalence was compared using chi-squared testing. Logistic regression explored IBD-related factors associated with RBD (RBD1Q), adjusting for age, sex, race. RBD prevalence was higher in IBD (14.1% vs. 5.1%; p = 0.002). Differential RBD prevalence was driven by changes in women; 13.3% IBD and 1.0% controls had RBD. For men, 16.0% IBD and 11.9% controls had RBD. IBD was associated with > 3-fold RBD likelihood (OR = 3.18, 95% CI [1.48,6.82], p = 0.003). Men with RBD and IBD were more likely than IBD males without RBD to have IBD-related hospitalizations (95.2% vs. 63.0%; p = 0.004). RBD is more prevalent in IBD than controls and is associated with severe IBD.