A patient developing anaphylaxis and sensitivity to two different GnRH analogues and a review of literature

Deniz Ökdemir; Ökdemir D; Nihal Hatipoğlu; Hatipoğlu N; Himmet Haluk Akar; Akar HH; Ülkü Gül Şıraz; Gül Ü; Ülkü Gül; Akın L; Leyla Akın; Fulya Tahan; Tahan F; Kurtoğlu S; Selim Kurtoğlu

doi:10.1515/jpem-2014-0402

A patient developing anaphylaxis and sensitivity to two different GnRH analogues and a review of literature

Deniz Ökdemir, Ökdemir D, Nihal Hatipoğlu, Hatipoğlu N, Himmet Haluk Akar, Akar HH, Ülkü Gül Şıraz, Gül Ü, Ülkü Gül, Akın L, Leyla Akın, Fulya Tahan, Tahan F, Kurtoğlu S, Selim Kurtoğlu

Journal of pediatric endocrinology & metabolism : JPEM · 2015 · vol. 28(7-8) , pp. 923–5 · doi:10.1515/jpem-2014-0402 · PMID:25719301 · W2314072529

Review OA: closed CC0

View on OpenAlex View on PubMed View at publisher

⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-08-03 ⓘ

This paper reports a rare case of anaphylaxis to two different gonadotropin-releasing hormone analogues in a child with precocious puberty and reviews the literature on this adverse effect.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Gonadotropin-releasing hormone analogues are used in the treatment of prostate cancer, breast cancer, endometriosis, and uterine leiomyomas in adults and often in the treatment of precocious puberty in children. Many adverse effects have been reported for gonadotropin-releasing hormone analogues, but anaphylaxis is rarely reported as an adverse effect. Frequent cross-reactions, particularly during childhood, and diversity of the time of onset of anaphylactic manifestations complicate the diagnosis. A patient who exhibited anaphylactic allergic reactions to two different agents used in the treatment of central precocious puberty presented here because the case has an atypical course and is the first in the literature.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Anaphylaxis Antineoplastic Agents, Hormonal Leuprolide Puberty, Precocious Triptorelin Pamoate Adult Adult Anaphylaxis Anaphylaxis Anaphylaxis Antineoplastic Agents, Hormonal Antineoplastic Agents, Hormonal Child Child Female Female Humans Humans Leuprolide Leuprolide

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (2)

References (10)

Leuprolide acetate-induced leukocytoclastic vasculitis via openalex
Long-term effects on bone mineral density and bone metabolism of 6 months' treatment with gonadotropin-releasing hormone analogues in Japanese women: comparison of buserelin acetate with leuprolide acetate via openalex
W2004772981 via openalex
W2059748956 via openalex
W2061172182 via openalex
W2410752591 via openalex
W6639626525 via openalex
W1896152811 via openalex
W6665633586 via openalex
W1921675692 via openalex

Source provenance

europepmc: last seen: 2026-10-20T06:13:28.455750+00:00
openalex: last seen: 2026-06-04T00:00:01.174412+00:00
pubmed: last seen: 2026-10-08T21:15:04.544443+00:00
unpaywall: last seen: 2026-10-19T06:34:38.229974+00:00

License: CC0 · commercial use OK

[1] Long-term effects on bone mineral density and bone metabolism of 6 months' treatment with gonadotropin-releasing hormone analogues in Japanese women: comparison of buserelin acetate with leuprolide acetate 2005

[2] Leuprolide acetate-induced leukocytoclastic vasculitis 2007