Supplementary Information from Mathematical modelling of macrophage and natural killer cell immune response during early stages of peritoneal endometriosis lesion onset
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This supplementary information details parameter tables, parameter estimation, steady-state analysis, immune dysfunction results, bifurcation diagrams, and analysis of a modified macrophage system relevant to modeling peritoneal endometriosis.
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Abstract
The Supplementary Information file contains six sections, as follows. Section S1: The parameter and initial conditions tables containing the default values for the model parameters. Section S2: A description of the approach used to determine parameters that were not taken directly from previous modelling or experimental literature. Section S3: Steady state analysis of the ODE system, which details the analysis behind Equation (11) in the main manuscript. Section S4: Results for the immune dysfunction investigation with varying endometrial cell attachment rate. Section S5: The bifurcation diagrams which provide the basis for the disease transition plots in Figure 6 of the main manuscript. Section S6: Analysis for a modified system that incorporates upregulation of M2-type macrophages by attached endometrial cells.
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