〈Cases Reports〉 Severe endometriosis treated with long-term GnRHa : case report

Y Kotani; Mitsuru Shiota; Masahiko Umemoto; Takako Tobiume; Koshiro Obata; Hiroshi Hoshiai

〈Cases Reports〉 Severe endometriosis treated with long-term GnRHa : case report

Y Kotani, Mitsuru Shiota, Masahiko Umemoto, Takako Tobiume, Koshiro Obata, Hiroshi Hoshiai

In: Acta Medica · 2012 · vol. 37(2) , pp. 99–101 · W584240717

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This case report describes a patient with severe endometriosis who received long-term gonadotropin-releasing hormone agonist (GnRHa) therapy for 13 years post-surgery without observed side effects.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-11 · read from full text ⓘ

This 2012 case report describes a 37-year-old G0P0 woman with severe endometriosis who underwent a colostomy for ileus of sigmoid colon and rectal endometriosis at age 21, followed by total abdominal hysterectomy, chocolate cystectomy, and partial rectectomy at age 22. After ovarian endometrioma recurrence and development of ureteral endometriosis, she received gonadotrophin-releasing hormone agonist (GnRHa) therapy and remained on continuous treatment for 13 years; the report states that decreased bone mineral density and menopausal syndrome were not observed during this period. The paper notes that GnRHa is generally rarely used for long durations because of side effects, and that ongoing monitoring and dose adjustment were used in this case. This paper is centrally about endometriosis — it reports long-term GnRHa treatment in a single patient with severe endometriosis.

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- Integration of CiNii Books functions for fiscal year 2025 has completed - Trial version of CiNii Research Knowledge Graph Search feature is available on CiNii Labs - 【Updated on November 26, 2025】Regarding the recording of “Research Data” and “Evidence Data” - Start the collection of all publicly IRDB content - Incorporate Research Data from KAKEN Severe endometriosis treated with long-term GnRHa : case report Bibliographic Information - Published - 2012-12-01 - Resource Type - departmental bulletin paper - Publisher - Kinki University Medical Association Search this article Description [Abstract] Gonadotrophin-releasing hormone agonist (GnRHa) therapy for endometriosis is rarely used for long periods of time because it leads to decreased bone density and menopausal syndrome. Here, we describe a patient with severe endometriosis who underwent a colostomy and hysterectomy at a young age and has been on GnRHa therapy for 13 years since the surgery. The patient is a 37-year-old G0P0 woman who underwent a colostomy for ileus of the sigmoid colon and rectal endometriosis at the age of 21 years. At the age of 22 years, she underwent total abdominal hysterectomy, chocolate cystectomy, and partial rectectomy. After the surgery, her ovarian endometrioma recurred and ureteral endometriosis developed. She was then started on GnRHa therapy and has been on continuous therapy for 13 years up to the present. Side effects as such as decreased bone mineral density and menopausal syndrome have not been observed. Although GnRHa therapy is generally not used chronically because of its side effects, it has been possible to use it in this patient over a long period of time by ongoing monitoring for the development of deleterious side effects and adjusting the dose as needed. Journal - - ACTA MEDICA KINKI UNIVERSITY - ACTA MEDICA KINKI UNIVERSITY 37 (2), 99-101, 2012-12-01 Kinki University Medical Association Details 詳細情報について - - CRID - 1050282677521981824 - - NII Article ID - 120005736847 - - ISSN - 03866092 - - Text Lang - en - - Article Type - departmental bulletin paper - - Data Source - - IRDB - CiNii Articles

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