Synthesis, characterization and biological activities of novel mononuclear nickel(II), copper(II) and chromium(III) complexes with N,N-dilaurylsubstituted thiazolidine-4-one-5-acetic acid ligand

Synthesis, characterization and biological activities of novel mononuclear nickel(II), copper(II) and chromium(III) complexes with N,N-dilaurylsubstituted thiazolidine-4-one-5-acetic acid ligand | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Synthesis, characterization and biological activities of novel mononuclear nickel(II), copper(II) and chromium(III) complexes with N,N-dilaurylsubstituted thiazolidine-4-one-5-acetic acid ligand Mehmet Suat Aksoy, Ayhan Yıldırım, Aslı Göçenoğlu Sarıkaya This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4510981/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract For the first time, a thiazolidine-4-one-5-acetic acid with two long hydrocarbon chains was chosen as ligand and the corresponding metal complexes with Cr(III), Ni(II) and Cu(II) salts were prepared. Analytical and spectroscopic studies have shown that the metal complexes are most likely to have a distorted octahedral geometry comprised of carboxylate and amide carbonyl O atoms and four isopropyl alcohol ligands inside the coordination sphere. According to molar conductivity measurements, all three complexes are not electrolyte in nature. The newly prepared complexes have been tested for their antifungal and antibacterial activity against C. albicans and S. aureus respectively. The Ni(II) complex exhibited good antifungal activity against C. albicans , while the Cu(II) complex showed better antibacterial activity against S. aureus than the other complexes. Pseudothiohydantoin derivatives Heterocyclic ligands Transition metal complexes Antimicrobial activity DFT calculations Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4510981","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":312979891,"identity":"0b4c5b1d-3ffc-4c3e-be9e-34066952d548","order_by":0,"name":"Mehmet Suat Aksoy","email":"","orcid":"","institution":"Bursa Uludağ University","correspondingAuthor":false,"prefix":"","firstName":"Mehmet","middleName":"Suat","lastName":"Aksoy","suffix":""},{"id":312979894,"identity":"15d9487d-2cc7-4124-a94b-d45ae71d0582","order_by":1,"name":"Ayhan Yıldırım","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA50lEQVRIiWNgGAWjYDACZuYGiQQGCQZ+BuYGBh6wUAIhLYwQLZINjEhaDuDVA9QCogwOEKvF4Dhj442HeyyijW8ktkm8qall4GfPMWD+uAePlsOMzRYJzyRytwG1SM45dpxBsueNAcOBZ3i1tEkkHIBokeZhO8ZgcCMHqAWPy+BaNs8Aafl3jMGeaC0bJIBaeNtqGAwkCGiRBPsFqGXGmYfNlnP7DvBInHlWcOAMHi185w8fvPnjQF1uf3vywRtvvtXJ8bcnb3xQgUeLAprcYXDU4NHAwCDfgMqvw6d4FIyCUTAKRigAADf+W0MOHdX9AAAAAElFTkSuQmCC","orcid":"","institution":"Bursa Uludağ University","correspondingAuthor":true,"prefix":"","firstName":"Ayhan","middleName":"","lastName":"Yıldırım","suffix":""},{"id":312979896,"identity":"4b55c24c-90ef-4c86-8506-d96db0d969d3","order_by":2,"name":"Aslı Göçenoğlu Sarıkaya","email":"","orcid":"","institution":"Bursa Uludağ University","correspondingAuthor":false,"prefix":"","firstName":"Aslı","middleName":"Göçenoğlu","lastName":"Sarıkaya","suffix":""}],"badges":[],"createdAt":"2024-05-31 20:38:13","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4510981/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4510981/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":58458627,"identity":"b2982cab-c99e-422d-b55d-7cf7a5d449c8","added_by":"auto","created_at":"2024-06-17 01:46:33","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":909718,"visible":true,"origin":"","legend":"","description":"","filename":"MainManuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4510981/v1_covered_25ab6f37-9c16-4016-bf9c-5078c1e1ee19.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Synthesis, characterization and biological activities of novel mononuclear nickel(II), copper(II) and chromium(III) complexes with N,N-dilaurylsubstituted thiazolidine-4-one-5-acetic acid ligand","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Pseudothiohydantoin derivatives, Heterocyclic ligands, Transition metal complexes, Antimicrobial activity, DFT calculations","lastPublishedDoi":"10.21203/rs.3.rs-4510981/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4510981/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eFor the first time, a thiazolidine-4-one-5-acetic acid with two long hydrocarbon chains was chosen as ligand and the corresponding metal complexes with Cr(III), Ni(II) and Cu(II) salts were prepared. 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