Effect of monoclonal antibody to integrin аvβ3 on adherent ability of eutopic endometrium cells in women with ndometriosis

AIM: To explore the effect of monoclonal antibody to integrin avβ3 on the adherent ability of eutopic endometrium cells in women with endometriosis. METHODS: The cells from eutopic endometrium of women with endometriosis were cultured in 96-well plates. The effect of Lm609 and 7E3, two monoclonal antibodies to integrin avβ3, on the adherent ability of endometrium cells at different concentrations was examined with the MTT assay. The experiments at each concentration were repeated three times for each case. RESULTS: The monoclonal antibody to integrin avβ3 had greater effects on the adherent ability of eutopic endometrium cells in the experimental groups than those in the control group, with no significant difference between different concentrations. CONCLUSION: Lm609 and 7E3, the monoclonal antibodies to integrin avβ3, can inhibit the adherent ability of endometrium cells and may thus inhibit the formation of endometriosis.