Preoperative albumin-to-alkaline phosphatase ratio is an independent prognostic factor for postoperative survival after gallbladder carcinoma radical surgery

Purpose: The relationships of the albumin-to-alkaline phosphatase ratio (AAPR) and the results in Gallbladder cancer (GBC) cases undergoing radical surgical process have been rarely discussed. The present work attempted to assess the prognosis implication of AAPR in GBC cases before operation. Methods: : We retrospectively selected 202 consecutive GBC cases treated from 2010 to 2017. Through univariate and multivariate studies, elements impacting overall survival (OS) and recurrence-free survival (RFS) were explored. Results: : Among the 202 cases, 93 (46%) achieved AAPR<0.4. The middle OS in cases with low AAPR before operation reached 26 months, less than that for high AAPR cases before operation (38 months, P<0.001). Low AAPR before operation displayed relationships to smaller surviving periods in univariate studies (HR, 2.738; 95%CI, 1.256-5.843; P<0.001). According to multivariate study, low AAPR cases achieved a lower OS (HR, 2.247; 95%CI, 1.483-3.404; P=0.028) and RFS (HR, 1.640; 95%CI, 1.037-3.210; P=0.041) than high AAPR cases. Conclusion: AAPR is an independent indicator of poor prognosis in GBC patients after GBC radical surgery.