A Systematic Review of Graft-Related Complications and recurrence following Minimally Invasive Sacrocolpopexy with a Biological Graft

A Systematic Review of Graft-Related Complications and recurrence following Minimally Invasive Sacrocolpopexy with a Biological Graft | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL BJOG: An International Journal of Obstetrics and Gynaecology This is a preprint and has not been peer reviewed. Data may be preliminary. 21 March 2025 V1 Latest version Share on A Systematic Review of Graft-Related Complications and recurrence following Minimally Invasive Sacrocolpopexy with a Biological Graft Authors : Marije A. Boom 0000-0003-2095-3274 [email protected] , Margot van Genderen , Paul M. Verheijen , Esther C.J. Consten , Henk Schreuder , and Steven E. Schraffordt Koops Authors Info & Affiliations https://doi.org/10.22541/au.174255508.86659684/v1 471 views 250 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background Biological grafts are proposed as an alternative to synthetic grafts in sacrocolpopexy (SC) to reduce complications such as graft exposure and immunologic reactions. However, concerns remain long-term durability. This systematic review and meta-analysis assess recurrence rates and graft-related complications (GRC) in minimally invasive sacrocolpopexy (MISC) using biological grafts. Objectives To evaluate the recurrence and GRC following MISC with biological grafts and to compare outcomes across different materials. Search Strategy PubMed, Embase and Cochrane databases were searched up to August 2024. Selection Criteria Studies with ≥10 patients undergoing MISC with biological grafts, reporting recurrence or GRC with ≥6 months follow-up, were included. Data Collection and Analysis Two independent reviewers assessed study quality using the Newcastle-Ottawa Scale (NOS). A random-effects meta-analysis estimated pooled recurrence and GRC with 95% confidence intervals (CI). Main Results Five studies (353 patients) met inclusion criteria. Recurrence rates ranged from 2.4% to 52.6% (pooled: 25.6% [95% CI: 8.1–48.2%]). Graft exposure occurred in 0.8% (95% CI: 0.0–4.2%). ADM had the lowest recurrence (2.4%) with no reported exposures, whereas Tutoplast® cadaveric fascia lata showed the highest recurrence (52.6%) and exposure (5.3%). The pooled reoperation rate for recurrence was 16.8% (95% CI: 0.0–51.7%). Conclusion This systematic review identified a higher recurrence rate with biological grafts in MISC than typically reported for synthetic grafts in other literature, while exposure rates appeared to be comparable. Given study heterogeneity, further research is required to determine the optimal graft choice balancing durability and complication risk. Supplementary Material File (20032025_a systematic review sacrocolpopexy version 2.docx) Download 318.39 KB File (20032025_figures.docx) Download 527.46 KB File (20032025_tables.docx) Download 32.21 KB Information & Authors Information Version history V1 Version 1 21 March 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Collection BJOG: An International Journal of Obstetrics and Gynaecology Keywords gynaecological surgery: laparoscopy gynaecological surgery: prolapse gynaecological surgery: robotic urogynaecology Authors Affiliations Marije A. Boom 0000-0003-2095-3274 [email protected] Universitair Medisch Centrum Groningen Afdeling Chirurgie View all articles by this author Margot van Genderen Stichting Meander Medisch Centrum View all articles by this author Paul M. Verheijen Stichting Meander Medisch Centrum View all articles by this author Esther C.J. Consten Universitair Medisch Centrum Groningen Afdeling Chirurgie View all articles by this author Henk Schreuder Universitair Medisch Centrum Utrecht View all articles by this author Steven E. Schraffordt Koops Stichting Meander Medisch Centrum View all articles by this author Metrics & Citations Metrics Article Usage 471 views 250 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Marije A. Boom, Margot van Genderen, Paul M. Verheijen, et al. A Systematic Review of Graft-Related Complications and recurrence following Minimally Invasive Sacrocolpopexy with a Biological Graft. Authorea . 21 March 2025. DOI: https://doi.org/10.22541/au.174255508.86659684/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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