Long-term adhesive interface stability and ultra-structural properties by phosphosilicate-based bioactive glass primer

Long-term adhesive interface stability and ultra-structural properties by phosphosilicate-based bioactive glass primer | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Long-term adhesive interface stability and ultra-structural properties by phosphosilicate-based bioactive glass primer Jael Escobar, Macarena Aburto, Miguel A. Muñoz, Issis V. Luque-Martinez This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5898469/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 17 Dec, 2025 Read the published version in BMC Oral Health → Version 1 posted 11 You are reading this latest preprint version Abstract Phosphosilicate-based bioactive glasses (BGs) are promising remineralization materials due to their bioactivity, which could enhance the dentin adhesive interface. This study aimed to evaluate the immediate and 12-month effects of a BG-containing primer (BG-primer) on the biomechanical and ultrastructural properties of dentin bonding using two adhesive strategies. Experimental groups (n = 5) applied BG-primer before either an etch-and-rinse (ER) or self-etch (SE) adhesive strategy on third molar dentin, while controls used ER/SE without BG-primer. Specimens were subjected to micro-tensile bond strength (µTBS) testing immediately and after 12 months. Data were analyzed using two-way ANOVA and Tukey's test (α = 0.05). SEM was used to evaluate nanoleakage (NL) and BG-primer localization, while ATR-FTIR spectroscopy analyzed BG in dry conditions, immediate hydration, and after six hours. BG-primer significantly increased µTBS at 12 months (p < 0.05) without affecting NL. BG particles colocalized near the hybrid layer, maintaining its structural integrity. ATR-FTIR revealed hydration-induced modifications in BG, persisting after six hours. The BG-primer improved long-term adhesive performance in SE systems and stabilized the ER interface without compromising immediate bonding. BG reactivity and ion release (calcium, silicon, phosphate) likely explain the enhanced biomechanical behavior of the adhesive interface. bond strength remineralization universal adhesive Figures Figure 1 Figure 2 Figure 3 Introduction Bioactive glasses [BG] are biomaterials introduced in recent years in tissue engineering, mainly for their capacity for bone regeneration. However, their use as a possible dentin remineralizing agent is more recent, and their effect on the adhesive bonding interface continues to be studied [ 1 , 2 ]. At the osseous level, it can repair defects due to its biocompatibility and great bioactive capacity to induce mineral restitution through forming hydroxyl carbonate apatite [HCA], silicate, and calcium phosphate oxides [ 1–5 ]. However, although dentin is the most similar substrate to bone tissue, it has a much more limited remodeling capacity, which poses a significant challenge for the BG [ 1 , 6 ]. Unlike bone, dentin has a high mineral density of about 60–70%, lacks direct blood supply, and is partially devoid of cells; the remaining 30% is provided by organic collagen, non-collagenous proteins, and water [ 6 ,7]. The healing process of bone is regenerative, while dentin's is reparative, failing to replicate key morphological features [7]. These differences are essential to understand the difficulty of generating remineralization strategies in this tissue, and even more so during the restoration process, where the interaction with resinous adhesive polymers is also generated [8]. Of the different BG compositions, those based on phosphosilicate could be more similar to the dentin substrate, where sodium could interact with the crystals surrounding the mineralizing glass core, in addition to good biological behavior [ 1 , 6 , 7, 10]. This suggested bioactivity[10] makes BG a promising candidate for remineralizing the restorative bond interface. In these adhesive interfaces, the dentin tissue is the main challenge in the hybridization process caused by the numerous defects or interfibrillar spaces that are not permeated by the adhesive polymer, which threatens the stability of the bond over time [ 6 , 8, 9]. Therefore, strategies that allow remineralization at the ultrastructural level at the adhesive interface, such as possible mineral replacement of the BG, are necessary to improve adhesive restorations' longevity and optimize the mechanical properties of the bond [ 6 ]. Therefore, it is essential to evaluate the remineralization process on dentin bonding within the interface with adequate characterizations (physicochemical and mechanical) to verify that it is effective [ 6 , 1 1]. Thus, this study proposes to evaluate the immediate and 12-month effect of calcium sodium phosphosilicate-based bioactive glass [BG-primer] on the biomechanical and ultrastructural properties in dentin bonding by two different adhesive strategies. As a null hypothesis, it is suggested that the BG-primer does not influence the formed interface's immediate and long-term biomechanical and ultrastructural properties. Materials and methods Ethics approval The study was approved by the scientific and ethical committee of the Valparaiso University, and has the Ethics approval and consent to participate [ID: CB029-2014]. All experiments involved in this study were conducted in accordance with relevant ethical guidelines and regulations, including those established by the Declaration of Helsinki, and national regulatory framework. Tooth Selection and Preparation Twenty extracted molars were selected for therapeutic reasons, free of caries, and donated under informed consent. The teeth were stored in physiological saline solution. The third molars were debrided using a curette to remove residual organic tissue and subsequently cleaned in an ultrasonic bath for ten cycles. Enamel was removed by wet grinding to expose the occlusal dentin. Complete dentin exposure (absence of exposed pulp horns and enamel staining on the occlusal surface) was confirmed using a stereoscopic loupe at 40x magnification. The smear layer was standardized using 600-grit SiC sandpaper. Experimental Design The teeth were divided into four groups (n = 5) based on the use of BG-primer and the adhesive strategy for dentin hybridization: self-etch (SE) or etch-and-rinse (ER), both using Scotchbond Universal Adhesive (3M ESPE, Minnesota, USA) according to the manufacturer's instructions (Table 1 ). Table 1. Materials used and Adhesive protocol description for each group. BG= Bioglass, Bis- GMA: bisphenol glycidyl methacrylate; UDMA: urethane dimethacrylate; TEGDMA: Triethylene glycol dimethacrylate; Bis-EMA: ethoxylated bisphenol-A dimethacrylate; MDP: methacryloyloxydecyl dihydrogen phosphate; HEMA: 2- hydroxyethyl methacrylate. Si: Silice; O= Oxygen, H= Hydrogen, P= Phosphate; Na= Sodium. Availability of Data and Materials All data generated or analyzed during this study are included in this published article and its tables and figures. Restorative Procedure and Specimen Preparation The adhesive protocols were applied as detailed in Table 1 and performed by a single operator. Composite resin restorations were built incrementally (2 mm layers) using Filtek Z250 (3M ESPE, Minnesota, USA) and light-cured for 15 seconds at 1200 mW/cm² (Bluephase, Ivoclar, Liechtenstein). The restored teeth were stored in distilled water at 37°C for 24 hours prior to further testing. Microtensile Bond Strength Test (μTBS) Restored teeth were sectioned along the "X," "Y," and "Z" axes to produce resin-dentin samples with a cross-sectional area of 0.8 mm². Half of the samples were preserved in distilled water at 37°C for 12 months for long-term evaluation. Specimens were subjected to tensile testing at a crosshead speed of 0.5 mm/min until fracture to determine the μTBS at the dentin-resin interface. The μTBS was calculated by dividing the failure load by the cross-sectional bond area. Failure modes were classified as cohesive ([C], exclusively within dentin or resin), adhesive ([A], at the resin-dentin interface), or mixed ([M], involving both cohesive and adhesive failure). Fracture patterns were analyzed under a stereoscopic loupe at 40x magnification. Specimens with premature failures (PF) were included in the mean calculations. All data was recorded in a table. Nanoleakage (NL) and BG-Primer Localization (L) in the Adhesive Interface Three specimens per tooth were selected for immediate testing to evaluate nanoleakage (NL) and BG localization (L) within the adhesive interface using scanning electron microscopy (SEM). The protocol was adapted from Muñoz et al. [12]. Specimens were immersed in ammoniacal silver nitrate solution for 24 hours in the dark, rinsed with distilled water, and immersed in a photo-developing solution under fluorescent light for 8 hours. Polishing was performed using a sequence of wet sandpapers (600–2500 grit) followed by 1 μm and 0.25 μm diamond paste on a polishing cloth. Specimens were ultrasonically cleaned, air-dried, mounted on stubs, and coated with graphite-gold (QUORUM Q150R & ES Plus, East Sussex, UK). Resin-dentin interfaces were analyzed using a field-emission SEM in backscattered mode (HITACHI SU 3500, Tokyo, Japan). SEM images captured areas of nanoleakage and BG localization within the adhesive and hybrid layers. Quantitative nanoleakage analysis (% area) and qualitative BG presence (yes/no) were performed using UTHSCSA ImageTool 3.0 software (The University of Texas Health Science Center, San Antonio, Texas) by a blinded researcher. Additionally, images of the target surface (n=2) were captured to observe the immediate reaction of the BG-primer upon contact with the wet substrate under conditions identical to those applied prior to adhesion. ATR-FTIR Chemical Analysis ATR-FTIR spectroscopy was performed on BG powder under three conditions: dry, immediately hydrated, and after 6 hours of hydration in distilled water. FTIR spectra were collected using a spectrometer (Nicolet iS5; Thermo-Nicolet Instruments, Madison, WI, USA) with a diamond crystal (Smart Orbit, Thermo Scientific, USA). Spectra were recorded in the range of 4000 to 400 cm −1 at a spectral resolution of 4 cm⁻¹, using the co-addition of 32 scans. Measurements were repeated three times to ensure reproducibility. Characteristic absorption bands of mineral components were analyzed as described in Table 2. Background signals were subtracted for semi-quantitative comparison among groups. The crystallinity index (CI) was calculated using peak heights at 602 cm⁻¹ (B), 564 cm⁻¹ (A), and 595 cm⁻¹ (C) with the formula CI = ∑AB/C. Spectral normalization and analysis were conducted using OMINIC software (Thermo Scientific, USA). Table 2. General band assignment for the ATR-FTIR spectra evaluated. Peak Wavenumber (cm -1 ) Name Definition of the assignment 2300-2700 H-O-H Hydrogen bonded OH stretching 1200-1300 SiO 3 Si-O-Si asymmetric stretching vibration 1400-1580 v 3 CO 3 Vibration mode of carbonate ~963 PO 4 v 1 Vibration mode of phosphate band ~450 PO 4 v 2 Vibration mode of phosphate band ~1033 PO 4 v 3 Vibration mode of phosphate band ~562 PO 4 v 3 Vibration mode of phosphate band Si: Silice; O= Oxygen, H= Hydrogen, P= Phosphate. Statistical Analysis Data from μTBS tests were analyzed using two-way ANOVA and Tukey’s test (α = 0.05). To the NL test, the data were analyzed by Shapiro-Wilk and one-way ANOVA. Qualitative analyses were conducted to evaluate BG localization in the adhesive interface and dentin surface. Results Microtensile Bond Strength The immediate and 12-month μTBS values are presented in Table 3. Statistical analysis revealed no significant differences between the experimental groups (ER+BG and SE+BG) and their respective controls (ER and SE) in the immediate μTBS evaluation when the BG-primer was incorporated into the adhesive strategy (p > 0.05). Table 3. Microtensile bond strength (μTBS) values (means ± standard deviations) of the different experimental conditions* Adhesive Strategy μTBS (MPa) * Immediate 12 months Self-etch (SE) 26.7 ± 2.4 B,b 28.2 ± 3.9 B,b BG-primer + SE 25.3 ± 8.3 B,b 37.5 ± 1.3 A,a Etch-and-rinse (ER) 36.6 ± 7.5 A,a 30.8 ± 6.4 B,b BG-primer + ER 37.6 ± 6.3 A,a 33.7 ± 2.5 A,a *Similar capital letters show statistical similarity between the groups (vertical sense), and lower letters show statistical similarity between the times of evaluation (horizontal sense). MPa= Megapascal, BG= Bioglass. For the immediate evaluation period, ER strategies exhibited higher bond strength values than SE strategies, regardless of whether the BG-primer was used (p < 0.05). After 12 months of water storage, both ER and SE strategies demonstrated significantly higher bond strength values when the BG-primer was applied compared to their respective controls (p < 0.05). At 12 months, no statistical differences were observed between SE+BG and ER+BG or between the control groups. However, the ER control group exhibited significantly lower bond strength values at 12 months compared to its immediate results. In contrast, the ER+BG group maintained consistent bond strength between immediate and long-term evaluations. For the SE+BG group, there was a significant improvement in bond strength after 12 months, indicating better long-term performance. Nanoleakage and BG-Primer Location in the Adhesive Interface The overall results for BG-primer localization at the adhesive interface and the fracture patterns are shown in Table 4. Nanoleakage percentages in the adhesive interface were similar between control and experimental groups for both ER and SE strategies (p > 0.05). However, BG particles were observed near the hybrid layer in the experimental groups (Figure 1, Figure 2-C). Fracture pattern analysis indicated that tensile stress was applied perpendicularly to the adhesive interface, predominantly resulting in adhesive/mixed fractures. This confirms proper application of the adhesive protocols. The SEM images (Figure 1) demonstrated silver nitrate infiltration near the hybrid layer in both adhesive strategies, as indicated by white arrows. Experimental groups showed the presence of BG particles co-localized near the hybrid layer, marked with yellow arrows (Figure 2-D). The application of the BG-primer on the wet dentin surface resulted in observable positioning and precipitation upon contact with the substrate, leading to the occlusion of dentinal tubules. In contrast, no such effects were observed in specimens where the BG-primer was not applied (Figure 2-A,B,D). ATR-FTIR Chemical Analysis Qualitative analysis of BG powder by ATR-FTIR revealed characteristic peaks associated with carbonates, phosphates, and silicon in asymmetric and stretching modes. After 6 hours of hydration, spectral modifications were observed, including a reduction in the intensity of the supplementary peak at 1027 cm⁻¹ (Figure 3). Quantitative analysis showed a significant decrease in the crystallinity index when BG powder was exposed to an aqueous solution. This index increased significantly after 6 hours of exposure (p < 0.05). Discussion The null hypothesis, stating that the BG-primer does not influence the immediate or long-term biomechanical and ultrastructural properties of the adhesive interface, was partially rejected. BG-primer improved bond strength values after 12 months of aging in the ER strategy. Notably, the immediate evaluation showed no statistical differences between the groups, indicating that the BG-primer did not disrupt the adhesive process and effectively preserved the adhesive interface in the SE strategy over time. Long-term analysis revealed significantly higher μTBS values for the ER+BG and SE+BG groups compared to controls, suggesting that BG positively influences the long-term biomechanical properties of the adhesive interface (Table 2). These improvements are likely attributed to the ionic release from the bioactive glass, which triggers a biological response at the substrate interface. This response includes bonding between calcium ions in the substrate and functional monomers, as well as the precipitation of hydroxyapatite in solution [14–16]. Hydroxyapatite formation occurs after BG immersion in solution, initiated by silicate absorption on the surface, followed by cation exchange with protons from the surrounding fluid [16–19]. This exchange forms a poorly connected silica-rich layer, facilitating the precipitation and subsequent crystallization of a Ca- and P-rich apatite layer [18, 19]. Such mechanisms have been extensively studied in bone tissue, where bioactive glass implants lead to the formation of a bone-like apatite layer [9, 20]. In dentin, similar chemical interactions between BG components and the mineral substrate enable remineralization within the hybrid layer, facilitated by the release of Ca and P ions [14, 17]. Ultrastructural evaluation by SEM revealed BG particles localized near the dentin-resin interface immediately after application, without compromising the integrity of the universal adhesive in either experimental group (Figures 1B and 2B). The BG-primer remained effective within the hybrid layer without interfering with the adhesive composition of the ER or SE strategies. The key difference between these strategies lies in the use of acid etching, which induces greater demineralization in the ER group, leading to different bonding patterns [8, 12, 21]. In the ER control group, bond strength significantly decreased over time due to the inherent degradation of the hybrid layer [8, 21]. However, the addition of BG-primer mitigated this degradation, likely due to remineralization processes occurring at the interface [11]. In contrast, the SE experimental group demonstrated improved long-term bond strength, attributed to the absence of phosphoric acid etching. This preservation of surface calcium ions allowed more effective interactions with BG, promoting remineralization [10, 11]. ATR-FTIR spectroscopy confirmed the structural transformations of BG in aqueous solutions, with characteristic vibration bands indicative of structural changes. The ~1050 cm⁻¹ band, associated with the anti-symmetric stretch of Si-O-Si, and the ~3400 cm⁻¹ band, related to molecular water and OH groups, demonstrated shifts upon hydration [22, 23]. Despite low P₂O₅ content, phosphate groups were detected, with overlapping bands around 900–1200 cm⁻¹ attributed to Si-O and P-O stretches [23, 24]. These results align with the mobilization of phosphate and silicate groups in solution, contributing to improved bond strength in non-demineralized samples stored in water over time [23–25]. The decrease in bioglass crystallinity observed after 6 hours in aqueous solution reflects hydrolysis of Si-O-Si bonds and partial cation dissolution. This disrupts the glass network, increasing the proportion of amorphous regions [6, 9, 16, 26]. Released ions such as Ca²⁺, Na⁺, and PO₄³⁻ alter the local composition, further contributing to the transition from crystalline to amorphous phases [26]. These structural changes enhance bioactivity, enabling the remineralization process within the adhesive interface [6, 11, 26]. Based on the results, BG-primer effectively promotes chemical changes in dentin substrates immersed in biological fluids. By releasing silica, sodium, calcium, and phosphorus ions, BG induces the precipitation of hydroxyapatite on the dentin surface [1, 6, 9]. This process results in a chemically bonded layer that gradually transforms into crystalline hydroxyapatite, achieving remineralization of the substrate [9]. In conclusion, BG-primer enhances long-term bond strength for both ER and SE strategies, counteracting the typical degradation of adhesive interfaces [8, 11]. Its bioactivity, evidenced by ionic release and remineralization properties, makes bioactive glass a valuable material for stabilizing dentin-adhesive interfaces and promoting long-term adhesion stability. Declarations Acknowledgments The authors wish to express their sincere gratitude to the Research Center in Dental and Medical Sciences (CICOM), for their support in facilitating access to and use of the equipment. Funding sources This work was supported by the National Institutes of Research ANID: Fondecyt grant [1161435] (M. Muñoz) ANID Fondecyt grant [1241161] (I. Luque-Martínez). References Moura J, et al. In vitro osteogenesis on a highly bioactive glass-ceramic (Biosilicate). J Biomed Mater Res A. 2007;82:545–557. doi: 10.1002/jbm.a.31165. PMID: 17311315. Skallevold HE, et al. Bioactive Glass Applications in Dentistry. Int J Mol Sci. 2019;20:23. doi: 10.3390/ijms20235960. Yang C, Wu H, Li G. Bioactive ophiopogon in release form bioglass-collagen-phosphatidylserine scaffolds to enhance bone repair in vitro. Mater Lett. 2020;265. doi: 10.1016/j.matlet.2020.127436. Najeeb S, et al. Nano glass ionomer cement: modification for biodental applications. In: Advanced Dental Biomaterials. 2019;217–227. doi: 10.1016/B978-0-08-102476-8.00010-4. Najeeb S, et al. Modifications in Glass Ionomer Cements: Nano-Sized Fillers and Bioactive Nanoceramics. Int J Mol Sci. 2016;17:7. doi: 10.3390/ijms17071134. Fernando D, et al. Bioactive glass for dentin remineralization: A systematic review. Mater Sci Eng C Mater Biol Appl. 2017;76:1369–1377. doi: 10.1016/j.msec.2017.03.083. Kim J, Lee G, Chang WS, Ki SH, Park JC. Comparison and Contrast of Bone and Dentin in Genetic Disorder, Morphology and Regeneration: A Review. J Bone Metab. 2021;28:1–10. doi: 10.11005/jbm.2021.28.1.1. Van Meerbeek B, et al. From Buonocore's Pioneering Acid-Etch Technique to Self-Adhering Restoratives: A Status Perspective of Rapidly Advancing Dental Adhesive Technology. J Adhes Dent. 2020;22:7–34. doi: 10.3290/j.jad.a43994. Saffarpour M, et al. Efficacy of Modified Bioactive Glass for Dentin Remineralization and Obstruction of Dentinal Tubules. J Dent (Tehran). 2017;14:212–222. PMCID: PMC5745225. Kaur G, et al. Mechanical properties of bioactive glasses, ceramics, glass-ceramics and composites: State-of-the-art review and future challenges. Mater Sci Eng C Mater Biol Appl. 2019;104:109895. doi: 10.1016/j.msec.2019.109895. Bertassoni LE, et al. Biomechanical perspective on the remineralization of dentin. Caries Res. 2009;43:70–77. doi: 10.1159/000201593. Muñoz MA, et al. Immediate bonding properties of universal adhesives to dentine. J Dent. 2013;41:404–411. doi: 10.1016/j.jdent.2013.03.001. Chang MC, Tanaka J. FT-IR study for hydroxyapatite/collagen nanocomposite cross-linked by glutaraldehyde. Biomaterials. 2002;23:4811–4818. doi: 10.1016/s0142-9612(02)00232-6. Ravarian R, et al. Nanoscale chemical interaction enhances the physical properties of bioglass composites. ACS Nano. 2013;7:8469–8473. doi: 10.1021/nn402157n. ElBatal FH, El-Bassyouni GT. Bioactivity of Hench Bioglass and Corresponding Glass-Ceramic and the Effect of Transition Metal Oxides. Silicon. 2011;3:185–197. doi: 10.1007/s12633-011-9095-6. Plewinski M, et al. The effect of crystallization of bioactive bioglass 45S5 on apatite formation and degradation. Dent Mater. 2013;29:1256–1264. doi: 10.1016/j.dental.2013.09.016. Saravanapavan P, et al. Bioactivity of gel-glass powders in the CaO-SiO2 system: a comparison with ternary (CaO-P2O5-SiO2) and quaternary glasses (SiO2-CaO-P2O5-Na2O). J Biomed Mater Res A. 2003;66:110–119. doi: 10.1002/jbm.a.10532. Kangasniemi IM, et al. Dissolution and scanning electron microscopic studies of Ca,P particle-containing bioactive glasses. J Biomed Mater Res. 1993;27:1225–1233. doi: 10.1002/jbm.820271003. Maçon AL, et al. A unified in vitro evaluation for apatite-forming ability of bioactive glasses and their variants. J Mater Sci Mater Med. 2015;26:115. doi: 10.1007/s10856-015-5403-9. Sawant K, Pawar A. Bioactive glass in dentistry: A systematic review. Saudi J Oral Sci. 2020;7:1. doi: 10.4103/sjos.SJOralSci_56_19. Nagarkar S, Theis-Mahon N, Perdigao J. Universal dental adhesives: Current status, laboratory testing, and clinical performance. J Biomed Mater Res B Appl Biomater. 2019;107:2121–2131. doi: 10.1002/jbm.b.34305. Vyas VK, et al. Destructive and non-destructive behavior of nickel oxide doped bioactive glass and glass-ceramic. J Aust Ceram Soc. 2017;53:939–951. doi: 10.1007/s41779-017-0110-2. Lefebvre L, et al. Structural transformations of bioactive glass 45S5 with thermal treatments. Acta Mater. 2007;55:3305–3313. doi: 10.1002/(SICI)1097-4636(199604)30:43.0.CO;2-T. Ravarian R, et al. Synthesis, characterization and bioactivity investigation of bioglass/hydroxyapatite composite. Ceram Int. 2010;36:291–297. doi: 10.1016/j.ceramint.2009.09.016. Prasad PP, et al. A Review on Understanding the Crystallization Process of Bioglass in Recent Decade. J Mines Metals Fuels. 2022;70:444–449. doi: 10.18311/jmmf/2022/32022. Tilocca A, Cormack AN. The initial stages of bioglass dissolution: a Car–Parrinello molecular-dynamics study of the glass–water interface. Proc R Soc A. 2011;467:2102–211. doi: 10.1098/rspa.2010.0519. Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 17 Dec, 2025 Read the published version in BMC Oral Health → Version 1 posted Editorial decision: Revision requested 25 Mar, 2025 Reviews received at journal 24 Mar, 2025 Reviewers agreed at journal 14 Mar, 2025 Reviews received at journal 23 Feb, 2025 Reviewers agreed at journal 22 Feb, 2025 Reviewers agreed at journal 16 Feb, 2025 Reviewers invited by journal 15 Feb, 2025 Editor invited by journal 31 Jan, 2025 Editor assigned by journal 30 Jan, 2025 Submission checks completed at journal 29 Jan, 2025 First submitted to journal 29 Jan, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5898469","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":423808942,"identity":"03bcfe22-f220-4533-91b1-d67f476d6589","order_by":0,"name":"Jael Escobar","email":"","orcid":"","institution":"Pontificia Universidad Católica de Chile","correspondingAuthor":false,"prefix":"","firstName":"Jael","middleName":"","lastName":"Escobar","suffix":""},{"id":423808943,"identity":"00fcf093-3b37-4484-bd65-7a94019dcbb6","order_by":1,"name":"Macarena Aburto","email":"","orcid":"","institution":"Pontificia Universidad Católica de Chile","correspondingAuthor":false,"prefix":"","firstName":"Macarena","middleName":"","lastName":"Aburto","suffix":""},{"id":423808944,"identity":"59368e92-d650-4e2b-a40f-52af511a1968","order_by":2,"name":"Miguel A. Muñoz","email":"","orcid":"","institution":"Universidad de Valparaíso","correspondingAuthor":false,"prefix":"","firstName":"Miguel","middleName":"A.","lastName":"Muñoz","suffix":""},{"id":423808945,"identity":"92619c07-835b-450f-8409-6eb042e01b40","order_by":3,"name":"Issis V. Luque-Martinez","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAwklEQVRIiWNgGAWjYBACNiA+wMBgAWIzPgCRfERqkQCxmQ1gIsQAsBY2CaK08PEff3jwB4NEYt+N5GPVvG0M8gS1sEnkGBzmAWqZeSMt7TZQi2EbYS08DIeBDkvccCPH7DbPGYYEwrbwH38AdtiGG/nfionTwpBgcIAHYgsbM08FMVrAfjGQMJ555pmx5JwKCcJ+ke8//vjjjwob2b7jyQ8/vDGwkecnpAUCQHF4AMySIE4DBBwgRfEoGAWjYBSMKAAAfs82vLgHsLcAAAAASUVORK5CYII=","orcid":"","institution":"Universidad de Valparaíso","correspondingAuthor":true,"prefix":"","firstName":"Issis","middleName":"V.","lastName":"Luque-Martinez","suffix":""}],"badges":[],"createdAt":"2025-01-24 22:53:07","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-5898469/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-5898469/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12903-025-07399-9","type":"published","date":"2025-12-17T15:57:54+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":77975574,"identity":"49a6d684-5df0-48a4-9696-431e7d6b9206","added_by":"auto","created_at":"2025-03-07 11:40:24","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":332429,"visible":true,"origin":"","legend":"\u003cp\u003eSEM photomicrographs of SE/ER strategies (A, B) and their BG-primer counterparts (A', B'). White arrows indicate silver nitrate infiltration near the hybrid layer, while yellow arrows mark BG particle localization.\u003c/p\u003e","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-5898469/v1/d80ccadd5176d39d6202afa7.png"},{"id":77975949,"identity":"d6fb2c0c-a4ee-4726-bf14-5e910fa581af","added_by":"auto","created_at":"2025-03-07 11:48:24","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":1310050,"visible":true,"origin":"","legend":"\u003cp\u003eSEM photomicrographs of BG-primer after application on the dentin surface (A-B), and its difference with the control (D) without BG. In addition, it was possible to observe BG particles at higher magnification in the hybrid layer from bond strength specimens (C).\u003c/p\u003e","description":"","filename":"floatimage2.png","url":"https://assets-eu.researchsquare.com/files/rs-5898469/v1/b30ecca69c52cb15eae2e446.png"},{"id":77975572,"identity":"b2aa3241-b0d3-46c9-85d1-64b48ea206b8","added_by":"auto","created_at":"2025-03-07 11:40:24","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":243414,"visible":true,"origin":"","legend":"\u003cp\u003eATR-FTIR spectra of BG under different analysis conditions, showing changes in crystallinity index following exposure to an aqueous solution\u003c/p\u003e","description":"","filename":"floatimage3.png","url":"https://assets-eu.researchsquare.com/files/rs-5898469/v1/c2fd6ac92e5fbf54e1a612af.png"},{"id":98813975,"identity":"d97fa2e2-edf7-4ed5-9931-33985d2b64a3","added_by":"auto","created_at":"2025-12-22 16:08:51","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2607611,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5898469/v1/8cf560cf-13d8-47de-9d07-a13fbd114a38.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Long-term adhesive interface stability and ultra-structural properties by phosphosilicate-based bioactive glass primer","fulltext":[{"header":"Introduction","content":"\u003cp\u003eBioactive glasses [BG] are biomaterials introduced in recent years in tissue engineering, mainly for their capacity for bone regeneration. However, their use as a possible dentin remineralizing agent is more recent, and their effect on the adhesive bonding interface continues to be studied [\u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003e1\u003c/span\u003e, \u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003e2\u003c/span\u003e]. At the osseous level, it can repair defects due to its biocompatibility and great bioactive capacity to induce mineral restitution through forming hydroxyl carbonate apatite [HCA], silicate, and calcium phosphate oxides [\u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003e1\u0026ndash;5\u003c/span\u003e]. However, although dentin is the most similar substrate to bone tissue, it has a much more limited remodeling capacity, which poses a significant challenge for the BG [\u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003e1\u003c/span\u003e, \u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003e6\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eUnlike bone, dentin has a high mineral density of about 60\u0026ndash;70%, lacks direct blood supply, and is partially devoid of cells; the remaining 30% is provided by organic collagen, non-collagenous proteins, and water [\u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003e6\u003c/span\u003e,7]. The healing process of bone is regenerative, while dentin's is reparative, failing to replicate key morphological features [7]. These differences are essential to understand the difficulty of generating remineralization strategies in this tissue, and even more so during the restoration process, where the interaction with resinous adhesive polymers is also generated [8].\u003c/p\u003e \u003cp\u003eOf the different BG compositions, those based on phosphosilicate could be more similar to the dentin substrate, where sodium could interact with the crystals surrounding the mineralizing glass core, in addition to good biological behavior [\u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003e1\u003c/span\u003e, \u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003e6\u003c/span\u003e, 7, 10]. This suggested bioactivity[10] makes BG a promising candidate for remineralizing the restorative bond interface.\u003c/p\u003e \u003cp\u003eIn these adhesive interfaces, the dentin tissue is the main challenge in the hybridization process caused by the numerous defects or interfibrillar spaces that are not permeated by the adhesive polymer, which threatens the stability of the bond over time [\u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003e6\u003c/span\u003e, 8, 9]. Therefore, strategies that allow remineralization at the ultrastructural level at the adhesive interface, such as possible mineral replacement of the BG, are necessary to improve adhesive restorations' longevity and optimize the mechanical properties of the bond [\u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003e6\u003c/span\u003e]. Therefore, it is essential to evaluate the remineralization process on dentin bonding within the interface with adequate characterizations (physicochemical and mechanical) to verify that it is effective [\u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003e6\u003c/span\u003e, \u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003e1\u003c/span\u003e1].\u003c/p\u003e \u003cp\u003eThus, this study proposes to evaluate the immediate and 12-month effect of calcium sodium phosphosilicate-based bioactive glass [BG-primer] on the biomechanical and ultrastructural properties in dentin bonding by two different adhesive strategies. As a null hypothesis, it is suggested that the BG-primer does not influence the formed interface's immediate and long-term biomechanical and ultrastructural properties.\u003c/p\u003e"},{"header":"Materials and methods","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003eEthics approval\u003c/h2\u003e \u003cp\u003e The study was approved by the scientific and ethical committee of the Valparaiso University, and has the Ethics approval and consent to participate [ID: CB029-2014]. All experiments involved in this study were conducted in accordance with relevant ethical guidelines and regulations, including those established by the Declaration of Helsinki, and national regulatory framework.\u003c/p\u003e \u003c/div\u003e\n\u003ch3\u003eTooth Selection and Preparation\u003c/h3\u003e\n\u003cp\u003eTwenty extracted molars were selected for therapeutic reasons, free of caries, and donated under informed consent. The teeth were stored in physiological saline solution.\u003c/p\u003e \u003cp\u003eThe third molars were debrided using a curette to remove residual organic tissue and subsequently cleaned in an ultrasonic bath for ten cycles. Enamel was removed by wet grinding to expose the occlusal dentin. Complete dentin exposure (absence of exposed pulp horns and enamel staining on the occlusal surface) was confirmed using a stereoscopic loupe at 40x magnification. The smear layer was standardized using 600-grit SiC sandpaper.\u003c/p\u003e\n\u003ch3\u003eExperimental Design\u003c/h3\u003e\n\u003cp\u003eThe teeth were divided into four groups (n\u0026thinsp;=\u0026thinsp;5) based on the use of BG-primer and the adhesive strategy for dentin hybridization: self-etch (SE) or etch-and-rinse (ER), both using Scotchbond Universal Adhesive (3M ESPE, Minnesota, USA) according to the manufacturer\u0026apos;s instructions (Table \u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e).\u003c/p\u003e\n\u003cdiv align=\"left\" class=\"colspec\"\u003e\u003cstrong\u003eTable 1.\u003c/strong\u003e Materials used and Adhesive protocol description for each group.\u003c/div\u003e\n\u003cdiv align=\"left\" class=\"colspec\"\u003e\u003cimg src=\"data:image/png;base64,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\"\u003e\u003c/div\u003e\n\u003cp\u003e\u003c/p\u003e\n\u003cp\u003eBG= Bioglass, Bis- GMA: bisphenol glycidyl methacrylate; UDMA: urethane dimethacrylate; TEGDMA: Triethylene glycol dimethacrylate; Bis-EMA: ethoxylated bisphenol-A dimethacrylate; MDP: methacryloyloxydecyl dihydrogen phosphate; HEMA: 2- hydroxyethyl methacrylate. Si: Silice; O= Oxygen, H= Hydrogen, P= Phosphate; Na= Sodium.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of Data and Materials\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll data generated or analyzed during this study are included in this published article and its tables and figures.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eRestorative Procedure and Specimen Preparation\u003cbr\u003e\u003c/strong\u003eThe adhesive protocols were applied as detailed in Table 1 and performed by a single operator. Composite resin restorations were built incrementally (2 mm layers) using Filtek Z250 (3M ESPE, Minnesota, USA) and light-cured for 15 seconds at 1200 mW/cm\u0026sup2; (Bluephase, Ivoclar, Liechtenstein). The restored teeth were stored in distilled water at 37\u0026deg;C for 24 hours prior to further testing.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMicrotensile Bond Strength Test (\u0026mu;TBS)\u003cbr\u003e\u003c/strong\u003eRestored teeth were sectioned along the \u0026quot;X,\u0026quot; \u0026quot;Y,\u0026quot; and \u0026quot;Z\u0026quot; axes to produce resin-dentin samples with a cross-sectional area of 0.8 mm\u0026sup2;. Half of the samples were preserved in distilled water at 37\u0026deg;C for 12 months for long-term evaluation. Specimens were subjected to tensile testing at a crosshead speed of 0.5 mm/min until fracture to determine the \u0026mu;TBS at the dentin-resin interface.\u003c/p\u003e\n\u003cp\u003eThe \u0026mu;TBS was calculated by dividing the failure load by the cross-sectional bond area. Failure modes were classified as cohesive ([C], exclusively within dentin or resin), adhesive ([A], at the resin-dentin interface), or mixed ([M], involving both cohesive and adhesive failure). Fracture patterns were analyzed under a stereoscopic loupe at 40x magnification. Specimens with premature failures (PF) were included in the mean calculations. All data was recorded in a table.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eNanoleakage (NL) and BG-Primer Localization (L) in the Adhesive Interface\u003cbr\u003e\u003c/strong\u003eThree specimens per tooth were selected for immediate testing to evaluate nanoleakage (NL) and BG localization (L) within the adhesive interface using scanning electron microscopy (SEM). The protocol was adapted from Mu\u0026ntilde;oz et al. [12]. Specimens were immersed in ammoniacal silver nitrate solution for 24 hours in the dark, rinsed with distilled water, and immersed in a photo-developing solution under fluorescent light for 8 hours.\u003c/p\u003e\n\u003cp\u003ePolishing was performed using a sequence of wet sandpapers (600\u0026ndash;2500 grit) followed by 1 \u0026mu;m and 0.25 \u0026mu;m diamond paste on a polishing cloth. Specimens were ultrasonically cleaned, air-dried, mounted on stubs, and coated with graphite-gold (QUORUM Q150R \u0026amp; ES Plus, East Sussex, UK). Resin-dentin interfaces were analyzed using a field-emission SEM in backscattered mode (HITACHI SU 3500, Tokyo, Japan).\u003c/p\u003e\n\u003cp\u003eSEM images captured areas of nanoleakage and BG localization within the adhesive and hybrid layers. Quantitative nanoleakage analysis (% area) and qualitative BG presence (yes/no) were performed using UTHSCSA ImageTool 3.0 software (The University of Texas Health Science Center, San Antonio, Texas) by a blinded researcher. Additionally, images of the target surface (n=2) were captured to observe the immediate reaction of the BG-primer upon contact with the wet substrate under conditions identical to those applied prior to adhesion.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eATR-FTIR Chemical Analysis\u003cbr\u003e\u003c/strong\u003eATR-FTIR spectroscopy was performed on BG powder under three conditions: dry, immediately hydrated, and after 6 hours of hydration in distilled water. FTIR spectra were collected using a spectrometer (Nicolet iS5; Thermo-Nicolet Instruments, Madison, WI, USA) with a diamond crystal (Smart Orbit, Thermo Scientific, USA). Spectra were recorded in the range of 4000 to 400 cm\u003csup\u003e\u0026minus;1\u003c/sup\u003e at a spectral resolution of 4 cm⁻\u0026sup1;, using the co-addition of 32 scans. Measurements were repeated three times to ensure reproducibility.\u003c/p\u003e\n\u003cp\u003eCharacteristic absorption bands of mineral components were analyzed as described in Table 2. Background signals were subtracted for semi-quantitative comparison among groups. The crystallinity index (CI) was calculated using peak heights at 602 cm⁻\u0026sup1; (B), 564 cm⁻\u0026sup1; (A), and 595 cm⁻\u0026sup1; (C) with the formula CI = \u0026sum;AB/C. Spectral normalization and analysis were conducted using OMINIC software (Thermo Scientific, USA).\u0026nbsp;\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"602\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"3\" valign=\"top\" style=\"width: 602px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eTable 2.\u003c/strong\u003e General band assignment for the ATR-FTIR spectra evaluated.\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 156px;\"\u003e\n \u003cp\u003e\u003cstrong\u003ePeak Wavenumber (cm\u003csup\u003e-1\u003c/sup\u003e)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eName\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 369px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eDefinition of the assignment\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 156px;\"\u003e\n \u003cp\u003e2300-2700\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\n \u003cp\u003eH-O-H\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 369px;\"\u003e\n \u003cp\u003eHydrogen bonded OH stretching\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 156px;\"\u003e\n \u003cp\u003e1200-1300\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\n \u003cp\u003eSiO\u003csub\u003e3\u003c/sub\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 369px;\"\u003e\n \u003cp\u003eSi-O-Si asymmetric stretching vibration\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 156px;\"\u003e\n \u003cp\u003e1400-1580\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\n \u003cp\u003ev\u003csup\u003e3\u003c/sup\u003e CO\u003csub\u003e3 \u0026nbsp;\u003c/sub\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 369px;\"\u003e\n \u003cp\u003eVibration mode of carbonate\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 156px;\"\u003e\n \u003cp\u003e~963\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\n \u003cp\u003ePO\u003csub\u003e4\u0026nbsp;\u003c/sub\u003e\u003csup\u003e\u0026nbsp;\u0026nbsp;\u003c/sup\u003ev\u003csup\u003e1\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 369px;\"\u003e\n \u003cp\u003eVibration mode of phosphate band\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 156px;\"\u003e\n \u003cp\u003e~450\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\n \u003cp\u003ePO\u003csub\u003e4\u0026nbsp;\u003c/sub\u003e\u003csup\u003e\u0026nbsp;\u0026nbsp;\u003c/sup\u003ev\u003csup\u003e2\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 369px;\"\u003e\n \u003cp\u003eVibration mode of phosphate band\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 156px;\"\u003e\n \u003cp\u003e~1033\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\n \u003cp\u003ePO\u003csub\u003e4\u0026nbsp;\u003c/sub\u003e\u003csup\u003e\u0026nbsp;\u003c/sup\u003ev\u003csup\u003e3\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 369px;\"\u003e\n \u003cp\u003eVibration mode of phosphate band\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"top\" style=\"width: 156px;\"\u003e\n \u003cp\u003e~562\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 76px;\"\u003e\n \u003cp\u003ePO\u003csub\u003e4\u0026nbsp;\u003c/sub\u003e\u003csup\u003e\u0026nbsp;\u003c/sup\u003ev\u003csup\u003e3\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"top\" style=\"width: 369px;\"\u003e\n \u003cp\u003eVibration mode of phosphate band\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eSi: Silice; O= Oxygen, H= Hydrogen, P= Phosphate.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical Analysis\u003cbr\u003e\u003c/strong\u003eData from \u0026mu;TBS tests were analyzed using two-way ANOVA and Tukey\u0026rsquo;s test (\u0026alpha; = 0.05). To the NL test, the data were analyzed by Shapiro-Wilk and one-way ANOVA. Qualitative analyses were conducted to evaluate BG localization in the adhesive interface and dentin surface.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003eMicrotensile Bond Strength\u003cbr\u003e\u003c/strong\u003eThe immediate and 12-month \u0026mu;TBS values are presented in Table 3. Statistical analysis revealed no significant differences between the experimental groups (ER+BG and SE+BG) and their respective controls (ER and SE) in the immediate \u0026mu;TBS evaluation when the BG-primer was incorporated into the adhesive strategy (p \u0026gt; 0.05).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 3.\u003c/strong\u003e Microtensile bond strength (\u0026mu;TBS) values (means \u0026nbsp;\u0026plusmn; standard deviations) of the different experimental conditions*\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"602\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 229px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eAdhesive Strategy\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 373px;\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026mu;TBS (MPa) *\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 180px;\"\u003e\n \u003cp\u003e\u003cstrong\u003eImmediate\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 193px;\"\u003e\n \u003cp\u003e\u003cstrong\u003e12 months\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 229px;\"\u003e\n \u003cp\u003eSelf-etch (SE)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 180px;\"\u003e\n \u003cp\u003e26.7 \u0026plusmn; 2.4 B,b\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 193px;\"\u003e\n \u003cp\u003e28.2 \u0026plusmn; 3.9 B,b\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 229px;\"\u003e\n \u003cp\u003eBG-primer + SE\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 180px;\"\u003e\n \u003cp\u003e25.3 \u0026plusmn; 8.3 B,b\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 193px;\"\u003e\n \u003cp\u003e37.5 \u0026plusmn; 1.3 A,a\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 229px;\"\u003e\n \u003cp\u003eEtch-and-rinse (ER)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 180px;\"\u003e\n \u003cp\u003e36.6 \u0026plusmn; 7.5 A,a\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 193px;\"\u003e\n \u003cp\u003e30.8 \u0026plusmn; 6.4 B,b\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 229px;\"\u003e\n \u003cp\u003eBG-primer + ER\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 180px;\"\u003e\n \u003cp\u003e37.6 \u0026plusmn; 6.3 A,a\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 193px;\"\u003e\n \u003cp\u003e33.7 \u0026nbsp;\u0026plusmn; 2.5 A,a\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e*Similar capital letters show statistical similarity between the groups (vertical sense), and lower letters show statistical similarity between the times of evaluation (horizontal sense). MPa= Megapascal, BG= Bioglass.\u003c/p\u003e\n\u003cp\u003eFor the immediate evaluation period, ER strategies exhibited higher bond strength values than SE strategies, regardless of whether the BG-primer was used (p \u0026lt; 0.05). After 12 months of water storage, both ER and SE strategies demonstrated significantly higher bond strength values when the BG-primer was applied compared to their respective controls (p \u0026lt; 0.05).\u003c/p\u003e\n\u003cp\u003eAt 12 months, no statistical differences were observed between SE+BG and ER+BG or between the control groups. However, the ER control group exhibited significantly lower bond strength values at 12 months compared to its immediate results. In contrast, the ER+BG group maintained consistent bond strength between immediate and long-term evaluations. For the SE+BG group, there was a significant improvement in bond strength after 12 months, indicating better long-term performance.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eNanoleakage and BG-Primer Location in the Adhesive Interface\u0026nbsp;\u003cbr\u003e\u003c/strong\u003eThe overall results for BG-primer localization at the adhesive interface and the fracture patterns are shown in Table 4. Nanoleakage percentages in the adhesive interface were similar between control and experimental groups for both ER and SE strategies (p \u0026gt; 0.05). However, BG particles were observed near the hybrid layer in the experimental groups (Figure 1, Figure 2-C).\u003c/p\u003e\n\u003cp\u003eFracture pattern analysis indicated that tensile stress was applied perpendicularly to the adhesive interface, predominantly resulting in adhesive/mixed fractures. This confirms proper application of the adhesive protocols.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;The SEM images (Figure 1) demonstrated silver nitrate infiltration near the hybrid layer in both adhesive strategies, as indicated by white arrows. Experimental groups showed the presence of BG particles co-localized near the hybrid layer, marked with yellow arrows (Figure 2-D). The application of the BG-primer on the wet dentin surface resulted in observable positioning and precipitation upon contact with the substrate, leading to the occlusion of dentinal tubules. In contrast, no such effects were observed in specimens where the BG-primer was not applied (Figure 2-A,B,D).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003cstrong\u003eATR-FTIR Chemical Analysis\u003cbr\u003e\u003c/strong\u003eQualitative analysis of BG powder by ATR-FTIR revealed characteristic peaks associated with carbonates, phosphates, and silicon in asymmetric and stretching modes. After 6 hours of hydration, spectral modifications were observed, including a reduction in the intensity of the supplementary peak at 1027 cm⁻\u0026sup1; (Figure 3).\u003c/p\u003e\n\u003cp\u003eQuantitative analysis showed a significant decrease in the crystallinity index when BG powder was exposed to an aqueous solution. This index increased significantly after 6 hours of exposure (p \u0026lt; 0.05).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThe null hypothesis, stating that the BG-primer does not influence the immediate or long-term biomechanical and ultrastructural properties of the adhesive interface, was partially rejected. BG-primer improved bond strength values after 12 months of aging in the ER strategy. Notably, the immediate evaluation showed no statistical differences between the groups, indicating that the BG-primer did not disrupt the adhesive process and effectively preserved the adhesive interface in the SE strategy over time.\u003c/p\u003e\n\u003cp\u003eLong-term analysis revealed significantly higher \u0026mu;TBS values for the ER+BG and SE+BG groups compared to controls, suggesting that BG positively influences the long-term biomechanical properties of the adhesive interface (Table 2). These improvements are likely attributed to the ionic release from the bioactive glass, which triggers a biological response at the substrate interface. This response includes bonding between calcium ions in the substrate and functional monomers, as well as the precipitation of hydroxyapatite in solution [14\u0026ndash;16]. Hydroxyapatite formation occurs after BG immersion in solution, initiated by silicate absorption on the surface, followed by cation exchange with protons from the surrounding fluid [16\u0026ndash;19]. This exchange forms a poorly connected silica-rich layer, facilitating the precipitation and subsequent crystallization of a Ca- and P-rich apatite layer [18, 19]. Such mechanisms have been extensively studied in bone tissue, where bioactive glass implants lead to the formation of a bone-like apatite layer [9, 20]. In dentin, similar chemical interactions between BG components and the mineral substrate enable remineralization within the hybrid layer, facilitated by the release of Ca and P ions [14, 17].\u003c/p\u003e\n\u003cp\u003eUltrastructural evaluation by SEM revealed BG particles localized near the dentin-resin interface immediately after application, without compromising the integrity of the universal adhesive in either experimental group (Figures 1B and 2B). The BG-primer remained effective within the hybrid layer without interfering with the adhesive composition of the ER or SE strategies. The key difference between these strategies lies in the use of acid etching, which induces greater demineralization in the ER group, leading to different bonding patterns [8, 12, 21].\u003c/p\u003e\n\u003cp\u003eIn the ER control group, bond strength significantly decreased over time due to the inherent degradation of the hybrid layer [8, 21]. However, the addition of BG-primer mitigated this degradation, likely due to remineralization processes occurring at the interface [11]. In contrast, the SE experimental group demonstrated improved long-term bond strength, attributed to the absence of phosphoric acid etching. This preservation of surface calcium ions allowed more effective interactions with BG, promoting remineralization [10, 11].\u003c/p\u003e\n\u003cp\u003eATR-FTIR spectroscopy confirmed the structural transformations of BG in aqueous solutions, with characteristic vibration bands indicative of structural changes. The ~1050 cm⁻\u0026sup1; band, associated with the anti-symmetric stretch of Si-O-Si, and the ~3400 cm⁻\u0026sup1; band, related to molecular water and OH groups, demonstrated shifts upon hydration [22, 23]. Despite low P₂O₅ content, phosphate groups were detected, with overlapping bands around 900\u0026ndash;1200 cm⁻\u0026sup1; attributed to Si-O and P-O stretches [23, 24]. These results align with the mobilization of phosphate and silicate groups in solution, contributing to improved bond strength in non-demineralized samples stored in water over time [23\u0026ndash;25].\u003c/p\u003e\n\u003cp\u003eThe decrease in bioglass crystallinity observed after 6 hours in aqueous solution reflects hydrolysis of Si-O-Si bonds and partial cation dissolution. This disrupts the glass network, increasing the proportion of amorphous regions [6, 9, 16, 26]. Released ions such as Ca\u0026sup2;⁺, Na⁺, and PO₄\u0026sup3;⁻ alter the local composition, further contributing to the transition from crystalline to amorphous phases [26]. These structural changes enhance bioactivity, enabling the remineralization process within the adhesive interface [6, 11, 26].\u003c/p\u003e\n\u003cp\u003eBased on the results, BG-primer effectively promotes chemical changes in dentin substrates immersed in biological fluids. By releasing silica, sodium, calcium, and phosphorus ions, BG induces the precipitation of hydroxyapatite on the dentin surface [1, 6, 9]. This process results in a chemically bonded layer that gradually transforms into crystalline hydroxyapatite, achieving remineralization of the substrate [9].\u003c/p\u003e\n\u003cp\u003eIn conclusion, BG-primer enhances long-term bond strength for both ER and SE strategies, counteracting the typical degradation of adhesive interfaces [8, 11]. Its bioactivity, evidenced by ionic release and remineralization properties, makes bioactive glass a valuable material for stabilizing dentin-adhesive interfaces and promoting long-term adhesion stability.\u0026nbsp;\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgments\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors wish to express their sincere gratitude to the Research Center in Dental and Medical Sciences (CICOM), for their support in facilitating access to and use of the equipment.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding sources\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis work was supported by the National Institutes of Research\u0026nbsp;ANID: Fondecyt grant [1161435] (M. Mu\u0026ntilde;oz) ANID Fondecyt grant [1241161] (I. Luque-Mart\u0026iacute;nez).\u003c/p\u003e\n\n"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eMoura J, et al. In vitro osteogenesis on a highly bioactive glass-ceramic (Biosilicate). \u003cem\u003eJ Biomed Mater Res A.\u003c/em\u003e2007;82:545\u0026ndash;557. doi: 10.1002/jbm.a.31165. PMID: 17311315. \u003c/li\u003e\n\u003cli\u003eSkallevold HE, et al. Bioactive Glass Applications in Dentistry. \u003cem\u003eInt J Mol Sci.\u003c/em\u003e 2019;20:23. doi: 10.3390/ijms20235960. \u003c/li\u003e\n\u003cli\u003eYang C, Wu H, Li G. Bioactive ophiopogon in release form bioglass-collagen-phosphatidylserine scaffolds to enhance bone repair in vitro. \u003cem\u003eMater Lett.\u003c/em\u003e 2020;265. doi: 10.1016/j.matlet.2020.127436.\u003c/li\u003e\n\u003cli\u003eNajeeb S, et al. Nano glass ionomer cement: modification for biodental applications. In: Advanced Dental Biomaterials. 2019;217\u0026ndash;227. doi: 10.1016/B978-0-08-102476-8.00010-4.\u003c/li\u003e\n\u003cli\u003eNajeeb S, et al. Modifications in Glass Ionomer Cements: Nano-Sized Fillers and Bioactive Nanoceramics. \u003cem\u003eInt J Mol Sci.\u003c/em\u003e 2016;17:7. doi: 10.3390/ijms17071134.\u003c/li\u003e\n\u003cli\u003eFernando D, et al. Bioactive glass for dentin remineralization: A systematic review. \u003cem\u003eMater Sci Eng C Mater Biol Appl.\u003c/em\u003e2017;76:1369\u0026ndash;1377. doi: 10.1016/j.msec.2017.03.083.\u003c/li\u003e\n\u003cli\u003eKim J, Lee G, Chang WS, Ki SH, Park JC. Comparison and Contrast of Bone and Dentin in Genetic Disorder, Morphology and Regeneration: A Review. \u003cem\u003eJ Bone Metab.\u003c/em\u003e 2021;28:1\u0026ndash;10. doi: 10.11005/jbm.2021.28.1.1.\u003c/li\u003e\n\u003cli\u003eVan Meerbeek B, et al. From Buonocore\u0026apos;s Pioneering Acid-Etch Technique to Self-Adhering Restoratives: A Status Perspective of Rapidly Advancing Dental Adhesive Technology. \u003cem\u003eJ Adhes Dent.\u003c/em\u003e 2020;22:7\u0026ndash;34. doi: 10.3290/j.jad.a43994.\u003c/li\u003e\n\u003cli\u003eSaffarpour M, et al. Efficacy of Modified Bioactive Glass for Dentin Remineralization and Obstruction of Dentinal Tubules. \u003cem\u003eJ Dent (Tehran).\u003c/em\u003e 2017;14:212\u0026ndash;222. PMCID: PMC5745225.\u003c/li\u003e\n\u003cli\u003eKaur G, et al. Mechanical properties of bioactive glasses, ceramics, glass-ceramics and composites: State-of-the-art review and future challenges. \u003cem\u003eMater Sci Eng C Mater Biol Appl.\u003c/em\u003e 2019;104:109895. doi: 10.1016/j.msec.2019.109895.\u003c/li\u003e\n\u003cli\u003eBertassoni LE, et al. Biomechanical perspective on the remineralization of dentin. \u003cem\u003eCaries Res.\u003c/em\u003e 2009;43:70\u0026ndash;77. doi: 10.1159/000201593.\u003c/li\u003e\n\u003cli\u003eMu\u0026ntilde;oz MA, et al. Immediate bonding properties of universal adhesives to dentine. \u003cem\u003eJ Dent.\u003c/em\u003e 2013;41:404\u0026ndash;411. doi: 10.1016/j.jdent.2013.03.001.\u003c/li\u003e\n\u003cli\u003eChang MC, Tanaka J. FT-IR study for hydroxyapatite/collagen nanocomposite cross-linked by glutaraldehyde. \u003cem\u003eBiomaterials.\u003c/em\u003e 2002;23:4811\u0026ndash;4818. doi: 10.1016/s0142-9612(02)00232-6.\u003c/li\u003e\n\u003cli\u003eRavarian R, et al. Nanoscale chemical interaction enhances the physical properties of bioglass composites. \u003cem\u003eACS Nano.\u003c/em\u003e2013;7:8469\u0026ndash;8473. doi: 10.1021/nn402157n.\u003c/li\u003e\n\u003cli\u003eElBatal FH, El-Bassyouni GT. Bioactivity of Hench Bioglass and Corresponding Glass-Ceramic and the Effect of Transition Metal Oxides. \u003cem\u003eSilicon.\u003c/em\u003e 2011;3:185\u0026ndash;197. doi: 10.1007/s12633-011-9095-6.\u003c/li\u003e\n\u003cli\u003ePlewinski M, et al. The effect of crystallization of bioactive bioglass 45S5 on apatite formation and degradation. \u003cem\u003eDent Mater.\u003c/em\u003e 2013;29:1256\u0026ndash;1264. doi: 10.1016/j.dental.2013.09.016.\u003c/li\u003e\n\u003cli\u003eSaravanapavan P, et al. Bioactivity of gel-glass powders in the CaO-SiO2 system: a comparison with ternary (CaO-P2O5-SiO2) and quaternary glasses (SiO2-CaO-P2O5-Na2O). \u003cem\u003eJ Biomed Mater Res A.\u003c/em\u003e 2003;66:110\u0026ndash;119. doi: 10.1002/jbm.a.10532.\u003c/li\u003e\n\u003cli\u003eKangasniemi IM, et al. Dissolution and scanning electron microscopic studies of Ca,P particle-containing bioactive glasses. \u003cem\u003eJ Biomed Mater Res.\u003c/em\u003e 1993;27:1225\u0026ndash;1233. doi: 10.1002/jbm.820271003.\u003c/li\u003e\n\u003cli\u003eMa\u0026ccedil;on AL, et al. A unified in vitro evaluation for apatite-forming ability of bioactive glasses and their variants. \u003cem\u003eJ Mater Sci Mater Med.\u003c/em\u003e 2015;26:115. doi: 10.1007/s10856-015-5403-9.\u003c/li\u003e\n\u003cli\u003eSawant K, Pawar A. Bioactive glass in dentistry: A systematic review. \u003cem\u003eSaudi J Oral Sci.\u003c/em\u003e 2020;7:1. doi: 10.4103/sjos.SJOralSci_56_19.\u003c/li\u003e\n\u003cli\u003eNagarkar S, Theis-Mahon N, Perdigao J. Universal dental adhesives: Current status, laboratory testing, and clinical performance. \u003cem\u003eJ Biomed Mater Res B Appl Biomater.\u003c/em\u003e 2019;107:2121\u0026ndash;2131. doi: 10.1002/jbm.b.34305.\u003c/li\u003e\n\u003cli\u003eVyas VK, et al. Destructive and non-destructive behavior of nickel oxide doped bioactive glass and glass-ceramic. \u003cem\u003eJ Aust Ceram Soc.\u003c/em\u003e 2017;53:939\u0026ndash;951. doi: 10.1007/s41779-017-0110-2.\u003c/li\u003e\n\u003cli\u003eLefebvre L, et al. Structural transformations of bioactive glass 45S5 with thermal treatments. \u003cem\u003eActa Mater.\u003c/em\u003e2007;55:3305\u0026ndash;3313. doi: 10.1002/(SICI)1097-4636(199604)30:4\u0026lt;509::AID-JBM9\u0026gt;3.0.CO;2-T.\u003c/li\u003e\n\u003cli\u003eRavarian R, et al. Synthesis, characterization and bioactivity investigation of bioglass/hydroxyapatite composite. \u003cem\u003eCeram Int.\u003c/em\u003e 2010;36:291\u0026ndash;297. doi: 10.1016/j.ceramint.2009.09.016.\u003c/li\u003e\n\u003cli\u003ePrasad PP, et al. A Review on Understanding the Crystallization Process of Bioglass in Recent Decade. \u003cem\u003eJ Mines Metals Fuels.\u003c/em\u003e 2022;70:444\u0026ndash;449. doi: 10.18311/jmmf/2022/32022.\u003c/li\u003e\n\u003cli\u003eTilocca A, Cormack AN. The initial stages of bioglass dissolution: a Car\u0026ndash;Parrinello molecular-dynamics study of the glass\u0026ndash;water interface. \u003cem\u003eProc R Soc A.\u003c/em\u003e 2011;467:2102\u0026ndash;211. doi: 10.1098/rspa.2010.0519.\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-oral-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"ohea","sideBox":"Learn more about [BMC Oral Health](http://bmcoralhealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/ohea/default.aspx","title":"BMC Oral Health","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"bond strength, remineralization, universal adhesive","lastPublishedDoi":"10.21203/rs.3.rs-5898469/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-5898469/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003ePhosphosilicate-based bioactive glasses (BGs) are promising remineralization materials due to their bioactivity, which could enhance the dentin adhesive interface. This study aimed to evaluate the immediate and 12-month effects of a BG-containing primer (BG-primer) on the biomechanical and ultrastructural properties of dentin bonding using two adhesive strategies. Experimental groups (n\u0026thinsp;=\u0026thinsp;5) applied BG-primer before either an etch-and-rinse (ER) or self-etch (SE) adhesive strategy on third molar dentin, while controls used ER/SE without BG-primer. Specimens were subjected to micro-tensile bond strength (\u0026micro;TBS) testing immediately and after 12 months. Data were analyzed using two-way ANOVA and Tukey's test (α\u0026thinsp;=\u0026thinsp;0.05). SEM was used to evaluate nanoleakage (NL) and BG-primer localization, while ATR-FTIR spectroscopy analyzed BG in dry conditions, immediate hydration, and after six hours. BG-primer significantly increased \u0026micro;TBS at 12 months (p\u0026thinsp;\u0026lt;\u0026thinsp;0.05) without affecting NL. BG particles colocalized near the hybrid layer, maintaining its structural integrity. ATR-FTIR revealed hydration-induced modifications in BG, persisting after six hours. The BG-primer improved long-term adhesive performance in SE systems and stabilized the ER interface without compromising immediate bonding. BG reactivity and ion release (calcium, silicon, phosphate) likely explain the enhanced biomechanical behavior of the adhesive interface.\u003c/p\u003e","manuscriptTitle":"Long-term adhesive interface stability and ultra-structural properties by phosphosilicate-based bioactive glass primer","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-03-07 11:40:19","doi":"10.21203/rs.3.rs-5898469/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2025-03-25T07:17:46+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-03-24T19:36:27+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"157891912276906629421960138360481711551","date":"2025-03-14T15:50:05+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-02-24T03:13:23+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"220644600978954234000186783733716178248","date":"2025-02-22T07:42:33+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"163247436102029133952369688797727670245","date":"2025-02-17T01:45:35+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2025-02-15T05:36:56+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2025-01-31T05:42:59+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-01-30T05:55:59+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-01-29T14:43:26+00:00","index":"","fulltext":""},{"type":"submitted","content":"BMC Oral Health","date":"2025-01-29T14:42:15+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-oral-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"ohea","sideBox":"Learn more about [BMC Oral Health](http://bmcoralhealth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/ohea/default.aspx","title":"BMC Oral Health","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"37a309f1-c3cf-492b-b38c-b6accb8ba96b","owner":[],"postedDate":"March 7th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2025-12-22T16:02:09+00:00","versionOfRecord":{"articleIdentity":"rs-5898469","link":"https://doi.org/10.1186/s12903-025-07399-9","journal":{"identity":"bmc-oral-health","isVorOnly":false,"title":"BMC Oral Health"},"publishedOn":"2025-12-17 15:57:54","publishedOnDateReadable":"December 17th, 2025"},"versionCreatedAt":"2025-03-07 11:40:19","video":"","vorDoi":"10.1186/s12903-025-07399-9","vorDoiUrl":"https://doi.org/10.1186/s12903-025-07399-9","workflowStages":[]},"version":"v1","identity":"rs-5898469","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-5898469","identity":"rs-5898469","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}