Correlation between STAT3 gene polymorphisms and endometriosis &infertility

Objective:To investigate the correlation between STAT3 gene polymorphisms and endometriosis infertility.Methods:Thirty patients with endometriosis and infertility who visited our hospital from June 2013 to June 2014 were selected as the observation group.At the same time,35 healthy women were selected as the control group.STAT3 gene polymorphisms of the patients in the two groups were detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)method.Results:The frequency of STAT3 gene polymorphisms of C(70% vs.30%)and G(90% vs.10%)allele were significantly different between the observation group and control group respectively(2χ=8.320,P0.05).There were 17 cases of CC,8cases of CG and 5cases of GG types in the observation group,which accounted for 56.7%,26.7% and 16.6% respectively.There are 30 cases of CC,3cases of CG and 2 cases of GG types in the control group,which accounted for 85.7%,8.6% and 5.7%respectively.The difference was significant between the two groups(2χ=6.810,P0.05).In addition,genotype G allele(CG+GG)increases the risk of endometriosis associated with infertility compared with the CC genotype[OR=4.59(95%CI=1.40-15.09)](P0.05).Conclusions:STAT3 gene(rs2293152)polymorphism may be associated with endometriosis and infertility.