Transcriptional expression of CAV1 is associated with dietary patterns, quality diet, physical activity, and alcoholism in adults with excess body weight, and comorbidities from Cartagena, Colombia

Transcriptional expression of CAV1 is associated with dietary patterns, quality diet, physical activity, and alcoholism in adults with excess body weight, and comorbidities from Cartagena, Colombia | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Transcriptional expression of CAV1 is associated with dietary patterns, quality diet, physical activity, and alcoholism in adults with excess body weight, and comorbidities from Cartagena, Colombia Deivis Javier Villanueva-Pájaro, Moisés Alberto Árquez-Mendoza, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7939460/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Excess body adiposity has pandemic dimensions, and is the main risk factor for the increased prevalence of Chronic Non-Communicable Diseases such as type 2 diabetes, metabolic syndrome, and various cancers around the world. Therefore, overweight and obesity were included in the World Health Organization's sustainable development goals for 2030. In this context, a growing body of basic experimental and clinical evidence suggests that the expression of CAV1 and the caveolin-1 protein in adipose tissue would be associated with the development of adipogenesis and obesity. However, the available evidence about CAV1 expression in human obesity appears controversial because it has not been analyzed in the context of environmental risk factors. Methods: Cross-sectional study. Proportionally stratified probability sampling. The main objective was to evaluate associations between transcriptional expression of CAV1 in blood serum of adults from Cartagena in states of normal-weight, overweight, and obesity, by severity of obesity, and comorbidities with dietary quality, dietary patterns, smoking, alcoholism, physical activity, blood biochemistry, and with cardiovascular risk (CVR) by anthropometry, and CVR by the Framingham International and Colombia scales. Models by Multiple Linear Regression, and Multiple Logistic Regression were applied in search of associations. Results: CAV1 is overexpressed in all groups, with a tendency to increase with increasing BMI. A good-quality diet, weekly alcohol intake, and moderate-intensity physical exercise were associated with reduced CAV1 expression, while poor- and regular-quality diets, and Western and Mediterranean dietary patterns were associated with increased CAV1 expression. Conclusions: The degree of transcriptional expression of CAV1 in blood serum of adults from Cartagena, would be determined in part by the delicate balance between the increase and decrease of each specific dietary component consumed, represented as dietary pattern and dietary quality, as well as determined by other environmental factors such as physical activity, alcoholism, which together would contribute to the generalized adipogenesis, and finally, excess body adiposity. Molecular Genetics Molecular Epidemiology Molecular Biology Diet Diet Quality Obesity Overweight Gene Expression Caveolin 1 Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7939460","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":534436853,"identity":"6565032a-cbd1-4875-b368-2cb717a46815","order_by":0,"name":"Deivis Javier 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competing interests.","formattedTitle":"\u003cp\u003e\u003cstrong\u003eTranscriptional expression of \u003c/strong\u003e\u003cem\u003e\u003cstrong\u003eCAV1\u003c/strong\u003e\u003c/em\u003e\u003cstrong\u003e is associated with dietary patterns, quality diet, physical activity, and alcoholism in adults with excess body weight, and comorbidities from Cartagena, Colombia\u003c/strong\u003e\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[{"identity":"b409eda6-7f63-4286-a909-92d4e33acea6","identifier":"10.13039/100007637","name":"Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)","awardNumber":"BPIN2020000100364","order_by":0}],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"Universidad del 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\u003c/strong\u003eExcess body adiposity has pandemic dimensions, and is the main risk factor for the increased prevalence of Chronic Non-Communicable Diseases such as type 2 diabetes, metabolic syndrome, and various cancers around the world. Therefore, overweight and obesity were included in the World Health Organization's sustainable development goals for 2030. In this context, a growing body of basic experimental and clinical evidence suggests that the expression of \u003cem\u003eCAV1\u003c/em\u003eand the caveolin-1 protein in adipose tissue would be associated with the development of adipogenesis and obesity. However, the available evidence about \u003cem\u003eCAV1\u003c/em\u003eexpression in human obesity appears controversial because it has not been analyzed in the context of environmental risk factors.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e Cross-sectional study. Proportionally stratified probability sampling. The main objective was to evaluate associations between transcriptional expression of \u003cem\u003eCAV1 \u003c/em\u003ein blood serum of adults from Cartagena in states of normal-weight, overweight, and obesity, by severity of obesity, and comorbidities with dietary quality, dietary patterns, smoking, alcoholism, physical activity, blood biochemistry, and with cardiovascular risk (CVR) by anthropometry, and CVR by the Framingham International and Colombia scales. Models by Multiple Linear Regression, and Multiple Logistic Regression were applied in search of associations.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e \u003cem\u003eCAV1 \u003c/em\u003eis overexpressed in all groups, with a tendency to increase with increasing BMI. A good-quality diet, weekly alcohol intake, and moderate-intensity physical exercise were associated with reduced \u003cem\u003eCAV1 \u003c/em\u003eexpression, while poor- and regular-quality diets, and Western and Mediterranean dietary patterns were associated with increased \u003cem\u003eCAV1\u003c/em\u003e expression.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions: \u003c/strong\u003eThe degree of transcriptional expression of \u003cem\u003eCAV1\u003c/em\u003e in blood serum of adults from Cartagena, would be determined in part by the delicate balance between the increase and decrease of each specific dietary component consumed, represented as dietary pattern and dietary quality, as well as determined by other environmental factors such as physical activity, alcoholism, which together would contribute to the generalized adipogenesis, and finally, excess body adiposity.\u003c/p\u003e","manuscriptTitle":"Transcriptional expression of CAV1 is associated with dietary patterns, quality diet, physical activity, and alcoholism in adults with excess body weight, and comorbidities from Cartagena, Colombia","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-10-27 11:35:56","doi":"10.21203/rs.3.rs-7939460/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"caba6a4a-a339-4f53-88fc-aa3a5e6ef487","owner":[],"postedDate":"October 27th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":56825858,"name":"Molecular Genetics"},{"id":56825859,"name":"Molecular Epidemiology"},{"id":56825860,"name":"Molecular Biology"}],"tags":[],"updatedAt":"2025-10-27T11:35:56+00:00","versionOfRecord":[],"versionCreatedAt":"2025-10-27 11:35:56","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7939460","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7939460","identity":"rs-7939460","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}