Is Single Nucleotide Polymorphism ADIPOQ (NM_004797.4):c.214+62G>T (rs1501299) Associated With Uterine Leiomyomas? A Pilot Study

Jan Bieńkiewicz, Beata Smolarz, Miłosz Wilczyński, Anna Stepowicz, Grzegorz Jabłoński, Anna Obłękowska, Andrzej Malinowski, Hanna Romanowicz
In: Pathology and Oncology Research · 2022 · vol. 27 , pp. 1609966 · doi:10.3389/pore.2021.1609966 · PMID:35250389 · W4213087119
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This pilot study investigated the association between ADIPOQ SNP rs1501299 and uterine leiomyomas, finding no statistically significant correlation between allele/genotype distributions and fibroid risk in the studied groups.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This pilot case-control genetic study assessed whether allele and genotype frequencies of the adiponectin gene SNP ADIPOQ (NM_004797.4):c.214+62G>T (rs1501299) are associated with uterine leiomyomas, comparing 90 women surgically treated for uterine fibroids to 90 BMI- and age-matched disease-free controls. Genotyping was performed using PCR-RFLP, and analyses additionally stratified participants into lean, overweight, and obese groups based on BMI. The study found no statistically significant differences in allele or genotype distributions between the leiomyoma group and controls, with only a weak within-stratum correlation for allele distributions between obese test patients and lean controls. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Objective: Although polymorphisms of adiponectin gene ( ADIPOQ ) in obesity-related conditions have been the target of research efforts, little is known about this genetic marker in uterine leiomyomas. The aim of this pilot study was to analyze the frequencies of alleles and genotypes of Single Nucleotide Polymorphism ADIPOQ (NM_004797.4):c.214+62G>T (rs1501299) and to correlate it with the risk of uterine fibroids. Study Design: The Test Group comprised 90 women treated surgically for uterine leiomyomas in the Department of Operative Gynecology, Endoscopy and Gynecologic Oncology, Polish Mother’s Memorial Hospital-Research Institute. 90 disease-free individuals were used as Controls. Patients within both groups were additionally stratified into lean, overweight and obese, according to Body Mass Index. Statistical analysis was performed between the two major groups and, furthermore, within the abovementioned subgroups. Results: The study revealed no statistically significant differences in the distribution of alleles and genotypes of SNP ADIPOQ (NM_004797.4):c.214+62G>T (rs1501299) between the two main groups. A weak correlation within distributions of alleles was observed between obese Test Patients and lean Controls. Conclusion: This pilot study has revealed no association between SNP ADIPOQ (NM_004797.4):c.214+62G>T (rs1501299) and uterine fibroids. Further studies on larger groups are warranted to elucidate whether this SNP may be correlated with uterine leiomyomas.

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