Health-related quality of life and cancer related fatigue in patients with non-metastatic head and neck cancers

Health-related quality of life and cancer related fatigue in patients with non-metastatic head and neck cancers | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Health-related quality of life and cancer related fatigue in patients with non-metastatic head and neck cancers Fateme Sheida, Rohollah Abbasi, Ahmad Ameri, Leili Tapak, Alireza Mansouri, and 5 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5280411/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Objective: This study aimed to assess health-related quality of life (HRQoL) and cancer-related fatigue (CRF) in patients with non-metastatic head and neck cancers over a six-month period following treatment initiation. Methods: Patients with non-metastatic head and neck cancers referring to two oncology clinics in Hamadan, Iran, from April 2022 to March 2023 were evaluated using the Brief Fatigue Inventory (BFI) and the European Organization for Research and Treatment of Cancer Quality of Life questionnaire (EORTC QLQ C-30) version 3. Scores were recorded at baseline and six-month post-treatment. All statistical analyses were performed using SPSS version 27, with a P-value of <0.05 considered statistically significant. Results: Of the 47 patients in this study, 83% were male (n=39) and the mean age was 54.28±9.61 years. The oral cavity (n=25, 53.2%) and larynx (n=11, 23.4%) were the most frequent tumor sites. Significant increase in CRF were observed between baseline and six-month post-treatment (3.07 vs. 3.50, P <0.001). The result of EORTC QLQ C-30 showed that mean global QoL score was 73.91±8.89 at baseline and 63.40±9.20 six-month post-treatment (P<0.001). The majority of functional scales items reduced significantly (P<0.001), and symptom scale items increased over time. Conclusion: In conclusion, this study demonstrates a significant decline in QoL and an increase in CRF among patients with non-metastatic head and neck cancers during the first six months of treatment. The findings emphasize the multifactorial impact of cancer treatments on physical, psychological, and financial aspects of patients’ life and vital need for supportive care. Cancer-related fatigue Head and neck neoplasms Brief Fatigue Inventory Cancer survivorship Health-related quality of life Introduction Neoplasms affecting the oral and nasal cavities, larynx, pharynx, and sinuses are collectively referred to as head and neck cancer (HNC). According to GLOBOCAN estimation, HNCs rank seventh among all types of cancers prevalence in all over the world, with over 660,000 newly diagnosed cases and 325,000 deaths occurring each year ( 1 ). The complicated nature of the disease necessitates that patients often undergo intensive multi-modal treatments and face a substantial likelihood of experiencing functional and social restrictions, including challenges with chewing, swallowing, ingestion, breathing, and communication, as well as alterations in appearance, which lead to a loss of social contact, and adverse effects linked to treatment, including chemo-radiation and surgery; all these can significantly impact a patient's commitment to treatment, quality of life (QoL), contributing to psychological distress such as anxiety, depression, and fatigue, alongside other mental health-related symptoms and disorders ( 2 – 4 ). The health-related quality of life (HRQoL) refers to an individual's own understanding of how the disease and its treatments impact several aspects of their daily life and existence, including psychological, social, and physical. One of the key factors that impact QoL in patients with cancer is fatigue. Cancer-related fatigue (CRF) is characterized as a disturbing and prolonged subjective experience of mental and/or physical tiredness that is associated with cancer or its treatment, not correlated with recent physical activity, and impairs normal daily activities ( 5 ). Consequently, it is essential to monitoring and prioritize improving CRF and QoL as essential treatment objectives, especially for HNC, where multimodal therapies not only improve tumor control but also influence the expectations of patients, concerns, and coping behaviors ( 6 , 7 ). Therefore, the objective of the present study is evaluating health-related quality of life and cancer related fatigue in patients with non-metastatic head and neck cancers over a six-month period following treatment initiation. Methods and Materials Study Patients In this cross-sectional study, patients aged ≥ 18 years old and had a confirmed diagnosis of non-metastatic head and neck cancer were invited to participate. The study was conducted at Be'sat Hospital and Mahdieh Medical Center in Hamadan, Iran, from April 2022 to March 2023. Patients who refused to participate, individuals with the metastasis or relapse of the disease, and those with a proven depressive disorder were not qualified. Participants granted written consent after being informed. The study protocol received approval from the Research Ethics Committee of the Medical School of Hamadan University of Medical Sciences (IR.UMSHA.REC.1401.1062). Data collection Data were collected through interviews, by a trained research assistant, with three measurement instruments, including sociodemographic questionnaire, the European Organization for Research and Treatment of Cancer Quality of Life questionnaire (EORTC QLQ C-30) version 3, and Brief Fatigue Inventory (BFI) questionnaire. Patients completed the EORTC QLQ-C30 and BFI questionnaires before the start of treatment and at a regular follow-up visit- 6 months after starting the treatment. Brief Fatigue Inventory (BFI) The BFI's Persian version was used for assessing CRF; it has already been verified and established by Ghaderi et al. It is a one-page questionnaire, consists of 10 questions. The first question, a yes or no one, determines the presence of unusual fatigue in the past week. If the response was yes, then, responding to three separate questions, participants are asked to rate their state of fatigue during the previous 24 hours on a scale from "No fatigue" to "Fatigue as severe as you can imagine." The six questions that follow assess how much fatigue has impacted their lives during the previous 24 hours. The objectives cover general activity level, emotional state, mobility, regular work, interpersonal relationships, and overall life satisfaction. To summarize, the BFI scale assigns scores to the following categories: no fatigue = 0, mild fatigue = 0 to 3, moderate fatigue = 4 to 6, severe fatigue = 7 to 9, and very severe fatigue = 10 ( 8 – 10 ). Quality of Life questionnaire The EORTC QLQ-C30, 3rd version is a 30-item survey designed to assess the HRQoL in individuals diagnosed with non-metastatic HNC. The Persian version of the questionnaire undergone prior evaluation and validation by Montazeri et al. ( 11 ). The QLQ-C30 consists of a combination of multiple-item scales and single-item measures. It includes five functional scales (social, physical, cognitive, role, and emotional), three symptom scales (fatigue, pain, nausea, and vomiting), a global health status/quality of life scale, and six single questions. Scoring was conducted according to the guidelines provided in the EORTC QLQ-C30 Scoring Manual. The scales have a range of 0 to 100. A high score on the functional scales indicates a superior level of functioning, while a high score on the symptom scales indicates a significant degree of symptomatology. A high score on the global Quality of Life (QoL) assessment indicates a high general quality of living ( 12 ). Date analysis This observational study was conducted over one year, and a convenience sample of 47 patients was enrolled based on the estimated number of patients with non-metastatic HNC treated in our departments during that period. Data was recorded by interviewers using a standardized checklist. The Shapiro-Wilk test was used to assess the normality of the variables. Descriptive statistics were generated for all data, with continuous variables presented as means and standard deviations (SD), and categorical variables as frequencies and percentages. Changes in the EORTC QLQ-C30 and Brief Fatigue Inventory (BFI) scores between baseline and six months after treatment were analyzed using the Wilcoxon signed-rank. Spearman’s rank correlation coefficient was used to assess correlations between changes in fatigue and quality of life over time. To evaluate the influence of clinical and sociodemographic factors on outcomes, the Mann-Whitney and Kruskal–Wallis test was used. All statistical analyses were performed using SPSS version 27, with a P-value of < 0.05 considered statistically significant. Results A total of 47 patients were included in this study, with the majority being male (n = 39, 83%) and the mean age being 54.28 ± 9.61 years. The oral cavity (n = 25, 53.2%) and larynx (n = 11, 23.4%) were the most frequent tumor sites. Other baseline characteristics of the patients, including demographic, pathological, and clinical variables, are presented in Table 1 . Table 1 Baseline characteristics of the enrolled patients Variable Frequency n (%) Sex Female 8 (17.0) Male 39 (83.0) Marital status Single 3 (6.4) Married 44 (93.6) Education Under diploma 11 (23.4) Diploma 13 (27.7) Higher 22 (48.9) Employment status Unemployed 7 (14.9) Retired 8 (17.0) Freelancer 15 (31.9) Employee 10 (21.3) Manual worker 7 (14.9) Smoking/Opium Yes 40 (85.1) No 7 (14.9) Disease characteristics Disease stage 1 10 (19.1) 2 23 (21.3) 3 13 (38.3) 4 10 (21.3) T stage 1 10 (21.3) 2 23 (48.9) 3 13 (27.7) 4 1 (2.1) N stage 0 19 (40.4) 1 16 (34.0) 2 9 (19.1) 3 3 (6.4) Tumor Sites Oropharynx 4 (8.5) Nasopharynx 3 (6.4) Hypopharynx 4 (8.5) Larynx 11 (23.4) Oral cavity 25 (53.2) Weeks passed since diagnosis ≤ 4 25 (53.2) > 4 22 (46.8) Treatment Chemotherapy Yes 31 (66.0) No 16 (34.0) Radiotherapy Yes 43 (91.5) No 4 (8.5) Brachytherapy Yes 1 (2.1) No 45 (95.7) Surgery Yes 32 (68.1) No 15 (31.9) Table 2 shows the mean and standard deviation (SD) of the patients' fatigue scores (based on BFI) and QoL (based on EORTC-QLQ-C30 scales) over time. There were significant differences in CRF between the baseline and six months after treatment (3.07 vs. 3.50, P <0.001). The mean score for global QoL was 73.91±8.89 and 63.40±9.20, at baseline and six months after treatment, respectively (P<0.001). The mean score of the five functional scales ranged from 76.44-86.95 at baseline and 69.92-79.34 after 6 months. The majority of the functional scale items were shown to have significantly decreased in the QoL analysis based on the EORTC-QLQ-C30 scales (P<0.001). The highest symptom scales score on QLQ-C30 was for pain (27.89-30.79, P=0.074; baseline and after 6 months, respectively); and in overall symptom scale items showed an increase over time. Overall, from the time of diagnosis to six months after treatment, the patients' fatigue and overall quality of life became worsened. Table 2 Scores of EORTC QLQ-C30 and Brief Fatigue Inventory (BFI) among patients at baseline and 6 months after starting the treatment. In functional scaled and global QoL, the scores go from 0 to 100 and the higher values indicate better HRQoL; but in symptom scales, the higher values indicate a higher level of symptoms and lower HRQoL. Baseline Mean ± SD 6 Months Mean ± SD P Value Scales of EORTC QLQ-C30 Functional Scales physical functioning (PF2) 84.20 ± 7.48 77.39 ± 8.00 < 0.001 role functioning (RF2) 76.44 ± 9.67 69.92 ± 10.89 < 0.001 emotional functioning (EF) 80.43 ± 14.61 72.64 ± 10.78 < 0.001 cognitive functioning (CF) 86.95 ± 14.87 79.34 ± 13.23 < 0.001 social functioning (SF) 77.17 ± 11.84 74.63 ± 12.03 0.229 global health status/QoL 73.91 ± 8.89 63.40 ± 9.20 < 0.001 Symptom Scales fatigue (FA) 19.23 ± 11.33 27.77 ± 11.65 < 0.001 nausea and vomiting (NV) 3.98 ± 8.00 5.79 ± 10.66 0.248 pain (PA) 27.89 ± 11.14 30.79 ± 9.91 0.074 dyspnea (DY) 7.97 ± 14.37 14.49 ± 16.70 0.020 insomnia (SL) 10.14 ± 17.02 23.18 ± 18.41 < 0.001 appetite loss (AP) 13.04 ± 16.44 18.84 ± 16.70 0.033 constipation (CO) 1.44 ± 6.87 0.72 ± 4.91 0.564 diarrhea (DI) 0.72 ± 4.91 2.89 ± 9.49 0.083 financial difficulties (FI) 18.84 ± 16.70 24.63 ± 16.38 0.033 Brief Fatigue Inventory (BFI) Fatigue index 3.07 ± 0.43 3.50 ± 0.43 < 0.001 The Spearman's rank correlation analysis (Table 3) showed a statistically significant correlation between changes in BFI scores and changes in fatigue (r=0.297, P<0.05) and diarrhea (r=0.373, P<0.05) across the course of follow-up. The correlation between changes in global QoL scores and impairment in emotional functioning (r=0.399, P<0.01) and social functioning (r=0.353, P<0.05) has been found to be statistically significant. Presented in Table 4 are the effects of sociodemographic and clinical factors on HRQoL and CRF among patients 6 months after initiating the treatment. The findings indicated that the BFI score was higher in female patients, married, and workers. Additionally, it was greater in patients without a smoking or opioid use history, with stage 4 disease, nasopharyngeal tumors, and those undergoing chemotherapy and surgery as part of their treatment regimen. The previously listed variables did not show statistical significance (P>0.05). Table 3 The spearman’s rank correlation analysis for changes in the scores of the BFI and QoL scales over time. Abbreviations: Δ, the variable score difference at the beginning and end of the study; BFI, Brief Fatigue Inventory; Global QoL, global health status; PF2, physical functioning; RF2, role functioning; EF, emotional functioning; CF, cognitive functioning; SF, social functioning; FA, fatigue; NV, nausea and vomiting; PA, pain; DY, dyspnea; SL, insomnia; AP, appetite loss; CO, constipation; DI, diarrhea; FI, financial difficulties. *: Correlation is significant at the 0.05 level; **: Correlation is significant at the 0.01 level. ΔBFI ΔGlobal QoL ΔPF2 ΔRF2 ΔEF ΔCF ΔSF ΔFA ΔNV ΔPA ΔDY ΔSL ΔAP ΔCO ΔDI ΔFI ΔBFI -0.079 -0.038 -0.048 -0.177 -0.175 0.053 0.297* -0.218 0.063 0.014 -0.135 -0.050 -0.049 0.373* -0.094 ΔGlobal QoL -0.079 0.174 0.002 0.399** -0.135 0.353* -0.272 0.160 -0.109 -0.030 -0.099 -0.082 -0.063 0.051 -0.138 ΔPF2 -0.038 0.174 -0.070 -0.018 0.104 0.454** -0.384** -0.037 -0.036 -0.007 -0.135 -0.138 0.180 -0.231 -0.151 ΔRF2 -0.048 0.002 -0.070 -0.228 -0.091 -0.210 -0.136 -0.128 0.048 0.121 -0.007 -0.072 0.163 0.026 -0.186 ΔEF -0.177 0.399** -0.018 -0.228 0.129 0.041 0.080 0.330* -0.147 -0.071 -0.118 0.015 -0.316* -0.112 0.321* ΔCF -0.175 -0.135 0.104 -0.091 0.129 -0.193 -0.004 0.218 -0.051 -0.401** -0.229 0.150 -0.144 -0.279 0.164 ΔSF 0.053 0.353* 0.454** -0.210 0.041 -0.093 -0.251 -0.256 0.009 -0.004 -0.068 0.042 -0.008 0.073 -0.314* ΔFA 0.297* -0.272 -0.384** -0.136 0.080 -0.004 -0.251 0.031 -0.049 -0.034 0.048 0.179 0.034 -0.017 0.461** ΔNV -0.218 0.160 -0.037 -0.128 0.330* 0.218 -0.256 0.031 -0.166 0.109 0.157 -0.056 -0.183 -0.043 0.339* ΔPA 0.063 -0.109 -0.036 0.048 -0.147 -0.051 0.009 -0.049 -0.166 0.152 -0.143 -0.094 0.166 0.054 -0.086 ΔDY 0.014 -0.030 -0.007 0.121 -0.071 -0.401** -0.004 -0.034 0.109 0.152 0.089 -0.432** 0.033 0.065 0.089 ΔSL -0.135 -0.099 -0.135 -0.007 -0.118 -0.229 -0.068 0.048 0.157 -0.143 0.089 -0.040 0.134 -0.038 0.057 ΔAP -0.050 -0.082 -0.138 -0.072 0.015 0.150 0.042 0.179 -0.056 -0.094 -0.432** -0.040 -0.105 0.078 0.182 ΔCO -0.049 -0.063 0.180 0.163 -0.316* -0.144 -0.008 0.034 -0.183 0.166 0.033 0.134 -0.105 -0.325* -0.140 ΔDI 0.373* 0.051 -0.231 0.026 -0.112 -0.279 0.073 -0.017 -0.043 0.054 0.065 -0.038 0.078 -0.325* -0.099 ΔFI -0.094 -0.138 -0.151 -0.186 0.321* 0.164 -0.314* 0.461** 0.339* -0.086 0.089 0.057 0.182 -0.140 -0.099 Table 4 Effects of the sociodemographic and clinical variables on the scores of a) Global QoL and functional scales of EORTC QLQ C-30 and Brief Fatigue Inventory (BFI) b) Symptom scales of EORTC QLQ C-30 among patients at 6 months after treatment. Abbreviations: Global QoL, global health status; PF2, physical functioning; RF2, role functioning; EF, emotional functioning; CF, cognitive functioning; SF, social functioning; FA, fatigue; NV, nausea and vomiting; PA, pain; DY, dyspnea; SL, insomnia; AP, appetite loss; CO, constipation; DI, diarrhea; FI, financial difficulties 4-a) Global QoL and functional scales of EORTC QLQ C-30, and BFI Variable BFI Global QoL PF2 RF2 EF CF SF Sex Female 3.51 ± 0.74 65.62 ± 14.39 73.33 ± 10.07 66.66 ± 15.43 75.00 ± 10.91 83.33 ± 12.59 75.00 ± 15.43 Male 3.49 ± 0.35 62.93 ± 7.91 78.24 ± 7.38 70.61 ± 9.82 72.14 ± 10.83 78.50 ± 13.37 74.56 ± 11.45 P Value 0.456 0.421 0.112 0.189 0.543 0.366 0.818 Marital status Single 3.22 ± 0.15 58.33 ± 8.33 80.00 ± 6.66 66.66 ± 0.00 80.55 ± 12.72 83.33 ± 0.00 77.77 ± 19.24 Married 3.51 ± 0.44 63.75 ± 9.25 77.20 ± 8.13 70.15 ± 11.24 72.09 ± 10.58 79.06 ± 13.65 74.41 ± 11.69 P Value 0.184 0.285 0.519 0.573 0.216 0.518 0.860 Education Under diploma 3.48 ± 0.56 65.00 ± 11.65 76.66 ± 7.20 75.00 ± 11.78 76.66 ± 8.60 83.33 ± 13.60 76.66 ± 11.65 Diploma 3.52 ± 0.35 63.46 ± 9.94 78.46 ± 7.27 66.66 ± 13.60 71.15 ± 8.06 78.20 ± 8.00 73.07 ± 8.43 Higher 3.50 ± 0.44 62.50 ± 8.03 77.57 ± 8.85 69.69 ± 8.35 70.83 ± 12.26 78.03 ± 15.75 73.48 ± 13.27 P Value 0.806 0.936 0.551 0.089 0.070 0.329 0.477 Employment status Unemployed 3.58 ± 0.77 67.85 ± 12.19 74.28 ± 8.96 69.04 ± 14.99 73.80 ± 11.20 80.95 ± 11.50 76.19 ± 13.11 Retired 3.48 ± 0.28 67.70 ± 5.34 78.33 ± 5.90 68.75 ± 5.89 72.91 ± 9.70 81.25 ± 10.68 77.08 ± 15.26 Freelancer 3.54 ± 0.37 61.30 ± 10.13 78.09 ± 8.83 70.23 ± 13.36 73.21 ± 9.34 78.57 ± 13.75 72.61 ± 10.55 Employee 3.30 ± 0.36 61.66 ± 7.02 80.00 ± 8.31 66.66 ± 7.85 71.66 ± 8.95 80.00 ± 15.31 75.00 ± 11.78 Manual worker 3.61 ± 0.33 60.71 ± 9.27 74.28 ± 7.12 76.19 ± 8.90 71.42 ± 17.90 76.19 ± 16.26 73.80 ± 13.11 P Value 0.231 0.264 0.373 0.309 0.954 0.970 0.983 Smoking/Opium Yes 3.48 ± 0.42 63.24 ± 9.50 78.11 ± 7.93 70.08 ± 11.58 72.86 ± 8.90 78.63 ± 12.65 73.93 ± 11.33 No 3.57 ± 0.51 64.28 ± 7.92 73.33 ± 7.69 69.04 ± 6.29 71.42 ± 19.15 83.33 ± 16.66 78.57 ± 15.85 P Value 0.975 0.647 0.125 0.868 0.665 0.264 0.520 Disease stage 1 3.56 ± 0.75 59.25 ± 11.36 80.00 ± 8.16 74.07 ± 16.89 68.51 ± 17.06 79.62 ± 18.21 75.92 ± 12.10 2 3.31 ± 0.31 62.50 ± 11.28 80.00 ± 10.42 68.33 ± 9.46 77.50 ± 8.82 81.66 ± 12.29 75.00 ± 14.16 3 3.50 ± 0.33 65.19 ± 7.92 76.86 ± 5.82 69.60 ± 8.80 72.05 ± 8.80 78.43 ± 11.43 74.50 ± 11.95 4 3.62 ± 0.35 65.00 ± 6.57 73.33 ± 7.69 68.33 ± 9.46 72.50 ± 7.90 78.33 ± 13.72 73.33 ± 11.65 P Value 0.178 0.282 0.153 0.875 0.307 0.934 0.941 Tumor Sites Oropharynx 3.33 ± 0.29 66.66 ± 0.00 80.00 ± 5.44 70.83 ± 8.33 85.41 ± 4.16 95.83 ± 8.33 83.33 ± 13.60 Nasopharynx 3.66 ± 0.57 55.55 ± 9.62 77.77 ± 7.69 72.22 ± 9.62 72.22 ± 9.62 83.33 ± 0.00 83.33 ± 16.66 Hypopharynx 3.44 ± 0.31 66.66 ± 0.00 76.66 ± 6.66 66.66 ± 0.00 77.08 ± 12.50 79.16 ± 20.97 70.83 ± 8.33 Larynx 3.46 ± 0.56 65.00 ± 8.60 80.00 ± 9.93 76.66 ± 14.05 67.50 ± 13.86 78.33 ± 15.81 71.66 ± 8.05 Oral cavity 3.52 ± 0.40 62.66 ± 10.51 76.00 ± 7.93 67.33 ± 10.18 72.00 ± 8.63 76.66 ± 10.75 74.00 ± 12.80 P Value 0.910 0.354 0.736 0.364 0.076 0.093 0.352 Chemotherapy Yes 3.52 ± 0.33 65.27 ± 6.94 76.66 ± 7.37 70.00 ± 9.18 73.05 ± 8.38 79.44 ± 12.13 75.00 ± 11.37 No 3.45 ± 0.60 59.89 ± 11.87 78.75 ± 9.17 69.79 ± 13.90 71.87 ± 14.55 79.16 ± 15.51 73.95 ± 13.56 P Value 0.818 0.030 0.328 0.578 0.961 0.911 0.753 Radiotherapy Yes 3.49 ± 0.44 64.08 ± 9.10 77.14 ± 8.21 70.23 ± 10.75 73.01 ± 10.85 78.96 ± 12.78 74.20 ± 11.75 No 3.58 ± 0.42 56.25 ± 7.97 80.00 ± 5.44 66.66 ± 13.60 68.75 ± 10.48 83.33 ± 19.24 79.16 ± 15.95 P Value 0.779 0.088 0.431 0.588 0.306 0.645 0.506 Surgery Yes 3.50 ± 0.36 62.63 ± 8.83 76.77 ± 7.67 67.74 ± 9.56 71.77 ± 8.51 77.95 ± 11.69 73.11 ± 12.67 No 3.49 ± 0.58 65.00 ± 10.05 78.66 ± 8.80 74.44 ± 12.38 74.44 ± 14.59 82.22 ± 16.01 77.77 ± 10.28 P Value 0.824 0.431 0.528 0.098 0.180 0.170 0.101 4-b) Symptom scales of EORTC QLQ C-30 Variable FA NV PA DY SL AP CP DI FI Sex Female 33.33 ± 14.54 10.41 ± 17.67 33.33 ± 12.59 16.66 ± 17.81 29.16 ± 21.36 16.66 ± 17.81 0.00 ± 0.00 0.00 ± 0.00 29.16 ± 11.78 Male 26.60 ± 10.81 4.82 ± 8.58 30.26 ± 9.37 14.03 ± 16.67 21.92 ± 17.80 19.29 ± 16.67 0.87 ± 5.40 3.50 ± 10.36 23.68 ± 17.16 P Value 0.193 0.439 0.496 0.686 0.361 0.686 0.646 0.342 0.356 Marital status Single 18.51 ± 6.41 5.55 ± 9.62 33.33 ± 0.00 22.22 ± 19.24 11.11 ± 19.24 11.11 ± 19.24 0.00 ± 0.00 22.22 ± 19.24 33.33 ± 0.00 Married 28.42 ± 11.70 5.81 ± 10.84 30.62 ± 10.24 13.95 ± 16.63 24.03 ± 18.29 19.37 ± 16.63 0.77 ± 4.91 1.55 ± 7.10 24.03 ± 16.78 P Value 0.125 0.887 0.621 0.407 0.232 0.407 0.792 < 0.001 0.317 Education Under diploma 24.44 ± 8.76 1.66 ± 5.27 33.33 ± 11.11 16.66 ± 17.56 10.00 ± 16.10 16.66 ± 17.56 0.00 ± 0.00 3.33 ± 10.54 20.00 ± 17.21 Diploma 29.91 ± 13.89 3.84 ± 7.30 26.92 ± 8.43 12.82 ± 16.87 28.20 ± 12.51 20.51 ± 16.87 0.00 ± 0.00 2.56 ± 9.24 17.94 ± 17.29 Higher 28.28 ± 11.74 6.81 ± 9.83 31.81 ± 10.16 13.63 ± 16.77 25.75 ± 20.39 18.18 ± 16.98 1.51 ± 7.10 3.03 ± 9.80 30.03 ± 14.21 P Value 0.400 0.422 0.151 0.588 0.009 0.588 1.000 0.849 0.773 Employment status Unemployed 28.57 ± 12.59 9.52 ± 18.89 35.71 ± 14.99 14.28 ± 17.81 23.80 ± 16.26 14.28 ± 17.81 0.00 ± 0.00 0.00 ± 0.00 28.57 ± 12.59 Retired 22.22 ± 5.93 8.33 ± 12.59 31.25 ± 5.89 4.16 ± 11.78 20.83 ± 17.25 12.50 ± 17.25 0.00 ± 0.00 4.16 ± 11.78 29.16 ± 11.78 Freelancer 28.57 ± 14.26 4.76 ± 7.81 32.14 ± 7.91 21.42 ± 16.57 28.57 ± 22.09 16.66 ± 17.29 2.38 ± 8.90 2.38 ± 8.90 21.42 ± 16.57 Employee 32.22 ± 12.22 6.66 ± 8.60 25.00 ± 11.78 10.00 ± 16.10 26.66 ± 14.05 26.66 ± 14.05 0.00 ± 0.00 0.00 ± 0.00 26.66 ± 21.08 Manual worker 25.39 ± 8.39 0.00 ± 0.00 30.95 ± 6.29 19.04 ± 17.81 9.52 ± 16.26 23.80 ± 16.26 0.00 ± 0.00 9.52 ± 16.26 19.04 ± 17.81 P Value 0.425 0.459 0.357 0.152 0.237 0.317 0.683 0.270 0.636 Smoking/Opium Yes 27.63 ± 11.92 5.12 ± 8.68 29.91 ± 10.24 13.67 ± 16.61 23.07 ± 18.97 19.65 ± 16.61 0.85 ± 5.33 2.56 ± 8.99 23.93 ± 17.01 No 28.57 ± 10.84 9.52 ± 18.89 35.71 ± 6.29 19.04 ± 17.81 23.80 ± 16.26 14.28 ± 17.81 0.00 ± 0.00 4.76 ± 12.59 28.57 ± 12.59 P Value 0.725 0.830 0.141 0.433 0.858 0.433 0.672 0.573 0.456 Disease stage 1 32.09 ± 12.96 5.55 ± 8.33 35.18 ± 10.01 14.81 ± 17.56 18.51 ± 17.56 18.51 ± 17.56 0.00 ± 0.00 7.40 ± 14.69 22.22 ± 16.66 2 25.55 ± 15.75 1.66 ± 5.27 30.00 ± 7.02 16.66 ± 17.56 30.00 ± 18.92 13.33 ± 17.21 0.00 ± 0.00 6.66 ± 14.05 26.66 ± 14.05 3 26.79 ± 7.91 7.84 ± 10.40 31.37 ± 10.00 11.76 ± 16.41 19.60 ± 16.90 19.60 ± 16.90 0.00 ± 0.00 0.00 ± 0.00 25.49 ± 14.57 4 27.77 ± 12.00 6.66 ± 16.10 26.66 ± 11.65 16.66 ± 17.56 26.66 ± 21.08 23.33 ± 16.10 3.33 ± 10.54 0.00 ± 0.00 23.33 ± 22.49 P Value 0.602 0.363 0.401 0.851 0.545 0.604 0.308 0.106 0.896 Tumor Sites Oropharynx 25.00 ± 10.63 4.16 ± 8.33 33.33 ± 0.00 8.33 ± 16.66 8.33 ± 16.66 8.33 ± 16.66 0.00 ± 0.00 0.00 ± 0.00 16.66 ± 19.24 Nasopharynx 29.62 ± 12.83 5.55 ± 9.62 38.88 ± 9.62 22.22 ± 19.24 22.22 ± 19.24 22.22 ± 19.24 0.00 ± 0.00 11.11 ± 19.24 33.33 ± 0.00 Hypopharynx 33.33 ± 9.07 8.33 ± 9.62 33.33 ± 0.00 25.00 ± 16.66 33.33 ± 27.21 25.00 ± 16.66 8.33 ± 16.66 0.00 ± 0.00 25.00 ± 16.66 Larynx 24.44 ± 11.47 3.33 ± 7.02 25.00 ± 11.78 16.66 ± 17.56 20.00 ± 17.21 23.33 ± 16.10 0.00 ± 0.00 6.66 ± 14.05 26.66 ± 21.08 Oral cavity 28.44 ± 12.45 6.66 ± 12.72 31.33 ± 10.00 12.00 ± 16.32 25.33 ± 17.42 17.33 ± 16.99 0.00 ± 0.00 1.33 ± 6.66 24.00 ± 15.27 P Value 0.714 0.880 0.246 0.479 0.378 0.529 0.033 0.263 0.739 Chemotherapy Yes 25.92 ± 9.82 6.66 ± 12.06 30.00 ± 10.17 14.44 ± 16.80 23.33 ± 17.83 20.00 ± 16.60 1.11 ± 6.08 0.00 ± 0.00 24.44 ± 17.36 No 31.25 ± 14.18 4.16 ± 7.45 32.29 ± 9.56 14.58 ± 17.07 22.91 ± 20.06 16.66 ± 17.21 0.00 ± 0.00 8.33 ± 14.90 25.00 ± 14.90 P Value 0.193 0.639 0.522 0.979 0.893 0.419 0.465 0.005 0.863 Radiotherapy Yes 26.71 ± 11.26 5.95 ± 10.93 30.15 ± 9.90 15.07 ± 16.79 23.01 ± 18.75 18.25 ± 16.79 0.79 ± 5.14 3.17 ± 9.90 24.60 ± 16.55 No 38.88 ± 11.11 4.16 ± 8.33 37.50 ± 8.33 8.33 ± 16.66 25.00 ± 16.66 25.00 ± 16.66 0.00 ± 0.00 0.00 ± 0.00 25.00 ± 16.66 P Value 0.053 0.843 0.149 0.440 0.785 0.440 0.758 0.523 0.942 Surgery Yes 28.31 ± 12.11 6.45 ± 11.92 29.03 ± 10.51 10.75 ± 15.83 24.73 ± 17.14 19.35 ± 16.72 0.00 ± 0.00 1.07 ± 5.98 25.80 ± 16.57 No 26.66 ± 10.95 4.44 ± 7.62 34.44 ± 7.62 22.22 ± 16.26 20.00 ± 21.08 17.77 ± 17.21 2.22 ± 8.60 6.66 ± 13.80 22.22 ± 16.26 P Value 0.760 0.777 0.080 0.029 0.352 0.763 0.151 0.061 0.510 Discussion The study's findings on HRQoL and CRF of 47 patients with non-metastatic head and neck cancers showed a significant decline in QoL and increase in CRF of the patients. The mean age of studies patients was 54.28 ± 9.61 years suggests that these cancers are more commonly diagnosed in middle-aged individuals, and majority of them were male (83%), which could be attributed to sex-specific patterns of modifiable risk factors such as tobacco and alcohol use; both are in consistent with epidemiological trends of the disease and pervious research ( 6 , 13 ). In line with pervious literatures, oral cavity and larynx where the most common tumor cites and most patients received chemo radiation and/or surgery in their treatment plans ( 14 ). A significant variation in the fatigue scores (as measured by the BFI) from the time of the disease diagnosis to 6 months after treatment was shown in the present study. CRF, as it is defined by the National Comprehensive Cancer Network (NCCN) as “a distressing, persistent, subjective sense of physical, emotional, and/or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and interferes with usual functioning ( 15 ),” is far deeper than an isolated symptom. Based on a meta-analysis on the prevalence of fatigue in different cancers, 61.9%, 18.8%, and 13.1% of patients with head and neck cancers experienced mild, moderate, and severe fatigue respectively ( 16 ), which shows the high importance of this issue in patients’ life. On the other hand, fatigue has adverse effects on patients' social life, mood, and daily activities, leads to significantly reduce their overall quality of life and potentially indicate a shorter survival duration ( 17 , 18 ). Despite the BFI score, the EORTC fatigue scale revealed significant increases, supporting the view that fatigue is among the most debilitating symptoms, arising from several psychological and physical reasons. Increasing nausea, vomiting, insomnia, dyspnea, and pain, together with low appetite and inability to eat, may lead to exhaustion and psychological disorders, as assessed in the current study using the EORTC QLQ-C30 symptom scales. Moreover, the scores of many functional scales, including physical, role, emotional, and cognitive functioning, as well as global quality of life decreased, indicating that after six months of treatment, patients face significant impairments in their lives. These findings are in line with prior research indicating that numerous cancer therapies and other disease related consequences like financial problems, result in a deterioration of HRQoL, particularly in the early months; they also emphasize the importance of comprehensive and especially multidisciplinary supportive care strategies focused on both therapeutic and psychological interventions to reduce fatigue and enhance overall QoL for patients ( 19 – 21 ). A notable finding is the significant increase in financial difficulties during the six-month period. This is not unexpected, as cancer treatment frequently makes significant costs, and the financial stress can get worsen by losing income if patients are unable to keep working, which is more common in head and neck cancer patients due to the post-cancer cosmetic and appearance effects of these tumors. Financial difficulty may lead to mental health issues, impacting emotional well-being and potentially limiting patients' compliance to treatments. These findings emphasize the necessity of providing financial support and counseling to cancer patients alongside with their medical treatment ( 22 , 23 ). This study has limitations that should be noted. First, the sample size was relatively small, with 47 patients, which may limit the generalizability of the findings. A larger multi-center cohort would have provided more precise data with including the impact of different treatment modalities or tumor locations on HRQoL and CRF. Also, the present study only coverd a 6-month period follow-up; longer follow-up would be necessary to evaluate the persistence of CRF and the long-term effects of treatments on HRQoL, and finally their effects on patients’ survival. Conclusion In conclusion, this study demonstrates a significant decline in QoL and an increase in CRF among patients with non-metastatic head and neck cancers during the first six months of treatment. The findings emphasize the multifactorial impact of cancer treatments on physical, emotional, and cognitive functioning, as well as the severe financial and psychological burdens experienced by patients. These results highlight the need for comprehensive multidisciplinary care, including psychological support, financial counseling, and interventions aimed at managing CRF, to improve the overall well-being of head and neck cancer patients. Declarations Ethics approval and consent to participate The study was approved by the Hamadan University Medical Ethics Review Board (IR.UMSHA.REC.1401.1062) and accordance with the Helsinki declaration. Written informed consent was obtained from all study participants after they had received a written and verbal explanation of the study ( 5 ). Consent for publication Not Applicable Competing interests The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding The present study has no funding. Author Contribution F.S., Z.K.A., R.A., and L.T. participated in the research design. F.S., A.A., A.M. and M.R.J. and participated in writing the first draft. E.S and M.M.A participated in the performance of the research and analytic tools. F.S., M.K., and Z.K.A. participated in data analysis. All authors reviewed and confirmed the final manuscript. Acknowledgement Our gratitude extends to the individuals who participated in the research and the dedicated study-sites staff. Data Availability The datasets used and analyzed during the current study are available from the corresponding author on reasonable request. References Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2021;71(3):209–49. Bossi P, Di Pede P, Guglielmo M, Granata R, Alfieri S, Iacovelli NA, et al. Prevalence of fatigue in head and neck cancer survivors. Annals of Otology, Rhinology & Laryngology. 2019;128(5):413–9. Fan CY, Chao HL, Lin CS, Huang WY, Chen CM, Lin KT, et al. Risk of depressive disorder among patients with head and neck cancer: a nationwide population-based study. Head & Neck. 2018;40(2):312–23. Nelke KH, Pawlak W, Gerber H, Leszczyszyn J. Head and neck cancer patients' quality of life. Advances in clinical and experimental medicine: official organ Wroclaw Medical University. 2014;23(6):1019–27. Fabi A, Bhargava R, Fatigoni S, Guglielmo M, Horneber M, Roila F, et al. Cancer-related fatigue: ESMO Clinical Practice Guidelines for diagnosis and treatment. Annals of Oncology. 2020;31(6):713–23. Baudelet M, Van den Steen L, Tomassen P, Bonte K, Deron P, Huvenne W, et al. Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy. Head & neck. 2019;41(10):3594–603. Kramer B, Wenzel A, Boerger M, Lippert B, Feist K, Petrasch R, et al. Long-term quality of life and nutritional status of patients with head and neck cancer. Nutrition and cancer. 2019;71(3):424–37. Ghaderi M, Azadi A, Rahmani A, Sanaat Z, Nazemiyeh H, Shamsi A, et al. Fatigue and its related factors among Iranian cancer survivors. Journal of caring sciences. 2021;10(4):210. Mendoza TR, Wang XS, Cleeland CS, Morrissey M, Johnson BA, Wendt JK, et al. The rapid assessment of fatigue severity in cancer patients: use of the Brief Fatigue Inventory. Cancer. 1999;85(5):1186–96. Sedighi Pashaki A, Sheida F, Moaddab Shoar L, Hashem T, Fazilat-Panah D, Nemati Motehaver A, et al. 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Cancer-related fatigue: ESMO Clinical Practice Guidelines for diagnosis and treatment. Annals of Oncology. 2020;31(6):713–23. Baudelet M, Van den Steen L, Tomassen P, Bonte K, Deron P, Huvenne W, et al. Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy. Head & neck. 2019;41(10):3594–603. Kramer B, Wenzel A, Boerger M, Lippert B, Feist K, Petrasch R, et al. Long-term quality of life and nutritional status of patients with head and neck cancer. Nutrition and cancer. 2019;71(3):424–37. Ghaderi M, Azadi A, Rahmani A, Sanaat Z, Nazemiyeh H, Shamsi A, et al. Fatigue and its related factors among Iranian cancer survivors. Journal of caring sciences. 2021;10(4):210. Mendoza TR, Wang XS, Cleeland CS, Morrissey M, Johnson BA, Wendt JK, et al. The rapid assessment of fatigue severity in cancer patients: use of the Brief Fatigue Inventory. Cancer. 1999;85(5):1186–96. Sedighi Pashaki A, Sheida F, Moaddab Shoar L, Hashem T, Fazilat-Panah D, Nemati Motehaver A, et al. A randomized, controlled, parallel-group, trial on the long-term effects of melatonin on fatigue associated with breast cancer and its adjuvant treatments. Integrative Cancer Therapies. 2023;22:15347354231168624. Montazeri A, Harirchi I, Vahdani M, Khaleghi F, Jarvandi S, Ebrahimi M, et al. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30): translation and validation study of the Iranian version. Supportive Care in Cancer. 1999;7:400–6. Keshtpour Amlashi Z, Sheida F, Anbiaee R, Tapak L, Hosseini SR, Mosaedian H, et al. The Effect of Melatonin on Increasing the Health Related Quality of Life in Non-Metastatic Breast Cancer Patients: Three-Year Follow up a Clinical Trial. Integrative Cancer Therapies. 2024;23:15347354241237520. Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. Head and neck squamous cell carcinoma. Nature reviews Disease primers. 2020;6(1):92. Kao NH, Iyer NG, Chua A, Nagadia RH. Early quality of life outcomes after surgery in head and neck cancer survivors with EORTC QLQ-C30 and EORTC QLQ-HN35 in an Asian tertiary centre. Supportive Care in Cancer. 2022;30(5):4537–46. Berger AM, Mooney K, Alvarez-Perez A, Breitbart WS, Carpenter KM, Cella D, et al. Cancer-related fatigue, version 2.2015. Journal of the National Comprehensive Cancer Network. 2015;13(8):1012–39. Kang Y-E, Yoon J-H, Park N-h, Ahn Y-C, Lee E-J, Son C-G. Prevalence of cancer-related fatigue based on severity: a systematic review and meta-analysis. Scientific reports. 2023;13(1):12815. Quinten C, Maringwa J, Gotay CC, Martinelli F, Coens C, Reeve BB, et al. Patient self-reports of symptoms and clinician ratings as predictors of overall cancer survival. Journal of the National Cancer Institute. 2011;103(24):1851–8. Bower JE. Cancer-related fatigue—mechanisms, risk factors, and treatments. Nature reviews Clinical oncology. 2014;11(10):597–609. Klein J, Livergant J, Ringash J. Health related quality of life in head and neck cancer treated with radiation therapy with or without chemotherapy: a systematic review. Oral oncology. 2014;50(4):254–62. Thong MS, Van Noorden CJ, Steindorf K, Arndt V. Cancer-related fatigue: causes and current treatment options. Current treatment options in oncology. 2020;21(2):17. Ahmadi MS, Sheida F, Ameri A, Javadinia SA, Farahani F, Soltaninia O, et al. Ewing’s sarcoma of mandible: practical approach to a challenging case. Case Reports in Oncology. 2022;15(3):927–35. Dee EC, Chino F. Financial hardship in cancer care—the need to define and intervene on actionable metrics. JAMA Network Open. 2022;5(7):e2223149-e. Lu L, O'Sullivan E, Sharp L. Cancer-related financial hardship among head and neck cancer survivors: Risk factors and associations with health‐related quality of life. Psycho‐oncology. 2019;28(4):863–71. Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5280411","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":369080246,"identity":"35d0082f-8346-4107-bc8b-b0d97d77b188","order_by":0,"name":"Fateme Sheida","email":"","orcid":"","institution":"Hamadan University of Medical Sciences","correspondingAuthor":false,"prefix":"","firstName":"Fateme","middleName":"","lastName":"Sheida","suffix":""},{"id":369080247,"identity":"b8cc0ad2-8be4-4505-ace9-cf85f1e79917","order_by":1,"name":"Rohollah Abbasi","email":"","orcid":"","institution":"Hamadan University of Medical 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07:08:28","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-5280411/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-5280411/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":71428614,"identity":"47f91640-afe4-4560-ab43-d037ee5d3f31","added_by":"auto","created_at":"2024-12-15 04:16:37","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1088305,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5280411/v1/1b86c793-0386-480d-8484-7b061733bf29.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Health-related quality of life and cancer related fatigue in patients with non-metastatic head and neck cancers","fulltext":[{"header":"Introduction","content":"\u003cp\u003eNeoplasms affecting the oral and nasal cavities, larynx, pharynx, and sinuses are collectively referred to as head and neck cancer (HNC). According to GLOBOCAN estimation, HNCs rank seventh among all types of cancers prevalence in all over the world, with over 660,000 newly diagnosed cases and 325,000 deaths occurring each year (\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e1\u003c/span\u003e). The complicated nature of the disease necessitates that patients often undergo intensive multi-modal treatments and face a substantial likelihood of experiencing functional and social restrictions, including challenges with chewing, swallowing, ingestion, breathing, and communication, as well as alterations in appearance, which lead to a loss of social contact, and adverse effects linked to treatment, including chemo-radiation and surgery; all these can significantly impact a patient's commitment to treatment, quality of life (QoL), contributing to psychological distress such as anxiety, depression, and fatigue, alongside other mental health-related symptoms and disorders (\u003cspan additionalcitationids=\"CR3\" citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e–\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e4\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eThe health-related quality of life (HRQoL) refers to an individual's own understanding of how the disease and its treatments impact several aspects of their daily life and existence, including psychological, social, and physical. One of the key factors that impact QoL in patients with cancer is fatigue. Cancer-related fatigue (CRF) is characterized as a disturbing and prolonged subjective experience of mental and/or physical tiredness that is associated with cancer or its treatment, not correlated with recent physical activity, and impairs normal daily activities (\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e5\u003c/span\u003e). Consequently, it is essential to monitoring and prioritize improving CRF and QoL as essential treatment objectives, especially for HNC, where multimodal therapies not only improve tumor control but also influence the expectations of patients, concerns, and coping behaviors (\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e, \u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e7\u003c/span\u003e). Therefore, the objective of the present study is evaluating health-related quality of life and cancer related fatigue in patients with non-metastatic head and neck cancers over a six-month period following treatment initiation.\u003c/p\u003e "},{"header":"Methods and Materials","content":"\u003cp\u003eStudy Patients\u003c/p\u003e\u003cp\u003eIn this cross-sectional study, patients aged ≥ 18 years old and had a confirmed diagnosis of non-metastatic head and neck cancer were invited to participate. The study was conducted at Be'sat Hospital and Mahdieh Medical Center in Hamadan, Iran, from April 2022 to March 2023. Patients who refused to participate, individuals with the metastasis or relapse of the disease, and those with a proven depressive disorder were not qualified. Participants granted written consent after being informed. The study protocol received approval from the Research Ethics Committee of the Medical School of Hamadan University of Medical Sciences (IR.UMSHA.REC.1401.1062).\u003c/p\u003e\u003cp\u003eData collection\u003c/p\u003e\u003cp\u003eData were collected through interviews, by a trained research assistant, with three measurement instruments, including sociodemographic questionnaire, the European Organization for Research and Treatment of Cancer Quality of Life questionnaire (EORTC QLQ C-30) version 3, and Brief Fatigue Inventory (BFI) questionnaire. Patients completed the EORTC QLQ-C30 and BFI questionnaires before the start of treatment and at a regular follow-up visit- 6 months after starting the treatment.\u003c/p\u003e\u003cp\u003eBrief Fatigue Inventory (BFI)\u003c/p\u003e\u003cp\u003eThe BFI's Persian version was used for assessing CRF; it has already been verified and established by Ghaderi et al. It is a one-page questionnaire, consists of 10 questions. The first question, a yes or no one, determines the presence of unusual fatigue in the past week. If the response was yes, then, responding to three separate questions, participants are asked to rate their state of fatigue during the previous 24 hours on a scale from \"No fatigue\" to \"Fatigue as severe as you can imagine.\" The six questions that follow assess how much fatigue has impacted their lives during the previous 24 hours. The objectives cover general activity level, emotional state, mobility, regular work, interpersonal relationships, and overall life satisfaction. To summarize, the BFI scale assigns scores to the following categories: no fatigue = 0, mild fatigue = 0 to 3, moderate fatigue = 4 to 6, severe fatigue = 7 to 9, and very severe fatigue = 10 (\u003cspan additionalcitationids=\"CR9\" citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e–\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e10\u003c/span\u003e).\u003c/p\u003e\u003cp\u003eQuality of Life questionnaire\u003c/p\u003e\u003cp\u003eThe EORTC QLQ-C30, 3rd version is a 30-item survey designed to assess the HRQoL in individuals diagnosed with non-metastatic HNC. The Persian version of the questionnaire undergone prior evaluation and validation by Montazeri et al. (\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e11\u003c/span\u003e). The QLQ-C30 consists of a combination of multiple-item scales and single-item measures. It includes five functional scales (social, physical, cognitive, role, and emotional), three symptom scales (fatigue, pain, nausea, and vomiting), a global health status/quality of life scale, and six single questions. Scoring was conducted according to the guidelines provided in the EORTC QLQ-C30 Scoring Manual. The scales have a range of 0 to 100. A high score on the functional scales indicates a superior level of functioning, while a high score on the symptom scales indicates a significant degree of symptomatology. A high score on the global Quality of Life (QoL) assessment indicates a high general quality of living (\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e12\u003c/span\u003e).\u003c/p\u003e\u003cp\u003eDate analysis\u003c/p\u003e\u003cp\u003eThis observational study was conducted over one year, and a convenience sample of 47 patients was enrolled based on the estimated number of patients with non-metastatic HNC treated in our departments during that period. Data was recorded by interviewers using a standardized checklist. The Shapiro-Wilk test was used to assess the normality of the variables. Descriptive statistics were generated for all data, with continuous variables presented as means and standard deviations (SD), and categorical variables as frequencies and percentages. Changes in the EORTC QLQ-C30 and Brief Fatigue Inventory (BFI) scores between baseline and six months after treatment were analyzed using the Wilcoxon signed-rank. Spearman’s rank correlation coefficient was used to assess correlations between changes in fatigue and quality of life over time. To evaluate the influence of clinical and sociodemographic factors on outcomes, the Mann-Whitney and Kruskal–Wallis test was used. All statistical analyses were performed using SPSS version 27, with a P-value of \u0026lt; 0.05 considered statistically significant.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eA total of 47 patients were included in this study, with the majority being male (n\u0026thinsp;=\u0026thinsp;39, 83%) and the mean age being 54.28\u0026thinsp;\u0026plusmn;\u0026thinsp;9.61 years. The oral cavity (n\u0026thinsp;=\u0026thinsp;25, 53.2%) and larynx (n\u0026thinsp;=\u0026thinsp;11, 23.4%) were the most frequent tumor sites. Other baseline characteristics of the patients, including demographic, pathological, and clinical variables, are presented in Table \u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e.\u003c/p\u003e\n\u003cdiv class=\"gridtable\"\u003e\n \u003cdiv class=\"colspec\" align=\"left\"\u003e\u0026nbsp;\u003c/div\u003e\n \u003cdiv class=\"colspec\" align=\"left\"\u003e\u0026nbsp;\u003c/div\u003e\n \u003cdiv class=\"colspec\" align=\"left\"\u003e\u0026nbsp;\u003c/div\u003e\n \u003ctable id=\"Tab1\" border=\"1\"\u003e\n \u003ccaption\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 1\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eBaseline characteristics of the enrolled patients\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eVariable\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eFrequency n (%)\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eSex\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eFemale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e8 (17.0)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eMale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e39 (83.0)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eMarital status\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSingle\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3 (6.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eMarried\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e44 (93.6)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" align=\"left\"\u003e\n \u003cp\u003eEducation\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eUnder diploma\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e11 (23.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eDiploma\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13 (27.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eHigher\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e22 (48.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"5\" align=\"left\"\u003e\n \u003cp\u003eEmployment status\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eUnemployed\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e7 (14.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eRetired\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e8 (17.0)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eFreelancer\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15 (31.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eEmployee\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e10 (21.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eManual worker\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e7 (14.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eSmoking/Opium\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e40 (85.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e7 (14.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"3\" align=\"left\"\u003e\n \u003cp\u003e\u003cem\u003eDisease characteristics\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"4\" align=\"left\"\u003e\n \u003cp\u003eDisease stage\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e10 (19.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e23 (21.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13 (38.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e10 (21.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"4\" align=\"left\"\u003e\n \u003cp\u003eT stage\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e10 (21.3)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e23 (48.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13 (27.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1 (2.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"4\" align=\"left\"\u003e\n \u003cp\u003eN stage\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e19 (40.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16 (34.0)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e9 (19.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3 (6.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"5\" align=\"left\"\u003e\n \u003cp\u003eTumor Sites\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eOropharynx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4 (8.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNasopharynx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3 (6.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eHypopharynx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4 (8.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eLarynx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e11 (23.4)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eOral cavity\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e25 (53.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eWeeks passed since diagnosis\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026le;\u0026thinsp;4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e25 (53.2)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026gt;\u0026thinsp;4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e22 (46.8)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"3\" align=\"left\"\u003e\n \u003cp\u003e\u003cem\u003eTreatment\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eChemotherapy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e31 (66.0)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16 (34.0)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eRadiotherapy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e43 (91.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4 (8.5)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eBrachytherapy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1 (2.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e45 (95.7)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eSurgery\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e32 (68.1)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e15 (31.9)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cdiv class=\"gridtable\"\u003e\n \u003cdiv class=\"colspec\" align=\"left\"\u003e\u0026nbsp;\u003c/div\u003e\n \u003cdiv class=\"colspec\" align=\"left\"\u003e\u0026nbsp;\u003c/div\u003e\n \u003cdiv class=\"colspec\" align=\"left\"\u003e\n \u003cp\u003eTable 2 shows the mean and standard deviation (SD) of the patients\u0026apos; fatigue scores (based on BFI) and QoL (based on EORTC-QLQ-C30 scales) over time. There were significant differences in CRF between the baseline and six months after treatment (3.07 vs. 3.50, P\u0026thinsp;\u0026lt;0.001). The mean score for global QoL was 73.91\u0026plusmn;8.89 and 63.40\u0026plusmn;9.20, at baseline and six months after treatment, respectively (P\u0026lt;0.001). The mean score of the five functional scales ranged from 76.44-86.95 at baseline and 69.92-79.34 after 6 months. The majority of the functional scale items were shown to have significantly decreased in the QoL analysis based on the EORTC-QLQ-C30 scales (P\u0026lt;0.001). The highest symptom scales score on QLQ-C30 was for pain (27.89-30.79, P=0.074; baseline and after 6 months, respectively); and in overall symptom scale items showed an increase over time. Overall, from the time of diagnosis to six months after treatment, the patients\u0026apos; fatigue and overall quality of life became worsened.\u003c/p\u003e\u0026nbsp;\n \u003c/div\u003e\n \u003cdiv class=\"colspec\" align=\"left\"\u003e\u0026nbsp;\u003c/div\u003e\n \u003ctable id=\"Tab2\" border=\"1\"\u003e\n \u003ccaption\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable 2\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003e\u003cem\u003eScores of EORTC QLQ-C30 and Brief Fatigue Inventory (BFI) among patients at baseline and 6 months after starting the treatment. In functional scaled and global QoL, the scores go from 0 to 100 and the higher values indicate better HRQoL; but in symptom scales, the higher values indicate a higher level of symptoms and lower HRQoL.\u003c/em\u003e\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eBaseline\u003c/p\u003e\n \u003cp\u003eMean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e6\u0026thinsp;Months\u003c/p\u003e\n \u003cp\u003eMean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"4\" align=\"left\"\u003e\n \u003cp\u003eScales of EORTC QLQ-C30\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"4\" align=\"left\"\u003e\n \u003cp\u003eFunctional Scales\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cem\u003ephysical functioning (PF2)\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e84.20\u0026thinsp;\u0026plusmn;\u0026thinsp;7.48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e77.39\u0026thinsp;\u0026plusmn;\u0026thinsp;8.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cem\u003erole functioning (RF2)\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e76.44\u0026thinsp;\u0026plusmn;\u0026thinsp;9.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e69.92\u0026thinsp;\u0026plusmn;\u0026thinsp;10.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cem\u003eemotional functioning (EF)\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e80.43\u0026thinsp;\u0026plusmn;\u0026thinsp;14.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e72.64\u0026thinsp;\u0026plusmn;\u0026thinsp;10.78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cem\u003ecognitive functioning (CF)\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e86.95\u0026thinsp;\u0026plusmn;\u0026thinsp;14.87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e79.34\u0026thinsp;\u0026plusmn;\u0026thinsp;13.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cem\u003esocial functioning (SF)\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e77.17\u0026thinsp;\u0026plusmn;\u0026thinsp;11.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e74.63\u0026thinsp;\u0026plusmn;\u0026thinsp;12.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.229\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eglobal health status/QoL\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e73.91\u0026thinsp;\u0026plusmn;\u0026thinsp;8.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e63.40\u0026thinsp;\u0026plusmn;\u0026thinsp;9.20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"4\" align=\"left\"\u003e\n \u003cp\u003eSymptom Scales\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cem\u003efatigue (FA)\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e19.23\u0026thinsp;\u0026plusmn;\u0026thinsp;11.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e27.77\u0026thinsp;\u0026plusmn;\u0026thinsp;11.65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cem\u003enausea and vomiting (NV)\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3.98\u0026thinsp;\u0026plusmn;\u0026thinsp;8.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e5.79\u0026thinsp;\u0026plusmn;\u0026thinsp;10.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.248\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cem\u003epain (PA)\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e27.89\u0026thinsp;\u0026plusmn;\u0026thinsp;11.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e30.79\u0026thinsp;\u0026plusmn;\u0026thinsp;9.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.074\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cem\u003edyspnea (DY)\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e7.97\u0026thinsp;\u0026plusmn;\u0026thinsp;14.37\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e14.49\u0026thinsp;\u0026plusmn;\u0026thinsp;16.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.020\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cem\u003einsomnia (SL)\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e10.14\u0026thinsp;\u0026plusmn;\u0026thinsp;17.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e23.18\u0026thinsp;\u0026plusmn;\u0026thinsp;18.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cem\u003eappetite loss (AP)\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e13.04\u0026thinsp;\u0026plusmn;\u0026thinsp;16.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e18.84\u0026thinsp;\u0026plusmn;\u0026thinsp;16.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.033\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cem\u003econstipation (CO)\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1.44\u0026thinsp;\u0026plusmn;\u0026thinsp;6.87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.72\u0026thinsp;\u0026plusmn;\u0026thinsp;4.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.564\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cem\u003ediarrhea (DI)\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.72\u0026thinsp;\u0026plusmn;\u0026thinsp;4.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2.89\u0026thinsp;\u0026plusmn;\u0026thinsp;9.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.083\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cem\u003efinancial difficulties (FI)\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e18.84\u0026thinsp;\u0026plusmn;\u0026thinsp;16.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e24.63\u0026thinsp;\u0026plusmn;\u0026thinsp;16.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.033\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"4\" align=\"left\"\u003e\n \u003cp\u003eBrief Fatigue Inventory (BFI)\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eFatigue index\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3.07\u0026thinsp;\u0026plusmn;\u0026thinsp;0.43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3.50\u0026thinsp;\u0026plusmn;\u0026thinsp;0.43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cdiv class=\"gridtable\"\u003e\n \u003cdiv class=\"colspec\" align=\"left\"\u003e\u0026nbsp;\u003c/div\u003e\n \u003cdiv class=\"colspec\" align=\"char\"\u003e\u0026nbsp;\u003c/div\u003e\n \u003cdiv class=\"colspec\" align=\"char\"\u003e\n \u003cp\u003eThe Spearman\u0026apos;s rank correlation analysis (Table 3) showed a statistically significant correlation between changes in BFI scores and changes in fatigue (r=0.297, P\u0026lt;0.05) and diarrhea (r=0.373, P\u0026lt;0.05) across the course of follow-up. The correlation between changes in global QoL\u0026nbsp;scores and impairment in emotional functioning (r=0.399, P\u0026lt;0.01) and social functioning (r=0.353, P\u0026lt;0.05) has been found to be statistically significant. Presented in Table 4 are the effects of sociodemographic and clinical factors on HRQoL and CRF among patients 6 months after initiating the treatment. The findings indicated that the BFI score was higher in female patients, married, and workers. Additionally, it was greater in patients without a smoking or opioid use history, with stage 4 disease, nasopharyngeal tumors, and those undergoing chemotherapy and surgery as part of their treatment regimen. The previously listed variables did not show statistical significance (P\u0026gt;0.05).\u003c/p\u003e\n \u003c/div\u003e\n \u003cdiv class=\"colspec\" align=\"char\"\u003e\u0026nbsp;\u003c/div\u003e\n \u003cdiv class=\"colspec\" align=\"char\"\u003e\u0026nbsp;\u003c/div\u003e\n \u003ctable id=\"Tab3\" border=\"1\"\u003e\n \u003ccaption\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable\u0026nbsp;3\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eThe spearman\u0026rsquo;s rank correlation analysis for changes in the scores of the BFI and QoL scales over time. Abbreviations: \u0026Delta;, the variable score difference at the beginning and end of the study; BFI, Brief Fatigue Inventory; Global QoL, global health status; PF2, physical functioning; RF2, role functioning; EF, emotional functioning; CF, cognitive functioning; SF, social functioning; FA, fatigue; NV, nausea and vomiting; PA, pain; DY, dyspnea; SL, insomnia; AP, appetite loss; CO, constipation; DI, diarrhea; FI, financial difficulties. *: Correlation is significant at the 0.05 level; **: Correlation is significant at the 0.01 level.\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;BFI\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;Global QoL\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;PF2\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;RF2\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;EF\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;CF\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;SF\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;FA\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;NV\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;PA\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;DY\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;SL\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;AP\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;CO\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;DI\u003c/p\u003e\n \u003c/th\u003e\n \u003cth align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;FI\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;BFI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.079\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.038\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.048\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.177\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.175\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.053\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.297*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.218\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.063\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.014\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.135\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.050\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.049\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.373*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.094\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;Global QoL\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.079\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.174\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.002\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.399**\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.135\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.353*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.272\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.160\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.109\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.030\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.099\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.082\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.063\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.051\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.138\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;PF2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.038\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.174\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.070\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.018\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.104\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.454**\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.384**\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.037\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.036\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.007\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.135\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.138\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.180\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.231\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.151\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;RF2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.048\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.002\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.070\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.228\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.091\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.210\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.136\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.128\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.048\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.121\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.007\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.072\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.163\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.026\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.186\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;EF\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.177\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.399**\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.018\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.228\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.129\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.041\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.080\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.330*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.147\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.071\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.118\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.015\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.316*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.112\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.321*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;CF\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.175\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.135\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.104\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.091\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.129\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.193\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.004\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.218\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.051\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.401**\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.229\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.150\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.144\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.279\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.164\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;SF\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.053\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.353*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.454**\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.210\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.041\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.093\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.251\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.256\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.009\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.004\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.068\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.042\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.008\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.073\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.314*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;FA\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.297*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.272\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.384**\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.136\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.080\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.004\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.251\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.031\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.049\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.034\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.048\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.179\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.034\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.017\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.461**\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;NV\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.218\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.160\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.037\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.128\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.330*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.218\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.256\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.031\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.166\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.109\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.157\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.056\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.183\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.043\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.339*\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;PA\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.063\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.109\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.036\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.048\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.147\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.051\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.009\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.049\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.166\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.152\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.143\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.094\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.166\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.054\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.086\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;DY\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.014\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.030\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.007\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.121\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.071\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.401**\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.004\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.034\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.109\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.152\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.089\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.432**\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.033\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.065\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.089\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;SL\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.135\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.099\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.135\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.007\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.118\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.229\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.068\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.048\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.157\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.143\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.089\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.040\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.134\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.038\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.057\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;AP\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.050\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.082\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.138\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.072\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.015\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.150\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.042\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.179\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.056\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.094\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.432**\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.040\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.105\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.078\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.182\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;CO\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.049\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.063\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.180\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.163\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.316*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.144\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.008\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.034\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.183\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.166\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.033\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.134\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.105\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.325*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.140\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;DI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.373*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.051\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.231\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.026\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.112\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.279\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.073\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.017\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.043\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.054\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.065\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.038\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.078\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.325*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.099\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u0026Delta;FI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.094\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.138\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.151\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.186\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.321*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.164\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.314*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.461**\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.339*\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.086\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.089\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.057\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e0.182\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.140\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"char\"\u003e\n \u003cp\u003e-0.099\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cdiv class=\"gridtable\"\u003e\n \u003cdiv class=\"colspec\" align=\"left\"\u003e\u0026nbsp;\u003c/div\u003e\n \u003cdiv class=\"colspec\" align=\"left\"\u003e\u0026nbsp;\u003c/div\u003e\n \u003cdiv class=\"colspec\" align=\"left\"\u003e\u0026nbsp;\u003c/div\u003e\n \u003cdiv class=\"colspec\" align=\"left\"\u003e\u0026nbsp;\u003c/div\u003e\n \u003ctable id=\"Tab4\" border=\"1\"\u003e\n \u003ccaption\u003e\n \u003cdiv class=\"CaptionNumber\"\u003eTable\u0026nbsp;4\u003c/div\u003e\n \u003cdiv class=\"CaptionContent\"\u003e\n \u003cp\u003eEffects of the sociodemographic and clinical variables on the scores of a) Global QoL and functional scales of EORTC QLQ C-30 and Brief Fatigue Inventory (BFI) b) Symptom scales of EORTC QLQ C-30 among patients at 6 months after treatment. Abbreviations: Global QoL, global health status; PF2, physical functioning; RF2, role functioning; EF, emotional functioning; CF, cognitive functioning; SF, social functioning; FA, fatigue; NV, nausea and vomiting; PA, pain; DY, dyspnea; SL, insomnia; AP, appetite loss; CO, constipation; DI, diarrhea; FI, financial difficulties\u003c/p\u003e\n \u003c/div\u003e\n \u003c/caption\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003cth colspan=\"17\" align=\"left\"\u003e\n \u003cp\u003e4-a) Global QoL and functional scales of EORTC QLQ C-30, and BFI\u003c/p\u003e\n \u003c/th\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"3\" align=\"left\"\u003e\n \u003cp\u003eVariable\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eBFI\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eGlobal QoL\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003ePF2\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eRF2\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eEF\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eCF\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eSF\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" align=\"left\"\u003e\n \u003cp\u003eSex\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eFemale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.51\u0026thinsp;\u0026plusmn;\u0026thinsp;0.74\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e65.62\u0026thinsp;\u0026plusmn;\u0026thinsp;14.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e73.33\u0026thinsp;\u0026plusmn;\u0026thinsp;10.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e66.66\u0026thinsp;\u0026plusmn;\u0026thinsp;15.43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e75.00\u0026thinsp;\u0026plusmn;\u0026thinsp;10.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e83.33\u0026thinsp;\u0026plusmn;\u0026thinsp;12.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e75.00\u0026thinsp;\u0026plusmn;\u0026thinsp;15.43\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eMale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.49\u0026thinsp;\u0026plusmn;\u0026thinsp;0.35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e62.93\u0026thinsp;\u0026plusmn;\u0026thinsp;7.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e78.24\u0026thinsp;\u0026plusmn;\u0026thinsp;7.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e70.61\u0026thinsp;\u0026plusmn;\u0026thinsp;9.82\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e72.14\u0026thinsp;\u0026plusmn;\u0026thinsp;10.83\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e78.50\u0026thinsp;\u0026plusmn;\u0026thinsp;13.37\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e74.56\u0026thinsp;\u0026plusmn;\u0026thinsp;11.45\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.456\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.421\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.112\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.189\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.543\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.366\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.818\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" align=\"left\"\u003e\n \u003cp\u003eMarital status\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eSingle\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.22\u0026thinsp;\u0026plusmn;\u0026thinsp;0.15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e58.33\u0026thinsp;\u0026plusmn;\u0026thinsp;8.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e80.00\u0026thinsp;\u0026plusmn;\u0026thinsp;6.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e66.66\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e80.55\u0026thinsp;\u0026plusmn;\u0026thinsp;12.72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e83.33\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e77.77\u0026thinsp;\u0026plusmn;\u0026thinsp;19.24\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eMarried\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.51\u0026thinsp;\u0026plusmn;\u0026thinsp;0.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e63.75\u0026thinsp;\u0026plusmn;\u0026thinsp;9.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e77.20\u0026thinsp;\u0026plusmn;\u0026thinsp;8.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e70.15\u0026thinsp;\u0026plusmn;\u0026thinsp;11.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e72.09\u0026thinsp;\u0026plusmn;\u0026thinsp;10.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e79.06\u0026thinsp;\u0026plusmn;\u0026thinsp;13.65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e74.41\u0026thinsp;\u0026plusmn;\u0026thinsp;11.69\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.184\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.285\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.519\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.573\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.216\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.518\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.860\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"4\" align=\"left\"\u003e\n \u003cp\u003eEducation\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eUnder diploma\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.48\u0026thinsp;\u0026plusmn;\u0026thinsp;0.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e65.00\u0026thinsp;\u0026plusmn;\u0026thinsp;11.65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e76.66\u0026thinsp;\u0026plusmn;\u0026thinsp;7.20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e75.00\u0026thinsp;\u0026plusmn;\u0026thinsp;11.78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e76.66\u0026thinsp;\u0026plusmn;\u0026thinsp;8.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e83.33\u0026thinsp;\u0026plusmn;\u0026thinsp;13.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e76.66\u0026thinsp;\u0026plusmn;\u0026thinsp;11.65\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eDiploma\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.52\u0026thinsp;\u0026plusmn;\u0026thinsp;0.35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e63.46\u0026thinsp;\u0026plusmn;\u0026thinsp;9.94\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e78.46\u0026thinsp;\u0026plusmn;\u0026thinsp;7.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e66.66\u0026thinsp;\u0026plusmn;\u0026thinsp;13.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e71.15\u0026thinsp;\u0026plusmn;\u0026thinsp;8.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e78.20\u0026thinsp;\u0026plusmn;\u0026thinsp;8.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e73.07\u0026thinsp;\u0026plusmn;\u0026thinsp;8.43\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eHigher\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.50\u0026thinsp;\u0026plusmn;\u0026thinsp;0.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e62.50\u0026thinsp;\u0026plusmn;\u0026thinsp;8.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e77.57\u0026thinsp;\u0026plusmn;\u0026thinsp;8.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e69.69\u0026thinsp;\u0026plusmn;\u0026thinsp;8.35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e70.83\u0026thinsp;\u0026plusmn;\u0026thinsp;12.26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e78.03\u0026thinsp;\u0026plusmn;\u0026thinsp;15.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e73.48\u0026thinsp;\u0026plusmn;\u0026thinsp;13.27\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.806\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.936\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.551\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.089\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.070\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.329\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.477\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"6\" align=\"left\"\u003e\n \u003cp\u003eEmployment status\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eUnemployed\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.58\u0026thinsp;\u0026plusmn;\u0026thinsp;0.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e67.85\u0026thinsp;\u0026plusmn;\u0026thinsp;12.19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e74.28\u0026thinsp;\u0026plusmn;\u0026thinsp;8.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e69.04\u0026thinsp;\u0026plusmn;\u0026thinsp;14.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e73.80\u0026thinsp;\u0026plusmn;\u0026thinsp;11.20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e80.95\u0026thinsp;\u0026plusmn;\u0026thinsp;11.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e76.19\u0026thinsp;\u0026plusmn;\u0026thinsp;13.11\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eRetired\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.48\u0026thinsp;\u0026plusmn;\u0026thinsp;0.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e67.70\u0026thinsp;\u0026plusmn;\u0026thinsp;5.34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e78.33\u0026thinsp;\u0026plusmn;\u0026thinsp;5.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e68.75\u0026thinsp;\u0026plusmn;\u0026thinsp;5.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e72.91\u0026thinsp;\u0026plusmn;\u0026thinsp;9.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e81.25\u0026thinsp;\u0026plusmn;\u0026thinsp;10.68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e77.08\u0026thinsp;\u0026plusmn;\u0026thinsp;15.26\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eFreelancer\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.54\u0026thinsp;\u0026plusmn;\u0026thinsp;0.37\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e61.30\u0026thinsp;\u0026plusmn;\u0026thinsp;10.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e78.09\u0026thinsp;\u0026plusmn;\u0026thinsp;8.83\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e70.23\u0026thinsp;\u0026plusmn;\u0026thinsp;13.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e73.21\u0026thinsp;\u0026plusmn;\u0026thinsp;9.34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e78.57\u0026thinsp;\u0026plusmn;\u0026thinsp;13.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e72.61\u0026thinsp;\u0026plusmn;\u0026thinsp;10.55\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eEmployee\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.30\u0026thinsp;\u0026plusmn;\u0026thinsp;0.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e61.66\u0026thinsp;\u0026plusmn;\u0026thinsp;7.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e80.00\u0026thinsp;\u0026plusmn;\u0026thinsp;8.31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e66.66\u0026thinsp;\u0026plusmn;\u0026thinsp;7.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e71.66\u0026thinsp;\u0026plusmn;\u0026thinsp;8.95\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e80.00\u0026thinsp;\u0026plusmn;\u0026thinsp;15.31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e75.00\u0026thinsp;\u0026plusmn;\u0026thinsp;11.78\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eManual worker\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.61\u0026thinsp;\u0026plusmn;\u0026thinsp;0.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e60.71\u0026thinsp;\u0026plusmn;\u0026thinsp;9.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e74.28\u0026thinsp;\u0026plusmn;\u0026thinsp;7.12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e76.19\u0026thinsp;\u0026plusmn;\u0026thinsp;8.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e71.42\u0026thinsp;\u0026plusmn;\u0026thinsp;17.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e76.19\u0026thinsp;\u0026plusmn;\u0026thinsp;16.26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e73.80\u0026thinsp;\u0026plusmn;\u0026thinsp;13.11\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.231\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.264\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.373\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.309\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.954\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.970\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.983\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" align=\"left\"\u003e\n \u003cp\u003eSmoking/Opium\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.48\u0026thinsp;\u0026plusmn;\u0026thinsp;0.42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e63.24\u0026thinsp;\u0026plusmn;\u0026thinsp;9.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e78.11\u0026thinsp;\u0026plusmn;\u0026thinsp;7.93\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e70.08\u0026thinsp;\u0026plusmn;\u0026thinsp;11.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e72.86\u0026thinsp;\u0026plusmn;\u0026thinsp;8.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e78.63\u0026thinsp;\u0026plusmn;\u0026thinsp;12.65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e73.93\u0026thinsp;\u0026plusmn;\u0026thinsp;11.33\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.57\u0026thinsp;\u0026plusmn;\u0026thinsp;0.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e64.28\u0026thinsp;\u0026plusmn;\u0026thinsp;7.92\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e73.33\u0026thinsp;\u0026plusmn;\u0026thinsp;7.69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e69.04\u0026thinsp;\u0026plusmn;\u0026thinsp;6.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e71.42\u0026thinsp;\u0026plusmn;\u0026thinsp;19.15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e83.33\u0026thinsp;\u0026plusmn;\u0026thinsp;16.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e78.57\u0026thinsp;\u0026plusmn;\u0026thinsp;15.85\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.975\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.647\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.125\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.868\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.665\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.264\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.520\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"5\" align=\"left\"\u003e\n \u003cp\u003eDisease stage\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.56\u0026thinsp;\u0026plusmn;\u0026thinsp;0.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e59.25\u0026thinsp;\u0026plusmn;\u0026thinsp;11.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e80.00\u0026thinsp;\u0026plusmn;\u0026thinsp;8.16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e74.07\u0026thinsp;\u0026plusmn;\u0026thinsp;16.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e68.51\u0026thinsp;\u0026plusmn;\u0026thinsp;17.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e79.62\u0026thinsp;\u0026plusmn;\u0026thinsp;18.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e75.92\u0026thinsp;\u0026plusmn;\u0026thinsp;12.10\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.31\u0026thinsp;\u0026plusmn;\u0026thinsp;0.31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e62.50\u0026thinsp;\u0026plusmn;\u0026thinsp;11.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e80.00\u0026thinsp;\u0026plusmn;\u0026thinsp;10.42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e68.33\u0026thinsp;\u0026plusmn;\u0026thinsp;9.46\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e77.50\u0026thinsp;\u0026plusmn;\u0026thinsp;8.82\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e81.66\u0026thinsp;\u0026plusmn;\u0026thinsp;12.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e75.00\u0026thinsp;\u0026plusmn;\u0026thinsp;14.16\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.50\u0026thinsp;\u0026plusmn;\u0026thinsp;0.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e65.19\u0026thinsp;\u0026plusmn;\u0026thinsp;7.92\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e76.86\u0026thinsp;\u0026plusmn;\u0026thinsp;5.82\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e69.60\u0026thinsp;\u0026plusmn;\u0026thinsp;8.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e72.05\u0026thinsp;\u0026plusmn;\u0026thinsp;8.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e78.43\u0026thinsp;\u0026plusmn;\u0026thinsp;11.43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e74.50\u0026thinsp;\u0026plusmn;\u0026thinsp;11.95\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.62\u0026thinsp;\u0026plusmn;\u0026thinsp;0.35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e65.00\u0026thinsp;\u0026plusmn;\u0026thinsp;6.57\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e73.33\u0026thinsp;\u0026plusmn;\u0026thinsp;7.69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e68.33\u0026thinsp;\u0026plusmn;\u0026thinsp;9.46\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e72.50\u0026thinsp;\u0026plusmn;\u0026thinsp;7.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e78.33\u0026thinsp;\u0026plusmn;\u0026thinsp;13.72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e73.33\u0026thinsp;\u0026plusmn;\u0026thinsp;11.65\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.178\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.282\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.153\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.875\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.307\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.934\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.941\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"6\" align=\"left\"\u003e\n \u003cp\u003eTumor Sites\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eOropharynx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.33\u0026thinsp;\u0026plusmn;\u0026thinsp;0.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e66.66\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e80.00\u0026thinsp;\u0026plusmn;\u0026thinsp;5.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e70.83\u0026thinsp;\u0026plusmn;\u0026thinsp;8.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e85.41\u0026thinsp;\u0026plusmn;\u0026thinsp;4.16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e95.83\u0026thinsp;\u0026plusmn;\u0026thinsp;8.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e83.33\u0026thinsp;\u0026plusmn;\u0026thinsp;13.60\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eNasopharynx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.66\u0026thinsp;\u0026plusmn;\u0026thinsp;0.57\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e55.55\u0026thinsp;\u0026plusmn;\u0026thinsp;9.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e77.77\u0026thinsp;\u0026plusmn;\u0026thinsp;7.69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e72.22\u0026thinsp;\u0026plusmn;\u0026thinsp;9.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e72.22\u0026thinsp;\u0026plusmn;\u0026thinsp;9.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e83.33\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e83.33\u0026thinsp;\u0026plusmn;\u0026thinsp;16.66\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eHypopharynx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.44\u0026thinsp;\u0026plusmn;\u0026thinsp;0.31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e66.66\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e76.66\u0026thinsp;\u0026plusmn;\u0026thinsp;6.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e66.66\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e77.08\u0026thinsp;\u0026plusmn;\u0026thinsp;12.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e79.16\u0026thinsp;\u0026plusmn;\u0026thinsp;20.97\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e70.83\u0026thinsp;\u0026plusmn;\u0026thinsp;8.33\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eLarynx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.46\u0026thinsp;\u0026plusmn;\u0026thinsp;0.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e65.00\u0026thinsp;\u0026plusmn;\u0026thinsp;8.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e80.00\u0026thinsp;\u0026plusmn;\u0026thinsp;9.93\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e76.66\u0026thinsp;\u0026plusmn;\u0026thinsp;14.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e67.50\u0026thinsp;\u0026plusmn;\u0026thinsp;13.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e78.33\u0026thinsp;\u0026plusmn;\u0026thinsp;15.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e71.66\u0026thinsp;\u0026plusmn;\u0026thinsp;8.05\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eOral cavity\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.52\u0026thinsp;\u0026plusmn;\u0026thinsp;0.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e62.66\u0026thinsp;\u0026plusmn;\u0026thinsp;10.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e76.00\u0026thinsp;\u0026plusmn;\u0026thinsp;7.93\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e67.33\u0026thinsp;\u0026plusmn;\u0026thinsp;10.18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e72.00\u0026thinsp;\u0026plusmn;\u0026thinsp;8.63\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e76.66\u0026thinsp;\u0026plusmn;\u0026thinsp;10.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e74.00\u0026thinsp;\u0026plusmn;\u0026thinsp;12.80\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.910\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.354\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.736\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.364\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.076\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.093\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.352\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" align=\"left\"\u003e\n \u003cp\u003eChemotherapy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.52\u0026thinsp;\u0026plusmn;\u0026thinsp;0.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e65.27\u0026thinsp;\u0026plusmn;\u0026thinsp;6.94\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e76.66\u0026thinsp;\u0026plusmn;\u0026thinsp;7.37\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e70.00\u0026thinsp;\u0026plusmn;\u0026thinsp;9.18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e73.05\u0026thinsp;\u0026plusmn;\u0026thinsp;8.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e79.44\u0026thinsp;\u0026plusmn;\u0026thinsp;12.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e75.00\u0026thinsp;\u0026plusmn;\u0026thinsp;11.37\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.45\u0026thinsp;\u0026plusmn;\u0026thinsp;0.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e59.89\u0026thinsp;\u0026plusmn;\u0026thinsp;11.87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e78.75\u0026thinsp;\u0026plusmn;\u0026thinsp;9.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e69.79\u0026thinsp;\u0026plusmn;\u0026thinsp;13.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e71.87\u0026thinsp;\u0026plusmn;\u0026thinsp;14.55\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e79.16\u0026thinsp;\u0026plusmn;\u0026thinsp;15.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e73.95\u0026thinsp;\u0026plusmn;\u0026thinsp;13.56\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.818\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.030\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.328\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.578\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.961\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.911\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.753\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" align=\"left\"\u003e\n \u003cp\u003eRadiotherapy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.49\u0026thinsp;\u0026plusmn;\u0026thinsp;0.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e64.08\u0026thinsp;\u0026plusmn;\u0026thinsp;9.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e77.14\u0026thinsp;\u0026plusmn;\u0026thinsp;8.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e70.23\u0026thinsp;\u0026plusmn;\u0026thinsp;10.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e73.01\u0026thinsp;\u0026plusmn;\u0026thinsp;10.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e78.96\u0026thinsp;\u0026plusmn;\u0026thinsp;12.78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e74.20\u0026thinsp;\u0026plusmn;\u0026thinsp;11.75\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.58\u0026thinsp;\u0026plusmn;\u0026thinsp;0.42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e56.25\u0026thinsp;\u0026plusmn;\u0026thinsp;7.97\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e80.00\u0026thinsp;\u0026plusmn;\u0026thinsp;5.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e66.66\u0026thinsp;\u0026plusmn;\u0026thinsp;13.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e68.75\u0026thinsp;\u0026plusmn;\u0026thinsp;10.48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e83.33\u0026thinsp;\u0026plusmn;\u0026thinsp;19.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e79.16\u0026thinsp;\u0026plusmn;\u0026thinsp;15.95\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.779\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.088\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.431\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.588\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.306\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.645\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.506\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" align=\"left\"\u003e\n \u003cp\u003eSurgery\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.50\u0026thinsp;\u0026plusmn;\u0026thinsp;0.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e62.63\u0026thinsp;\u0026plusmn;\u0026thinsp;8.83\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e76.77\u0026thinsp;\u0026plusmn;\u0026thinsp;7.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e67.74\u0026thinsp;\u0026plusmn;\u0026thinsp;9.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e71.77\u0026thinsp;\u0026plusmn;\u0026thinsp;8.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e77.95\u0026thinsp;\u0026plusmn;\u0026thinsp;11.69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e73.11\u0026thinsp;\u0026plusmn;\u0026thinsp;12.67\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.49\u0026thinsp;\u0026plusmn;\u0026thinsp;0.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e65.00\u0026thinsp;\u0026plusmn;\u0026thinsp;10.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e78.66\u0026thinsp;\u0026plusmn;\u0026thinsp;8.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e74.44\u0026thinsp;\u0026plusmn;\u0026thinsp;12.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e74.44\u0026thinsp;\u0026plusmn;\u0026thinsp;14.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e82.22\u0026thinsp;\u0026plusmn;\u0026thinsp;16.01\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e77.77\u0026thinsp;\u0026plusmn;\u0026thinsp;10.28\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.824\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.431\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.528\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.098\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.180\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.170\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.101\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"17\" align=\"left\"\u003e\n \u003cp\u003e4-b) Symptom scales of EORTC QLQ C-30\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003eVariable\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eFA\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eNV\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003ePA\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eDY\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eSL\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eAP\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eCP\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eDI\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e\u003cstrong\u003eFI\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" align=\"left\"\u003e\n \u003cp\u003eSex\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eFemale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e33.33\u0026thinsp;\u0026plusmn;\u0026thinsp;14.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e10.41\u0026thinsp;\u0026plusmn;\u0026thinsp;17.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e33.33\u0026thinsp;\u0026plusmn;\u0026thinsp;12.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e16.66\u0026thinsp;\u0026plusmn;\u0026thinsp;17.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e29.16\u0026thinsp;\u0026plusmn;\u0026thinsp;21.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e16.66\u0026thinsp;\u0026plusmn;\u0026thinsp;17.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e29.16\u0026thinsp;\u0026plusmn;\u0026thinsp;11.78\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eMale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e26.60\u0026thinsp;\u0026plusmn;\u0026thinsp;10.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4.82\u0026thinsp;\u0026plusmn;\u0026thinsp;8.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e30.26\u0026thinsp;\u0026plusmn;\u0026thinsp;9.37\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e14.03\u0026thinsp;\u0026plusmn;\u0026thinsp;16.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e21.92\u0026thinsp;\u0026plusmn;\u0026thinsp;17.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e19.29\u0026thinsp;\u0026plusmn;\u0026thinsp;16.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.87\u0026thinsp;\u0026plusmn;\u0026thinsp;5.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.50\u0026thinsp;\u0026plusmn;\u0026thinsp;10.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e23.68\u0026thinsp;\u0026plusmn;\u0026thinsp;17.16\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.193\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.439\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.496\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.686\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.361\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.686\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.646\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.342\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.356\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" align=\"left\"\u003e\n \u003cp\u003eMarital status\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eSingle\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e18.51\u0026thinsp;\u0026plusmn;\u0026thinsp;6.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e5.55\u0026thinsp;\u0026plusmn;\u0026thinsp;9.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e33.33\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e22.22\u0026thinsp;\u0026plusmn;\u0026thinsp;19.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e11.11\u0026thinsp;\u0026plusmn;\u0026thinsp;19.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e11.11\u0026thinsp;\u0026plusmn;\u0026thinsp;19.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e22.22\u0026thinsp;\u0026plusmn;\u0026thinsp;19.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e33.33\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eMarried\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e28.42\u0026thinsp;\u0026plusmn;\u0026thinsp;11.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e5.81\u0026thinsp;\u0026plusmn;\u0026thinsp;10.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e30.62\u0026thinsp;\u0026plusmn;\u0026thinsp;10.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e13.95\u0026thinsp;\u0026plusmn;\u0026thinsp;16.63\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e24.03\u0026thinsp;\u0026plusmn;\u0026thinsp;18.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e19.37\u0026thinsp;\u0026plusmn;\u0026thinsp;16.63\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.77\u0026thinsp;\u0026plusmn;\u0026thinsp;4.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e1.55\u0026thinsp;\u0026plusmn;\u0026thinsp;7.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e24.03\u0026thinsp;\u0026plusmn;\u0026thinsp;16.78\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.125\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.887\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.621\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.407\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.232\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.407\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.792\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;0.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.317\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"4\" align=\"left\"\u003e\n \u003cp\u003eEducation\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eUnder diploma\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e24.44\u0026thinsp;\u0026plusmn;\u0026thinsp;8.76\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1.66\u0026thinsp;\u0026plusmn;\u0026thinsp;5.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e33.33\u0026thinsp;\u0026plusmn;\u0026thinsp;11.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e16.66\u0026thinsp;\u0026plusmn;\u0026thinsp;17.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e10.00\u0026thinsp;\u0026plusmn;\u0026thinsp;16.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e16.66\u0026thinsp;\u0026plusmn;\u0026thinsp;17.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.33\u0026thinsp;\u0026plusmn;\u0026thinsp;10.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e20.00\u0026thinsp;\u0026plusmn;\u0026thinsp;17.21\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eDiploma\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e29.91\u0026thinsp;\u0026plusmn;\u0026thinsp;13.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3.84\u0026thinsp;\u0026plusmn;\u0026thinsp;7.30\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e26.92\u0026thinsp;\u0026plusmn;\u0026thinsp;8.43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e12.82\u0026thinsp;\u0026plusmn;\u0026thinsp;16.87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e28.20\u0026thinsp;\u0026plusmn;\u0026thinsp;12.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e20.51\u0026thinsp;\u0026plusmn;\u0026thinsp;16.87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e2.56\u0026thinsp;\u0026plusmn;\u0026thinsp;9.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e17.94\u0026thinsp;\u0026plusmn;\u0026thinsp;17.29\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eHigher\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e28.28\u0026thinsp;\u0026plusmn;\u0026thinsp;11.74\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e6.81\u0026thinsp;\u0026plusmn;\u0026thinsp;9.83\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e31.81\u0026thinsp;\u0026plusmn;\u0026thinsp;10.16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e13.63\u0026thinsp;\u0026plusmn;\u0026thinsp;16.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e25.75\u0026thinsp;\u0026plusmn;\u0026thinsp;20.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e18.18\u0026thinsp;\u0026plusmn;\u0026thinsp;16.98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e1.51\u0026thinsp;\u0026plusmn;\u0026thinsp;7.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.03\u0026thinsp;\u0026plusmn;\u0026thinsp;9.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e30.03\u0026thinsp;\u0026plusmn;\u0026thinsp;14.21\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.400\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.422\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.151\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.588\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.009\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.588\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e1.000\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.849\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.773\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"6\" align=\"left\"\u003e\n \u003cp\u003eEmployment status\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eUnemployed\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e28.57\u0026thinsp;\u0026plusmn;\u0026thinsp;12.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e9.52\u0026thinsp;\u0026plusmn;\u0026thinsp;18.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e35.71\u0026thinsp;\u0026plusmn;\u0026thinsp;14.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e14.28\u0026thinsp;\u0026plusmn;\u0026thinsp;17.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e23.80\u0026thinsp;\u0026plusmn;\u0026thinsp;16.26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e14.28\u0026thinsp;\u0026plusmn;\u0026thinsp;17.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e28.57\u0026thinsp;\u0026plusmn;\u0026thinsp;12.59\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eRetired\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e22.22\u0026thinsp;\u0026plusmn;\u0026thinsp;5.93\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e8.33\u0026thinsp;\u0026plusmn;\u0026thinsp;12.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e31.25\u0026thinsp;\u0026plusmn;\u0026thinsp;5.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e4.16\u0026thinsp;\u0026plusmn;\u0026thinsp;11.78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e20.83\u0026thinsp;\u0026plusmn;\u0026thinsp;17.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e12.50\u0026thinsp;\u0026plusmn;\u0026thinsp;17.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e4.16\u0026thinsp;\u0026plusmn;\u0026thinsp;11.78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e29.16\u0026thinsp;\u0026plusmn;\u0026thinsp;11.78\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eFreelancer\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e28.57\u0026thinsp;\u0026plusmn;\u0026thinsp;14.26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4.76\u0026thinsp;\u0026plusmn;\u0026thinsp;7.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e32.14\u0026thinsp;\u0026plusmn;\u0026thinsp;7.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e21.42\u0026thinsp;\u0026plusmn;\u0026thinsp;16.57\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e28.57\u0026thinsp;\u0026plusmn;\u0026thinsp;22.09\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e16.66\u0026thinsp;\u0026plusmn;\u0026thinsp;17.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e2.38\u0026thinsp;\u0026plusmn;\u0026thinsp;8.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e2.38\u0026thinsp;\u0026plusmn;\u0026thinsp;8.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e21.42\u0026thinsp;\u0026plusmn;\u0026thinsp;16.57\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eEmployee\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e32.22\u0026thinsp;\u0026plusmn;\u0026thinsp;12.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e6.66\u0026thinsp;\u0026plusmn;\u0026thinsp;8.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e25.00\u0026thinsp;\u0026plusmn;\u0026thinsp;11.78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e10.00\u0026thinsp;\u0026plusmn;\u0026thinsp;16.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e26.66\u0026thinsp;\u0026plusmn;\u0026thinsp;14.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e26.66\u0026thinsp;\u0026plusmn;\u0026thinsp;14.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e26.66\u0026thinsp;\u0026plusmn;\u0026thinsp;21.08\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eManual worker\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e25.39\u0026thinsp;\u0026plusmn;\u0026thinsp;8.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e30.95\u0026thinsp;\u0026plusmn;\u0026thinsp;6.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e19.04\u0026thinsp;\u0026plusmn;\u0026thinsp;17.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e9.52\u0026thinsp;\u0026plusmn;\u0026thinsp;16.26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e23.80\u0026thinsp;\u0026plusmn;\u0026thinsp;16.26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e9.52\u0026thinsp;\u0026plusmn;\u0026thinsp;16.26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e19.04\u0026thinsp;\u0026plusmn;\u0026thinsp;17.81\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.425\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.459\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.357\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.152\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.237\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.317\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.683\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.270\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.636\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" align=\"left\"\u003e\n \u003cp\u003eSmoking/Opium\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e27.63\u0026thinsp;\u0026plusmn;\u0026thinsp;11.92\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e5.12\u0026thinsp;\u0026plusmn;\u0026thinsp;8.68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e29.91\u0026thinsp;\u0026plusmn;\u0026thinsp;10.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e13.67\u0026thinsp;\u0026plusmn;\u0026thinsp;16.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e23.07\u0026thinsp;\u0026plusmn;\u0026thinsp;18.97\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e19.65\u0026thinsp;\u0026plusmn;\u0026thinsp;16.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.85\u0026thinsp;\u0026plusmn;\u0026thinsp;5.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e2.56\u0026thinsp;\u0026plusmn;\u0026thinsp;8.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e23.93\u0026thinsp;\u0026plusmn;\u0026thinsp;17.01\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e28.57\u0026thinsp;\u0026plusmn;\u0026thinsp;10.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e9.52\u0026thinsp;\u0026plusmn;\u0026thinsp;18.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e35.71\u0026thinsp;\u0026plusmn;\u0026thinsp;6.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e19.04\u0026thinsp;\u0026plusmn;\u0026thinsp;17.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e23.80\u0026thinsp;\u0026plusmn;\u0026thinsp;16.26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e14.28\u0026thinsp;\u0026plusmn;\u0026thinsp;17.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e4.76\u0026thinsp;\u0026plusmn;\u0026thinsp;12.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e28.57\u0026thinsp;\u0026plusmn;\u0026thinsp;12.59\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.725\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.830\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.141\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.433\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.858\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.433\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.672\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.573\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.456\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"5\" align=\"left\"\u003e\n \u003cp\u003eDisease stage\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e32.09\u0026thinsp;\u0026plusmn;\u0026thinsp;12.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e5.55\u0026thinsp;\u0026plusmn;\u0026thinsp;8.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e35.18\u0026thinsp;\u0026plusmn;\u0026thinsp;10.01\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e14.81\u0026thinsp;\u0026plusmn;\u0026thinsp;17.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e18.51\u0026thinsp;\u0026plusmn;\u0026thinsp;17.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e18.51\u0026thinsp;\u0026plusmn;\u0026thinsp;17.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e7.40\u0026thinsp;\u0026plusmn;\u0026thinsp;14.69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e22.22\u0026thinsp;\u0026plusmn;\u0026thinsp;16.66\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e25.55\u0026thinsp;\u0026plusmn;\u0026thinsp;15.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e1.66\u0026thinsp;\u0026plusmn;\u0026thinsp;5.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e30.00\u0026thinsp;\u0026plusmn;\u0026thinsp;7.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e16.66\u0026thinsp;\u0026plusmn;\u0026thinsp;17.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e30.00\u0026thinsp;\u0026plusmn;\u0026thinsp;18.92\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e13.33\u0026thinsp;\u0026plusmn;\u0026thinsp;17.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e6.66\u0026thinsp;\u0026plusmn;\u0026thinsp;14.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e26.66\u0026thinsp;\u0026plusmn;\u0026thinsp;14.05\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e26.79\u0026thinsp;\u0026plusmn;\u0026thinsp;7.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e7.84\u0026thinsp;\u0026plusmn;\u0026thinsp;10.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e31.37\u0026thinsp;\u0026plusmn;\u0026thinsp;10.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e11.76\u0026thinsp;\u0026plusmn;\u0026thinsp;16.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e19.60\u0026thinsp;\u0026plusmn;\u0026thinsp;16.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e19.60\u0026thinsp;\u0026plusmn;\u0026thinsp;16.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e25.49\u0026thinsp;\u0026plusmn;\u0026thinsp;14.57\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e27.77\u0026thinsp;\u0026plusmn;\u0026thinsp;12.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e6.66\u0026thinsp;\u0026plusmn;\u0026thinsp;16.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e26.66\u0026thinsp;\u0026plusmn;\u0026thinsp;11.65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e16.66\u0026thinsp;\u0026plusmn;\u0026thinsp;17.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e26.66\u0026thinsp;\u0026plusmn;\u0026thinsp;21.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e23.33\u0026thinsp;\u0026plusmn;\u0026thinsp;16.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.33\u0026thinsp;\u0026plusmn;\u0026thinsp;10.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e23.33\u0026thinsp;\u0026plusmn;\u0026thinsp;22.49\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.602\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.363\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.401\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.851\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.545\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.604\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.308\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.106\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.896\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"6\" align=\"left\"\u003e\n \u003cp\u003eTumor Sites\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eOropharynx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e25.00\u0026thinsp;\u0026plusmn;\u0026thinsp;10.63\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4.16\u0026thinsp;\u0026plusmn;\u0026thinsp;8.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e33.33\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e8.33\u0026thinsp;\u0026plusmn;\u0026thinsp;16.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e8.33\u0026thinsp;\u0026plusmn;\u0026thinsp;16.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e8.33\u0026thinsp;\u0026plusmn;\u0026thinsp;16.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e16.66\u0026thinsp;\u0026plusmn;\u0026thinsp;19.24\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNasopharynx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e29.62\u0026thinsp;\u0026plusmn;\u0026thinsp;12.83\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e5.55\u0026thinsp;\u0026plusmn;\u0026thinsp;9.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e38.88\u0026thinsp;\u0026plusmn;\u0026thinsp;9.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e22.22\u0026thinsp;\u0026plusmn;\u0026thinsp;19.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e22.22\u0026thinsp;\u0026plusmn;\u0026thinsp;19.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e22.22\u0026thinsp;\u0026plusmn;\u0026thinsp;19.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e11.11\u0026thinsp;\u0026plusmn;\u0026thinsp;19.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e33.33\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eHypopharynx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e33.33\u0026thinsp;\u0026plusmn;\u0026thinsp;9.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e8.33\u0026thinsp;\u0026plusmn;\u0026thinsp;9.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e33.33\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e25.00\u0026thinsp;\u0026plusmn;\u0026thinsp;16.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e33.33\u0026thinsp;\u0026plusmn;\u0026thinsp;27.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e25.00\u0026thinsp;\u0026plusmn;\u0026thinsp;16.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e8.33\u0026thinsp;\u0026plusmn;\u0026thinsp;16.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e25.00\u0026thinsp;\u0026plusmn;\u0026thinsp;16.66\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eLarynx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e24.44\u0026thinsp;\u0026plusmn;\u0026thinsp;11.47\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e3.33\u0026thinsp;\u0026plusmn;\u0026thinsp;7.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e25.00\u0026thinsp;\u0026plusmn;\u0026thinsp;11.78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e16.66\u0026thinsp;\u0026plusmn;\u0026thinsp;17.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e20.00\u0026thinsp;\u0026plusmn;\u0026thinsp;17.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e23.33\u0026thinsp;\u0026plusmn;\u0026thinsp;16.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e6.66\u0026thinsp;\u0026plusmn;\u0026thinsp;14.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e26.66\u0026thinsp;\u0026plusmn;\u0026thinsp;21.08\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eOral cavity\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e28.44\u0026thinsp;\u0026plusmn;\u0026thinsp;12.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e6.66\u0026thinsp;\u0026plusmn;\u0026thinsp;12.72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e31.33\u0026thinsp;\u0026plusmn;\u0026thinsp;10.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e12.00\u0026thinsp;\u0026plusmn;\u0026thinsp;16.32\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e25.33\u0026thinsp;\u0026plusmn;\u0026thinsp;17.42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e17.33\u0026thinsp;\u0026plusmn;\u0026thinsp;16.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e1.33\u0026thinsp;\u0026plusmn;\u0026thinsp;6.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e24.00\u0026thinsp;\u0026plusmn;\u0026thinsp;15.27\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.714\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.880\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.246\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.479\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.378\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.529\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.033\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.263\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.739\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" align=\"left\"\u003e\n \u003cp\u003eChemotherapy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e25.92\u0026thinsp;\u0026plusmn;\u0026thinsp;9.82\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e6.66\u0026thinsp;\u0026plusmn;\u0026thinsp;12.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e30.00\u0026thinsp;\u0026plusmn;\u0026thinsp;10.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e14.44\u0026thinsp;\u0026plusmn;\u0026thinsp;16.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e23.33\u0026thinsp;\u0026plusmn;\u0026thinsp;17.83\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e20.00\u0026thinsp;\u0026plusmn;\u0026thinsp;16.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e1.11\u0026thinsp;\u0026plusmn;\u0026thinsp;6.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e24.44\u0026thinsp;\u0026plusmn;\u0026thinsp;17.36\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e31.25\u0026thinsp;\u0026plusmn;\u0026thinsp;14.18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4.16\u0026thinsp;\u0026plusmn;\u0026thinsp;7.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e32.29\u0026thinsp;\u0026plusmn;\u0026thinsp;9.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e14.58\u0026thinsp;\u0026plusmn;\u0026thinsp;17.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e22.91\u0026thinsp;\u0026plusmn;\u0026thinsp;20.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e16.66\u0026thinsp;\u0026plusmn;\u0026thinsp;17.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e8.33\u0026thinsp;\u0026plusmn;\u0026thinsp;14.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e25.00\u0026thinsp;\u0026plusmn;\u0026thinsp;14.90\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.193\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.639\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.522\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.979\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.893\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.419\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.465\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.005\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.863\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" align=\"left\"\u003e\n \u003cp\u003eRadiotherapy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e26.71\u0026thinsp;\u0026plusmn;\u0026thinsp;11.26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e5.95\u0026thinsp;\u0026plusmn;\u0026thinsp;10.93\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e30.15\u0026thinsp;\u0026plusmn;\u0026thinsp;9.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e15.07\u0026thinsp;\u0026plusmn;\u0026thinsp;16.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e23.01\u0026thinsp;\u0026plusmn;\u0026thinsp;18.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e18.25\u0026thinsp;\u0026plusmn;\u0026thinsp;16.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.79\u0026thinsp;\u0026plusmn;\u0026thinsp;5.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e3.17\u0026thinsp;\u0026plusmn;\u0026thinsp;9.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e24.60\u0026thinsp;\u0026plusmn;\u0026thinsp;16.55\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e38.88\u0026thinsp;\u0026plusmn;\u0026thinsp;11.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4.16\u0026thinsp;\u0026plusmn;\u0026thinsp;8.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e37.50\u0026thinsp;\u0026plusmn;\u0026thinsp;8.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e8.33\u0026thinsp;\u0026plusmn;\u0026thinsp;16.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e25.00\u0026thinsp;\u0026plusmn;\u0026thinsp;16.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e25.00\u0026thinsp;\u0026plusmn;\u0026thinsp;16.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e25.00\u0026thinsp;\u0026plusmn;\u0026thinsp;16.66\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.053\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.843\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.149\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.440\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.785\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.440\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.758\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.523\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.942\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" align=\"left\"\u003e\n \u003cp\u003eSurgery\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e28.31\u0026thinsp;\u0026plusmn;\u0026thinsp;12.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e6.45\u0026thinsp;\u0026plusmn;\u0026thinsp;11.92\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e29.03\u0026thinsp;\u0026plusmn;\u0026thinsp;10.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e10.75\u0026thinsp;\u0026plusmn;\u0026thinsp;15.83\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e24.73\u0026thinsp;\u0026plusmn;\u0026thinsp;17.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e19.35\u0026thinsp;\u0026plusmn;\u0026thinsp;16.72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e1.07\u0026thinsp;\u0026plusmn;\u0026thinsp;5.98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e25.80\u0026thinsp;\u0026plusmn;\u0026thinsp;16.57\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e26.66\u0026thinsp;\u0026plusmn;\u0026thinsp;10.95\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e4.44\u0026thinsp;\u0026plusmn;\u0026thinsp;7.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e34.44\u0026thinsp;\u0026plusmn;\u0026thinsp;7.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e22.22\u0026thinsp;\u0026plusmn;\u0026thinsp;16.26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e20.00\u0026thinsp;\u0026plusmn;\u0026thinsp;21.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e17.77\u0026thinsp;\u0026plusmn;\u0026thinsp;17.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e2.22\u0026thinsp;\u0026plusmn;\u0026thinsp;8.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e6.66\u0026thinsp;\u0026plusmn;\u0026thinsp;13.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e22.22\u0026thinsp;\u0026plusmn;\u0026thinsp;16.26\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003eP Value\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.760\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.777\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.080\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.029\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.352\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.763\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.151\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" align=\"left\"\u003e\n \u003cp\u003e0.061\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd align=\"left\"\u003e\n \u003cp\u003e0.510\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThe study's findings on HRQoL and CRF of 47 patients with non-metastatic head and neck cancers showed a significant decline in QoL and increase in CRF of the patients. The mean age of studies patients was 54.28\u0026thinsp;\u0026plusmn;\u0026thinsp;9.61 years suggests that these cancers are more commonly diagnosed in middle-aged individuals, and majority of them were male (83%), which could be attributed to sex-specific patterns of modifiable risk factors such as tobacco and alcohol use; both are in consistent with epidemiological trends of the disease and pervious research (\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e, \u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e13\u003c/span\u003e). In line with pervious literatures, oral cavity and larynx where the most common tumor cites and most patients received chemo radiation and/or surgery in their treatment plans (\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e14\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eA significant variation in the fatigue scores (as measured by the BFI) from the time of the disease diagnosis to 6 months after treatment was shown in the present study. CRF, as it is defined by the National Comprehensive Cancer Network (NCCN) as \u0026ldquo;a distressing, persistent, subjective sense of physical, emotional, and/or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and interferes with usual functioning (\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e),\u0026rdquo; is far deeper than an isolated symptom. Based on a meta-analysis on the prevalence of fatigue in different cancers, 61.9%, 18.8%, and 13.1% of patients with head and neck cancers experienced mild, moderate, and severe fatigue respectively (\u003cspan citationid=\"CR29\" class=\"CitationRef\"\u003e16\u003c/span\u003e), which shows the high importance of this issue in patients\u0026rsquo; life. On the other hand, fatigue has adverse effects on patients' social life, mood, and daily activities, leads to significantly reduce their overall quality of life and potentially indicate a shorter survival duration (\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e17\u003c/span\u003e, \u003cspan citationid=\"CR31\" class=\"CitationRef\"\u003e18\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eDespite the BFI score, the EORTC fatigue scale revealed significant increases, supporting the view that fatigue is among the most debilitating symptoms, arising from several psychological and physical reasons. Increasing nausea, vomiting, insomnia, dyspnea, and pain, together with low appetite and inability to eat, may lead to exhaustion and psychological disorders, as assessed in the current study using the EORTC QLQ-C30 symptom scales. Moreover, the scores of many functional scales, including physical, role, emotional, and cognitive functioning, as well as global quality of life decreased, indicating that after six months of treatment, patients face significant impairments in their lives. These findings are in line with prior research indicating that numerous cancer therapies and other disease related consequences like financial problems, result in a deterioration of HRQoL, particularly in the early months; they also emphasize the importance of comprehensive and especially multidisciplinary supportive care strategies focused on both therapeutic and psychological interventions to reduce fatigue and enhance overall QoL for patients (\u003cspan additionalcitationids=\"CR20\" citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR34\" class=\"CitationRef\"\u003e21\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eA notable finding is the significant increase in financial difficulties during the six-month period. This is not unexpected, as cancer treatment frequently makes significant costs, and the financial stress can get worsen by losing income if patients are unable to keep working, which is more common in head and neck cancer patients due to the post-cancer cosmetic and appearance effects of these tumors. Financial difficulty may lead to mental health issues, impacting emotional well-being and potentially limiting patients' compliance to treatments. These findings emphasize the necessity of providing financial support and counseling to cancer patients alongside with their medical treatment (\u003cspan citationid=\"CR35\" class=\"CitationRef\"\u003e22\u003c/span\u003e, \u003cspan citationid=\"CR36\" class=\"CitationRef\"\u003e23\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eThis study has limitations that should be noted. First, the sample size was relatively small, with 47 patients, which may limit the generalizability of the findings. A larger multi-center cohort would have provided more precise data with including the impact of different treatment modalities or tumor locations on HRQoL and CRF. Also, the present study only coverd a 6-month period follow-up; longer follow-up would be necessary to evaluate the persistence of CRF and the long-term effects of treatments on HRQoL, and finally their effects on patients\u0026rsquo; survival.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eIn conclusion, this study demonstrates a significant decline in QoL and an increase in CRF among patients with non-metastatic head and neck cancers during the first six months of treatment. The findings emphasize the multifactorial impact of cancer treatments on physical, emotional, and cognitive functioning, as well as the severe financial and psychological burdens experienced by patients. These results highlight the need for comprehensive multidisciplinary care, including psychological support, financial counseling, and interventions aimed at managing CRF, to improve the overall well-being of head and neck cancer patients.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e \u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e \u003cp\u003e The study was approved by the Hamadan University Medical Ethics Review Board (IR.UMSHA.REC.1401.1062) and accordance with the Helsinki declaration. Written informed consent was obtained from all study participants after they had received a written and verbal explanation of the study (\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e5\u003c/span\u003e).\u003c/p\u003e \u003c/p\u003e \u003cp\u003e \u003cstrong\u003eConsent for publication\u003c/strong\u003e \u003cp\u003eNot Applicable\u003c/p\u003e \u003c/p\u003e\u003cp\u003e \u003ch2\u003eCompeting interests\u003c/h2\u003e \u003cp\u003eThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.\u003c/p\u003e \u003c/p\u003e\u003ch2\u003eFunding\u003c/h2\u003e \u003cp\u003eThe present study has no funding.\u003c/p\u003e\u003ch2\u003eAuthor Contribution\u003c/h2\u003e\u003cp\u003eF.S., Z.K.A., R.A., and L.T. participated in the research design. F.S., A.A., A.M. and M.R.J. and participated in writing the first draft. E.S and M.M.A participated in the performance of the research and analytic tools. F.S., M.K., and Z.K.A. participated in data analysis. All authors reviewed and confirmed the final manuscript.\u003c/p\u003e\u003ch2\u003eAcknowledgement\u003c/h2\u003e\u003cp\u003eOur gratitude extends to the individuals who participated in the research and the dedicated study-sites staff.\u003c/p\u003e\u003ch2\u003eData Availability\u003c/h2\u003e\u003cp\u003eThe datasets used and analyzed during the current study are available from the corresponding author on reasonable request.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eSung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2021;71(3):209\u0026ndash;49.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBossi P, Di Pede P, Guglielmo M, Granata R, Alfieri S, Iacovelli NA, et al. Prevalence of fatigue in head and neck cancer survivors. Annals of Otology, Rhinology \u0026amp; Laryngology. 2019;128(5):413\u0026ndash;9.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eFan CY, Chao HL, Lin CS, Huang WY, Chen CM, Lin KT, et al. Risk of depressive disorder among patients with head and neck cancer: a nationwide population-based study. Head \u0026amp; Neck. 2018;40(2):312\u0026ndash;23.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eNelke KH, Pawlak W, Gerber H, Leszczyszyn J. Head and neck cancer patients' quality of life. Advances in clinical and experimental medicine: official organ Wroclaw Medical University. 2014;23(6):1019\u0026ndash;27.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eFabi A, Bhargava R, Fatigoni S, Guglielmo M, Horneber M, Roila F, et al. Cancer-related fatigue: ESMO Clinical Practice Guidelines for diagnosis and treatment. Annals of Oncology. 2020;31(6):713\u0026ndash;23.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBaudelet M, Van den Steen L, Tomassen P, Bonte K, Deron P, Huvenne W, et al. Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy. Head \u0026amp; neck. 2019;41(10):3594\u0026ndash;603.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eKramer B, Wenzel A, Boerger M, Lippert B, Feist K, Petrasch R, et al. Long-term quality of life and nutritional status of patients with head and neck cancer. Nutrition and cancer. 2019;71(3):424\u0026ndash;37.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eGhaderi M, Azadi A, Rahmani A, Sanaat Z, Nazemiyeh H, Shamsi A, et al. Fatigue and its related factors among Iranian cancer survivors. Journal of caring sciences. 2021;10(4):210.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eMendoza TR, Wang XS, Cleeland CS, Morrissey M, Johnson BA, Wendt JK, et al. The rapid assessment of fatigue severity in cancer patients: use of the Brief Fatigue Inventory. Cancer. 1999;85(5):1186\u0026ndash;96.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eSedighi Pashaki A, Sheida F, Moaddab Shoar L, Hashem T, Fazilat-Panah D, Nemati Motehaver A, et al. A randomized, controlled, parallel-group, trial on the long-term effects of melatonin on fatigue associated with breast cancer and its adjuvant treatments. Integrative Cancer Therapies. 2023;22:15347354231168624.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eMontazeri A, Harirchi I, Vahdani M, Khaleghi F, Jarvandi S, Ebrahimi M, et al. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30): translation and validation study of the Iranian version. Supportive Care in Cancer. 1999;7:400\u0026ndash;6.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eKeshtpour Amlashi Z, Sheida F, Anbiaee R, Tapak L, Hosseini SR, Mosaedian H, et al. The Effect of Melatonin on Increasing the Health Related Quality of Life in Non-Metastatic Breast Cancer Patients: Three-Year Follow up a Clinical Trial. Integrative Cancer Therapies. 2024;23:15347354241237520.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eJohnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. Head and neck squamous cell carcinoma. Nature reviews Disease primers. 2020;6(1):92.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eSung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2021;71(3):209\u0026ndash;49.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBossi P, Di Pede P, Guglielmo M, Granata R, Alfieri S, Iacovelli NA, et al. Prevalence of fatigue in head and neck cancer survivors. Annals of Otology, Rhinology \u0026amp; Laryngology. 2019;128(5):413-9.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eFan CY, Chao HL, Lin CS, Huang WY, Chen CM, Lin KT, et al. Risk of depressive disorder among patients with head and neck cancer: a nationwide population-based study. Head \u0026amp; Neck. 2018;40(2):312\u0026ndash;23.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eNelke KH, Pawlak W, Gerber H, Leszczyszyn J. Head and neck cancer patients' quality of life. Advances in clinical and experimental medicine: official organ Wroclaw Medical University. 2014;23(6):1019\u0026ndash;27.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eFabi A, Bhargava R, Fatigoni S, Guglielmo M, Horneber M, Roila F, et al. Cancer-related fatigue: ESMO Clinical Practice Guidelines for diagnosis and treatment. Annals of Oncology. 2020;31(6):713\u0026ndash;23.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eBaudelet M, Van den Steen L, Tomassen P, Bonte K, Deron P, Huvenne W, et al. Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy. Head \u0026amp; neck. 2019;41(10):3594\u0026ndash;603.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eKramer B, Wenzel A, Boerger M, Lippert B, Feist K, Petrasch R, et al. Long-term quality of life and nutritional status of patients with head and neck cancer. Nutrition and cancer. 2019;71(3):424\u0026ndash;37.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eGhaderi M, Azadi A, Rahmani A, Sanaat Z, Nazemiyeh H, Shamsi A, et al. Fatigue and its related factors among Iranian cancer survivors. Journal of caring sciences. 2021;10(4):210.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eMendoza TR, Wang XS, Cleeland CS, Morrissey M, Johnson BA, Wendt JK, et al. The rapid assessment of fatigue severity in cancer patients: use of the Brief Fatigue Inventory. Cancer. 1999;85(5):1186\u0026ndash;96.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eSedighi Pashaki A, Sheida F, Moaddab Shoar L, Hashem T, Fazilat-Panah D, Nemati Motehaver A, et al. A randomized, controlled, parallel-group, trial on the long-term effects of melatonin on fatigue associated with breast cancer and its adjuvant treatments. Integrative Cancer Therapies. 2023;22:15347354231168624.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eMontazeri A, Harirchi I, Vahdani M, Khaleghi F, Jarvandi S, Ebrahimi M, et al. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30): translation and validation study of the Iranian version. Supportive Care in Cancer. 1999;7:400\u0026ndash;6.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eKeshtpour Amlashi Z, Sheida F, Anbiaee R, Tapak L, Hosseini SR, Mosaedian H, et al. The Effect of Melatonin on Increasing the Health Related Quality of Life in Non-Metastatic Breast Cancer Patients: Three-Year Follow up a Clinical Trial. Integrative Cancer Therapies. 2024;23:15347354241237520.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eJohnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. Head and neck squamous cell carcinoma. 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Cancer-related fatigue: causes and current treatment options. Current treatment options in oncology. 2020;21(2):17.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eAhmadi MS, Sheida F, Ameri A, Javadinia SA, Farahani F, Soltaninia O, et al. Ewing\u0026rsquo;s sarcoma of mandible: practical approach to a challenging case. Case Reports in Oncology. 2022;15(3):927\u0026ndash;35.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eDee EC, Chino F. Financial hardship in cancer care\u0026mdash;the need to define and intervene on actionable metrics. JAMA Network Open. 2022;5(7):e2223149-e.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLu L, O'Sullivan E, Sharp L. Cancer-related financial hardship among head and neck cancer survivors: Risk factors and associations with health‐related quality of life. Psycho‐oncology. 2019;28(4):863\u0026ndash;71.\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Cancer-related fatigue, Head and neck neoplasms, Brief Fatigue Inventory, Cancer survivorship, Health-related quality of life","lastPublishedDoi":"10.21203/rs.3.rs-5280411/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-5280411/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eObjective: This study aimed to assess health-related quality of life (HRQoL) and cancer-related fatigue (CRF) in patients with non-metastatic head and neck cancers over a six-month period following treatment initiation.\u003c/p\u003e\n\u003cp\u003eMethods: Patients with non-metastatic head and neck cancers referring to two oncology clinics in Hamadan, Iran, from April 2022 to March 2023 were evaluated using the Brief Fatigue Inventory (BFI) and the European Organization for Research and Treatment of Cancer Quality of Life questionnaire (EORTC QLQ C-30) version 3. Scores were recorded at baseline and six-month post-treatment. All statistical analyses were performed using SPSS version 27, with a P-value of \u0026lt;0.05 considered statistically significant.\u003c/p\u003e\n\u003cp\u003eResults: Of the 47 patients in this study, 83% were male (n=39) and the mean age was 54.28±9.61 years. The oral cavity (n=25, 53.2%) and larynx (n=11, 23.4%) were the most frequent tumor sites. Significant increase in CRF were observed between baseline and six-month post-treatment (3.07 vs. 3.50, P \u0026lt;0.001). The result of EORTC QLQ C-30 showed that mean global QoL score was 73.91±8.89 at baseline and 63.40±9.20 six-month post-treatment (P\u0026lt;0.001). The majority of functional scales items reduced significantly (P\u0026lt;0.001), and symptom scale items increased over time.\u003c/p\u003e\n\u003cp\u003eConclusion: In conclusion, this study demonstrates a significant decline in QoL and an increase in CRF among patients with non-metastatic head and neck cancers during the first six months of treatment. The findings emphasize the multifactorial impact of cancer treatments on physical, psychological, and financial aspects of patients’ life and vital need for supportive care.\u003c/p\u003e","manuscriptTitle":"Health-related quality of life and cancer related fatigue in patients with non-metastatic head and neck cancers","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-11-05 09:09:21","doi":"10.21203/rs.3.rs-5280411/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"46ab3abc-e373-4cc6-9f14-371ddddb0b40","owner":[],"postedDate":"November 5th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-12-15T04:08:29+00:00","versionOfRecord":[],"versionCreatedAt":"2024-11-05 09:09:21","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-5280411","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-5280411","identity":"rs-5280411","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}