CLINICAL ASPECTS OF BLADDER ENDOMETRIOSIS: OVERVIEW OF CURRENT DATA

1. Rusina E.I., YArmolinskaya M.I, P'yankova V.O., Glubokij infil'trativnyj endometrioz [Deep infiltrative endometriosis]. Spornye voprosy: za i protiv [Controversial issues: pros and cons]. Ginekologiya [Gynecology]. 2020. Vol. 22, no. 5. pp. 51-65. DOI: 10.26442/20795696.2020.5.200274. 2. YArmolinskaya M.I., Florova M.S. Vozmozhnosti terapii dienogestom 2 mg u bol'nyh naruzhnym genital'nym endometriozom [Possibilities of dienogest 2 mg therapy in patients with external genital endometriosis]. Problemy reprodukcii [Reproduction problems]. 2017; 23 (1): 70–9. DOI: 10.17116/re pro201723170-79. 3. Bafort C. et al. Laparoscopic surgery for endometriosis. Cochrane Database of Systematic Reviews. 2020. no. 10. 4. Borghese G. et al. Preoperative ureteral stenting in women with deep posterior endometriosis and ureteral involvement: Is it useful? International Journal of Gynecology & Obstetrics. 2022. Vol. 158. No. 1. Pp. 179-186. 5. Buggio L. et al. Oral and depot progestin therapy for endometriosis: towards a personalized medicine. Expert Opinion on Pharmacotherapy. 2017. Vol. 18. No. 15. Pp. 1569-1581. 6. Chauhan S. et al. Endometriosis: a review of clinical diagnosis, treatment, and pathogenesis. Cureus. 2022. Vol. 14. No. 9. https://doi.org/10.7759/cureus.28864. 7. Collinet P. et al. Management of endometriosis: CNGOF-HAS practice guidelines (short version). Gynecologie, Obstetrique, Fertilite & Senologie. 2018. Vol. 46. No. 3. Pp. 144-155. doi: 10.1016/j.gofs.2018.02.027. 8. Comptour A. et al. Identification of predictive factors in endometriosis for improvement in patient quality of life. Journal of Minimally Invasive Gynecology. 2020. Vol. 27. No. 3. Pp. 712-720. DOI: 10.1016/j.jmig.2019.05.013. 9. Condous G. et al. Non-invasive imaging techniques for diagnosis of pelvic deep endometriosis and endometriosis classification systems: An International Consensus Statement. Human Reproduction Open. 2024. Vol. 2024. No. 3. P. hoae029. https://doi.org/10.1093/hropen/hoae029. 10. D’Alterio M.N. et al. Management challenges of deep infiltrating endometriosis. International journal of fertility & sterility. 2021. Vol. 15. No. 2. P. 88. https://doi.org/10.22074/IJFS.2020.134689. 11. Darwish B. et al. Surgical outcomes of urinary tract deep infiltrating endometriosis. Journal of Minimally Invasive Gynecology. 2017. Vol. 24. No. 6. Pp. 998-1006. https://doi.org/10.1016/j.jmig.2017.06.005. 12. Edi R., Cheng T. Endometriosis: evaluation and treatment. American family physician. 2022. Vol. 106. No. 4. Pp. 397-404. 13. Ferrero S., Evangelisti G., Barra F. Current and emerging treatment options for endometriosis. Expert opinion on pharmacotherapy. 2018. Vol. 19. No. 10. Pp. 1109-1125. DOI: 10.1080/14656566.2018.1494154. 14. Ferrero S., Barra F., Leone Roberti Maggiore U. Current and emerging therapeutics for the management of endometriosis. Drugs. 2018. Vol. 78. No. 10. Pp. 995-1012. https://doi.org/10.1007/s40265-018-0928-0. 15. Gonçalves D.R. et al. Endometriosis of the bladder: Clinical and surgical outcomes after laparoscopic surgery. Surg Technol Int. 2019. Vol. 34. Pp. 275-281. 16. Horne A.W. et al. Surgical removal of superficial peritoneal endometriosis for managing women with chronic pelvic pain: time for a rethink? Bjog. 2019. Vol. 126. No. 12. P. 1414. 17. Ianieri M.M., Mautone D., Ceccaroni M. Recurrence in deep infiltrating endometriosis: a systematic review of the literature. Journal of minimally invasive gynecology. 2018. Vol. 25. No. 5. Pp. 786-793. DOI: 10.1016/j.jmig.2017.12.025. 18. Kanto A. et al. A case report of bladder and intestinal endometriosis, and the relationship between sex hormone receptor expression and PIK3CA mutation analysis. BMC Women's Health. 2021. Vol. 21. Pp. 1-5. https://doi.org/10.1186/s12905-021-01269-6. 19. Kalaitzopoulos D.R. et al. Treatment of endometriosis: a review with comparison of 8 guidelines. BMC women's health. 2021. Vol. 21. Pp. 1-9. DOI: 10.1186/s12905-021-01545-5. 20. Kim J. et al. Effects of hormone therapy on the clinical outcomes of endoscopic intervention in patients with endometriosis-related ureteral obstruction. Investigative and Clinical Urology. 2022. Vol. 64. No. 1. P. 13. https://doi.org/10.4111/icu.20220224. 21. Leonardi M. et al. Endometriosis and the urinary tract: from diagnosis to surgical treatment. Diagnostics. 2020. Vol. 10. No. 10. P. 771. DOI: 10.3390/diagnostics10100771. 22. Maggiore U.L.R. et al. Bladder endometriosis: a systematic review of pathogenesis, diagnosis, treatment, impact on fertility, and risk of malignant transformation. European urology. 2017. Vol. 71. No. 5. Pp. 790-807. https://doi.org/10.1016/j.eururo.2016.12.015. 23. Maccagnano C. et al. Diagnosis and treatment of bladder endometriosis: state of the art. Urologia internationalis. 2012. Vol. 89. No. 3. Pp. 249-258. doi:10.1159/000339519. 24. National Guideline Alliance (UK). (2017). Endometriosis: diagnosis and management. National Institute for Health and Care Excellence (NICE). 25. Nirgianakis K. et al. Effectiveness of dietary interventions in the treatment of endometriosis: a systematic review. Reproductive sciences. 2022. Pp. 1-17. https://doi.org/10.1007/ s43032-020-00418-w. 26. Osuga Y. et al. Relugolix, an oral gonadotropin-releasing hormone (GnRH) receptor antagonist, in women with endometriosis (EM)-associated pain: phase 2 safety and efficacy 24-week results. Endocrine Abstracts. Bioscientifica, 2017. Vol. 49. 27. Piriyev E., Schiermeier S., Römer T. Laparoscopic approach in bladder endometriosis, intraoperative and postoperative outcomes. in vivo. 2023. Vol. 37. No. 1. Pp. 357-365. https://doi.org/10.21873/invivo.13086. 28. Restaino S. et al. Robotic surgery vs laparoscopic surgery in patients with diagnosis of endometriosis: a systematic review and meta-analysis. Journal of Robotic Surgery. 2020. Vol. 14. Pp. 687-694. 29. Saccardi C., Vitagliano A., Litta P. Bladder endometriosis: a summary of current evidence. Minerva Ginecologica. 2017. Vol. 69. No. 5. Pp. 468-476. 30. Shah P. et al. Bladder endometriosis: management by cystoscopic and laparoscopic approaches. Journal of Minimally Invasive Gynecology. 2019. Vol. 26. No. 5. Pp. 807-808. https://doi.org/10.1016/j.jmig.2018.09.782. 31. Sherman A.K., MacLachlan L.S. A review of urinary tract endometriosis. Current Urology Reports. 2022. Vol. 23. No. 10. Pp. 219-223. https://doi.org/10.1007/s11934-022-01107-8. 32. Song S.Y. et al. Efficacy of levonorgestrel releasing intrauterine system as a postoperative maintenance therapy of endometriosis: A meta-analysis. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2018. Vol. 231. Pp. 85-92. 33. Supermainam S., Koh E.T. Laparoscopic partial bladder cystectomy for bladder endometriosis: a combined cystoscopic and laparoscopic approach. Journal of Minimally Invasive Gynecology. 2020. Vol. 27. No. 3. Pp. 575-576. https://doi.org/10.1016/j.jmig.2019.06.020. 34. Taylor H.S. et al. An evidence‐based approach to assessing surgical versus clinical diagnosis of symptomatic endometriosis. International Journal of Gynecology & Obstetrics. 2018. Vol. 142. No. 2. Pp. 131-142. DOI: 10.1002/ijgo.12521. 35. Tomasi M.C. et al. Symptoms and surgical technique of bladder endometriosis: a systematic review. Journal of Minimally Invasive Gynecology. 2022. Vol. 29. No. 12. Pp. 1294-1302. DOI: 10.1016/j.jmig.2022.10.003. 36. Topdağı Yılmaz E.P. et al. Management of patients with urinary tract endometriosis by gynecologists. Journal of the Turkish German Gynecological Association. 2021. Vol. 2. Pp. 112-119. https://doi.org/10.4274/jtgga.galenos.2020.2020.0054. 37. Trigui M. et al. Bladder endometriosis: A serious disease. Urology Case Reports. 2023. Vol. 48. P. 102400.https://doi.org/10.1016/j.eucr.2023.102400. 38. Vercellini P. et al. “We Can Work It Out:” The Hundred Years' War between Experts of Surgical and Medical Treatment for Symptomatic Deep Endometriosis. Journal of Minimally Invasive Gynecology. 2018. Vol. 25. No. 3. Pp. 356-359. DOI: 10.1016/j.jmig.2017.09.026. 39. Westney O.L., Amundsen C.L., Mcguire E.J. Bladder endometriosis: conservative management. The Journal of urology. 2000. Vol. 163. No. 6. Pp. 1814-1817. DOI: 10.1016/s0022-5347(05)67550-7. 40. Working group of ESGE, ESHRE, and WES et al. Recommendations for the surgical treatment of endometriosis. Part 2: deep endometriosis. Human Reproduction Open. 2020. No. 1. p. hoaa002. Материал поступил в редакцию 31.05.25 CLINICAL ASPECTS OF BLADDER ENDOMETRIOSIS: OVERVIEW OF CURRENT DATA F.F. Minnullina, Candidate of Medical Sciences, Head of the Department of Obstetrics and Gynecology, Head of the Gynecological Department No. 2 Institute of Basic Medicine and Biology FSAEI HE Kazan (Volga) Federal University (420012, Russia, Kazan, Karl Marx St., 76, building 1) State Autonomous Health Care Institution Sadykov City Clinical Hospital No. 7 (420103, Russia, Kazan, Marshal Chuikova St., 54) E-mail: [email protected] L.M. Mukhametzyanova, Lecturer, Department of Obstetrics and Gynecology, Obstetrician-Gynecologist of the Gynecological Department No. 2 Institute of Fundamental Medicine and Biology FSAEI HE Kazan (Volga) Federal University (420012, Russia, Kazan, Karl Marx St., 76, building 1) State Autonomous Health Care Institution Sadykov City Clinical Hospital No. 7 (420103, Russia, Kazan, Marshal Chuikova St., 54) E-mail: [email protected] Ch.R. Valieva, Student Institute of Fundamental Medicine and Biology FSAEI HE Kazan (Volga) Federal University (420012, Russia, Kazan, Karl Marx St., 76, building 1) E-mail: [email protected] R.S. Botina, Student Institute of Fundamental Medicine and Biology FSAEI HE Kazan (Volga) Federal University (420012, Russia, Kazan, Karl Marx St., 76, building 1) E-mail: [email protected] U.B. Israilova, Student Institute of Fundamental Medicine and Biology FSAEI HE Kazan (Volga) Federal University (420012, Russia, Kazan, Karl Marx St., 76, building 1) E-mail: [email protected] B.I. Iskendarov, Student Institute of Fundamental Medicine and Biology FSAEI HE Kazan (Volga) Federal University (420012, Russia, Kazan, Karl Marx St., 76, building 1) E-mail: [email protected] R.R. Zyabbarov, Student Institute of Fundamental Medicine and Biology FSAEI HE Kazan (Volga) Federal University (420012, Russia, Kazan, Karl Marx St., 76, building 1) E-mail: [email protected] N.R. Aliyev, Student Institute of Fundamental Medicine and Biology FSAEI HE Kazan (Volga) Federal University (420012, Russia, Kazan, Karl Marx St., 76, building 1) E-mail: [email protected] Abstract. Endometriosis is one of the common and significant diseases of the female genital system. The etiopathogenesis of the disease is not well understood. A rare form of the disease is bladder endometriosis, where overgrowth of endometrioid tissue occurs in the bladder wall. This localization is most characterized by hematuria, pain above the bosom, aggravated by urination and sexual intercourse. Treatment requires the involvement of a multidisciplinary team, including both conservative therapy and surgery. Purpose of the study. Systematic analysis and synthesis of current scientific data on pathogenesis, clinical manifestations, diagnostic methods, therapeutic approaches in bladder endometriosis. Material and methods. Analysis of scientific articles published over the past 10 years with PubMed, eLibrary, Google Scholar on bladder endometriosis. Systematic search of publications by keywords: "endometriosis", "bladder endometriosis", "bladder", "endometriosis".

endometriosis, bladder, infiltrative endometriosis, drug therapy, chronic pelvic pain.