MyVivarium: A cloud-based lab animal colony management application with realtime ambient sensing

Management of research-animal colonies is vital for lab productivity in preclinical research. Labs often rely on inefficient paper-based or spreadsheet-based methods to manage animal colonies. Dedicated software-based solutions are generally expensive and many lack remote access. Currently available open-source alternatives are difficult to implement and deploy. These solutions also do not have the capability to track ambient variables that affect colony well-being. We built MyVivarium, an open-source database management web application to address these gaps. MyVivarium can be easily deployed to the cloud and sustained for a cost comparable to starting and maintaining a lab website. Using MyVivarium, lab members can collaboratively track individual animals within a database. Physical identities of cages map onto the database using QR codes, enabling quick and easy record-keeping on mobile devices. Lab administrators can assign tasks to users with reminders for experiments or cage maintenance. Finally, we designed a low-cost system to sense ambient humidity, temperature, vivarium worker activity, and room illuminance. These data are then sent to MyVivarium in realtime providing information relevant to colony well-being. Taken together, MyVivarium is a novel, open-source, cloud-based application template that provides a low-cost, simple, and efficient way to digitally manage research-animal colonies. Competing Interest Statement The authors have declared no competing interest. Footnotes

and Introduction revised to increase clarity and conciseness; New Figure 3 added to show MyVivarium user metrics; New Figure 4 added to demonstrate task management tool effectiveness; New Supplemental Figure 3 added to show server usage metrics; New Supplemental file 1 added to show the results of web application speed and performance; Results section updated to reflect addition of Figures 3 and 4, supplemental figure 3, and supplemental data file 1; Demonstration of cross-institutional validation; Author List updated (new authors added). Results section updated to emphasize significance of approach; Additional References cited; Figure numbers updated. https://osf.io/7x8tc/?view_only=c3e4433a2ac64103a8f33c71ccd7504a 1 Client-side refers to end-user devices, like laptops and smartphones. Server-side refers to the devices that manage a web application.