Progress in Diagnosis and Treatment on Ovarian Clear Cell Adenocarcinoma

Ovarian clear cell adenocarcinoma(OCCA) is uncommon histotype in epithelial ovarian cancer,which is characterised by its association with endometriosis,and frequent mutations of ARID1A and PIK3CA.Patients in early stage amount for high proportion,and clinical manifestation of OCCA has no specifity.Morphology of cells in ascites,tumor marker and iconography are helpful to diagnosis before surgery.The treatment of OCCA mainly includes comprehensive staging surgery and combined chemotherapy such as paclitaxel,platinum,irinotecan,mitomycin and etoposide etc.Clinical stage,size of residual tumor,state of cytology of ascites could affect the prognosis of the patients.