Blood Serum Levels of Proinflammatory Cytokines (IL-1β, IL-6, TNFα, IL-8, IL-12p70, and IFNγ) in Patients with Uterine Myoma

We analyzed cytokine profile in blood serum of patients with uterine myoma and revealed significantly reduced level of IFNγ and a tendency towards a decrease in the levels of IL-1β and TNFα; the levels of IL-6, IL-8, and IL-12p70 did not differ from those in healthy women. The drop in the concentrations of factors responsible for inflammation and angiogenesis in tissues are unfavorable for proliferation and differentiation of the uterine tissues. Similar content being viewed by others References Voronin DN, Litsova AO. The local immune response in women with leiomyomas of different types and rates of growth. Ross. Immunol. Zh. 2014;8(1):73-78. Russian. Ovakimyan AS, Krechetova LV, Vtorushina VV, Vanko LV, Kozachenko IF, Adamyan LV. Plasma and peritoneal fluid IL-1β, IL-8, and substance P levels in patients with different forms of external genital endometriosis and chronic pelvic pain. Akush. Ginekol. 2015;(3):79-86. Russian. Sosnina AE, Sotnikova NYu, Antsiferova YuS, Boiko OM, Malyshkina AI, Petetyatko LP. The role of IL-8 in the pathogenesis of rapid growth of uterine leiomyoma. Byull. Sib. Otdel. Ross. Akad. Med. Nauk. 2008;28(Suppl. 1):64-68. Russian. Sosnina AE, Sotnikova NYu, Antsiferova YuS, Boiko OM, Malyshkina AI, Petetyatko LP. The relationship of the cytokine profile of phagocytic cells in uterine myoma with the rate and type of tumor growth. Med. Immunol. 2007;9(2-3):263-264. Russian. Shramko SV, Zorina VN, Bazhenova LG, Zorina RM, Ryabicheva TG, Chevychalova EV, Zorin NA. Regulatory transport proteins and cytokines in the blood of patients with proliferative diseases of the uterus. Akush. Ginekol. 2016;(5):104-109. Ruusian. Artis D, Spits H. The biology of innate lymphoid cells. Nature. 2015;517:293-301. Biancotto A, Wank A, Perl S, Cook W, Olnes MJ, Dagur PK, Fuchs JC, Langweiler M, Wang E, McCoy JP. Correction: Baseline Levels and Temporal Stability of 27 Multiplexed Serum Cytokine Concentrations in Healthy Subjects. PLoS One. 2015;10(7):e0132870. doi: https://doi.org/10.1371/journal.pone.0132870. Ciavattini A, Di Giuseppe J, Stortoni P, Montik N, Giannubilo SR, Litta P, Islam MS, Tranquilli AL, Reis FM, Ciarmela P. Uterine fibroids: pathogenesis and interactions with endometrium and endomyometrial junction. Obstet. Gynecol. Int. 2013;2013:173184. doi: https://doi.org/10.1155/2013/173184. Green DS, Young HA, Valencia JC. Current prospects of type II interferon γ signaling and autoimmunity. J. Biol. Chem. 2017;292(34):13,925-13,933. Islam MS, Greco S, Janjusevic M, Ciavattini A, Giannubilo SR, D’Adderio A, Biagini A, Fiorini R, Castellucci M, Ciarmela P. Growth factors and pathogenesis. Best Pract. Res. Clin. Obstet. Gynaecol. 2016;34:25-36. Kuebler JF, Czech-Schmidt G, Leonhardt J, Ure BM, Petersen C. Type-I but not type-II interferon receptor knockout mice are susceptible to biliary atresia. Pediatr. Res. 2006;59(6):790-794. Kurachi O, Matsuo H, Samoto T, Maruo T. Tumor necrosis factor-alpha expression in human uterine leiomyoma and its down-regulation by progesterone. J. Clin. Endocrinol. Metab. 2001;86(5):2275-2280. Plewka A, Madej P, Plewka D, Kowalczyk A, Miskiewicz A, Wittek P, Leks T, Bilski R. Immunohistochemical localization of selected pro-inflammatory factors in uterine myomas and myometrium in women of various ages. Folia Histochem. Cytobiol. 2013;51(1):73-83. Protic O, Toti P, Islam MS, Occhini R, Giannubilo SR, Catherino WH, Cinti S, Petraglia F, Ciavattini A, Castellucci M, Hinz B, Ciarmela P. Possible involvement of inflammatory/reparative processes in the development of uterine fibroids. Cell Tissue Res. 2016;364(2):415-427. Seliger B, Ruiz-Cabello F, Garrido F. IFN inducibility of major histocompatibility antigens in tumors. Adv. Cancer Res. 2008;101:249-276. Author information Authors and Affiliations Corresponding author Additional information Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 5, pp. 648-652, May 2018 Rights and permissions About this article Cite this article Konenkov, V.I., Koroleva, E.G., Orlov, N.B. et al. Blood Serum Levels of Proinflammatory Cytokines (IL-1β, IL-6, TNFα, IL-8, IL-12p70, and IFNγ) in Patients with Uterine Myoma. Bull Exp Biol Med 165, 698–701 (2018). https://doi.org/10.1007/s10517-018-4245-0 Received: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s10517-018-4245-0