LYNX: A Novel Targeted Stimuli-Responsive Liposomal Nanocarrier Guided by Motor Proteins, simulated  in silico

LYNX: A Novel Targeted Stimuli-Responsive Liposomal Nanocarrier Guided by Motor Proteins, simulated in silico | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 1 August 2025 V1 Latest version Share on LYNX: A Novel Targeted Stimuli-Responsive Liposomal Nanocarrier Guided by Motor Proteins, simulated in silico Author : Edna Loh 0009-0008-8393-6264 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.175407679.99653994/v1 169 views 117 downloads Contents Abstract Methods Results Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract This paper aims to simulate the mechanism of LYNX (Liposome sYstem for Navigated eXpression), a programmable, stimuli-responsive liposomal nanocarrier aiming to enhance intracellular gene delivery in cancer cells. (imput simulation details) MATLAB was used to simulate the intracellular movement of liposomes within the cell. Literature values of HeLa cell nuclear volume and cytoplasm from Bionumbers were used in the modelling of LYNX's movement to provide insight into LYNX's potential in vitro efficacy. Through these simulations, LYNX represents a promising non-viral vector platform that serves to enhance specificity, efficacy, and safety in gene therapy applications. A diagram showing a key component of LYNX, the DSPE-PEG-CC1 Complex. The complex shown is allows for dynein transport to the negative microtubule end Methods Due to the variability of liposome sizes, payloads and cell lineages, this in silico simulation will focus mainly on the established cancer cell lineage HeLa. Each LYNX molecule is simplified into a sphere within the cell cytoplasm, and all the vesicles are assumed to be unilamellar This is a caption Results This simulation shows the overall movement of vesicles Acknowledgements Information & Authors Information Version history V1 Version 1 01 August 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords biotechnology in silico liposome simulation therapy Authors Affiliations Edna Loh 0009-0008-8393-6264 [email protected] View all articles by this author Metrics & Citations Metrics Article Usage 169 views 117 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Edna Loh. LYNX: A Novel Targeted Stimuli-Responsive Liposomal Nanocarrier Guided by Motor Proteins, simulated in silico. Authorea . 01 August 2025. DOI: https://doi.org/10.22541/au.175407679.99653994/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. Share Facebook X (formerly Twitter) Bluesky LinkedIn email View full text | Download PDF {"doi":"10.22541/au.175407679.99653994/v1","type":"Article"} Now Reading: Share Figures Tables Close figure viewer Back to article Figure title goes here Change zoom level Go to figure location within the article Download figure Toggle share panel Toggle share panel Share Toggle information panel Toggle information panel Go to previous graphic Go to next graphic Go to previous table Go to next table All figures All tables View all material View all material xrefBack.goTo xrefBack.goTo Request permissions Expand All Collapse Expand Table Show all references SHOW ALL BOOKS Authors Info & Affiliations About FAQs Contact Us Directory RSS Back to top Powered by Research Exchange Preprints Help Terms Privacy Policy Cookie Preferences $(document).ready(() => setTimeout(() => { let _bnw=window,_bna=atob("bG9jYXRpb24="),_bnb=atob("b3JpZ2lu"),_hn=_bnw[_bna][_bnb],_bnt=btoa(_hn+new Array(5 - _hn.length % 4).join(" ")); $.get("/resource/lodash?t="+_bnt); },4000)); (function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'9feca11a798a300f',t:'MTc3OTI5MzYxMw=='};var a=document.createElement('script');a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();