Subcellular distribution and selectivity of the protein-binding component of the recognition system for sex-hormone-binding protein-estradiol complex in human decidual endometrium

G.V. Avvakumov; Natalja I. Zhuk; Oleg A. Strel'chyonok

doi:10.1016/0304-4165(86)90043-7

Subcellular distribution and selectivity of the protein-binding component of the recognition system for sex-hormone-binding protein-estradiol complex in human decidual endometrium

G.V. Avvakumov, Natalja I. Zhuk, Oleg A. Strel'chyonok

In: Biochimica et Biophysica Acta (BBA) - General Subjects · 1986 · vol. 881(3) , pp. 489–498 · doi:10.1016/0304-4165(86)90043-7 · PMID:3697379 · W2023982157

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Researchers investigated the subcellular localization and selectivity of the protein-binding component responsible for recognizing the sex hormone-binding globulin-estradiol complex within human decidual endometrium.

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Abstract

In order to assess the subcellular distribution of the protein-binding component of the recognition system for sex-hormone-binding protein-estradiol complex (Strel'chyonok, O.A., Avvakumov, G.V. and Survilo, L.I. (1984) Biochim. Biophys. Acta 802, 459-466), plasma membranes and other subcellular fractions were prepared from homogenate of human decidual endometrium (8-12 weeks of pregnancy). Specific binding of 125I-labeled sex-hormone-binding protein complexed with estradiol was found preferentially in the plasma membrane fraction. The protein-binding component of the recognition system was found to specifically bind sex-hormone-binding protein complexed with estrogens (estradiol, estriol, estrone, with close affinities) but not with androgens (testosterone and 5 alpha-dihydrotestosterone). Specific membrane binding of 125I-labeled sex-hormone-binding protein complexed with 17 alpha-pregna-2,4-dien-20-yn-[2,3-d]isoxazol-17-ol (danazol) was also detected. This allowed us to suggest a putative mechanism for the danazol pharmacological action on endometrium which involves the interaction of the steroid-protein complex with the plasma membrane of endometrial cells. It is proposed that sex-hormone-binding protein takes part in the guided transport of steroids into endometrial cells.

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References (26)

Danazol and gestagen displacement of testosterone and influence on sex-hormone-binding globulin capacity via openalex
Danazol and its principal metabolites interfere with binding of testosterone, cortisol, and thyroxin by plasma proteins. via openalex
Danazol and its principal metabolites interfere with binding of testosterone, cortisol, and thyroxin by plasma proteins. via openalex
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SciLite annotations

chemicals 13

estradiol estradiol estradiol estrone estradiol estriol estrone androgen testosterone danazol danazol steroid steroid

organisms 2

human human

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scilite: last seen: 2026-05-18T04:26:01.642840+00:00

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[1] Danazol and gestagen displacement of testosterone and influence on sex-hormone-binding globulin capacity 1982

[2] Danazol and its principal metabolites interfere with binding of testosterone, cortisol, and thyroxin by plasma proteins. 1982

[3] Danazol and its principal metabolites interfere with binding of testosterone, cortisol, and thyroxin by plasma proteins. 1982