High-dose atorvastatin ameliorates the uterine microenvironment in streptozotocin-induced diabetic rats

Burak Zeybek, Mete Ergenoğlu, Oytun Erbaş, Nuri Yıldırım, Ali Akdemir, Altuğ Yavaşoğlu, Hüseyin Aktuğ, Dilek Taşkıran
In: Gynecological Endocrinology · 2014 · vol. 30(11) , pp. 789–793 · doi:10.3109/09513590.2014.929657 · PMID:24989632 · W2135919100
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Atorvastatin treatment in diabetic rats reduced endometrial gland degeneration and fibrosis while increasing EGFR and decreasing VEGF expression compared to untreated diabetic rats.

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Abstract

Abstract The aim of this study was to investigate whether atorvastatin can ameliorate the uterine microenvironment in diabetes mellitus. Six non-diabetic (control) and 12 diabetic mature female Sprague-Dawley albino rats were used in this study. Diabetes was induced by intraperitoneal injections of 60 mg/kg streptozotocin, and 10 mg/kg/day of oral atorvastatin was administered for 4 weeks via orogastric tubes. The animals were euthanized, and blood samples were collected via cardiac puncture for biochemical analysis. Bilateral hysterectomy was performed for the histopathologic examination. Endometrial gland degeneration and stromal fibrosis scores concomitant with epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) immunoexpressions were analyzed. The endometrial gland degeneration scores, stromal fibrosis scores and VEGF immunoexpression was significantly lower, and the EGFR immunoexpression was significantly higher in the atorvastatin-treated diabetic rats when compared to the non-treated diabetic group, suggesting that atorvastatin ameliorates the uterine microenvironment in diabetes mellitus.

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chemicals 4
atorvastatin atorvastatin atorvastatin atorvastatin
organisms 5
rattus sp. lobaria tibetana rattus sp. multicellular animals rattus sp.

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