Gamma secretase inhibition reveals a possible crosstalk of LIFR, SOX2 and PODXL with the Notch-Msi1 signaling pathway in primary endometriotic cells.

This conference abstract investigates the molecular mechanisms within primary endometriotic cells by employing gamma secretase inhibition to probe signaling pathways. The researchers identified a potential crosstalk involving LIFR, SOX2, and PODXL with the Notch-Msi1 signaling axis under these experimental conditions. While the study highlights specific protein interactions in endometriosis cell lines, it is presented as a preliminary finding without detailed clinical or therapeutic outcomes. This paper is centrally about endometriosis — specifically exploring intracellular signaling pathways in primary endometriotic cells.

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