Intense 68 Ga-FAPI-04 Uptake in a Rare Case of Multifocal Abdominal Wall Endometriosis

Fibroblast activation protein inhibitor (FAPI) PET is an emerging molecular imaging modality that is widely used in oncology and increasingly investigated in nononcologic diseases. Abdominal wall endometriosis (AWE) is a rare form of endometriosis, characterized by ectopic endometrial tissue in the abdominal wall. We present a patient with a right external obturator mass, biopsy-confirmed as endometriosis, in whom 68Ga-FAPI-04 PET/CT revealed extensive multifocal AWE and adenomyosis. These lesions demonstrated intense FAPI uptake, in contrast to their low or absent FDG uptake. This case highlights the potential of FAPI PET for detecting atypically located endometriosis, a capability lacking in current imaging methods. Intense 68Ga-FAPI-04 Uptake in a Rare Case of Multifocal Abdominal Wall Endometriosis - Buy - PAP Plain Language SummaryA new imaging technique called FAPI PET, typically used in cancer diagnosis, shows promise for identifying non-cancerous conditions like abdominal wall endometriosis (AWE). In a case study, a patient with a confirmed endometriosis mass showed intense uptake of FAPI in PET scans, revealing extensive AWE and adenomyosis. This uptake was not seen with traditional FDG PET scans, suggesting FAPI PET could be more effective for detecting endometriosis in unusual locations. This advancement could improve diagnosis and treatment for patients with atypical endometriosis, which current imaging methods struggle to identify. Text is machine generated and may contain inaccuracies. FAQ