Physical Inactivity and Quality of Life in Frail Dialysis Patients

Physical Inactivity and Quality of Life in Frail Dialysis Patients | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Physical Inactivity and Quality of Life in Frail Dialysis Patients Rafaella Karolyni Batista dos Santos, Jéssica Fontes Floresta, and 8 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7648103/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 4 You are reading this latest preprint version Abstract Background Chronic kidney disease (CKD) leads to progressive kidney function decline, predisposing patients to frailty and reduced quality of life. Regular physical activity can benefit those undergoing renal replacement therapy. Objectives To evaluate the impact of physical activity on frailty and quality of life in CKD patients undergoing hemodialysis. Methods A cross-sectional, descriptive study with 64 CKD patients undergoing hemodialysis. Frailty was assessed using handgrip dynamometry, the 10-meter walk test, self-reported weight loss, and the International Physical Activity Questionnaire. Quality of life was measured using the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). Results The study identified 41 patients as pre-frail, 20 as frail, and 1 as non-frail. In comparing the frail and pre-frail groups, both exhibited a decline in quality of life. Significant differences were found between the groups in the physical, mental health, and overall domains, with the frail group showing worse outcomes. Additionally, both groups exhibited reduced levels of physical activity. Conclusions CKD patients undergoing hemodialysis demonstrate low levels of physical activity, frailty, and impaired quality of life. Chronic Kidney Disease Renal Dialysis Exercise Health Research Policy Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Review Version 1 posted Reviewers invited by journal 07 Apr, 2026 Editor assigned by journal 19 Sep, 2025 Submission checks completed at journal 19 Sep, 2025 First submitted to journal 18 Sep, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7648103","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":620779083,"identity":"9e5c8d2d-ff73-4f35-90e2-4e892181151f","order_by":0,"name":"Rafaella Karolyni Batista dos 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Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"Chronic Kidney Disease, Renal Dialysis, Exercise, Health Research Policy","lastPublishedDoi":"10.21203/rs.3.rs-7648103/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7648103/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground \u003c/strong\u003eChronic kidney disease (CKD) leads to progressive kidney function decline, predisposing patients to frailty and reduced quality of life. Regular physical activity can benefit those undergoing renal replacement therapy.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eObjectives \u003c/strong\u003eTo evaluate the impact of physical activity on frailty and quality of life in CKD patients undergoing hemodialysis.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods \u003c/strong\u003eA cross-sectional, descriptive study with 64 CKD patients undergoing hemodialysis. Frailty was assessed using handgrip dynamometry, the 10-meter walk test, self-reported weight loss, and the International Physical Activity Questionnaire. Quality of life was measured using the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults \u003c/strong\u003eThe study identified 41 patients as pre-frail, 20 as frail, and 1 as non-frail. In comparing the frail and pre-frail groups, both exhibited a decline in quality of life. Significant differences were found between the groups in the physical, mental health, and overall domains, with the frail group showing worse outcomes. Additionally, both groups exhibited reduced levels of physical activity.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions \u003c/strong\u003eCKD patients undergoing hemodialysis demonstrate low levels of physical activity, frailty, and impaired quality of life.\u003c/p\u003e","manuscriptTitle":"Physical Inactivity and Quality of Life in Frail Dialysis Patients","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-04-14 23:48:45","doi":"10.21203/rs.3.rs-7648103/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"reviewersInvited","content":"","date":"2026-04-07T19:47:05+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-09-19T09:02:16+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-09-19T08:59:35+00:00","index":"","fulltext":""},{"type":"submitted","content":"Sport Sciences for Health","date":"2025-09-18T09:46:38+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"sport-sciences-for-health","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"ssfh","sideBox":"Learn more about [Sport Sciences for Health](http://link.springer.com/journal/11332)","snPcode":"11332","submissionUrl":"https://submission.nature.com/new-submission/11332/3","title":"Sport Sciences for Health","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"40d991c9-9f13-420e-afb7-b2bc24e96a5e","owner":[],"postedDate":"April 14th, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[],"tags":[],"updatedAt":"2026-04-14T23:48:45+00:00","versionOfRecord":[],"versionCreatedAt":"2026-04-14 23:48:45","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7648103","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7648103","identity":"rs-7648103","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}