Genetic polymorphism and risk of venous thromboembolism among patients with endometrial hyperplasia

Objective: Endometrial hyperplasia is the result of hormonal changes linking with natural ovarian failure in the late reproductive and perimenopausal period. The most part of these patients need hormone therapy, but this treatment increase the risk of thrombosis (both arterial and venous), especially that some of our patients have hidden genetic determines of the thrombophilia. Methods: Data were collected for patients with endometrial hyperplasia from September 2008 to September 2016. Incidence of deep vein thrombosis was only one, after 3 months of hormonal treatment. Fishers exact test was used to estimate the association between the presence of hypercoagulation status and genetic determines of the thrombophilia.