Might uterus transplantation be an option for uterine factor infertility?

Akar ME
Journal of the Turkish German Gynecological Association · 2015 · doi:10.5152/jtgga.2015.15107 · PMID:25788850 · PMC4358312
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This review summarizes fifteen years of uterus allotransplantation research, noting significant progress in animal models and human cases while acknowledging remaining questions before clinical application for uterine factor infertility.

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This review summarizes fifteen years of progress in uterus allotransplantation research, noting that the technique has become better defined and successful pregnancies have been reported in both rat models and humans. Despite these advances, the authors highlight that numerous unanswered questions remain regarding safety and efficacy before clinical application can be widely adopted. Consequently, gestational surrogacy continues to serve as a primary treatment option for genetic parenthood in cases of uterine factor infertility. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

Current data on uterus allotransplantation research has been reviewed and summarized. Over the past 15 years, progress in uterus transplantation research has increased dramatically. As a consequence, the first pregnancy and delivery following uterus allotransplantation in rats have been reported. The technique has been better defined. Although clinical pregnancy and delivery following uterus allotransplantation has been reported in humans, there are still many questions to be answered before clinical application. Gestational surrogacy still remains an important option for being a genetic parent in selected cases with uterine factor infertility.
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ABSTRACT Current data on uterus allotransplantation research has been reviewed and summarized. Over the past 15 years, progress in uterus transplantation research has increased dramatically. As a consequence, the first pregnancy and delivery following uterus allotransplantation in rats have been reported. The technique has been better defined. Although clinical pregnancy and delivery following uterus allotransplantation has been reported in humans, there are still many questions to be answered before clinical application. Gestational surrogacy still remains an important option for being a genetic parent in selected cases with uterine factor infertility. Turkish Uterus transplantasyonu uterin faktöre bagli infertilitede tedavi secenegi olabilir mi? Uterus transplantasyon arastirmalari ile ilgili guncel literatur gozden gecirilip, ozetlendi. Son yillarda uterus transplantasyonu arastirmalarinda buyuk ve onemli gelismeler sonucunda, sicanda uterus allotransplantasyonu sonrasi ilk gebelik ve dogum bildirildi. Transplantasyon teknigi daha iyi tanimlandi. Insanda da uterus allotransplantasyonu sonrasi gebelik ve dogum bildirilmis olmasina ragmen, klinik uygulama oncesi halen cevaplanmasi gereken bircok soru mevcuttur. Secilmis uterin faktor infertilite vakalarinda , tasiyici annelik halen onemli bir tedavi secenegi olmaya devam etmektedir.

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