Multimodal imaging and photothermal/chemodynamic therapy of cervical cancer using GSH-responsive nanoparticles

The development of nanoparticles capable of inducing reactive oxygen species(ROS) formation has become an important strategy for cancer therapy. Simultaneously, the preparation of multifunctional nanoparticles that respond to the tumor microenvironment is crucial for the diagnosis and treatment of tumors. In this study, we designed a MoS 2 core coated with MnO 2 , which possessed a good photothermal effect and could produce Fenton-like Mn 2+ in response to highly expressed glutathione (GSH) in the tumor microenvironment, thereby generating a chemodynamic therapy (CDT). The nanoparticles were further modified with mPEG-NH 2 to improve their biocompatibility, resulting in the formation of MoS 2 @MnO 2 -PEG. These nanoparticles were shown to possess significant MRI and CT imaging capabilities, making them useful in tumor diagnosis. In vitro and in vivo experiments demonstrated the anti-tumor ability of MoS 2 @MnO 2 -PEG, with a significant killing effect on tumor cells under combined treatment. These nanoparticles hold great potential for CDT/PTT combined antitumor therapy and could be further explored in biomedical research.