Sister Joseph umbilical nodule coexisting with endometriosis from endometrial carcinoma

Ikeda S, Shun-ichi Ikeda, Shun‐ichi Ikeda, Masazumi Yajima, Yajima M, Hida K, Kazuhide Hida, Hattori M, Minako Hattori, Shimizu S, Shoko Shimizu, Umezaki I, Izumi Umezaki, Nishikawa T, Toshio Nishikawa, Hiroaki Ohta, Ohta H
Archives of gynecology and obstetrics · 2005 · vol. 273(4) , pp. 250–252 · doi:10.1007/s00404-005-0043-9 · PMID:16096837 · W2006311833
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This case report details an endometrial carcinoma patient whose umbilical nodule and pelvic lymph nodes were metastatic lesions containing endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-12 · read from full text ⓘ

This case report describes a 58-year-old woman diagnosed with endometrial carcinoma who underwent total hysterectomy, bilateral salpingo-oophorectomy, and pelvic plus paraaortic lymph node dissection, with negative peritoneal fluid cytology and no peritoneal dissemination aside from an umbilical nodule. A 2.0×1.5 cm Sister Joseph’s nodule was resected and found to be endometrial cancer metastasis that coexisted with endometriosis, and pelvic lymph nodes also contained metastatic lesions with endometriosis. The authors conclude that endometriosis can be present within metastatic sites and suggest that lymphatic spread to the umbilicus from endometrial cancer may share mechanisms with those involved in endometriosis, while noting the limitation inherent to a single-patient report. This paper is centrally about endometriosis — it reports endometriosis coexisting with an umbilical Sister Joseph’s nodule and pelvic lymph node metastases arising from endometrial carcinoma.

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Abstract

A 58-year-old woman was diagnosed with endometrial carcinoma. Total hysterectomy, bilateral salpingo-oophorectomy and paraaortic and a pelvic lymph node dissection were performed. The cytology of peritoneal fluid was negative. There was no peritoneal dissemination except umbilical nodule. A peritoneal 2.0x1.5 cm umbilical nodule was also resected. The nodule was identified as a metastasis from endometrial cancer with endometriosis. The pelvic lymph nodes also showed metastatic lesion with endometriosis. Our case showed that endometriosis coexisted with umbilical and pelvic lymph nodal metastatic lesions from endometrial cancer. This fact suggests that the mode of metastasis to the umbilicus via lymph flow from endometrial cancer is the same as that for endometriosis.
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Abstract

A 58-year-old woman was diagnosed with endometrial carcinoma. Total hysterectomy, bilateral salpingo-oophorectomy and paraaortic and a pelvic lymph node dissection were performed. The cytology of peritoneal fluid was negative. There was no peritoneal dissemination except umbilical nodule. A peritoneal 2.0×1.5 cm umbilical nodule was also resected. The nodule was identified as a metastasis from endometrial cancer with endometriosis. The pelvic lymph nodes also showed metastatic lesion with endometriosis. Our case showed that endometriosis coexisted with umbilical and pelvic lymph nodal metastatic lesions from endometrial cancer. This fact suggests that the mode of metastasis to the umbilicus via lymph flow from endometrial cancer is the same as that for endometriosis.

References

Schwartz IS (1987) Sister (Mary?) Joseph’s nodule. N Engl J Med 316:1348–1349 Barrow MV (1966) Metastatic tumours of the umbilicus. J Chronic Dis 19:1113–1117 Galvan V (1999) Sister Mary Joseph’s nodule: its clinical significance and management. An Med Interna 16:1949–1950 Ching AS, Lai CW (2002) Sonography of umbilical metastasis (Sister Mary Joseph’s nodule): from embryology to imaging. Abdom Imaging 27:746–749 Reingold IM (1966) Cutaneous metastases from internal carcinoma. Cancer 19:162–168 Insabato L, Pettinato G (1996) Endometriosis of the bowel with lymph node involvement. A report of three cases and review of the literature. Pathol Res Pract 192(9):957–961 Horn LC, Bilek K (1995) Frequency and histogenesis of pelvic retroperitoneal lymph node inclusions of the female genital tract. An immunohistochemical study of 34 cases. Pathol Res Pract 191(10):991–996 Brodland DG, Zitelli JA (1992) Mechanisms of metastasis. J Am Acad Dermatol 27:1–8 Sugarbaker PH (2001) Sister Mary Joseph’s sign. J Am Coll Surg 193(2):339–340 Majrmudar B, Wiskind AK, Croft BN, Dudley AG (1991) The Sister (Mary) Joseph nodule: its significance in gynecology. Gynecol Oncol 40:152–159 Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Ikeda, Si., Yajima, M., Hida, K. et al. Sister Joseph umbilical nodule coexisting with endometriosis from endometrial carcinoma. Arch Gynecol Obstet 273, 250–252 (2006). https://doi.org/10.1007/s00404-005-0043-9 Received: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s00404-005-0043-9

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma Endometrial Neoplasms Endometriosis Umbilicus Adenocarcinoma Adenocarcinoma Adenocarcinoma Endometrial Neoplasms Endometrial Neoplasms Endometriosis Female Humans Middle Aged Umbilicus

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